- Research article
- Open Access
Understanding how, why, for whom, and under what circumstances opt-out blood-borne virus testing programmes work to increase test engagement and uptake within prison: a rapid-realist review
BMC Health Services Research volume 19, Article number: 152 (2019)
Prisons represent a unique opportunity to diagnose blood-borne viruses. Opt-out testing is receiving increasing interest, as a result of mounting evidence to suggest that the manner in which a test offer is delivered, affects test uptake. Although the effectiveness of opt-out testing within the prison setting has been established, robust explanations are required for the variation in outcomes reported.
Rapid-realist review methodology was used to synthesise the literature on prison-based opt-out testing. The review was carried out in three phases. Phase one: An expert panel provided literature relevant to the implementation of opt-out testing within the English prison estate. Unstructured searches were also conducted to identify other social programmes where “opt-out” had been used to increase uptake. Phase two: a systematic search of six peer-review and five grey literature databases was carried out to identify empirical data on opt-out testing within the prison setting. Phase three: Additional non-exhaustive searches were carried out to identify literature that reinforced emergent concepts. The development of programme theory took place with each iteration and was validated in consultation with stakeholders.
Programme theory was constructed for two outcomes: the proportion of intake offered a test and the proportion offered that accepted testing. The proportion of intake offered testing was influenced by the timing of the test offer, which was often delayed due to barriers to prisoner access. The decision to accept testing was influenced by concerns about confidentiality, fear of a positive diagnosis, a prisoner’s personal interpretation of risk, discomfort with invasive procedures, trust in healthcare, and the fidelity of the opt-out offer.
This review identified important implementation considerations that moderate the effectiveness of opt-out testing programmes. It also highlighted a lack of appreciation for the theoretical underpinnings of opt-out programmes and tension around how to implement testing in a manner that adheres to both default theory and informed consent. It is anticipated that results will be used to inform the design and implementation of subsequent versions of these programmes, as well as catalyse further in-depth analysis into their operation within the unique context of prison.
Hepatitis C (HCV), hepatitis B (HBV), and the human immunodeficiency virus (HIV) are blood-borne viruses (BBVs), which cause significant morbidity and mortality globally. Biomedical innovation has provided effective treatment options for infection with these BBVs . However, in light of new global targets aimed at the elimination of viral hepatitis by 2030  and 90–90-90 HIV targets for 2020, the need for effective case-detection strategies is becoming increasingly acute [1, 3].
Opt-out testing for BBVs has been suggested as a method of case detection, in light of positive results from other opt-out health programmes, such as opt-out organ donation and opt-out antenatal HIV testing [4,5,6]. It involves a subtle shift in the way the test offer is delivered . Unlike opt-in testing, opt-out does not require a person to expressly agree to undergo a test, instead they are notified that testing will be performed unless they explicitly decline . Opt-out therefore represents a more paternalistic approach to eliciting consent .
Opt-out BBV testing has begun to filter into routine medical practice, often targeted at high-risk communities . Prisons represent a particularly high-risk environment, with the criminalisation of drug use and the association between drug dependency and crime, elevating the prevalence of BBV infection [10, 11]. In response, the Centers for Disease Control and Prevention has recommended opt-out HIV testing within US prisons  and in 2014, phased implementation of an opt-out testing strategy for HIV, HCV, and HBV, developed by Public Health England (PHE), the National Health Service England (NHSE), and Her Majesty’s Prison and Probation Service (HMPPS), began throughout the English prison estate . Dried-blood spot testing (DBST) has been recommended for use in the English strategy, as it requires minimal training and can be easier to perform for those with a history of injecting drugs .
Systematic review evidence suggests that opt-out programmes can increase test uptake, when compared with opt-in, whilst avoiding many of the ethical debates that surround mandatory testing . However, there exists considerable variation in the way opt-out BBV test programmes are implemented and consequently the outcomes produced [5, 13].
Although some explanations have been offered for these different outcomes [7, 13], there remains little robust theory to help better implement and run opt-out testing programmes within prison. This review sought to remedy this, by explaining how, why, for whom, and under what conditions opt-out programmes testing for HIV, HCV, and HBV within prison are likely to be effective [14, 15]. Results were targeted at the English prison estate, although it was hoped that they would also serve as a general guide for other programmes in other contexts.
Realist methodology is increasingly being used to explore the “black box” of complex health programmes, with the aim of constructing an explanatory framework for how, why, and when they work . Applied to secondary research, realist reviews have emerged as robust ways of developing these insights [15, 16, 19]. However, realist reviews are expansive and consequently resource intensive . Out of necessity, RRRs emerged as an alternative, time-responsive, approach suited to small and emerging bodies of literature, or as a first step of a multi-phase project [16, 20, 21].
RRRs develop programme theory, an explanation for how a programme brings about intended and unintended changes to a social phenomenon within a given context [18, 22, 23]. RRRs develop this theory by describing the interaction between the programme’s context, the generative forces stimulated by the intervention (mechanisms), and outcomes. Programme theory is therefore often expressed using the Context-Mechanism-Outcome (CMO) heuristic of realist evaluation . As the constituents of these CMOs can be interpreted in different ways, the review team clarified their shared understanding early in the review process (see glossary of terms in Table 1) [18, 22].
The RRR followed the broad steps detailed by Saul et al. (2013). The review team began by securing support from the London BBV Core Steering Group, a commissioning body tasked with overseeing BBV service provision (including opt-out testing) for the London prison estate. The group was comprised of stakeholders from NHSE, PHE, HMPPS, the Hepatitis C Trust, and representatives from the different healthcare providers at each London prison, and therefore acted as both an expert panel and reference group (providing knowledge on current practice). Through collaboration with the Steering Group, a series of research questions were developed :
“What are the key outcomes of public health interest, from opt-out testing within a prison context?”
“What are the generative forces, catalysed by opt-out testing programmes for BBVs within prison, that produce these outcomes?”
“How does the physical and social context of different prisons, influence the expression of these generative forces?”
“What is recommended to improve these public health outcomes?”
To answer these questions, iterative searching was used to construct, refine, and reinforce a programme theory for opt-out BBV testing using the literature (Fig. 1) [15, 16]. As the search and analysis process varied between each phase, it is described sequentially. All search results were handled using MENDELY bibliographic software.
In phase one, the review team narrowed the scope of the review and developed a provisional programme theory [15, 16]. To do this, the Steering Group supplied the research team with documents used in the development of the English opt-out test programme . In collaboration with the Steering Group, a generic process for opt-out testing was developed and two outcomes of public health interest identified.
Provisional programme theory was then constructed around these two outcomes. Documents sent by the Steering Group were supplemented with literature identified via a series of unstructured searches, carried out on Google/scholar and MEDLINE for previous programmes that used opt-out to enhance uptake. Phase one articles did not undergo a formal process of eligibility review or quality appraisal, as they were only used to develop the framework that structured subsequent review iterations .
With the provisional programme theory developed, the review team then conducted a systematic search for empirical data to refine that theory. A structured search algorithm was developed for bibliographic databases and piloted in MEDLINE, in consultation with a database expert based at the Royal Free London NHS Foundation Trust’s Medical Library. Search terms focused on opt-out testing within a prison context and were informed by Rumble’s et al. (2015) search strategy for a systematic review of routine test methods for BBVs in prison (Table 2) .
The search did not specify testing for HCV, HBV, or HIV, meaning articles discussing cousin interventions, which nonetheless could be useful for theory refinement, would be identified . MEDLINE, PsycInfo, EMBASE, Scopus, CINHAL+, and ASSIA were all searched using the systematic algorithm (amended as required for each database) in June 2017 (Additional file 1). A search of five grey literature databases (ProQuest Dissertations and Theses Global, DART-Europe-E-Theses Portal, Open Grey, Google Scholar, and “.GOV”) was also carried out in June 2017 .
Search results underwent a formal process of eligibility assessment and quality appraisal. Each stage was conducted independently by at least two authors, with disagreements resolved by discussion with a third author. Citations had titles and abstracts reviewed against the following criteria: “Does the citation indicate a prison context?”; “Does the citation indicate testing for a physical disease?”; and “Does the citation discuss physical disease in a population not an individual?”
Any citations that failed to answer “yes” to these questions were excluded. Citations then had their full-text downloaded and were assessed against three dimensions of relevance: “Provides information related to mechanisms triggered by opt-out testing”; “Provides information on outcomes of opt-out testing”; “Provides contextual information related to opt-out testing within prisons”.
Articles that did not provide information on one of these dimensions were excluded. A traffic light system was then used to highlight how many dimensions were covered by each article (red articles covered one dimension, orange two, and green three). Each reviewer also assigned articles a subjective score from 1 to 10, to indicate how useful they believed it would be in the analysis. An average of the two reviewers’ scores was taken and assigned alongside the colour, enhancing transparency, and allowing for some prioritisation of articles. Articles designated red and with a low score (≤4), were reviewed by authors again and their inclusion discussed.
The Mixed Methods Quality Appraisal Tool  was used for quality assessment of primary research and the Critical Appraisal Skills Programme: Systematic Review Checklist for systematic reviews. The unit of analysis was the contributing evidence, although an overall quality score was assigned . If a piece of information within an article was deemed low quality, it was excluded, but other pieces of data of acceptable quality were retained from the article [15, 19]. As grey literature and literature review articles did not undergo quality assessment, data on context and mechanism were included if it was supported by, or consistent with, data from other empirical articles, but quantitative outcomes were not used.
Data from articles were annotated and coded as either context, mechanism, or outcome. This evidence was then grouped into a realist matrix, allowing for theming across the matrix . Data was synthesised with the provisional programme theory developed during phase one, via a process of adjudication and amalgamation, producing a refined list of CMO configurations (CMOc) . These were discussed in data meetings with authors and validated during meetings with the expert panel and reference group . One author also observed staff training and opt-out testing conducted within two English prisons, further helping validate CMOcs.
Following phase two, a refined programme theory had begun to take shape. However, to further reinforce the CMOcs developed, a series of purposive unstructured searches were undertaken on MEDLINE and Google/scholar [18, 26]. Searches primarily focused on acquiring qualitative and theoretical articles, discussing testing for BBVs in prison and non-prison settings. It was not an exhaustive process, but aimed to purposefully draw together a diverse range of literature, which was then used to reinforce the theoretical “backbone” of the refined programme theory .
Phase three articles did not undergo a formal process of eligibility assessment, but were assessed for quality using the Mixed Methods Quality Appraisal Tool . They did not contribute evidence to outcomes, but were included as they reinforced aspects of context and mechanism .
The expert panel supplied the research team with 26 documents and 18 articles were identified via unstructured searching (Fig. 2). A further 3435 citations were identified via database searching and 663 through grey literature searching. After duplicates were removed, 3381 titles and abstracts were screened, and 457 articles remained for full-text review. 11 documents from the expert panel and 9 articles from the unstructured search (Additional file 2) were used in framework, process, and provisional programme theory development. 29 empirical articles (Table 3) were used in programme theory refinement. These were supplemented with a further 11 articles identified through purposive unstructured searching (Additional file 3).
Process theory and contextual framework
Reports identified by the expert panel were used to develop a generic process for opt-out testing (Additional file 4). A range of potential outcomes of public health interest were identified. The research team focused on the proportion of intake offered a test and the proportion offered that accepted testing, as these outcomes were highlighted by the Steering Group as key targets for the opt-out intervention [16, 27]. A framework was also developed, to aid the research team conceptualise the sphere of contextual influences that could affect these outcomes (Fig. 3).
Provisional programme theory
Using data from phase one, provisional programme theory was constructed around the two outcomes selected (Fig. 4).
In terms of test uptake, educational information covering transmission risk, symptoms, and the importance of testing was anticipated to play a priming role during the test offer, helping prisoners more accurately interpret their risk of infection and assess costs and benefits of testing .
The way testing was offered was also expected to influence uptake. Offering testing in an opt-out manner is not be the norm for health workers, therefore training was considered essential to ensure test offers were opt-out in practice (Fig. 4) .
Finally, the unstructured searches carried out during phase one, found literature that suggested the Default Effect, a component of Nudge Theory, underpinned opt-out [18, 25]. The Default Effect suggests that for any choice or action, there is a tendency for individuals to stick with the default option . By aligning the default option of a BBV testing programme with the public health objective (prisoner takes a test), opt-out was hypothesised to encourage test uptake in a variety of ways [4, 33, 34]:
Switching cost: Individuals incur a cost (e.g. having to justify decision or fill out a form) when opting-out of testing. If this cost exceeds the benefit of opting out, then it is irrational for the individual to do so .
Loss aversion: Individuals tend to weight losses more heavily against equivalent gains. By making testing the default option, loss of benefits provided by testing are weighted more heavily against potential gains of not testing .
Cognitive effort: Making an active decision requires cognitive effort. By making testing the default option, opt-out testing exploits individuals bias not to expend this effort, encouraging those who do not exhibit a strong preference to test .
Refined programme theory
6 CMOcs for the proportion offered testing and 7 for test uptake are presented. Additional file 5 contains the full list of CMOcs developed from the RRR.
Under each CMOc, background information is provided. The configuration is then presented in italics, with components explicitly highlighted: C = context, MR = mechanism resource, MRE = mechanism reasoning response and O = outcome. Exemplifying data, where available, is then presented, providing the reader access to empirical evidence that contributed to theory development and refinement. As reported in other realist reviews, empirical evidence rarely presented a clear description of all three constituents, making abductive reasoning critical to ensure complete CMOc articulation.
Proportion offered testing
There was significant variation in the proportion offered testing between different prison-based opt-out programmes, ranging from 13 to 100% [13, 37,38,39,40,41,42,43]. Failure to offer testing was an implementation issue, operating at various conceptual levels of prison context (Fig. 3).
CMOc 1: Delayed test offer
The timing of the test offer was a salient factor affecting the proportion offered testing [5, 11, 13, 39, 42,43,44,45,46,47]. When prisoners first arrive, all new intake usually undergo a first night health check. Seven studies reported opt-out testing conducted during this process [8, 37, 38, 45, 46, 48]. Seven other articles reported testing taking place anywhere between 3 and 14 days after first reception, often during a secondary health check [39, 40, 44, 49,50,51,52]. Testing at a secondary clinic often occurred because of a perceived lack of time during the first night or because the first night health check was reserved for dealing with urgent healthcare problems that required immediate intervention [39, 40, 44, 49,50,51,52].
In a prison that has a rapid population turn-over (C), a programme mandated delay in engaging intake with an opt-out test offer (MR) reduces the proportion of intake offered a test (O), as some individuals have already been released or transferred (C).
This was exemplified during Beckwith’s et al. (2012) evaluation of rapid-HIV testing within three urban jails. A 3–4 day delay in the Baltimore Department of Corrections, resulted in a 13% test offer proportion compared to 100 and 89% respectively in the Philadelphia Prison System and District of Columbia Department of Corrections, which offered testing during a first night health check .
CMOc 2: Early testing and capacity to consent
A higher proportion of prisoner’s lack capacity to consent on the first night (e.g. undergoing substance abuse withdrawal) (C). As opt-out testing requires informed consent (C), health workers that identify this lack of capacity (MR) and view it as important (MRE) will not offer testing (O).
This was highlighted in two prospective control trials conducted in US jails, which found 10–11% of new intake were not medically competent to be tested immediately upon entrance, limiting the utility of first night testing [42, 43]. This dropped to 0–4% when testing took place 1–7 days after first reception [42, 43].
CMOc 3: Prioritisation of security and prison processes
Prison officers have a challenging role, particularly when budget cuts have strained the workforce (C). Opt-out testing often requires prison officers to collect prisoners, bring them to clinic, and supervise them (MR). Officers prioritise security and prison processes over escorting and monitoring prisoners at clinic (MRE), meaning prisoners frequently do not arrive, or are not allowed to be at the clinic, to be offered testing (O).
This process of prioritisation was demonstrated in quotes from qualitative work with prison officers: “the issue with the health should be considered, if its’ not life threatening.. .then security should be the priority” . This was also highlighted by health workers: “I think you can’t get away from the fact that we’re entirely dependent on prison officers to deliver healthcare services.. .We’ve lost, since I’ve been here, 25% of prison officers.. .Who would have thought that ‘do not attends’ are a massive problem in prison?” .
CMOc 4: Provider capacity to run clinics
Prisons are a demanding place to work (high burden of mental illness, physical morbidity, and regular medical emergencies) (C) and budget deficits result in health staff cuts (C). These working conditions reduce the capacity of health staff (MR), forcing them to prioritise certain activities (MRE), such as dealing with urgent conditions or emergencies, resulting in testing clinics being delayed or cancelled and prisoners not offered a test (O).
Insufficient staffing was most frequently reported in response to the question “what other barriers did you encounter when trying to complete an HIV test.. .at intake?”, delivered to providers in a New York City Jail .
CMOc 5: Refusal to attend clinic
When testing is conducted concurrently with other prison activities (C), attendance at clinic becomes an opportunity cost for the prisoner (MR). If health is a lower priority, relative to the other activity (MRE), the prisoner will not attend clinic (O).
CMOc 6: Rebooking prisoners
Budget deficits have led to health staff cuts (C). Stretched health workers (C) that are required to re-book prisoners (MR), prioritise medical emergencies and conducting other tasks that require immediate attention (MRE), further delaying the test offer (O). Overworked health staff (C) may also forget to rebook a prisoner (MRE), delaying the realisation of the test offer (O).
In high-turnover prison settings (C), a failure to rapidly rebook a prisoner (MR), reduces the proportion of people offered testing (O), as individuals may be released or transferred by the time they are rebooked (C).
The proportion of prisoners that accept a test under opt-out varied from 22 to 98% [13, 37,38,39,40,41,42,43]. There was a notable lack of switching costs, with most programmes simply requiring prisoners to verbally opt-out [8, 41, 48, 53]. Several costs and gains associated with opt-out BBV testing within a prison context were also identified. These were activated and modified depending on the presence of certain programme resources.
CMOc 1: Confidentiality and stigma (loss aversion)
BBVs are stigmatised within the prison context (C). Maintenance of confidentiality (MR) is therefore crucial, as prisoners will feel safe (MRE) to share personal information (O). If a prisoner distrusts prison healthcare’s ability to maintain confidentiality (MR), they may fear stigma (MRE), encouraging opt-out (O).
Officers view infectious prisoners as a personal risk and may attempt to elicit confidential information from health staff [51, 58]. The close contact between staff and prisoners also means information can be spread, both within and between staff and prisoner groups: “Would I tell somebody else, a close friend, if I knew they were in contact? Possibly yeah?” (prison officer) . Breaches in auditory and visual confidentiality can also occur when conducting testing, as a result of the confined environment, security requirements, and the increasing reliance on prisoners for the maintenance of the prison environment [39, 47, 51, 57,58,59,60,61].
CMOc 2: Coping with a positive diagnosis (loss aversion)
BBVs are a situational concern for many people within prison (C). The provision of supportive information (e.g. treatment options, dispelling myths around prognosis, and psychosocial support) (MR), reassures a prisoner about coping if they test positive (MRE), encouraging test uptake (O).
Failure to provide supportive information (MR) can leave people in prison feeling unable to cope with the perceived burden associated with a positive diagnosis (treatment, stigma, psychological distress, lifestyle changes) (MRE), encouraging opt-out (O).
This was captured in quotes from health staff: “Some clients will refuse to take the test out of fear of a positive result”  and prisoners: “Er, I don’t know really, [pause] er, I don’t really know, I mean, I think like I say, I think people are just frightened ye na. People are frightened to get the test ye na, thinking that it could be a killer not knowing what, not knowing what it actually is, what it actually does to you, I mean?” .
CMOc 3: Fear of an invasive procedure (loss aversion)
A proportion of prisoner’s fear needles (C). When testing is conducted using a venous sample method (MR), prisoners that are uncomfortable with the method of blood acquisition (MRE) may opt-out (O).
This was captured in quotes from health workers: “.. . I would say nine out of ten people say ‘I hate needles’ and tense up and freak out, and some people are really upset by it” and “They were definitely more compliant with it [oral testing]; they’re more willing to get it done as opposed to getting their blood drawn” . Less invasive sample measures, such as DBST or oral testing, may therefore help to minimise discomfort as a barrier to testing.
CMOc 4: Institutional recommendations and trust (loss aversion/recommendation)
Recommendations to test in circumstances of trust (C) provide an institutional social pressure (MR) that encourages an individual to comply with the perceived positive action (MRE), encouraging test uptake (O). However, institutional distrust is prevalent in prison (C). Institutional social pressure (MR) can be perceived as a coercive process of surveillance, triggering resistance from the individual (MRE) and encouraging opt-out (O) [59, 64, 67].
CMOc 5: Personal interpretation of risk (loss aversion)
Misconceptions around BBVs are common amongst prisoners (C). Prisoners that have been informed about modes of transmission and symptoms of the disease (MR) are empowered (MRE) to accurately interpret their risk of infection (O).
For prisoners that self-identify as “at risk” (C), testing can be an opportunity to confirm serostatus (MR), allowing the individual to either confront infection (MRE) or be reassured by a negative result (MRE), encouraging test uptake (O).
Prisoners that interpret themselves as low risk (C), but that face no other barriers to testing (MR), may still seek reassurance (MRE), encouraging test uptake (O). Prisoners that face other barriers to test uptake (e.g. fears around confidentiality or dislike of test method) (MR), may view testing as an unnecessary burden (MRE) and opt-out of testing (O).
A range of articles reported issues with the delivery of educational information, with this stage of testing often being truncated [13, 42, 43, 45,46,47, 54, 60]. In the absence of educational information, people in prison often inaccurately interpreted themselves as low risk, due to a lack of symptoms, or because they had tested previously [13, 37, 38, 40, 42,43,44, 46, 50].
CMOc 6: Defaults and capacity to consent (cognitive effort)
New prisoners often suffer from substance withdrawal, have untreated mental health conditions, are physically exhausted, and emotionally overwhelmed [11, 42, 43]. By making testing the default option and offering testing soon after prison entrance, individuals may be tested without understanding what it is they are testing for [8, 69].
New prisoners frequently lack capacity to provide informed consent (C). If the health worker fails to identify this and proceeds with an opt-out test offer (MR), these individuals may misunderstand what is taking place (MRE) or be unable to make an active decision to opt-out (MRE), instead appearing to comply with testing (O).
Grodensky et al. (2016) found that out of 871 patients undergoing an opt-out HIV test, 103 were not aware of being tested, 94 did not want to be tested, and 30 were not aware they were tested and did not want a test.
CMOc 7: Opt-out fidelity
The distinction between eliciting consent in an opt-in, opt-out, or mandatory manner is nuanced and difficult to operationalise in practice [5, 8, 48, 70]. The review highlighted variation in the delivery of an opt-out test, which may partially account for variation in test uptake.
If programme implementers misinterpret how to deliver an opt-out test (C), training and scripts provided to health workers (MR) will encourage them to comply (MRE) with the delivery of either an opt-in (O) or mandatory (O) test offer.
An opt-out test offer is not the norm (C). When health workers have little training, and no standard script (MR), the meaning of opt-out may be misinterpreted (MRE) resulting in either opt-in (O) or mandatory (O) test offers. The way testing is offered, when there is no standard script (MR), can also morph with each encounter, with rapport (C), situational distractions (C) and fatigue (C) all potentially influencing test delivery (O).
A survey conducted by Rosen et al. (2015) as part of an opt-out testing programme that had a 95% test uptake [8, 48], found that less than 40% of prisoners identified testing as voluntary, which was attributed to an ambiguous consent process and widespread failure of nurses to mention a prisoner’s right to decline the test .
60 articles were synthesised to provide CMOcs explaining how, why, for whom, and under what conditions opt-out programmes for HIV, HCV, and HBV might generate a high proportion of test offers and test uptake. The unstructured search conducted during phase one, identified a number of articles highlighting that the Default Effect underpins “opt-out”. It was notable that no documents supplied by the expert panel during phase one and none of the articles from phase two mentioned Nudge Theory or the Default Effect as a consideration in the development or subsequent evaluation of opt-out BBV testing within prison . It appears that these concepts, which underpin the intervention, have been widely forgotten, as “opt-out” is reproduced by stakeholders in different contexts .
Offered a test
Implementation factors were found to significantly limit the proportion of prison intake offered testing [8, 37, 38, 45, 46, 48]. Programmes that implement testing early can increase the proportion of people offered a test (particularly within high-turnover prisons), but may be inhibited by greater volumes of individuals unable to provide informed consent [42, 43]. Further work is required to determine whether the timing of the test offer has an impact on test uptake [42, 43]. Where possible, prisons with a short average incarceration length should look to conduct testing on the first night, during second reception, and at any appropriate subsequent clinics, in order to balance risk of release and capacity to consent [42, 43, 56].
It was noted that testing was also subject to a range of barriers, which limited provider access to prisoners. These barriers further delayed the realisation of the test offer and operated in causal chains , with several intermediate outcomes leading to the final outcome of a failed test offer (example in Fig. 5). Even when programmes specify an appropriate period within which the test offer should occur, given the average incarceration length of their population, it is likely that a proportion of prisoners will be engaged much later, all the time risking release.
The operational capacity of prison officers and health workers were reoccurring contextual features within these causal chains [5, 11, 47, 56]. Historic de-valuation of prisoner well-being is often enacted through budget cuts to the prison estate, reducing the operational capacity of the staff . Greater emphasis should be placed on prisoner well-being via appropriate funding of the prison estate, both out of public health and ethical necessity .
More immediate options for opt-out programmes struggling with engagement could include: complimentary sub-interventions to foster collaboration between health workers and prison officers, educational events in prison to encourage prioritisation of the programme, and incentivising clinic attendance for prisoners (e.g. by making it a compulsory pre-cursor for gym attendance) [44,45,46, 51, 55].
Varying numbers of people offered a test were found to opt-out [13, 37,38,39,40,41,42,43]. The lack of compelling switching costs, implemented by many opt-out programmes reviewed, may be explained by the absence of Nudge Theory in programme conception. Much of the power of opt-out strategies, when used in sectors like marketing, comes from “sleight of hand” tactics (e.g. using miniature font) [4, 34, 35]. Those implementing healthcare programmes do not have the luxury of such tactics and therefore need to optimise their use of defaults, whilst working within the ethical paradigm of informed consent [4, 34]. Programmes struggling with test uptake could therefore consider piloting minor switching costs (e.g. an opt-out justification form that prisoners are asked to complete ), although caution should be exercised to ensure that this does not become coercive.
The review also highlighted ethical considerations, related to the exploitation of individual bias not to expend cognitive effort under opt-out [4, 35]. Given the vulnerability of the population group, providers need to be vigilant of capacity to consent when offering testing, ensuring those that do not make an active decision about testing, do so from a lack of preference as opposed to inability as a result of substance withdrawal or mental illness [35, 42, 43].
Prisoners’ decision to accept testing or opt-out was however found to be influenced by a range of costs and benefits related to testing for BBVs. Although loss aversion suggests that this weighting should be in favour of testing, significant costs were identified, which provided a strong counterbalancing force (Fig. 6) [34, 35].
Resources such as confidentiality, education, trust, psychosocial support, and less invasive sample methods were found to be important at mitigating testing costs and encouraging test uptake (Fig. 6). These resources were frequently built into the opt-out programmes reviewed [5, 11, 27]. For programmes that experienced issues with the implementation of one or several of these resources, further research is required to unpick why these different programme resources were unsuccessfully realised within different prison contexts.
Finally, refined theory highlighted challenges to the fidelity of opt-out, which stemmed from the conceptualisation of the offer by programme implementers, misinterpretation by those delivering the test offer, and/or due to contextual pressures [5, 8, 48, 70]. The need to acquire consent can naturally lead to asking a person if they would “like to test” [42, 43], failing to fully adhere with principles of opt-out and potentially limiting uptake [7, 13]. However, not informing a prisoner that they have the right to decline, given the punitive context, borders on a mandatory approach [75, 76] and raises ethical questions if prisoner’s interpret it as such [8, 48].
Further work is required to determine what constitutes an opt-out offer and how adherence to opt-out can be ensured in practice. However, a written set of words for health workers to use when offering testing, could help to standardise the process [5, 7, 8, 48, 70]. A set of words conceived by NHSE and PHE commissioners, but not implemented during the English service reconfiguration, were synthesised with findings from this review to develop a recommended set of words that were then shared with the London BBV Core Steering Group (Additional file 6).
Much of the empirical data came from opt-out HIV testing conducted within US prisons, potentially limiting the applicability of refined theories to the English prison context, where HIV, HCV, and HBV are tested for together, commonly using DBST. However, validation with English stakeholders, as well as observation of opt-out training and testing in two English prisons, was undertaken in an attempt to ensure relevance .
Many articles did not include information about the wording of the offer, meaning reviewers were forced to assume that testing really was, for the most part, offered as opt-out [37,38,39,40,41, 46, 53, 55, 67, 77]. It is important that details, preferably a standard quote, for the process of gaining consent to test, are presented, providing transparency and allowing for an assessment of the true nature of the offer process [7, 8, 42, 43, 48].
The reviewers were also heavily reliant on author justifications for failure to offer testing and prisoner opt-out. Qualitative insights into the reasoning processes of different prison stakeholders were scarce and therefore often inferred. In all reviews that utilise realist synthesis methodology, there will be some judgement involved when making inferences between the data found in included studies [18, 78], however further qualitative research is required to provide greater insight into the decision-making process of relevant stakeholders.
The framework sketched out in this review is therefore intended to provide a starting point on which to build our understanding of opt-out BBV programmes in prison . The CMOcs presented are falsifiable and require further refinement using primary data . To help enable this process, and in line with best practice, the authors have attempted to maximise the transparency of the review process .
Opt-out testing programmes for BBVs within prison have been found to increase test uptake, however evaluative work has reported a high degree of variability in key outcomes. This synthesis highlighted important implementation considerations, which influence the effectiveness of these programmes. The fidelity of opt-out was also questionable, both at the programme level and because of inter and intra health worker variability in the way testing is offered.
Programme implementers are encouraged to utilise Nudge Theory within their opt-out BBV test design, to take full advantage of the Default Effect for public health benefit. They are also encouraged to think carefully about the timing of the test offer, work with prison authorities to overcome logistical barriers to accessing prisoners, explore ways of enhancing the fidelity of an opt-out offer, and ensure the realisation of key programme resources that can mitigate testing costs.
Dried blood spot testing
Human immunodeficiency virus
Her Majesty’s Prison and Probation Service
National Health Service England
Public Health England
Hagan LM, Wolpe PR, Schinazi RF. Treatment as prevention and cure towards global eradication of hepatitis C virus. Trends Microbiol. 2013;21:625–33.
The World Health Organization. Draft global health sector strategy on viral hepatitis. Geneva: The World Health Organization; 2015.
Brown AE, Nardone A, Delpech VC. WHO ‘treatment as prevention’ guidelines are unlikely to decrease HIV transmission in the UK unless undiagnosed HIV infections are reduced. AIDS. 2014;28:281–3.
Johnson EJ, Goldstein DG. Defaults and donation decisions. Transplantation. 2004;78:1713–16.
Public Health England. Blood-borne Virus Opt-Out Testing in Prisons: Preliminary Evaluation of Pathfinder Programme, Phase 1, April–September 2014. 2015.
Ibekwe E, Haigh C, Duncan F, Fatoye F. Clinical outcomes of routine opt-out antenatal human immunodeficiency virus screening: a systematic review. J Clin Nurs. 2017;26:341–55.
Montoy JCC, Dow WH, Kaplan BC. Patient choice in opt-in, active choice, and opt-out HIV screening: randomized clinical trial. BMJ. 2016;532:h6895.
Rosen DL, Golin CE, Grodensky CA, May J, Bowling JM, DeVellis RF, et al. Opt-out HIV testing in prison: informed and voluntary? AIDS Care. 2015;27:545–54.
Manson NC. Normative consent is not consent. Cambridge Q Healthc ethics. 2013;22:33–44.
Larney S, Kopinski H, Beckwith CG, Zaller ND, Jarlais D, Des HH, et al. Incidence and prevalence of hepatitis C in prisons and other closed settings: results of a systematic review and meta-analysis. Hepatology. 2013;58:1215–24.
Centres for Disease Control and Prevention. HIV Testing Implementation Guidance for Correctional Settings. 2009.
Craine N, Whitaker R, Perrett S, Zou L, Hickman M, Lyons M. A stepped wedge cluster randomized control trial of dried blood spot testing to improve the uptake of hepatitis C antibody testing within UK prisons. Eur J Pub Health. 2015;25:351–257.
Rumble C, Pevalin DJ, O’Moore É. Routine testing for blood-borne viruses in prisons: a systematic review. Eur J Pub Health. 2015;25:1078–88.
Kirsh SR, Aron DC, Johnson KD, Santurri LE, Stevenson LD, Jones KR, et al. A realist review of shared medical appointments: how, for whom, and under what circumstances do they work? BMC Health Serv Res. 2017;17:113.
Pawson R, Greenhalgh T, Harvey G, Walshe K. Realist review – a new method of systematic review designed for complex policy interventions. J Health Serv Res Policy. 2005;10:21–34.
Saul JE, Willis CD, Bitz J, Best A. A time-responsive tool for informing policy making: rapid realist review. Implement Sci. 2013;8:103.
Wong G, Greenhalgh T, Westhorp G, Buckingham J, Pawson R. RAMESES publication standards: realist syntheses. BMC Med. 2013;11:21.
Wong G, Westhorp G, Pawson R, Greenhalgh T. Realist Synthesis: RAMESES Training Materials; 2013.
Pawson R. Evidence-based policy. London: SAGE Publications Ltd; 2006.
Tsang JY, Blakeman T, Hegarty J, Humphreys J, Harvey G. Understanding the implementation of interventions to improve the management of chronic kidney disease in primary care: a rapid realist review. Implement Sci. 2015;11:47.
Parkinson M, SMM C, Rushmer R, Abley C. Investigating what works to support family carers of people with dementia: a rapid realist review. J Public Health. 2016;10:1–12.
Gee M, Bhanbhro S, Cook S, Killaspy H. Rapid realist review of the evidence: Achieving lasting change when mental health rehabilitation staff undertake recovery-oriented training. J Adv Nurs. 2017;73:1775–91.
Pawson R, Tilley N. Realistic evaluation. London: Sage; 1997.
Pluye P, Robert E, Cargo M, Bartlett G, O’Cathain A, Griffiths F, et al. Proposal: A mixed methods appraisal tool for systematic mixed studies reviews; 2011. p. 1–8.
Jagosh J, Pluye P, Macaulay AC, Salsberg J, Henderson J, Sirett E, et al. Assessing the outcomes of participatory research: protocol for identifying, selecting, appraising and synthesizing the literature for realist review. Implement Sci. 2011;6:24.
Papoutsi C, Mattick K, Pearson M, Brennan N, Briscoe S, Wong G. Social and professional influences on antimicrobial prescribing for doctors-in-training: a realist review. J Antimicrob Chemother. 2017;72:2418–30.
Public Health England. Opt-out blood-borne virus test algorithm guidance notes. London: Public Health England; 2014.
Shaw J, Senior J, Hassan L, King D, Mwasambilli N, Lennox C, et al. An evaluation of the reception screening process used within prisons in England and Wales. Manchester: The Offender Health Research Network; 2008.
Public Health England. BBV bulletin: Special Edition. 2016.
The Hepatitis C Trust. The blood-borne virus opt-out testing policy for prisons in England: An analysis of need towards full implementation. London: The Hepatitis C Trust; 2016.
Public Health England. Blood-borne virus (BBV) testing flash card. 2014.
The Hepatitis C Trust. Guidance on hepatitis C care pathway. 2016.
Bayer R, Fairchild AL. Changing the paradigm for HIV testing-the end of exceptionalism. N Engl J Med. 2006;355:647–9.
Halpern S, Ubel P, Asch D. Harnessing the power of default options to improve health care. N Engl J Med. 2007;357:1340–4.
Thaler R, Sunstein C. Nudge: improving decisions about health, wealth and happiness. London: Penguine Books; 2009.
Keller PA, Harlam B, Loewenstein G, Volpp KG. Enhanced active choice: a new method to motivate behavior change. J Consum Psychol. 2011;21:376–83.
Centers for Disease Control and Prevention. Routine HIV screening during intake medical evaluation at a County Jail - Fulton County, Georgia, 2011–2012. MMWR Morb Mortal Wkly Rep. 2013;62:495–7.
Spaulding AC, Kim MJ, Corpening KT, Carpenter T, Watlington P, Bowden CJ. Establishing an HIV screening program led by staff nurses in a county jail. J Public Heal Manag Pract. 2015;21:538–45.
Lucas KD, Eckert V, Behrends CN, Wheeler C, MacGowan RJ, Mohle-Boetani JC. Evaluation of routine HIV opt-out screening and continuum of care services following entry into eight prison reception centers--California, 2012. MMWR Morb Mortal Wkly Rep. 2016;65:178–81.
Nelwan EJ, Isa A, Alisjahbana B, Triani N, Djamaris I, Djaja I, et al. Routine or targeted HIV screening of Indonesian prisoners. Int J Prison Health. 2016;12:17–26.
Beckwith CG, Bazerman L, Cornwall AH, Patry E, Poshkus M, Fu J, et al. An evaluation of a routine opt-out rapid HIV testing program in a Rhode Island jail. AIDS Educ Prev. 2011;23(3 SUPPL):96–109.
Kavasery R, Maru DS-R, Cornman-Homonoff J, Sylla LN, Smith D, Altice FL. Routine opt-out HIV testing strategies in a female jail setting: a prospective controlled trial. PLoS One. 2009;4:e7648.
Kavasery R, Maru DS-R, Sylla LN, Smith D, Altice FL. A prospective controlled trial of routine opt-out HIV testing in a Men’s jail. PLoS One. 2009;4:e8056.
Rice D. Design, implementation and evaluation of a jail-based HIV screening program. [Doctor of Public Health thesis on the Internet]. Massachusetts: Boston University; 2010 [cited 2017]. Available from: https://search.proquest.com/docview/761149301/?pq-origsite=primo
Peter P. Impact of opt-out and opt-in HIV testing and education program on discovering HIV in jail populations. [PhD thesis on the Internet]. Minneapolis: Walden University; 2009 [cited 2017]. Available from: https://search.proquest.com/docview/965596136/?pq-origsite=primo
Cole J, Hotton A, Zawitz C, Kessler H. Opt-out screening for chlamydia trachomatis and Neisseria gonorrhoeae in female detainees at Cook County jail in Chicago. IL Sex Transm Dis. 2014;41:161–5.
Sabharwal CJ, Muse KH, Alper H, Begier E, McNeill M, Galeta G, et al. Jail-based providers’ perceptions of challenges to routine HIV testing in new York City jails. J Correct Heal care. 2010;16:310–21.
Grodensky CA, Rosen DL, Hino S, Golin CE, Wohl DA. Opt-out HIV testing of inmates in North Carolina prisons: factors associated with not wanting a test and not knowing they were tested. AIDS Behav. 2016;20:859–69.
Centers for Disease Control and Prevention. HIV screening of male inmates during prison intake medical evaluation--Washington, 2006–2010. MMWR Morb Mortal Wkly Rep. 2011;60:811–3.
Public Health England. Pentonville prison BBV screening evaluation. London: Public Health England; 2016.
Jack K, Islip N, Linsley P, Thomson B, Patterson A. Prison officers’ views about hepatitis C testing and treatment: a qualitative enquiry. J Clin Nurs. 2017;26:1861–8.
Rosen DL, Wohl DA, Golin CE, Rigdon J, May J, White BL, et al. Comparing HIV case detection in prison during opt-in vs. opt-out testing policies. JAIDS J Acquir Immune Defic Syndr. 2016;71:e85–8.
Beckwith CG, Nunn A, Baucom S, Getachew A, Akinwumi A, Herdman B, et al. Rapid HIV testing in large urban jails. Am J Public Health. 2012;102:S184–6.
Walker J, Sanchez R, Davids J, Stevens M, Whitehorn L, Greenspan J, et al. Is routine testing mandatory or voluntary? [with reply]. Clin Infect Dis. 2005;40:319–21.
Schoenbachler BT, Smith BD, Seña AC, Hilton A, Bachman S, Lunda M, et al. Hepatitis C Virus Testing and Linkage to Care in North Carolina and South Carolina Jails, 2012–2014. Public Health Rep. 2016;131 2_suppl:98–104.
REACH. Prison BBV Champions Training. 2015.
Muessig KE, Rosen DL, Farel CE, White BL, Filene EJ, Wohl DA. “Inside these fences is our own little world”: prison-based HIV testing and HIV-related stigma among incarcerated men and women. AIDS Educ Prev. 2016;28:103–16.
MacDonald M. People with problematic drug use and HIV/AIDS in European prisons: an issue of patient confidentiality. Int J Prison Health. 2006;2:207–18.
Elkington KS, Jaiswal J, Spector AY, Reukauf H, Tesoriero JM, Nash D, et al. Can TasP approaches be implemented in correctional settings?: a review of HIV testing and linkage to community HIV treatment programs. J Health Care Poor Underserved. 2016;27:71–100.
Khaw F-M, Stobbart L, Murtagh MJ. “I just keep thinking I haven’t got it because I’m not yellow”: a qualitative study of the factors that influence the uptake of hepatitis C testing by prisoners. BMC Public Health. 2007;7:98.
Gagnon M, Jacob JD, Cormier L. Total Control. J Forensic Nurs. 2013;9:154–60.
Rhodes T, Treloar C. The social production of hepatitis C risk among injecting drug users: a qualitative synthesis. Addiction. 2008;103:1593–603.
Rosen DL. Factors associated with voluntary HIV testing and serostatus among North Carolina state prisoners, 2004--2006. [PhD thesis on the Internet]. Chapel Hill: University of North Carolina; 2007 [cited 2016]. Available from: https://search.proquest.com/docview/304843474/?pq-origsite=primo
Grinstead O, Seal DW, Wolitski R, Flanigan T, Fitzgerald C, Nealey-Moore J, et al. HIV and STD testing in prisons: perspectives of in-prison service providers. AIDS Educ Prev. 2003;15:547–60.
Hickman M, McDonald T, Judd A, Nichols T, Hope V, Skidmore S, et al. Increasing the uptake of hepatitis C virus testing among injecting drug users in specialist drug treatment and prison settings by using dried blood spots for diagnostic testing: a cluster randomized controlled trial. J Viral Hepat. 2008;15:250–4.
The Hepatitis C Trust. Increasing hepatitis B and C testing in the prison setting: The use of new diagnostics at HMP Manchester. 2012.
Beckwith CG, Zaller ND, Fu JJ, Montague BT, Rich JD. Opportunities to diagnose, treat, and prevent HIV in the criminal justice system. JAIDS J Acquir Immune Defic Syndr. 2010;55(Suppl 1):S49–55.
Noland CM, Vaughn NA, Sun S, Schlecht HP. Understanding patients’ perspectives on opt-out, incentivized, and mandatory HIV testing. Int J Health Sci (Qassim). 2015;9:293–303.
Walker J, Sanchez R, Davids J, Stevens M, Whitehorn L, Greenspan J, et al. Is routine testing mandatory or voluntary? Clin Infect Dis. 2005;40:319 doi:1058–4838/2005/4002–0021.
Public Health England. HMP Pentonville Blood Borne Virus Opt Out progress report. London: Public Health England; 2016.
Pawson R. The science of evaluation: a realist manifesto. London: SAGE Publications Ltd; 2013.
Jagosh J, Bush PL, Salsberg J, Macaulay AC, Greenhalgh T, Wong G, et al. A realist evaluation of community-based participatory research: partnership synergy, trust building and related ripple effects. BMC Public Health. 2015;15:725.
Prison Reform Trust. Bromley Briefings Prison Factfile. 2016.
Brunsden A. Hepatitis C in prisons: Evolving toward decency through adequate medical care and public health reform. Public Law Leg Theory Res Pap Ser. 2006;54:465.
Andrinopoulos K, Kerrigan D, Figueroa JP, Reese R, Gaydos CA, Bennett L, et al. Establishment of an HIV/sexually transmitted disease programme and prevalence of infection among incarcerated men in Jamaica. Int J STD AIDS. 2010;21:114–9.
Pierce MW. Screening for HIV in jails and prisons. Health Aff. 2014;33:1103.
Centers for Disease Control and Prevention. Routine jail-based HIV testing - Rhode Island, 2000–2007. MMWR Morb Mortal Wkly Rep. 2010;59:742–5.
Wong G, Pawson R, Owen L. Policy guidance on threats to legislative interventions in public health: a realist synthesis. BMC Public Health. 2011;11:222.
Dalkin SM, Greenhalgh J, Jones D, Cunningham B, Lhussier M. What’s in a mechanism? Development of a key concept in realist evaluation. Implement Sci. 2015;10:49.
PRISMA Group. PRISMA: Transparent reporting of systematic reviews and meta-analyses. 2009. http://www.prisma-statement.org/PRISMAStatement/PRISMAStatement.aspx. Accessed 2 Jan 2017.
Thanks to Dr. Justin Jagosh for supporting the authors in utilising the realist methodology. Thanks also to all members of the Blood-Borne Virus Steering Group for supporting this research by providing insight into the operation of opt-out testing in English prisons. Finally, thanks are extended to the NIHR HPRU in Blood Borne and Sexually Transmitted Infections Steering Committee: Caroline Sabin (Director), Anthony Nardone (PHE Lead), Catherine Mercer, Gwenda Hughes, Jackie Cassell, Greta Rait, Samreen Ijaz, Tim Rhodes, Kholoud Porter, Sema Mandal and William Rosenberg for providing critical feedback on the article.
This report is independent research by the National Institute for Health Research. The research was funded by the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at UCL in partnership with Public Health England (PHE) and in collaboration with the London School of Hygiene and Tropical Medicine. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the National Institute for Health Research, the Department of Health or Public Health England. The NIHR had no role in designing the research or in the collection, analysis, and interpretation of data.
Availability of data and materials
Datasets generated and analysed during the conduct of this review consist of published literature. No new data were generated and therefore data sharing is not applicable to this article.
Ethics approval and consent to participate
Consent for publication
The authors declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Search strategy (MEDLINE). An example search strategy used during phase 2. (DOCX 14 kb)
Results from unstructured search. Articles used in the development of a provisional programme theory during phase 1. (DOCX 17 kb)
Result from additional unstructured searches. Articles used to reinforce programme theory during phase 3. (DOCX 22 kb)
Generic process for opt-out. A diagram detailing the generic steps involved in the opt-out BBV test programme, implemented throughout English prisons. (DOCX 25 kb)
CMOcs. A table detailing the full list of CMOcs developed during the conduct of the rapid-realist review. (DOCX 227 kb)
Wording for opt-out offer. A script developed to help guide frontline health staff deliver an opt-out BBV test. Wording shared with NHS England commissioners. (DOCX 15 kb)
About this article
Cite this article
Francis-Graham, S., Ekeke, N.A., Nelson, C.A. et al. Understanding how, why, for whom, and under what circumstances opt-out blood-borne virus testing programmes work to increase test engagement and uptake within prison: a rapid-realist review. BMC Health Serv Res 19, 152 (2019). https://doi.org/10.1186/s12913-019-3970-z
- Blood-borne virus
- Hepatitis C
- Hepatitis B
- Human immunodeficiency virus