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Rural and urban differences in quality of dementia care of persons with dementia and caregivers across all domains: a systematic review

Abstract

Background

There are challenges in healthcare service delivery in rural areas, and this may be especially true for persons with dementia, who have higher needs to access to the healthcare system, and may have difficulties to commute easily and safely to these services. There is a growing body of literature regarding geographical disparities, but there is no comprehensive systematic review of geographical differences in persons with dementia across all domains of care quality. Therefore, the objective of this study is to conduct a systematic review of the literature on rural and urban differences in quality of dementia care outcomes of persons with dementia across all quality-of-care domains.

Methods

We performed a digital search in Ovid MEDLINE on July 16, 2019, updated on May 3, 2021, for French or English records. We selected studies that reported outcome from at least one domain of quality of dementia care (Access, Integration, Effective Care, Efficient Care, Population Health, Safety, and Patient-Centered) in both rural and urban persons with dementia or caregivers. We used rigorous, systematic methods for screening, selection, data extraction and we analyzed outcomes reported by at least two studies using vote counting and appraised the certainty of evidence. Finally, we explored sources of heterogeneity.

Results

From the 38 included studies, we found differences in many dementia care domains. Rural persons with dementia had higher mortality rates (Population Health), lower visits to any physicians (Access), more hospitalizations but shorter stays (Integration), higher antipsychotic medications (Safety), lower use of home care services and higher use of nursing home (Patient-Centered Care) compared to urban persons with dementia.

Conclusions

This comprehensive portrait of rural–urban differences in dementia care highlights possible geographically based inequities and can be used by researchers and decision makers to guide development of more equitable dementia care policies.

Peer Review reports

Background

Dementia is a global public health priority [1]. The number of persons with dementia (PWD) is increasing globally [1], and PWD receive suboptimal care and use health services more than older patients without dementia. PWD have more emergency department (ED) visits and hospitalizations [2,3,4,5], longer stays [6], higher long-term care admissions [6, 7] and mortality [6].

Health service resources are unevenly distributed, within and across countries. Their scarcity and spread in rural settings are a barrier to access to care for older persons and PWD alike. For instance, rural PWD have limited access to formal care [8], support services [9], specialist services [10, 11] and fewer physicians compared to urban PWD [10, 12]. This is compounded by possibly higher prevalence of dementia in rural regions, especially in high-income countries [13]. As optimal service provision may vary between rural and urban settings [8], it is important to uncover whether these differences yield equitable quality of care for PWD [14, 15].

Literature points to less desirable outcomes for older adults in rural regions (e.g., higher ED visits), especially if adjacent to urban centers [16]. However, mirroring the primary studies, reviews of this literature are focused on one or two quality-of-care domains (e.g., Access, Integration) [17]. To date, no systematic synthesis of differences in rural and urban PWD and caregivers across all quality-of-care domains exist. This knowledge is crucial to provide equitable dementia care. Therefore, aim of this study was to systematically review the literature on rural and urban differences in quality-of-care outcomes for PWD and caregivers across all domains.

Methods

We conducted a systematic review following the Cochrane Handbook on Systematic Reviews [18] and reported methods and findings following the Synthesis Without Meta-Analysis reporting guidelines [19].

Literature search

We searched Ovid MEDLINE database on July 16, 2019, updated on May 3, 2021, limiting to English or French peer-reviewed publications. Two authors (GAL, IV) elaborated the search strategy in collaboration with a Health Science Librarian. Two terms were operationalized: “Dementia”, developed by our team [20], and “Rural Health,” adapted from Grobler et al. [21] (Additional File 1).

Study selection

Two reviewers (GAL; TB) independently screened all titles and abstracts and evaluated full texts to ascertain eligibility. They referred to a third reviewer (IV) to resolve disagreement.

We included articles including cross-sectional, observational, case–control studies, which reported on original empirical data on quality-of-care outcomes of rural/suburban and urban patients or caregivers of patients with a dementia diagnosis living in the community. We included studies that contained outcomes on at least one domain of a validated Dementia Quality of Care framework [22] (described in Additional File 2) with community-dwelling PWD. We excluded intervention studies and questionnaire development or validation studies. A list of inclusion and exclusion criteria with further details is provided in Additional File 2.

Data extraction

Two reviewers (GAL; TB) extracted data independently and resolved discrepancies with a third reviewer (IV). We extracted descriptive data, such as study design, country of origin, publication year, number of patients, proportion of rural patients, and data sources.

We extracted data on quality-of-care outcomes that belonged to the following domains: Access (e.g., family physician visits, ED visits), Integration (e.g., hospitalization), Effective Care (e.g., timely diagnosis, anti-dementia medication), Efficient Care (e.g., costs), Population Health (e.g., mortality), Safety (e.g., potentially inappropriate prescriptions), and/or Patient-Centered Care (e.g., home care, long-term care). The eighth domain of the framework is Equity, which was used as our overarching theme. We included all quality-of-care outcomes, except for structure outcomes (e.g., number of physicians). This framework allowed us to evaluate the breadth of dementia care with a complete portrait of current literature on quality-of-care for rural and urban PWD and caregivers. Given the variable definitions of rural and urban groups across studies, we performed data transformations to harmonize the groups (Additional File 3).

Study quality appraisal

Two reviewers (ML; TB) independently evaluated study quality, using Quality Assessment Tool for Observational and Cross-Sectional Studies [23] and for Case–Control Studies [24]. The main reviewer (ML) was blinded to the findings. Disagreements were resolved by consulting a third reviewer (GAL). For studies with a sister publication, we considered the publication with poorer quality for our appraisal (more details in Additional File 3).

Analysis

Two authors (GAL; TB) analysed the data from unique studies using a vote count of the direction of the effects. Vote counting was done by contrasting the number of studies reporting higher scores, rates, or more PWD for the rural group with the number of studies reporting higher scores, rates, or more PWD for the urban group [25]. This is an appropriate method when effect estimates are not reported consistently or when the studies’ characteristics (i.e., study design, population) and the outcomes are too diverse to yield meaningful effect estimates [18].

We grouped results into quality-of-care outcomes within each domain (e.g., proportion of patients who died, mortality rate and survival rates were grouped into mortality within Population Health domain). We listed studies’ results and derived outcomes in a tabular form ordered first, by domain and second, by the first author’s alphabetical order. The direction of effects (e.g., higher vs. lower) was reported for outcomes discussed by at least two studies.

Assessment of the certainty of evidence

Certainty of evidence relates to how confident we are that the findings pooled from multiple studies reflect a true effect based on the assessment of the quality of the studies. As such, we assessed the certainty of the evidence for each outcome using the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) approach, which is appropriate when meta-analysis is not possible [26]. This GRADE evaluation is comprised of risk of bias, indirectness of studies’ research questions, imprecision (number of studies and number of patients per study), inconsistency of results, and likelihood of publication bias (Additional File 5). We summarized our findings in terms of direction of effect and level of certainty of evidence in bubble plots [18].

Assessment of the heterogeneity

As patterns emerged from synthesis, sources of heterogeneity were discussed with a group of experts. We conducted sensitivity analyses [27] to explore heterogeneity due to variations in healthcare systems [28,29,30,31,32] and countries’ income level [33]. For this, we grouped studies according to healthcare systems and to income levels, based on the country of origin of the data. Then, when possible, we reported differences in the direction of the vote count across these groups with the direction of overall findings (including all studies).

Results

Study selection

The search yielded 1958 records. After the removal of 70 duplicates and the exclusion of 1685 records based on titles and abstracts, we screened 203 full-text records for eligibility. We included 38 unique studies (42 publications; Fig. 1).

Fig. 1
figure 1

Flow diagram of records selection Legend: This figure indicates the flow chart of study selection. The identification step lists the number of records identified in the initial search and the updated search, and the number of duplicate records removed. The screening step lists the number of screened and number of records excluded based on titles and abstracts. The eligibility step lists the number of records for which full text were retrieved to determine eligibility of study and the number of records excluded per reason. And finally, the last step lists the number of records as well as the number of unique studies included in the review. The updated search yielded an additional 11 unique studies included in the review from those of the initial search

Quality appraisal of selected studies

The main methodological concerns for the 38 (15%) studies were that six studies [34,35,36,37,38,39] did not clearly define the time frame of their data collection; only one (2%) study [40] provided sample size justification, and most importantly, 21 (55%) studies [34,35,36,37,38, 40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55] did not clearly define rurality as an exposure (observational studies) or as a case definition (case–control studies). However, 31 (82%) studies [9, 34, 38,39,40,41,42,43,44, 46, 48, 50, 51, 53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70] adjusted their findings for at least one confounding variable, namely age.

Twenty-one (55%) studies [9, 41, 42, 48, 50, 53, 55,56,57,58,59,60, 62,63,64,65,66,67,68,69, 71, 72] had an overall good quality rating; ten (26%) studies [39, 40, 43, 44, 46, 51, 54, 61, 70, 73] had a fair rating; and five (18%) studies [34, 36, 38, 45, 47] had poor ratings. Two studies [35, 37] had serious methodological issues but were kept in the synthesis as their methodological issues were reflected in the assessment of the certainty of evidence (Additional File 4).

Description of individual studies

The characteristics of included studies are found in Table 1. Studies counted an average cumulative sample size of 118,741 individuals, 28% of whom were rural, with a mean age of 78.4 years and 63% were women. Twenty-two unique studies (61%) used administrative databases or insurance claims data [40,41,42,43, 46, 48,49,50, 53, 56,57,58,59, 61,62,63,64,65,66,67,68,69,70, 72, 74, 75].

Table 1 Description of included studies

Thirty-five studies (92%) were published after 2000 [9, 34, 35, 37, 38, 40,41,42,43,44,45,46,47,48, 50, 51, 53,54,55,56,57,58,59,60,61,62, 64,65,66,67,68,69,70,71,72,73]. Twelve studies (32%) were from the United States of America [35, 36, 38, 45, 50, 56, 60, 62, 66, 68, 70, 71], six studies (16%) were from Germany [43, 47, 57, 58, 67, 72, 73], five studies (13%) were from China [42, 44, 51, 55, 64], three studies were from Sweden [34, 59, 69], two studies were from each Ireland [48, 54], Canada [40, 53], Scotland [46, 63], and South Korea [41, 61]. Thus, 13 studies (34%) reported data from non-universal healthcare system [35,36,37,38, 45, 50, 56, 60, 62, 66, 68, 70, 71], 12 studies (32%) reported data from universal government-funded healthcare system [9, 34, 39, 40, 46, 48, 53, 54, 59, 63, 65, 69], and 13 studies (34%) reported data from universal public or public–private healthcare systems [41,42,43,44, 47, 51, 55, 57, 58, 61, 64, 67, 72, 73]. Most (84%) studies were from high-income countries [9, 34,35,36, 38,39,40,41, 43, 45,46,47,48,49,50, 53, 54, 56,57,58,59,60,61,62,63, 65,66,67,68,69, 71,72,73,74,75], however five (13%) studies were from upper-middle-income countries [42, 44, 51, 55, 64], and one (3%) study was from a lower-middle-income country [37].

Most studies reported on outcomes from one domain only (maximum of three domains per study). The most studied domains were Effective Care with 10 studies [38, 39, 41, 43, 45, 53, 57, 65, 69, 72], Population Health with 12 studies [42, 44, 48,49,50,51, 55, 62,63,64, 66, 68, 74], and Patient-Centered Care with 13 studies [9, 35, 36, 40, 47, 53, 54, 59, 66,67,68, 73, 74]. Only one study [45] compared suburban to urban and was excluded from further analyses.

Direction of pooled outcomes by quality-of-care domains.

The grouping of studies’ results into quality-of-care outcomes within each domain is described in Additional File 6.

Four unique studies were included in Access [40, 56, 58, 70, 75]. Two studies [56, 58] measured the number of visits to any type of physicians and both suggest that rural PWD have fewer visits compared to urban PWD. However, this may not be true the year following diagnosis [58]. Two studies [40, 58] investigated visits to primary care physicians, with inconclusive findings: one study [58] found more visits in rural PWD, while the other study [40] found fewer visits in rural PWD. Two studies [56, 70] looked at the number of patients with at ED visit and both found fewer rural PWD have an outpatient or ED visit compared to urban PWD. However, another study [75] found more rural PWD may have preventable ED visits than urban PWD.

Five unique studies were included in Integration [40, 50, 60, 68, 71]. Four studies [40, 50, 68, 71] examined the number of patients with a hospitalization and found rural PWD had more than urban PWD. Two studies [50, 60] looked at the length of hospital stays and found that these were shorter in rural PWD.

Nine unique studies were included in Effective Care [38, 39, 41, 43, 45, 53, 57, 65, 69, 72]. Two studies [38, 39] examined timely diagnosis and both found it less timely in rural compared to urban PWD. Two studies [53, 69] measured completeness of examinations and reported inconclusive findings: one study [69] found them to be more complete, and the other one [53] found them to be less complete for rural PWD. Finally, five unique studies [41, 43, 53, 57, 65, 72] looked at anti-dementia medications with inconclusive findings: two studies [53, 65] found fewer prescription and two studies [43, 57] found higher prescription in rural compared to urban PWD. The fifth study [41] found less persistent use in rural PWD.

Four studies were included in Efficient Care [34, 37, 54, 56]. Three of them [37, 54, 56] investigated medical care costs and pointed to lower costs: while two studies [54, 56] found lower costs, while one study [37] found higher medical costs in rural compared to urban PWD/family. Three studies [34, 37, 54] examined informal care costs/financial strain and pointed to higher informal costs/strain. While this was true for two studies [34, 37], the third study [54] found lower informal costs/financial strain in rural PWD.

Eleven unique studies were included in Population Health [42, 44, 48,49,50,51, 55, 62,63,64, 66, 68]. Findings suggest mortality is higher in rural compared to urban PWD. This was true for all 11 unique studies [42, 44, 48,49,50,51, 55, 62,63,64, 66, 68], except for one study [51], which compiled results from three different countries and found that while mortality rates were higher for rural PWD in China, they were lower for rural PWD in Mexico and Peru.

Four studies were included in Safety [43, 46, 53, 61]. These studies focused on potentially inappropriate medications for PWD, including neuroleptics/antipsychotics, benzodiazepine/sedatives, and antidepressants. All four studies [43, 46, 53, 61] looked at neuroleptic or antipsychotics medications and found higher prescriptions in rural compared to urban PWD. Two studies [43, 53] measured antidepressant medications and both found fewer prescriptions in rural PWD. The same two studies [43, 53] also measured benzodiazepines or sedatives and found mixed results: while one study [43] found fewer prescriptions, the other study [53] found more prescriptions in rural PWD.

Thirteen studies were included in Patient-Centered Care [9, 35, 36, 40, 47, 53, 54, 56, 59, 66,67,68, 73]. Seven studies [36, 40, 47, 56, 59, 67, 68] reported on home care services and pointed toward lower use of these services in rural compared to urban PWD: while four studies [36, 47, 56, 59] found that is true, the other three studies [40, 67, 68] found higher use in rural PWD.

Six studies [35, 36, 53, 59, 67, 73] reported on use of respite care/caregiver counselling, and findings are indicative of higher use of these services: While true in four studies [53, 59, 67, 73], two other studies[35, 36] found lower use of these services in rural PWD/family.

Seven studies [9, 36, 54, 56, 59, 67, 68] looked at nursing homes and findings point toward higher use in rural compared to urban PWD: While true for four studies [56, 59, 67, 68], the other three studies [9, 36, 54] found lower nursing home use in rural PWD.

Three studies [36, 47, 59] reported on day care services and found lower use of these services in rural compared to urban PWD: While two studies [36, 59] found this is true, the other study [47] found higher use of day care services in rural PWD.

Three studies [36, 47, 59] looked at use of Meals-on-Wheels and results are inconclusive: While one study [36] found more use, the other study [59] found less use in rural compared to urban PWD. The third study [47], however, found it may depend on the time since diagnosis with higher use immediately after the diagnosis and lower use as the disease progresses.

Three out of three studies [36, 47, 59] found lower use of home help / personal care, and three out of three studies [36, 40, 47] found lower use of self-help groups.

Assessment of the certainty of evidence

The findings for mortality (Population Health) were supported with the strongest evidence (risk of bias, indirectedness, number of studies and patients per study, and consistency of findings). Seven other outcomes reached moderate certainty level: visits to any physicians (Access), hospitalization and length of hospitalizations (Integration), anti-dementia medications (Effective Care), antidepressant medications (Safety), and home care services and nursing home (Patient-Centered Care). All other outcomes reached low or very low certainty levels, including all outcomes of Efficient Care.

Overall, the most frequent issue with the findings in this review was imprecision (17 outcomes out of 21 were based on few studies with few participants), followed by risk of bias (14 outcomes were based on studies with poor quality), indirectedness (11 outcomes were based on studies whose research question was not aligned directly with our research question), and inconsistency (10 outcomes were based on studies that were not in full agreement). A summary of findings along with certainty appraisal can be found in Fig. 2.

Fig. 2
figure 2

Summary of findings Legend: This bubble plot summarizes findings by showing the relationships between direction of rural/urban differences (x-axis), outcome (y-axis), certainty of evidence (size of bubbles) and quality of care domain (color of bubbles). Direction of rural/urban difference, ascertained by vote counting, is indicated in four columns: “Fewer/lower” indicates that a majority of studies that looked at a given outcome found fewer patients with dementia or caregivers (or lower results) in the rural group compared to urban group; “No change” indicates that a majority of the studies for a given outcome found no difference in the number of patient or in the results of rural and urban patients or caregivers; “More/higher” indicates that the majority of the studies for a given outcome found more patients with dementia or caregivers (or higher results) in the rural group compared to the urban group; “Mixed findings” indicates that half of the studies found fewer patients/lower results in the rural group and the other half found more patients/higher results in the rural group compared to the urban group for a given outcome. Certainty of evidence, ascertained by GRADE approach, is indicated by the size of the bubble (smallest bubbles indicate very low certainty and largest bubbles indicate high certainty). The superscripts indicate the source of concerns ascertained by GRADE approach: a- indirectedness of research questions; imprecision; b- risk of bias; imprecision; inconsistency; c– risk of bias; indirectedness of research questions; imprecision; d- risk of bias; imprecision; e–imprecision; f- indirectedness of research questions; inconsistency; g- indirectedness of research questions; imprecision; inconsistency; and h- risk of bias; indirectedness of research questions; imprecision; inconsistency. Green bubbles are for outcomes of Access domain, orange for Integration, light blue for Effective Care, purple for Efficient Care, red for Population Health, dark blue for Safety and yellow for Patient-Centered Care

Assessment of heterogeneity

While many studies from the United States of America specifically mentioned they were focused on Medicare patients, the others did not mention the type of healthcare coverage. We classified these studies as Not Specified – Most Likely Medicare since the population under study was likely eligible for universal, federally managed insurance due to their age [76].

We found two outcomes from two domains that may be sensitive to variations in healthcare systems: anti-dementia medications (Effective Care) and medical costs (Efficient Care). While two studies from countries with a universal government-funded healthcare system (Australia [65] and Canada [53]) found lower anti-dementia medication prescriptions in rural compared to urban PWD, the studies from Germany, with a public–private insurance healthcare [43, 57, 72], found the opposite. Similarly, the two studies with universal government-funded healthcare systems [54, 56] showed higher medical costs in rural PWD, but the study from a non-universal healthcare system [37] found lower costs for rural PWD.

All other outcomes either did not vary by type of healthcare system (i.e., visits to any physicians, hospitalizations, complete exam or timely diagnosis/consultations, informal care cost, antipsychotic/neuroleptic prescriptions, home care services, respite care services, and admissions to nursing home) or there was not enough variability in the type of healthcare systems to assess thoroughly (i.e., outpatient/ED visits, length of stay, benzodiazepines/sedatives and antidepressants prescriptions, day care and Meals-on-Wheels services).

Most outcomes and domains were explored in high-income countries only. Outcomes from two domains (Efficient Care and Population Health) were also examined in upper and lower middle-income countries. We found that rural PWD have lower medical costs in high-income countries compared to urban PWD, but they have higher medical costs in lower-middle-income countries. However, informal care costs do not seem to vary with the countries’ level of income. Mortality (Population Health) was lower in rural PWD in two upper-middle-income countries (Mexico and Peru), while the studies from upper-middle-income country (China) found higher mortality in rural compared to urban PWD, similar to the studies from high-income countries. There was not enough variability in the countries’ level of income to determine if the direction of any of the other outcomes varies accordingly (Additional File 7).

Discussion

We found important differences in the dementia care outcomes for rural and urban PWD and caregivers across many quality-of-care domains. The strongest evidence was for higher mortality (Population Health), followed by moderate evidence for fewer visits to any physicians (Access), higher hospitalizations but shorter stays (Integration), higher anti-dementia medications (Effective Care), higher antipsychotic medications (Safety), and lower use of home care and higher use of nursing home (Patient-Centered Care) in rural PWD compared to urban PWD.

We found good evidence for higher mortality (Population Health) in rural PWD compared to urban PWD. This is similar to findings from the general population where persons living in rural communities have higher rates of mortality than their urban counterparts [62, 77,78,79]. This alone should justify the pursuit for more equitable policies, and our study brings further urgency to the argument for PWD. We were unable to determine if the direction of mortality differences between rural and urban PWD depended on the type of healthcare systems or their countries’ level of income in our sensitivity analyses. Two upper-middle-income countries, with a public/private universal healthcare system (Mexico and Peru), had lower mortality in rural PWD, which contrasted with China, another upper-middle-income country with higher mortality in rural PWD. It is possible this difference was driven by the fact that China has recognized the need to improve rural care and has invested substantial resources [80] to combat this inequity. The fact that 13% of the studies included in this review came from China seems to support this hypothesis.

The literature on Access and Integration is relatively scarce but points with a moderate level of certainty toward fewer visits to any physicians and more hospitalizations, but shorter stays in rural PWD compared to urban PWD. Our findings are consistent with the literature for older adults, where rural Canadian residents were less likely to have seen a family physician or a specialist physician and more likely to visit an ED compared to urban residents [81]. These differences may be explained by documented shortages of physicians practicing in rural regions [11, 82, 83]. Alternatively, it is also possible nurses have more responsibilities in rural than urban contexts, and because visits to nurses are usually not included in administrative databases, the main data source from which our findings are derived, it could explain fewer visits to physicians [84]. Only one of the included studies reported on nurse visits and found that rural PWD had more of these visits than urban PWD [40].

We found higher hospitalizations in rural PWD compared to urban PWD. This could be explained by rural patients having to wait longer before consulting a physician due to the shortage of physicians or by having different health-seeking behaviours [85]. This finding is at odds with literature on rural older residents who do not have different hospitalisation rates than urban residents [81], and requires further investigation.

We found higher anti-dementia medications (Effective Care) in rural PWD compared to urban PWD with a moderate level of certainty. This could be explained by difference in clientele, such as clientele with more severe form of dementia due to delayed diagnosis in rural populations [68, 86], or differences in training/support of rural physicians [87,88,89]. However, our sensitivity analyses suggest that the type of healthcare systems may drive differences in the direction of anti-dementia medications comparisons, which may be due to variations in drug reimbursement plans. Indeed, insurance coverage can have an impact on prescription patterns [90, 91].

Despite being one of the most explored domains, Patient-Centered Care consisted of various types of outcomes (i.e., use of, need for, satisfaction with, and perceived availability of health services) and high variability of what each service entails (e.g., home care or home health services in different countries, regions, etc. may not provide the same services). This variability hindered our capacity to draw firm conclusions on outcomes other than use of these services, with a low to moderate level of certainty at best. In fact, many outcomes relating to this domain yielded inconsistent results. These inconsistencies were mentioned in a recent scoping review comparing palliative care in rural and urban PWD [92].

The literature on Efficient Care is insufficient to draw conclusions on rural and urban differences in PWD. Unfortunately, this domain remains understudied, despite meriting further considerations, especially because medical/formal costs may be deflected from the system costs into patients’ out-of-pocket or informal costs [93, 94]. The various countries’ level of income and type of healthcare systems may drive differences in the direction of medical care costs comparisons between rural and urban PWD, but the few studies make it difficult to make further conclusions. It is possible that rural/urban differences in resource allocation are exacerbated by the lack of resources in middle-income countries [95].

The evidence of other outcomes across other domains suffered from a low to very low certainty level. The most persistent issue associated with low certainty grades was the lack of studies of better quality addressing specific rural–urban differences, suggesting this is still an emerging field of interest.

Strengths and limitations

The strength of our review is its novelty and comprehensiveness: covering a wide range of outcomes for PWD and caregivers across all quality-of-care domains over 25 years of research. Furthermore, we used a rigorous systematic approach for the literature search, appraisal of study quality, data extraction, and we ascertained the certainty of the evidence supporting our findings. Each domain being highly associated to improved quality of care, they are highly correlated to one another. This should not mean that measuring one domain of care suffices to measure quality of care as a whole.

However, this review has limitations. While the breadth of the review was large, we were not able to synthesize the findings in a meta-analysis, due to the heterogeneity of outcomes. Thus, we performed a vote counting analysis, which provides little information on the magnitude of the effect [18]. Vote counting is appropriate when outcomes are not reported consistently or when the studies’ characteristics (i.e., study design, population) are too diverse to yield meaningful effect estimates [18]. The relatively recent and emerging literature also prevented us from further exploring sources of heterogeneity, either based on the various healthcare systems in which these studies were conducted, or between low- and middle-income countries and high-income countries. These sources of heterogeneity likely impact drug prescription patterns [43, 96, 97] as well as home care services and support to caregivers [98], and deserve further examination. Most outcomes were explored by a few, mostly observational studies, hindering our interpretation and exploration of other factors intersecting with geographical differences, such as sex/gender, and socio-economic status. However, observational studies are possibly the best evidence possible, as randomizing attribution to rural or urban is not realistic. Finally, our selection criteria were also limited since we conducted our search only in one online database.

Conclusion

While the literature on rural and urban differences in quality of dementia care outcomes is still novel, it already points toward disparities across many domains, especially higher mortality in PWD who live in rural areas compared to those who live in urban areas. This finding alone should justify the pursuit for more equitable policies for all PWD and their caregivers. Our findings that few studies are vested into documenting the pervasiveness of the health disparities based on geographical location bring further urgency to the conduct of such research. Failure to do so could lead to increased disparities. Another shortcoming in this research comes from the fact that most results come from high-income countries. It is imperative to provide decision makers with evidence to guide equitable policies and reduce health disparities for all PWD and their caregivers.

Availability of data and materials

All data generated or analysed during this study are included in this published article and its supplementary information files.

Abbreviations

PWD:

Persons with dementia

ED:

Emergency department

References

  1. World Health Organization. Dementia: a public health priority Geneva, Switzerland: World Health Organization; (2012). https://extranet.who.int/agefriendlyworld/wp-content/uploads/2014/06/WHO-Dementia-English.pdf. Accessed May 6 2021.

  2. Prince M, Comas-Herrera A, Knapp M, Guerchet M, Karagiannidou M. World Alzheimer Report 2016: Improving healthcare for people living with dementia coverage, quality and costs now and in the future.: (2016). https://www.alz.co.uk/research/world-report-2016. Accessed May 5 2021.

  3. LaMantia MA, Stump TE, Messina FC, Miller DK, Callahan CM. Emergency Department Use Among Older Adults with Dementia. Alzheimer Dis Assoc Disord. 2016;30(1):35–40.

    Article  Google Scholar 

  4. Phelan EA, Borson S, Grothaus L, Balch S, Larson EB. Association of incident dementia with hospitalizations. J Am Med Assoc. 2012;307(2):165–72.

    Article  CAS  Google Scholar 

  5. Rudolph JL, Zanin NM, Jones RN, Marcantonio ER, Fong TG, Yang FM, et al. Hospitalization in Community-Dwelling Persons with Alzheimer’s Disease: Frequency and Causes. J Am Geriatr Soc. 2010;58(8):1542–8.

    Article  Google Scholar 

  6. Bronskill SE, Maclagan LC, Walker JD, Guan J, Wang X, Ng R, et al. Trajectories of health system use and survival for community-dwelling persons with dementia: a cohort study. BMJ Open. 2020;10(7):e037485.

    Article  Google Scholar 

  7. Steele C, Rovner B, Chase GA, Folstein M. Psychiatric symptoms and nursing home placement of patients with Alzheimer’s disease. Am J Psychiatry. 1990;147(8):1049–51.

    Article  CAS  Google Scholar 

  8. Morgan D, Innes A, Kosteniuk J. Dementia care in rural and remote settings: A systematic review of formal or paid care. Maturitas. 2011;68(1):17–33.

    Article  Google Scholar 

  9. Giebel C, Hollinghurst J, Akbari A, Schnier C, Wilkinson T, North L, et al. Socio-economic predictors of time to care home admission in people living with dementia in Wales: A routine data linkage study. Int J Geriatr Psychiatry. 2021;36(4):511–20.

    Article  Google Scholar 

  10. Singhal BS, Khadilkar SV. Neurology in the developing world. Handb Clin Neurol. 2014;121:1773–82.

    Article  CAS  Google Scholar 

  11. Cyr ME, Etchin AG, Guthrie BJ, Benneyan JC. Access to specialty healthcare in urban versus rural US populations: a systematic literature review. BMC Health Serv Res. 2019;19(1):974.

    Article  Google Scholar 

  12. Canadian Institute for Health Information. Geographic distribution of physicians in Canada: beyond how many and where. 2006. Available from: https://secure.cihi.ca/estore/productFamily.htm?locale=en&pf=PFC609&lang=en&media=0.

  13. Russ TC, Batty GD, Hearnshaw GF, Fenton C, Starr JM. Geographical variation in dementia: systematic review with meta-analysis. Int J Epidemiol. 2012;41(4):1012–32.

    Article  Google Scholar 

  14. Donabedian A. Quality assessment and assurance: unity of purpose, diversity of means. Inquiry. 1988;25(1):173–92.

    CAS  Google Scholar 

  15. Albert-Ballestar S, García-Altés A. Measuring health inequalities: a systematic review of widely used indicators and topics. International journal for equity in health. 2021;20(1):73.

    Article  Google Scholar 

  16. Dufour I, Chouinard MC, Dubuc N, Beaudin J, Lafontaine S, Hudon C. Factors associated with frequent use of emergency-department services in a geriatric population: a systematic review. BMC Geriatr. 2019;19(1):185.

    Article  Google Scholar 

  17. Ramalho A, Castro P, Gonçalves-Pinho M, Teixeira J, Santos JV, Viana J, et al. Primary health care quality indicators: An umbrella review. PLoS ONE. 2019;14(8):e0220888.

    Article  CAS  Google Scholar 

  18. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane Handbook for Systematic Reviews of Interventions: John Wiley and Sons; 2019.

  19. Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE, Ellis S, et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ. 2020;368:l6890.

    Article  Google Scholar 

  20. Godard-Sebillotte C, Le Berre M, Schuster T, Trottier M, Vedel I. Impact of health service interventions on acute hospital use in community-dwelling persons with dementia: A systematic literature review and meta-analysis. PLoS ONE. 2019;14(6):e0218426.

    Article  CAS  Google Scholar 

  21. Grobler L, Marais BJ, Mabunda S. Interventions for increasing the proportion of health professionals practising in rural and other underserved areas. Cochrane Database Syst Rev. 2015;2015(6):Cd00531.

    Google Scholar 

  22. Sourial N, Godard-Sebillotte C, Bronskill SE, Arsenault-Lapierre G, Hacker G, Vedel I. Quality indicator framework for primary care of patients with dementia. Can Fam Physician. 2022;68(9):e270–8.

    Article  Google Scholar 

  23. National Health Institute: National Heart Lung and Blood Institute. Study Quality Assessment Tools: Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies: (2014). https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed May 5 2021.

  24. National Health Institute: National Heart Lung and Blood Institute. Study Quality Assessment Tools: Quality Assessment Tool for Case-Control Studies (2014). https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed May 5 2021.

  25. McKenzie JE, Brennan SE. Statistical synthesis when meta-analysis of effect estimates is not possible. 2021. In: Cochrane Handbook for Systematic Reviews of Interventions version 62 [Internet]. Cochrane. Available from: www.training.cochrane.org/handbook.

  26. Murad MH, Mustafa RA, Schünemann HJ, Sultan S, Santesso N. Rating the certainty in evidence in the absence of a single estimate of effect. Evidence Based Medicine. 2017;22(3):85–7.

    Article  Google Scholar 

  27. Langer L, Stewart R, Winters N. Sensitivity analysis in systematic reviews of qualitative evidence: an example from a mixed-methods systematic review. In: Filtering the information overload for better decisions. 23rd Cochrane Colloquium; Vienna, Austria. John Wiley & Sons; 2015, October 3–7.

  28. The Common Wealth Fund. International Health Care System Profiles: (2021). https://www.commonwealthfund.org/international-health-policy-center/system-profiles. Accessed May 5 2021.

  29. Scottish Government. Healthcare in Scotland. https://www.scotland.org/live-in-scotland/healthcare. Accessed May 4 2021.

  30. World Health Organization, Regional Office for the Western Pacific. Republic of Korea Health System Review. 2015. Available from: http://www.searo.who.int/entity/asia_pacific_observatory/publications/hits/hit_korea/en/.

  31. Global Health Workforce Alliance. Peru: World Health Organization; (2021). https://www.who.int/workforcealliance/countries/per/en/. Accessed May 5 2021.

  32. Pan American Health Organization. Health in the Americas+, 2017 Edition. Summary: Regional Outlook and Country Profiles: (2017). https://iris.paho.org/handle/10665.2/34321. Accessed May 5 2021.

  33. The World Bank. The World by Income and Region: (2021). https://datatopics.worldbank.org/world-development-indicators/the-world-by-income-and-region.html. Accessed October 25 2021.

  34. Ehrlich K, Bostrom AM, Mazaheri M, Heikkila K, Emami A. Family caregivers’ assessments of caring for a relative with dementia: a comparison of urban and rural areas. Int J Older People Nurs. 2015;10(1):27–37.

    Article  Google Scholar 

  35. Kosloski K, Schaefer JP, Allwardt D, Montgomery RJ, Karner TX. The role of cultural factors on clients’ attitudes toward caregiving, perceptions of service delivery, and service utilization. Home Health Care Serv Q. 2002;21(3):65–88.

    Article  Google Scholar 

  36. McCabe BW, Sand BJ, Yeaworth RC, Nieveen JL. Availability and utilization of services by Alzheimer’s disease caregivers. J Gerontol Nurs. 1995;21(1):14–22.

    Article  CAS  Google Scholar 

  37. Rao GN, Bharath S. Cost of dementia care in India: delusion or reality? Indian J Public Health. 2013;57(2):71–7.

    Article  Google Scholar 

  38. Wackerbarth SB, Johnson MM. The carrot and the stick: benefits and barriers in getting a diagnosis. Alzheimer Dis Assoc Disord. 2002;16(4):213–20.

    Article  Google Scholar 

  39. Antonelli Incalzi R, Marra C, Gemma A, Capparella O, Carbonin PU. Unrecognized dementia: sociodemographic correlates. Aging-Clinical & Experimental Research. 1992;4(4):327–32.

    Article  CAS  Google Scholar 

  40. Forbes DA, Morgan D, Janzen BL. Rural and urban Canadians with dementia: use of health care services. Can J Aging. 2006;25(3):321–30.

    Article  Google Scholar 

  41. Ahn SH, Choi NK, Kim YJ, Seong JM, Shin JY, Jung SY, et al. Drug persistency of cholinesterase inhibitors for patients with dementia of Alzheimer type in Korea. Arch Pharmacal Res. 2015;38(6):1255–62.

    Article  CAS  Google Scholar 

  42. Bo Z, Wan Y, Meng SS, Lin T, Kuang W, Jiang L, et al. The temporal trend and distribution characteristics in mortality of Alzheimer’s disease and other forms of dementia in China: Based on the National Mortality Surveillance System (NMS) from 2009 to 2015. PLoS ONE [Electronic Resource]. 2019;14(1):e0210621.

    Article  CAS  Google Scholar 

  43. Bohlken J, Schulz M, Rapp MA, Batzing-Feigenbaum J. Pharmacotherapy of dementia in Germany: Results from a nationwide claims database. Eur Neuropsychopharmacol. 2015;25(12):2333–8.

    Article  CAS  Google Scholar 

  44. Chen R, Hu Z, Wei L, Wilson K. Socioeconomic status and survival among older adults with dementia and depression. Brit J Psychiat. 2014;204(6):436–40.

    Article  Google Scholar 

  45. Clark PC, Kutner NG, Goldstein FC, Peterson-Hazen S, Garner V, Zhang R, et al. Impediments to timely diagnosis of Alzheimer’s disease in African Americans. J Am Geriatr Soc. 2005;53(11):2012–7.

    Article  Google Scholar 

  46. Guthrie B, Clark SA, McCowan C. The burden of psychotropic drug prescribingin people with dementia: a populationdatabase study. Age Ageing. 2010;39(5):637–42.

    Article  Google Scholar 

  47. Laporte Uribe F, Wolf-Ostermann K, Wubbeler M, Holle B. Care Arrangements in Dementia Care Networks: Findings From the DemNet-D Study Baseline and 1-Year Follow-Up. J Aging Health. 2018;30(6):882–903.

    Article  Google Scholar 

  48. McMichael AJ, Zafeiridi E, Passmore P, Cunningham EL, McGuinness B. Factors Associated with Mortality Including Nursing Home Transitions: A Retrospective Analysis of 25,418 People Prescribed Anti-Dementia Drugs in Northern Ireland. J Alzheimers Dis. 2020;73(3):1233–42.

    Article  Google Scholar 

  49. McMichael AJ, Zafeiridi E, Ryan M, Cunningham EL, Passmore AP, McGuinness B. Anticholinergic drug use and risk of mortality for people with dementia in Northern Ireland. Aging Ment Health. 2020:1–8.

  50. Naumova EN, Parisi SM, Castronovo D, ita M, Wenger J, Minihan P. Pneumonia and influenza hospitalizations in elderly people with dementia. J Am Geriatr Soc. 2009;57(12):2192–9.

    Article  Google Scholar 

  51. Prince M, Acosta D, Ferri CP, Guerra M, Huang Y, Llibre Rodriguez JJ, et al. Dementia incidence and mortality in middle-income countries, and associations with indicators of cognitive reserve: a 10/66 Dementia Research Group population-based cohort study. Lancet. 2012;380(9836):50–8.

    Article  Google Scholar 

  52. Seo N, Song I, Park H, Ha D, Shin JY. Trends in the prescribing of atypical antipsychotics in elderly patients with dementia in Korea. Int J Clin Pharmacol Ther. 2017;55(7):581–7.

    Article  Google Scholar 

  53. Sivananthan SN, Lavergne MR, McGrail KM. Caring for dementia: A population-based study examining variations in guideline-consistent medical care. Alzheimers Dement. 2015;11(8):906–16.

    Article  Google Scholar 

  54. Walsh S, Pertl M, Gillespie P, Lawlor B, Brennan S, O’Shea E. Factors influencing the cost of care and admission to long-term care for people with dementia in Ireland. Aging Ment Health. 2021;25(3):512–20.

    Article  Google Scholar 

  55. Wen H, Zhang Z, Huang J, Duan L, Wang Q. Mortality of dementia and its major subtypes in urban and rural communities of Beijing. Biomed Environ Sci. 2011;24(5):483–90.

    Google Scholar 

  56. Crouch E, Probst JC, Bennett K, Eberth JM. Differences in Medicare Utilization and Expenditures in the Last Six Months of Life among Patients with and without Alzheimer’s Disease and Related Disorders. J Palliat Med. 2019;22(2):126–31.

    Article  Google Scholar 

  57. Hoffmann F, van den Bussche H, Wiese B, Schon G, Koller D, Eisele M, et al. Impact of geriatric comorbidity and polypharmacy on cholinesterase inhibitors prescribing in dementia. BMC Psychiatry. 2011;11:190.

    Article  Google Scholar 

  58. Koller D, Eisele M, Kaduszkiewicz H, Schon G, Steinmann S, Wiese B, et al. Ambulatory health services utilization in patients with dementia - Is there an urban-rural difference? International Journal of Health Geographics [Electronic Resource]. 2010;9:59.

    Article  Google Scholar 

  59. Odzakovic E, Hyden LC, Festin K, Kullberg A. People diagnosed with dementia in Sweden: What type of home care services and housing are they granted? A cross-sectional study. Scandinavian Journal of Public Health. 2019;47(2):229–39.

    Article  Google Scholar 

  60. Opoku STY, Apenteng BA, Lin G. Temporal Trends and Rural-Urban Differences in Hospital Length of Stay for Alzheimer Disease and Related Disorders. Alzheimer Dis Assoc Disord. 2017;31(3):244–8.

    Article  Google Scholar 

  61. Seo N, Song I, Park H, Ha D, Shin JY. Trends in the prescribing of atypical antipsychotics in elderly patients with dementia in Korea. Int J Clin Pharmacol Ther. 2017;55(7):581–7.

    Article  Google Scholar 

  62. Singh GK, Siahpush M. Widening rural-urban disparities in all-cause mortality and mortality from major causes of death in the USA, 1969–2009. J Urban Health. 2014;91(2):272–92.

    Article  Google Scholar 

  63. Thomas BM, McGonigal G, McQuade CA, Starr JM, Whalley LJ. Survival in early onset dementia: effects of urbanization and socio-economic deprivation. Neuroepidemiology. 1997;16(3):134–40.

    Article  CAS  Google Scholar 

  64. Yin P, Feng X, Astell-Burt T, Page A, Liu J, Liu Y, et al. Temporal Trends and Geographic Variations in Dementia Mortality in China Between 2006 and 2012: Multilevel Evidence from a Nationally Representative Sample. Alzheimer Dis Assoc Disord. 2016;30(4):348–53.

    Article  Google Scholar 

  65. Zilkens RR, Duke J, Horner B, Semmens JB, Bruce DG. Australian population trends and disparities in cholinesterase inhibitor use, 2003 to 2010. Alzheimers Dement. 2014;10(3):310–8.

    Article  Google Scholar 

  66. Cross SH, Warraich HJ. Rural-Urban Disparities in Mortality from Alzheimer’s and Related Dementias in the United States, 1999–2018. J Am Geriatr Soc. 2021;69(4):1095–6.

    Article  Google Scholar 

  67. Forstner J, Wensing M, Koetsenruijter J, Wronski P. Claims data-based analysis of the influence of individual and regional characteristics on the utilisation of long-term care by people with dementia in Baden-Wurttemberg, Germany. BMC Geriatr. 2019;19(1):358.

    Article  Google Scholar 

  68. Rahman M, White EM, Thomas KS, Jutkowitz E. Assessment of Rural-Urban Differences in Health Care Use and Survival Among Medicare Beneficiaries With Alzheimer Disease and Related Dementia. JAMA Netw Open. 2020;3(10):e2022111-e.

    Article  Google Scholar 

  69. Roheger M, Eriksdotter M, Westling K, Kalbe E, Garcia-Ptacek S. Basic Diagnostic Work-Up Is More Complete in Rural than in Urban Areas for Patients with Dementia: Results of a Swedish Dementia Registry Study. J Alzheimers Dis. 2019;69(2):455–62.

    Article  Google Scholar 

  70. Wang N, Amaize A, Chen J. Accountable Care Hospitals and Preventable Emergency Department Visits for Rural Dementia Patients. J Am Geriatr Soc. 2021;69(1):185–90.

    Article  Google Scholar 

  71. Thorpe JM, Van Houtven CH, Sleath BL, Thorpe CT. Rural-urban differences in preventable hospitalizations among community-dwelling veterans with dementia. Journal of Rural Health. 2010;26(2):146–55.

    Article  Google Scholar 

  72. van den Bussche H, Kaduszkiewicz H, Koller D, Eisele M, Steinmann S, Glaeske G, et al. Antidementia drug prescription sources and patterns after the diagnosis of dementia in Germany: results of a claims data-based 1-year follow-up. Int Clin Psychopharmacol. 2011;26(4):225–31.

    Article  Google Scholar 

  73. Gräßel E, Luttenberger K, Trilling A, Donath C. Counselling for dementia caregivers-predictors for utilization and expected quality from a family caregiver’s point of view. Eur J Ageing. 2010;7(2):111–9.

    Article  Google Scholar 

  74. Cross SH, Kaufman BG, Taylor DH Jr, Kamal AH, Warraich HJ. Trends and Factors Associated with Place of Death for Individuals with Dementia in the United States. J Am Geriatr Soc. 2020;68(2):250–5.

    Article  Google Scholar 

  75. Wang N, Albaroudi A, Chen J. Decomposing Urban and Rural Disparities of Preventable ED Visits Among Patients with Alzheimer’s Disease and Related Dementias: Evidence of the Availability of Health Care Resources. J Rural Health. 2020;37(3):624–35.

    Article  Google Scholar 

  76. Ridic G, Gleason S, Ridic O. Comparisons of health care systems in the United States. Germany and Canada Mater Sociomed. 2012;24(2):112–20.

    Article  Google Scholar 

  77. Cheng L, Tan L, Zhang L, Wei S, Liu L, Long L, et al. Chronic disease mortality in rural and urban residents in Hubei Province, China, 2008–2010. BMC Public Health. 2013;13(1):713.

    Article  Google Scholar 

  78. Miller MK, Stokes CS, Clifford WB. A Comparison of the Rural-Urban Mortality Differential for Deaths From All Causes, Cardiovascular Disease and Cancer. J Rural Health. 1987;3(2):23–34.

    Article  CAS  Google Scholar 

  79. Thompson S, Gill J, Wang X, Padwal R, Pelletier R, Bello A, et al. Higher mortality among remote compared to rural or urban dwelling hemodialysis patients in the United States. Kidney Int. 2012;82(3):352–9.

    Article  Google Scholar 

  80. Zhang Y, Dong D, Xu L, Miao Z, Mao W, Sloan F, et al. Ten-year impacts of China’s rural health scheme: lessons for universal health coverage. BMJ Glob Health. 2021;6(4):e003714.

    Article  Google Scholar 

  81. Clark K, John P, Menec V, Cloutier D, Newall N, Connell M, et al. Healthcare utilisation among Canadian adults in rural and urban areas - The Canadian Longitudinal Study on Aging. Can J Rural Med. 2021;26(2):69–79.

    Article  Google Scholar 

  82. Gudbranson E, Glickman A, Emanuel EJ. Reassessing the Data on Whether a Physician Shortage Exists. JAMA. 2017;317(19):1945–6.

    Article  Google Scholar 

  83. Yang L, Wang H, Xue L. What about the health workforce distribution in rural China? An assessment based on eight-year data. Rural Remote Health. 2019;19(3):4978.

    Google Scholar 

  84. Neprash HT, Smith LB, Sheridan B, Moscovice I, Prasad S, Kozhimannil K. Nurse Practitioner Autonomy and Complexity of Care in Rural Primary Care. Med Care Res Rev. 2021;78(6):684–92.

    Article  Google Scholar 

  85. Rost K, Smith GR, Taylor JL. Rural-urban differences in stigma and the use of care for depressive disorders. J Rural Health. 1993;9(1):57–62.

    Article  CAS  Google Scholar 

  86. Bradford A, Kunik ME, Schulz P, Williams SP, Singh H. Missed and Delayed Diagnosis of Dementia in Primary Care: Prevalence and Contributing Factors. Alzheimer Dis Assoc Disord. 2009;23(4):306–14.

    Article  Google Scholar 

  87. Curran V, Hatcher L, Kirby F. CME needs of rural physicians: How do we compare to our urban colleagues? Can J Rural Med. 2000;5(3):131–8.

    Google Scholar 

  88. Reid SJ, Couper ID, Volmink J. Educational factors that influence the urban-rural distribution of health professionals in South Africa: A case-control study. S Afr Med J. 2011;101(1):29–33.

    Article  CAS  Google Scholar 

  89. Waters B, Hughes J, Forbes K, Wilkinson D. Comparative academic performance of medical students in rural and urban clinical settings. Med Educ. 2006;40(2):117–20.

    Article  Google Scholar 

  90. Kronish IM, Federman AD, Morrison RS, Boal J. Medication Utilization in an Urban Homebound Population. The Journals of Gerontology: Series A. 2006;61(4):411–5.

    Article  Google Scholar 

  91. Rand Europe. International variation in drug usage: An exploratory analysis of the "causes" of variation. 2014. Available from: https://www.rand.org/content/dam/rand/pubs/research_reports/RR800/RR899/RAND_RR899.pdf.

  92. Elliot V, Morgan D, Kosteniuk J, Bayly M, Froehlich Chow A, Cammer A, et al. Palliative and end-of-life care for people living with dementia in rural areas: A scoping review. PLoS ONE. 2021;16(1):e0244976.

    Article  CAS  Google Scholar 

  93. Martin BC, McMillan JA. The Impact of Implementing a More Restrictive Prescription Limit on Medicaid Recipients: Effects on Cost, Therapy, and Out-of-Pocket Expenditures. Med Care. 1996;34(7):686–701.

    Article  CAS  Google Scholar 

  94. Stabile M, Thompson S, Allin S, Boyle S, Reinhard B, Chevreul K, et al. Health Care Cost Containment Strategies Used In Four Other High-Income Countries Hold Lessons For The United States. Health Aff. 2013;32(4):643–52.

    Article  Google Scholar 

  95. Strasser R, Kam SM, Regalado SM. Rural Health Care Access and Policy in Developing Countries. Annu Rev Public Health. 2016;37:395–412.

    Article  Google Scholar 

  96. Basu S, Andrews J, Kishore S, Panjabi R, Stuckler D. Comparative Performance of Private and Public Healthcare Systems in Low- and Middle-Income Countries: A Systematic Review. PLoS Med. 2012;9(6):e1001244.

    Article  Google Scholar 

  97. Ferreira Camargo CH, Retzlaff G, Fernandes Justus F, Resende M. Patients with dementia syndrome in public and private services in southern Brazil. SciELO Brasil. 2015;9(1):64–70.

    Google Scholar 

  98. Alzheimer's Disease International. Women and Dementia: A Global Research Review - Care structures and support. 2015. Available from: https://www.alzint.org/u/Women-and-Dementia.pdf.

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Acknowledgements

We want to thank especially Laura Rojas-Rozo, MD, MSc for her insights as well as Genevieve Gore, MLIS, Mary Henein, MSc, Muriel Gueriton, MLIS, and Gajanan Velupillai, BSc, for their help with data collection. We also want to thank Juliette Champoux-Pellegrin for help with referencing and editing the manuscript. The author(s) read and approved the final manuscript.

Funding

This work was funded by the Quebec Research Network on Aging (Réseau québécois de recherche sur le vieillissement, RQRV) and the Canadian Consortium on Neurodegeneration in Aging (2014–2019) (CNA-137794). The Canadian Consortium on Neurodegeneration in Aging is supported by a grant from the CIHR with funding from several partners. The funding bodies had no role in the study design, data collection, its analysis and interpretation.

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Contributions

GAL and IV designed the study. GAL, TB, and ML collected the data. GAL, TB, ML, HB and IV interpreted the results. GAL and TB drafted the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Geneviève Arsenault-Lapierre.

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None of the authors have personal, commercial, political, governmental, academic, or financial conflicts of interest. The funding organization and/or sponsor had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; and in the preparation, editing, or censoring of the manuscript.

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Supplementary Information

Additional file 1

: Details of online search strategy.

Additional file 2:

Inclusion and exclusion criteria.

Additional file 3:

Transformation of data.

Additional file 4: Table 1

: Appraisal of the 35 unique observational studies (39 records). Table 2: Appraisal of the three case-control studies (three records) .

Additional file 5: Step-by-step of certainty of evidence appraisal

.

Additional file 6: Table 1

: Findings for access domain. Table 2: Findings for integration domain Table 3: Findings for effective care domain Table 4: Findings for efficient care domain. Table 5: Findings for population health domain Table 6: Findings for safety domain .Table 7: Findings for patient-centered care domain

Additional file 7: Table 1

: Sensitivity analyses for access domain. Table 2: Sensitivity analyses for integration domain. Table 3: Sensitivity analyses for effective care domain. Table 4: Sensitivity analyses for efficient care domain. Table 5: Sensitivity analyses for population health domain. Table 6: Sensitivity analyses for safety domain. Table 7: Sensitivity analyses for patient-centered care domain.

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Arsenault-Lapierre, G., Bui, T.X., Le Berre, M. et al. Rural and urban differences in quality of dementia care of persons with dementia and caregivers across all domains: a systematic review. BMC Health Serv Res 23, 102 (2023). https://doi.org/10.1186/s12913-023-09100-8

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