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Promoting quality use of medicines in South-East Asia: reports from country situational analyses



Irrational use of medicines is widespread in the South-East Asia Region (SEAR), where policy implementation to encourage quality use of medicines (QUM) is often low. The aim was to determine whether public-sector QUM is better in SEAR countries implementing essential medicines (EM) policies than in those not implementing them.


Data on six QUM indicators and 25 EM policies were extracted from situational analysis reports of 20 country (2-week) visits made during 2010–2015. The average difference (as percent) for the QUM indicators between countries implementing versus not implementing specific policies was calculated. Policies associated with better (> 1%) QUM were included in regression of a composite QUM score versus total number of policies implemented.


Twenty-two policies were associated with better (> 1%) QUM. Twelve policies were associated with 3.6–9.5% significantly better use (p < 0.05), namely: standard treatment guidelines; formulary; a government unit to promote QUM; continuing health worker education on prescribing by government; limiting over-the-counter (OTC) availability of systemic antibiotics; disallowing public-sector prescriber revenue from medicines sales; not charging fees at the point of care; monitoring advertisements of OTC medicines; public education on QUM; and a good drug supply system. There was significant correlation between the number of policies implemented out of 22 and the composite QUM score (r = 0.71, r2 = 0.50, p < 0.05).


Country situational analyses allowed rapid data collection that showed EM policies are associated with better QUM. SEAR countries should implement all such policies.

Peer Review reports


Inappropriate (irrational, incorrect, improper, poor quality) use of medicines is a serious public health problem world-wide [1,2,3,4,5] that wastes resources and may result in treatment failure and avoidable adverse drug events, including antimicrobial resistance [6,7,8], hospitalisation and death [9,10,11]. The World Health Organisation (WHO) has been promoting the concept of essential medicines and a range of policies to promote better quality (rational) use of medicines (QUM) for many years [12, 13]. The extent to which countries, including many in South-East Asia, monitor use or implement these recommended policies vary greatly [14, 15]. A review of interventions to promote better QUM in low and middle-income countries found that relatively few had been implemented and that most were small scale of short duration with small or modest effect [4, 5].

Analysis of secondary data on public-sector medicines use in primary care (from WHO’s database of medicines use surveys) and policy implementation as reported by Ministries of Health (MOH) (from questionnaires sent to Ministries of Health by WHO) showed that many essential medicines policies are associated with better QUM and that the more policies are implemented the better the use [16, 17]. Policies most strongly associated with QUM were: undergraduate training of doctors and nurses in standard treatment guidelines, the ministry of health having a unit promoting QUM, and provision of essential medicines free at point of care to all patients [16, 17].

The need for an integrated health systems approach, incorporating regular monitoring of medicines use and the sustainable implementation of multiple policies has long been recognised [18, 19]. However, development of such an approach remains elusive in many low and middle-income countries, where data are scant, infrastructure is lacking and responsibility for medicines management often falls between different departments with no clear accountability [20].

Since 2010 South-East Asian countries of the WHO have been undertaking 4-yearly rapid situational analyses of how medicines are used and managed with a view to developing a more integrated, coordinated health systems approach to promoting better QUM [21]. This process consists of rapid systematic data collection on medicines use and policy implementation by a multidisciplinary government team of four to eight people over 2 weeks using a predesigned workbook tool and ending with a national workshop to identify priorities for action [21]. During 2010–2015, all 11 jurisdictions (all South-East Asia countries including two Indian States) had conducted at least one situational analysis; eight had conducted two situational analyses separated by a period of 4 years; and the reports published on the WHO’s South-East Asia Regional Office (SEARO) website after government approval [21].

The aim of this paper was to investigate associations between the adoption (implementation or partial implementation) of national policies intended to improve QUM and patterns of medicine use in WHO South-East Asian countries. The analysis relies on data on medicines use in public-sector primary care, and policy implementation, extracted from the country situational analysis reports [21]. Specific objectives were to establish for the WHO South-East Asia region:

  1. 1.

    which policies are associated with better QUM,

  2. 2.

    whether the implementation of more policies is associated with better QUM, and

  3. 3.

    whether there was any improvement in policy implementation and QUM in countries that had undertaken two situational analyses.


The country reports of the situational analyses published on the website of the WHO Regional Office for South-East Asia (WHO/SEARO) [21] were reviewed and data extracted on QUM in public-sector primary care and the implementation of policies to encourage appropriate use. The methods for conducting country situational analyses have been described elsewhere [21, 22] and are summarised in Table 1. Briefly, data on policy implementation was collected by interviews of health staff and observation, and data on QUM by prescription survey following the International Network for the Rational Use of Drugs (INRUD)/WHO methodology [23, 24] at all the health facilities visited. The methods used to analyse the extracted data followed similar methods used by first author in analysing global data and are described elsewhere [16, 17] and summarised below.

Table 1 Summary of methods used in a country situational analysis

A dataset was created (Additional file 1) consisting of six standard QUM indicators [16, 17] and indicators for implementation of 25 policies hypothesised to influence medicines use [14,15,16,17], derived from data collected during 20 country situational analysis visits. Since different provinces or regions and different healthcare facilities were visited in the countries where two situational analyses were done, and the visits were separated by 3–5 years (during which time the implementation of some policies changed), these situational analyses were treated as separate records (country-year jurisdictions) in the dataset.

The QUM indicators (described in Table 2, together with the direction of more appropriate use) are all expressed as proportions and include all the indicators measured in the country situational analyses apart from one (the average number of drugs per patient). In the situational analysis reports [21], QUM indicators were reported as an average for each facility type, but for this analysis one result per QUM indicator was calculated, this being the average across all facilities.

Table 2 Quality Use of Medicines (QUM) indicators and direction of better use

The policy indicators (described in Table 3) are all expressed as categorical yes/no variables and include all those policies hypothesised to improve the appropriate use of medicines [16, 17] for which data were available in the country situational reports [21] and for which there were countries with and without the policy (for comparison). Some policies hypothesised to influence prescribing were not implemented by any country (e.g. monitoring all drug promotional activities), but if possible, similar more limited policies were substituted (e.g. monitoring of advertisements restricted to over-the-counter drugs). Where policy implementation was expressed as a range of values, the policy was converted to a yes/no value. For example, “some” public education and “some” health worker training was regarded as “yes” when assessing whether a country had implemented these policies. Details of decisions on whether a policy was marked as present or not can be seen in Table 3. Since country wealth may be a potential confounder (being associated with both better QUM and greater policy implementation), data on gross national income per capita (GNIpc) were extracted for each country in the year of the situational analysis from the United Nations (UN) Country Profile Data [25].

Table 3 Medicine Policy variables with information on how a policy was judged to be present or not


Analyses were done in Excel 2016 and Epi Info version Univariate analyses, with each policy as the unit of analysis, were used to identify policies that were associated with better QUM. The mean difference (expressed as a percentage) for each QUM indicator between “countries” (country-year jurisdiction) implementing and not implementing a specific policy was calculated. The directionality of “better” or “worse” use was aligned for each of the six QUM indicators and an average (overall) difference calculated for each specific policy, whereby a positive (+) number indicates “better” use and a minus (−) number indicates “worse” use. The mean differences for each QUM indicator, and the average difference across all QUM indicators for each policy were calculated and represent an estimate of the quantitative impact of each policy. Head-to-head comparisons of the impact of different policies and further multiple comparisons were not done.

Correlations of multiple policies with QUM indicators, where the “country-year jurisdiction” was the unit of analysis, were performed to see if adoption (implementation or partial implementation) of more policies was associated with better QUM. Since various policies are likely to impact differently on different QUM indicators, and to gain an idea of the overall impact on QUM by the package of policies that any one country was implementing in one specific year, a composite QUM variable was derived, in the same manner as has been done elsewhere [16]. Use of a composite QUM variable allowed comparison of data across all 20 situational analyses rather than only 15, since some QUM indicators were not measured in five situational analyses. For each individual QUM variable, we calculated how far that country’s value (referred to as “country-year” – see text) lay above or below the mean value from all “country-years” and then converted this difference into standard deviation units. The average of the standard deviation unit increments across all six QUM indicators for each country-year was calculated and this was then regressed against the number of implemented policies that were associated with an effect size of more than 1% (22 out of 25 policies) as estimated from the univariate analysis.

Although countries implement each policy differently, the adoption of more policies is likely to reflect stronger intention to promote QUM, which may be reflected variously by different QUM indicators. Hence, individual QUM indicators were also regressed on the number of policies a country implemented. Since there may be correlation between the results of different situational analyses done in the same country, a sensitivity analysis was done by restricting the regression analysis to the latest situational analysis of the country.

The impact of country economic status was assessed by including Gross National Income per capita (GNIpc) into multiple linear regression analyses and by repeating the regression analyses for countries with GNIpc above and below the median of USD 2230.

Finally, in those countries where a situational analysis was done twice, the mean difference between situational analyses, for each of the six QUM indicators, was calculated to see whether there had been any change in QUM over time, and whether any change was accompanied by a corresponding change in the number of policies implemented.


Data were extracted from 20 situational analysis reports covering all 11 countries of the WHO South-east Asia region – two reports from eight countries in different years, two reports from India (one North Indian and one South Indian state in the same year) and one report each from two countries (Democratic Peoples’ Republic [DPR] of Korea and Indonesia). QUM data for all six indicators were extracted from 15 country-visit reports, with 1–2 QUM variables missing from four reports (concerning injection use, prescribing from the Essential Medicines List [EML] and antibiotic use in upper respiratory tract infection [URTI] cases), and 5 out of six QUM indicators missing from one early report (Bangladesh 2010). A total of 206 public-sector health facilities were visited (average of 10–11 public-sector health facilities per country-visit, half of which were primary healthcare centres) and 30 prescriptions per facility were examined to estimate five of the six QUM indicators. The QUM indicator concerning the % URTI cases treated with antibiotics was estimated from visits to 151 public-sector health facilities (average of 7–8 facilities per country visit) with an average of 23 URTI prescriptions examined per facility. In two countries (Sri Lanka 2010 and Bangladesh 2010) no data on antibiotic use in URTI was available, in two countries (Bhutan 2011 and Maldives 2011) data on antibiotic use in URTI was available in only two health facilities and in one country (Indonesia 2011) from only three health facilities. Policy data for all 25 indicators were extracted from all 20 country-visit reports.

Comparison of QUM indicators in countries with and without specific policies

Table 4 shows the mean differences for each of the six QUM indicators, and the average difference across all six QUM indicators, between countries that did and did not implement the 25 policies hypothesised to be associated with better use. Figure 1 shows the mean difference (with 95% confidence interval)) across all six QUM indicators for each of the 25 policies. Twenty-two out of 25 policies were associated with better QUM, although in many cases the differences were small. Twelve policies were associated with statistically significantly (p < 0.05) better QUM of more than 3.6% – namely not charging patients any user fee or copayment for medicines at the point of care, undergraduate education of prescribers on the national treatment guidelines (STGs), distribution of STGs to health facilities (as demonstrated by finding them in facilities), a Ministry of Health (MOH) unit dedicated to promoting QUM, continuing education on prescribing for health workers by MOH, general non-availability of systemic antibiotics over-the-counter (OTC), monitoring of advertisements for OTC medicines, no revenue from medicine sales for public sector prescribers, having no stock-out problems, public education and having a national formulary. For the 22 (out of 25) policies associated with better overall QUM of more than 1%, 96 (73%) of a possible 132 comparisons (6 QUM indicators × 22 policies) were associated with better QUM.

Table 4 Differences in medicine use between countries with and without each of 25 policies hypothesised to be associated with better use
Fig. 1
figure 1

Differences in medicines use between countries with and without medicines policies. STG = Standard Treatment Guidelines; OTC = Over-the-Counter; MOH = Ministry of Health; CME = Continuing Medical Education; DTC = Drug and Therapeutic Committee; EML = Essential Medicines List; AMR = Antimicrobial Resistance; PHC = Primary Health Care

Some policies had large effects on one particular QUM indicator, but not on overall use (as judged by six QUM indicators). Generic prescribing policies were associated with greater generic prescribing; implementing the national EML (as indicated by having an updated EML and limiting public procurement to EML drugs) was associated with greater prescribing of EML medicines. However, low to modest prescriber workload (as defined by seeing less than 60 patients per day) was not associated with better overall QUM, although it was associated with lower antibiotic use.

Effects of multiple policies and national wealth

Figure 2 shows a scatter plot of the composite QUM indicator and the number of policies implemented (out of 22 policies associated with better QUM) for 20 situational analysis visits (country-years). There was moderate to strong positive correlation between the number of essential medicines policies implemented and the composite QUM indicator (r = 0.71, r2 = 0.50, p < 0.05). In sensitivity analyses (not shown graphically) the correlation increased when GNIpc was included in the regression analysis (r = 0.75, r2 = 0.57, p < 0.05) and the correlation was moderate to strong in the 10 country-visits with GNIpc above USD 2230 (r = 0.76, r2 = 0.58, p < 0.05) and below USD 2230 (r = 0.69, r2 = 0.48, p < 0.05). Furthermore, confining the regression analysis to data from the most recent situational analyses in 12 states (all 11 countries including 2 Indian states), in order to take account of possible clustering of results from the same site, also showed moderate to strong correlation between the composite QUM indicator and the number of essential medicines policies (r = 0.71, r2 = 0.50, p < 0.05).

Fig. 2
figure 2

Scatter plot of composite QUM score versus number of policies (out of 22) implemented

Figures 3, 4, 5, 6, 7 and 8 show the scatter plots for the individual QUM indicators versus policy implementation. Regression analyses of individual QUM indicators and the number of policies (out of 22) implemented showed that with an increasing number of essential medicines policies implemented there was: an increase in the % prescribed medicines belonging to the EML (r = 0.46, r2 = 0.21, p > 0.05) (Fig. 3); an increase in the % medicines prescribed by generic name (r = 0.62, r2 = 0.38, p < 0.05) (Fig. 4); a decrease in the % patients prescribed injections (r = − 0.24, r2 = 0.06, p > 0.05) (Fig. 5) and a decrease in the % URTI cases prescribed antibiotics (r = − 0.42, r2 = 0.18, p > 0.05) (Fig. 6). There was virtually no change in the % patients treated with antibiotics (r = − 0.1, r2 = 0.01, p > 0.05) (Fig. 7) or vitamins (r = − 0.1, r2 = 0.02, p > 0.05) (Fig. 8) with increasing number of policies implemented. In a sensitivity analysis where policies not hypothesised to influence antibiotic use were excluded (2 policies on generic prescribing and substitution and 3 policies on EML implementation), a stronger association was found between the number of policies (out of 17) implemented and the % URTI cases prescribed antibiotics (r = − 0.49, r2 = 0.24, p < 0.05).

Fig. 3
figure 3

% prescribed medicines from the Essential Medicines List versus number of policies (out of 22) implemented

Fig. 4
figure 4

% medicines prescribed by generic name versus number of policies (out of 22) implemented

Fig. 5
figure 5

% patients prescribed injections versus number of policies (out of 22) implemented

Fig. 6
figure 6

% Upper Respiratory Tract Infection cases prescribed antibiotics versus number of policies (out of 22) implemented

Fig. 7
figure 7

% patients prescribed antibiotics versus number of policies (out of 22) implemented

Fig. 8
figure 8

% patients prescribed vitamins versus number of policies (out of 22) implemented

Changes over time

In seven of the eight countries where a situational analysis had been done twice, separated by a period of 3–5 years, the average mean differences over time for the six individual QUM indicators and the average mean difference over the six QUM indicators, together with any change in the number of policies implemented are shown in Table 5. The data for Bangladesh were excluded because five of the six QUM indicators were missing from the first situational analysis in 2010. The data show a significant improvement in QUM together with increased policy implementation in Thailand, while in other countries there was no significant change in QUM and policy implementation. However, the small sample sizes (concerning health facilities and patient encounters) preclude further interpretation of the data.

Table 5 Changes over time in 8 countries where two country situational analyses were done


This study has two important findings. Firstly, some policies were associated with significantly better QUM; and secondly the more of these policies a country implemented the better was the QUM.

Policies statistically significantly associated with more than 7% better overall QUM were: not charging patients any user fee or co-payment for medicines at the point of care; implementation of STGs through undergraduate education of prescribers and adequate distribution (as indicated by finding STGs available at health facilities); an MOH unit dedicated to monitoring and promoting QUM; continuing medical education (CME) on prescribing for health workers by MOH; limiting the OTC availability of systemic antibiotics; not allowing public sector prescribers to gain revenue from the sales of medicines; and monitoring advertisements of OTC medicines. Other policies that had a significant but smaller association with better QUM included: more efficient drug supply system (as indicated by no stock-out problems reported); availability of a national formulary; public education programs on medicines use; and not charging patients any registration or consultation fee at health facilities.

The policies associated with better QUM in this study are similar to those policies associated with better QUM in an analysis of global secondary data [16, 17] (excluding those policies which were not commonly measured in both studies). The one exception was that CME was done by MOH, and was associated with better QUM in this study, but may not have been done by MOH in countries included in the previous analysis of global data, where CME was associated with poorer QUM.

The effectiveness of similar interventions has been reported elsewhere, including: education of prescribers [4, 5] and the public [26], an MOH unit dedicated to promoting QUM [27], administrative interventions such as hospital drug and therapeutic committees (DTCs) [28, 29], non-allowance of prescriber income from drug sales [30], non-allowance of antibiotics OTC [31], and monitoring of drug promotional activities [32]. As found in analysis of global data where provision of medicines free of charge was associated with better use [16, 17], so in this study not charging patients any fees for medicines (or fees that could be construed by patients as being for medicines e.g. registration and consultation fees) was associated with better use.

There was a significant moderate to strong positive correlation between the number of policies implemented and the composite QUM (over six indicators), and for two of the individual QUM indicators (% URTI cases prescribed antibiotics and % medicines prescribed by generic name). While the effect sizes were small for individual policies (< 10%), the effect sizes associated with implementation of multiple policies were large (30–95% over different QUM indicators) and comparable with the largest intervention effects reported elsewhere [4, 5]. We believe that the data on the possible impacts of multiple policies are important and likely to reflect a causal association. This is the second time we have found the correlations between numbers of implemented policies and better QUM measures, and these analyses were conducted in different and independent data-sets [16, 17].

Increased effect sizes with multiple (as opposed to single interventions) have been reported in many literature reviews [4, 5, 33,34,35]. The correlations between the composite QUM indicator and the number of policies implemented remained strong in both wealthier and poorer countries when the regression analysis was repeated for countries with a GNIpc above and below the median of USD 2230. This finding together with the fact that there was no correlation between GNIpc and the number of policies implemented suggests that it is likely that the better QUM seen with increasing policy implementation was due to the policies themselves and not due to wealth, as has been found elsewhere [16, 17].

The apparent improvement in QUM in association with increased policy implementation over time seen in Thailand may be a chance finding since the number of facilities was small and the same facilities were not visited during both visits. Nevertheless, Thailand increased its policy implementation more than other countries over the time-period and similar results have been reported elsewhere [36, 37]. Therefore, it is suggested that the method used in this study to measure QUM in relation to policy implementation may be a good method to monitor country progress on promoting QUM.

The data analysed in this study were collected from all countries during 2-week periods using a pre-designed workbook tool by government staff with facilitation from WHO, were discussed in each country and a report produced and published on WHO/SEARO website for future use [21]. The approach was mandated by Member States [38, 39] and proved relatively cheap and quick, so enabling government participation and action. This study further shows that the data collected from this approach is sufficient for regional analysis and development of a regional approach to promote better QUM.


Although there were moderate to strong correlations between medicines use and policy implementation in this study, causality cannot be proved and may be due to co-interventions. Small sample sizes disallowed multi-variable analyses. Nevertheless, these are the best data available on policy effectiveness in the public sector in South-East Asia given the absence in all countries of national longitudinal data which could be used to perform time series analysis to show association or possibly prove causality. It is acknowledged that much health care is provided in the private sector but there was insufficient data to investigate this. Nevertheless, the findings are very relevant since many prescribers work in both the public and private sectors and many private-sector prescribers copy public-sector ones e.g. private general practitioners copying public-sector specialists.

The policy data, recorded in the situational analysis country reports [21], was collected by direct observation and discussion with health officials and health facility staff during the country situational analysis visits and thus may be more accurate than data relying on MOH questionnaires, as used elsewhere [16, 17]. Nevertheless, there may be some misclassification since relatively few health facilities were visited and it was not always easy to interpret whether a policy was implemented or not. For example, there was enormous variation between countries and between health facilities in the same country concerning hospital DTC activities, and the content and extent of prescriber CME and public education provided by the MOH. Some policies measured in this study are likely to be effective through association with other health system factors and policies. For example, the general lack of availability of systemic antibiotics OTC in Bhutan and DPR Korea may be due to a lack of private sector as well as regulatory controls. The policy “no stock-outs reported” was assumed to reflect better drug supply which might then impact on QUM. However, a situation of “no stock-outs” could itself result from better QUM.

The prescribing (QUM) data were collected by direct examination of treatment in 30 outpatient patient encounters (plus 10–30 URTI cases where measured) per facility on the day of the visit using the INRUD/WHO methodology [23, 24]. Since all six QUM indicators were collected in 15 (75%) of the 20 country situational analysis visits, the QUM data may be more robust than what we used in other work, where we relied on previously published surveys with on average only three QUM indicators per country [16]. Nevertheless, while every effort was made to collect the data in a standard way, the variation between countries in documentation of patient treatment and the small sample sizes involved may have resulted in some inaccuracies in the results. Furthermore, some indicators such as injection use and antibiotic use in URTI cases could not be measured in some countries and in some health facilities within a country. However, any inaccuracies in the QUM and policy data would tend to weaken the correlations observed.

Another serious weakness is that the QUM measurements were based on small convenience samples (by MOH) of on average 10–11 public health facilities per country visit. Thus, the surveys were not generalisable to whole countries and no benchmarking of country performance can be done using these data. Nevertheless, implementation of some policies was judged by observation of what occurred in the health facilities where QUM surveys were done, and this may account for the stronger correlation between policy implementation and QUM seen in this study compared to previous analyses [16, 17].


Irrational use of medicines is a serious problem in South-East Asia. Essential medicines policies were found to be associated with better QUM and it is recommended that all countries: implement (through adequate education and distribution) national STGs, EML and formulary; establish an MOH unit dedicated to QUM; conduct CME on prescribing for health workers under close supervision of MOH; limit OTC availability of systemic antibiotics; disallow public sector prescribers to gain revenue from the sales of medicines; monitor advertisements of OTC medicines; run public education campaigns on QUM; do not charge patients user fees or co-payments for medicines at the point of care; and invest in a more efficient drug supply system. The situational analysis approach allows the relatively quick and cheap collection of data on QUM and policy implementation which can be used to monitor progress and plan future action.



Continuing medical education

DPR Korea:

Democratic Peoples’ Republic of Korea


Drug and therapeutic committee


Essential medicines


Essential medicines list


Gross National Income per capita


International Network for the Rational Use of Drugs


Ministry of Health




Quality use of medicines


South-East Asia Regional Office


Standard treatment guidelines


United Nations


Upper respiratory tract infection


World Health Organisation


  1. Holloway KA. Combating inappropriate use of medicines. Expert Rev Clin Pharmacol. 2011;4(3):335–48.

    Article  PubMed  Google Scholar 

  2. Holloway KA, van Dijk L. The world medicines situation. Rational use of medicines. WHO/EMP/MIE/2011.2.2. 3rd ed. Geneva: World Health Organization; 2011. Available: . (Accessed 25 July 2017)

    Google Scholar 

  3. World Health Organisation. Medicines use in primary care in developing and transitional countries: fact book summarizing results from studies reported between 1990 and 2006. WHO/EMP/MAR/2009.3. Geneva: World Health Organisation; 2009.

    Google Scholar 

  4. Holloway KA, Ivanovska V, Wagner AK, Vialle-Valentin C, Ross-Degnan D. Have we improved use of medicines in developing and transitional countries and do we know how to? Two decades of evidence. Tropical Med Int Health. 2013;18(6):656–64.

    Article  CAS  Google Scholar 

  5. Holloway KA, Ivanovska V, Wagner AK, Vialle-Valentin C, Ross-Degnan D. Prescribing for acute childhood infections in developing and transitional countries, 1990-2009. Paediatr Int Child Health. 2015;35(1):5–13.

    Article  PubMed  Google Scholar 

  6. Livermore DM. Bacterial resistance: origins, epidemiology, and impact. Clin Infect Dis. 2003;36(Suppl 1):S11–23.

    Article  PubMed  CAS  Google Scholar 

  7. Harbarth S, Samore MH. Antimicrobial resistance determinants and future control. Emerg Infect Dis. 2005;11:794–801e.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Goossens H. Antibiotic consumption and link to resistance. Clin Microbiol Infect. 2009;15(Suppl 3):12–5.

  9. Pirmohamed M, James S, Meakin S, Green C, Scott AK, Walley TJ, Farrar F, Park BK, Breckenridge AM. Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients. Br Med J. 2004;329:15–9.

    Article  Google Scholar 

  10. Howard RL, Avery AJ, Slavenburg S, Royal S, Pipe G, Lucassen P, Pirmohamed M. Which drugs cause preventable admissions to hospital? A systematic review. Br J Clin Pharmacol. 2006;63(2):136–47.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hitchen L. Adverse drug reactions result in 250 000 UK admissions a year. Br Med J. 2006;332:1109.

    Google Scholar 

  12. World Health Organisation. The rational use of drugs. Report of the conference of experts. Geneva: World Health Organisation; 1985.

    Google Scholar 

  13. World Health Organisation. Promoting rational use of medicines: core components. WHO policy perspectives of medicines. Geneva: World Health Organisation; 2002. p. 5.

    Google Scholar 

  14. World Health Organisation. Using indicators to measure country pharmaceutical situations: fact book on WHO level I and level II monitoring indicators. Who/TCM/2006.2. Geneva: World Health Organisation; 2006.

    Google Scholar 

  15. World Health Organisation. Country pharmaceutical situations: fact book on WHO Level 1 indicators 2007. WHO/EMP/MPC/2010.1. Geneva: World Health Organisation; 2010.

    Google Scholar 

  16. Holloway KA, Henry D. WHO essential medicines policies and use in developing and transitional countries: an analysis of reported policy implementation and medicines use surveys. PLoS Med. 2014;11(9):e1001724.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Holloway KA, Rosella L, Henry D. The impact of WHO essential medicines policies on inappropriate use of antibiotics. PLoS One. 2016;11(3):e0152020.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. World Health Organisation. Progress in the rational use of medicines. World health assembly resolution, WHA60.16. Geneva: World Health Organisation; 2007.

    Google Scholar 

  19. International Conferences for Improving the Use of Medicines, 1997, 2004 and 2011. URL: (Accessed 25 July 2017).

  20. Bigdeli M, Peters DH, Wagner AK, editors. WHO/HPSR. Medicines in health systems: advancing access, affordability and appropriate use. Geneva: WHO and Alliance for Research on Access to Medicines; 2014.

    Google Scholar 

  21. Country situation analyses of medicines in health care delivery in South-East Asia. URL: (Accessed 9 Jan 2018).

  22. Holloway KA, Kotwani A, Batmanabane G, Puri M, Tisocki K. Antibiotic use in South-East Asia and policies to promote appropriate use: reports from country situational analyses. Br Med J. 2017;358(Suppl 1):9–13.

    Google Scholar 

  23. World Health Organisation. How to investigate drug use in health facilities: selected drug use indicators. WHO/DAP/93.1. Geneva: World Health Organisation; 1993.

  24. Gove S. Integrated management of childhood illness by outpatient health workers: technical basis and overview. The WHO working group on guidelines for integrated management of the sick child. Bull World Health Organ. 1997;75(Suppl 1):7–24.

    PubMed  PubMed Central  Google Scholar 

  25. UN country profile data. URL: (Accessed 1 June 2017).

  26. Huttner B, Goossens H, Verheij T, Harbath S, for the CHAMP Consortium. Characteristics and outcomes of public campaigns with the aim to improve outpatient antibiotic use in high income countries. Lancet Infect Dis. 2009;10(1):17–31.

    Article  Google Scholar 

  27. Jaffer B. National approach of promote rational use of medicines: the Omani experience. WHO/NGO Technical Briefing Seminar, World Health Assembly, Geneva, 14th May 2007. Directorate of Rational Drug Use Department, MOH, Oman. Available: (Accessed 25 July 17).

  28. Vang C, Tomson G, Kounnavong S, Southammavong T, Phanyanouvong A, Johansson R, Eriksson B, Wahlstrom R. Improving the performance of drug and therapeutics committees in hospitals - a quasi-experimental study in Laos. Eur J Clin Pharmacol. 2006;62:57–63.

    Article  PubMed  Google Scholar 

  29. Lu CY, Ross-Degnan D, Soumerai SB, Pearson SA. Interventions designed to improve the quality and efficiency of medication use in managed care: a critical review of the literature – 2001-2007. BMC Health Serv Res. 2008;8:75.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Park S, Soumerai SB, Adams AS, Finkelstein JA, Jang S, et al. Antibiotic use following a Korean national policy to prohibit medication dispensing by physicians. Health Policy Plan. 2005;20(5):302–9.

    Article  PubMed  Google Scholar 

  31. Bavestrello L, Cabello A, Casanova D. Impact of regulatory measures in the trends of community consumption of antibiotics in Chile. Revista Medica De Chile. 2002;130(11):1265–72.

    PubMed  Google Scholar 

  32. World Health Organisation. Drug Promotion - what we know, what we have yet to learn – reviews of materials in the WHO/HAI database on drug promotion. EDM Research Series No.32, WHO/EDM/PAR/2004.3. Geneva: World Health Organisation; 2004.

    Google Scholar 

  33. Rowe AK, de Savigny D, Lanata CF, Victora CG. How can we achieve and maintain high-quality performance of health workers in low resource settings? Lancet. 2005;366(9490):1026–35.

    Article  PubMed  Google Scholar 

  34. Francke AL, Smit MC, De Veer AJE, Mistiaen P. Factors influencing the implementation of clinical guidelines for health care professionals: a meta-review. BMC Med Inform Decis Mak. 2008;8:38.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Sketris IS, Ingram EML, Lummis HL. Strategic opportunities for effective optimal prescribing and medication management. Can J Clin Pharmacol. 2009;16(1):e103–25.

    PubMed  Google Scholar 

  36. Boonyasiri A, Thamlikitkul V. Effectiveness of multifaceted interventions on rational use of antibiotics for patients for patients with upper respiratory tract infections and acute Diarrhoea. J Med Assoc Thai. 2014;97(Suppl 3):S13–9.

    PubMed  Google Scholar 

  37. Sumpradit N, Chongtrakul P, Anuwong K, Pumtong S, Kongsomboon K, Butdeemee P, Khonglormyati J, Chomyong S, Tongyoung P, Losiriwat S, Seesuk P, Suwanwaree P, Tangcharoensathien V. Antibiotics Smart use: a workable model for promoting the rational use of medicines in Thailand. Bull World Health Organ. 2012;90(12):905–13.

    Article  PubMed  PubMed Central  Google Scholar 

  38. World Health Organisation/South-East Asia Regional Office (WHO/SEARO). Regional committee resolution SEA/RC66/R7. Effective Management of Medicines. New Delhi: World Health Organization Regional Office for South-East Asia; 2013.

    Google Scholar 

  39. World Health Organisation/South-East Asia Regional Office (WHO/SEARO). Regional committee resolution SEA/RC64/R5. Effective National Essential Drug Policy including the rational use of medicines. New Delhi: World Health Organisation Regional Office for South-East Asia; 2011.

    Google Scholar 

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South-East Asia Regional Office (SEARO) of the World Health Organisation, New Delhi, India, funded the original country situational analyses. Extraction and analysis of data from the country reports published on the SEARO website and writing of this manuscript was done without funding. All the views expressed in this manuscript are solely the views of the authors and not those of WHO.

Availability of data and materials

The workbook tool used for data collection in the field is available on the WHO/SEARO website: also as Additional file 2. The dataset generated from data extracted from country situational analysis reports on the WHO/SEARO website: available as a Additional file 1, and further files showing more detailed analysis are available from the corresponding author on reasonable request.

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Authors and Affiliations



All authors have read and approved the manuscript. KAH is a public health doctor, formerly of WHO, who developed the methods for the situational analyses, facilitated all the situational analyses, analysed the data, and wrote the manuscript. AK is a professor of pharmacology with international expertise in drug use, medicines pricing and access, who supported three situational analyses during 2015, reviewed the methods, and helped write the manuscript. GB is a professor of pharmacology with international expertise in drug selection and use, who supported one situational analysis in 2015, reviewed the methods, and helped write the manuscript. BS is a pharmacologist, formerly of WHO, who supported one situational analysis in 2015 and who helped write the manuscript. SR is director of International Graduate Programs in Health Social Sciences at Mahidol University, Thailand, who supported one situational analysis in 2015 and who helped write the manuscript. DH is professor of evidence-based practice at Bond University, Australia, formerly director of the WHO Collaborating Centre for Training in Pharmaco-economics and Rational Pharmacotherapy at the University of Newcastle in Australia, who assisted in analysis of the data, interpretation of the findings, and writing of the manuscript.

Corresponding author

Correspondence to Kathleen Anne Holloway.

Ethics declarations

Ethics approval and consent to participate

All the data used in this study was obtained from published country reports of situational analyses of medicines management - all of which are publicly available online at: and

All administrative permissions, including formal approval by the respective Ministry’s of Health were obtained, prior to publication of the country reports on the WHO/SEARO website, as mandated by the World Health Organisation’s Regional Committee Resolution SEA/RC66/R7, Effective Management of Medicine, World Health Organization Regional Office for South-East Asia, New Delhi, 2013 (see reference [38]). Furthermore, various data from these country reports have already been extracted, analysed, and published on the WHO/SEARO website and internationally (see reference [22]).

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Not Applicable.

Competing interests

The authors declare that they have no competing interests.

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Additional files

Additional file 1:

Dataset created from extraction of data from country situational analysis reports, all available online at: and Excel file of the dataset created from data extracted from the country situational analysis reports and which was used in the analysis described in this manuscript. (XLSX 13 kb)

Additional file 2:

Medicines management in healthcare delivery: WHO/SEARO workbook tool and report template for undertaking a situational analysis of medicines management in health care delivery in low and middle-income countries, March 2016. Available online at: PDF file of the data collection instrument used to collect data in the country situational analyses and that was analysed in this manuscript. (PDF 1236 kb)

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Holloway, K.A., Kotwani, A., Batmanabane, G. et al. Promoting quality use of medicines in South-East Asia: reports from country situational analyses. BMC Health Serv Res 18, 526 (2018).

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