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Relationship between cardiovascular risk and lipid testing in one health care system: a retrospective cohort study



The US Preventive Services Taskforce (USPSTF) recommends routine lipid screening beginning age 35 for men [1]. For women age 20 and older, as well as men age 20–34, screening is recommended if cardiovascular risk factors are present. Prior research has focused on underutilization but not overuse of lipid testing. The objective is to document over- and under-use of lipid testing in an insured population of persons at low, moderate and high cardiovascular disease (CVD) risk for persons not already on statins.


The study is a retrospective cohort study that included all adults without prior CVD who were continuously enrolled in a large integrated healthcare system from 2005 to 2010.

Measures included lipid test frequency extracted from administrative data and Framingham cardiovascular risk equations applied using electronic medical record data. Five year lipid testing patterns were examined by age, sex and CVD risk. Generalized linear models were used to estimate the relative risk for over testing associated with patient characteristics.


Among males and females for whom testing is not recommended, 35.8 % and 61.5 % received at least one lipid test in the prior 5 years and 8.4 % and 24.4 % had two or more.

Over-testing was associated with age, race, comorbidity, primary care use and neighborhood income. Among individuals at moderate and high-risk (not already treated with statins) and for whom screening is recommended, between 21.4 % and 25.1 % of individuals received no screening in the prior 5 years.


Based on USPSTF lipid screening recommendations, this study documents substantial over-testing among individuals with low CVD risk and under-testing among individuals with moderate to high-risk not already on statins. Opportunity exists to better focus lipid screening efforts appropriate to CVD risk.

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Because hyperlipidemia is a leading risk factor for cardiovascular disease (CVD) that can be reduced by early intervention, the US Preventive Service Task Force (USPSTF) recommends routine lipid screening beginning at age 35 for men [1]. For women age 20 and older, as well as men age 20–34, screening is only recommended for persons at increased risk (i.e., diabetes, hypertension, tobacco use, obesity, previous personal history of CVD, or premature family history of CVD) because, without these risks, the absolute 10-year CVD risk is small regardless of lipid levels. The USPSTF also recommends repeat screening for individuals with CVD risk factors and lipid lowering agents based on Framingham CVD risk projections.

A recent guideline from the American College of Cardiologists and American Heart Association (ACC-AHA) recommends universal lipid screening begin earlier at age 20 for both men and women [2]. They also recommend using an updated global CVD risk calculator to identify young adults at high long-term (30 year) risk of cardiac mortality. Estimates of 30-year risk might be useful for those under age 40 with established risk factors, but screening in this age group remains controversial because there is no evidence that long-term use of statins improves CVD outcomes. The ACC-AHA guideline also encourages lipid screening using the updated risk calculator and recommends statins for adults ages 40–75 with a 7.5 % 10-year CVD risk or higher.

While older guidelines endorsed regular monitoring of low density lipoprotein (LDL) for those on statins, the new guideline omits this recommendation.

Over the last several decades, there has been considerable attention on underutilization of cholesterol screening [3, 4] and the under-treatment of hyperlipidemia in persons at risk [5, 6].

Latest published data from the Behavioral Risk Factor Surveillance Survey show use of cholesterol screening is increasing in persons aged 18 and older, rising from 72.7 % to 76.0 % between 2005 and 2009 [7]. In addition to underuse, attention in the research and policy community has focused on overuse of preventive and other services where expenses and risks outweigh the benefits.

Research confirms that overuse is widespread [8, 9], not only resulting in unnecessary costs from testing and downstream expenditures, but also in psychological and other risks from over-diagnosis [10]. Because of the risks involved, most research on overuse of screening and monitoring has focused on colorectal, breast, cervical and prostate cancer screening [8, 9]. There has been little attention to overutilization of lipid screening, particularly in persons who are at low-risk. One study of Medicare enrollees [11], almost all of whom are at moderate- or high-risk, found that multiple testing of lipids was common and likely unnecessary (i.e., 11.9 % of patients receiving three or more tests in a 1 year period). To our knowledge, no studies have examined overuse of lipid screening among low-risk or younger individuals, nor the characteristics that are associated with overuse. However, this examination is relevant. Identifying the under-use of recommended screenings could improve health outcomes for those at moderate- or high-risk, while identifying the over-use of screenings among persons at low-risk could point to opportunities for lowering population-level health care costs and reducing patient burden.

This investigation is part of the e-Care for Heart Wellness Study (RC1HL100590-01) [9] and focuses on the patterns of lipid testing among persons without prior CVD. The purpose of this study is to document over- and under-use of lipid testing as recommended by the USPSTF among an insured population including persons at low, moderate and high CVD risk. We also examine characteristics associated with over-testing among low risk persons.


Cohort participants received care from Group Health, an integrated healthcare system in Washington State that provides coverage and care to approximately 405,000 persons in an integrated group practice. Participants were adults aged 25–79 who were continuously enrolled at Group Health for 5 years between April 1, 2005 and March 31, 2010. Continuous enrollment was defined as having no gap greater than 45 days. Patients were excluded if they also had less than one primary care visit in the 2 years between April 1, 2008 and March 31, 2010 since the cardiovascular risk estimation relies on data derived from healthcare encounters. Patients were also excluded if they had a previous CVD diagnosis (i.e., myocardial infarction, angina, coronary surgery, cerebrovascular occlusion, transient ischemic attack, congestive heart failure and peripheral vascular disease), as lipid testing guidelines are different for those with existing CVD [2, 6]. We excluded persons with other significant diseases including cancer (except non-melanoma skin cancer), end-stage renal disease, hepatic failure and dementia because cholesterol testing may not be clinically relevant for this group. Finally, we also excluded persons who were dispensed 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins, because of the recommendation for lipid monitoring prior to 2013 [9]) and isotretinoin (one or more prescription fills in the study period).

To construct the study variables, we extracted data from Group Health’s electronic clinical and administrative data systems. These databases capture all care provided to enrollees at Group Health facilities and from external claims. Demographic variables (including age, sex, race, zip code and health plan) were extracted from health plan enrollment records as of April 1, 2010. Using methods developed by Krieger and colleagues [12], we created ecological-level income and education variables by aggregating zip codes into census tracks and merging them with median household income and education Census variables. To define rural and urban status, we used the rural–urban commuting area code schema (RUCAs, version 2.0) that reflect relative geographic densities based on population counts and community patterns [13]. To describe our population’s use of primary care, we counted the average number of primary care visits per year (to primary care physicians, nurse practitioners and physician assistants) across the 5 years. Finally, we counted the number of lipid tests on different days performed during the 5 year study period.

Biometric, laboratory and tobacco use data were extracted from the patient’s clinical data based on the most recent recorded value during the study period. In addition to continuous measures, body mass index was classified as normal weight (<25.0), overweight (25.0–29.9) and obese (≥30 kg/m2). Systolic blood pressure was classified as ≤ 140, 141–160, 161–180 and >180 mm/Hg. Lipid levels were based on the most recent value recorded and were aggregated into clinically-relevant categories of <200, 200–239 and ≥240 mg/dl for total cholesterol (TC); <40, 40–59 and ≥60 mg/dl for high density lipoprotein (HDL); and <100, 100–129, 130–159, 160–189 and ≥ 190 mg/dl for LDL. Tobacco status was classified as current smoker or non-smoker using the tobacco vital sign collected at the most recent visit. Diabetes was defined as having: two or more filled prescriptions for insulin or oral agents; one inpatient or two outpatient diagnoses of diabetes at any time during their enrollment at Group Health; a fasting glucose >126 mg/dl confirmed by a second out-of range test within 1 year; or a random glucose > 200 mg/dl also confirmed by a second test within 1 year. Treated hypertension was determined by looking for any filled prescription for an antihypertensive in the prior year. To measure comorbidity, we used Resource Utilization Bands (RUBs), the terminal categories of the Adjusted Clinical Group (ACG) system [14]. The ACG system is widely used to adjust for differences in case-mix among populations receiving health services in outpatient settings [15, 16].

Using our prior methods [17], we combined age, sex, systolic blood pressure, treatment for hypertension, diabetes status, smoking status, BMI, HDL and TC to calculate 10 year Framingham global CVD risk scores using both lab-based [6] and BMI-based approaches [17]. As recommended by the Adult Treatment Panel- III of the National Cholesterol Education Program (ATP-III) [9], patients were classified into three CVD risk categories: low (<10 %), moderate (10–20 %) and high (>20 %) to reflect standards for lipid management during the study period. The new ACC-AHA guideline (promulgated after the study period) encourages statin use for persons aged 40–75 with CVD risk ≥7.5 %, so we also created a secondary binary risk variable at this threshold to use in sensitivity analyses. Since lipid testing was not performed on approximately 40 % of the population during the study period, we used the BMI-based risk score as our primary measure of CVD risk [17]. Our prior research found BMI- and lab-based scores to be concordant in 78.2 % of patients. When discordant, the BMI-based risk was almost always in a higher category, with less than 2 % of adults with a BMI-based 10-year CVD risk of <10 % being reclassified to moderate (10–20 %) or high-risk (>20 %) based on laboratory testing when both risking methods were available [17]. Lab-based risk scores were used to characterize risk for individuals with missing BMI-based measures (n = 698, 1.2 %).

Demographic characteristics and CVD risk factors were summarized separately for men and women. To compare observed testing patterns to guideline recommendations, we first computed the proportion of patients who received zero, one, two, or three or more lipid tests during the prior 5 year period, stratified by age, sex and CVD risk. Because the USPSTF also recommends lipid testing among all adults aged 20 and older with diabetes, hypertension, tobacco use, or obesity, we further examined testing patterns for persons with low CVD risk scores with and without any of these individual risk factors. While the USPSTF also recommends early testing for persons with a premature CVD family history, population-based family history data were not available which prevented our ability to examine testing relative to this risk factor. Regression models were used to investigate whether patient characteristics were associated with receiving lipid testing more frequently than USPSTF recommendations, among those at low-risk excluding persons with diabetes, hypertension, tobacco use, or obesity. Over-testing was defined for those at low CVD risk as one or more test in the past 5 years for women of any age or men age <35, or two or more tests for men over 35. Generalized linear models with a log link and Poisson error distribution were used to estimate the relative risk of over-testing associated with patient characteristics. All analyses were conducted using Stata/MP version 12.0 for Windows statistical software (Stata Corp. LP, College Station, Texas). All study methods were approved by the Group Health Human Subjects Review Committee.


Figure 1 outlines the selection of the study subjects. Of the 111,333 persons who were aged 25–79, continuously enrolled at Group Health, with at least one visit in the prior 2 years, we excluded 46.5 % because of prevalent CVD or other significant disease, or with filled prescriptions for HMG-CoA reductase inhibitors or isotretinoin. The final study cohort of 59,604 persons was 58.8 % female with a mean age of 51.1 years (SD 12.3) (Table 1.) As is characteristic of insured populations in Washington state, the vast majority were white (83.3 %), lived in urban settings (97.4 %), and had commercial health insurance (79.9 %.) Furthermore, a large portion lived in neighborhoods which were more than 70 % college educated (45.6 %) but with median household incomes less than $60,000 per year (68.7 %) using 2000 census data. No large differences in demographics were apparent between men and women.

Fig. 1
figure 1

Study sample

Table 1 Population characteristics

Based on BMI-based Framingham calculations, most women (77.1 %) were classified as low-risk (<10 %), 17.1 % were at moderate-risk (10–20 %), and only 5.7 % were at high-risk (>20 %) and not already prescribed statin medications. However, among men, the proportions at moderate (31.9 %) and high-risk (29.2 %) not already prescribed statins were substantially higher. While the proportions of men and women whose last recorded systolic blood pressures was >140 mmHg were similar (15.3 % vs. 11.4 %), men were more likely to be smokers (13.5 % vs. 9.1 %) and be overweight or obese (77.2 % vs. 61.8 %.) No large differences were apparent in the proportions of men or women with diabetes (2.3 % vs. 2.0 %), or who had hypertension (19.9 % vs. 18.5 %.) When overall illness burden was summarized with RUB categories, the majority of the population had a moderate burden (RUB 3) (52.9 %) and only 9.6 % were classified with high or very high burdens (RUBs 4–5.) Expected differences between men and women in TC and HDL levels were apparent [18].

Given the difference in USPSTF lipid screening recommendations for men and women of different ages and risk levels [1], Table 2 presents the proportion of subjects who received lipid testing in the prior 5 years, by age, sex and CVD risk category. The table presents percentages of patients who received zero, one, two or three or more lipid tests during the prior 5 year period. For low-risk men less than age 35 years for whom cholesterol screening is not recommended [1], 37.6 % had at least one test in the prior 5 years and 10.7 % had two or more.

Table 2 Lipid testing in the past 5 years by sex, age & cardiovascular disease (CVD) risk

Among low-risk women of any age where screening is also not recommended, these percentages were greater, with 62.5 % having at least one test and 26.3 % having two or more in the prior 5 years. For persons at moderate-risk (10–20 %) who were not already on statins where the USPSTF recommends cholesterol testing at least once every 5 years [1], 25.1 % of men and 22.7 % of women had no cholesterol testing. Among persons at high-risk not already on statins where yearly testing is recommended, 21.4 % of men and 22.5 % of women had no record of lipid testing in the 5 years period. When we applied the new ACC-AHA guidelines [19], only a small minority of persons less than 40 shifted from low to higher risk (185/9,622, 1.9 %) when the new low-risk cut-point was applied (7.5 % vs. 10 % risk.) Using this new criterion, 40.6 % persons aged 40 and older at low-risk (<7.5 %) had one test in the prior 5 years and 28.8 % had two or more.

Because the USPSTF also recommends screening, regardless of aggregate CVD risk scores, for all adults 20 years or older who are obese, use tobacco, or have hypertension or diabetes, Table 3 presents the study’s main findings and displays testing for low-risk individuals with none (n = 20,162, 63.3 %) versus one or more or of these factors risks (n = 11,691, 36.7 %.) For low-risk men less than age 35 with no risks, 35.8 % had at least one test and 8.4 % and two or more.

Table 3 Lipid testing in the past 5 years for adults with low cardiovascular disease (CVD) risk (<10 %) by number of CVD risk factors

Similarly, for low-risk women of any age with no risks, 61.5 % had at least one test and 24.4 % had two or more.

Table 4 examines potential determinants of receipt of testing more frequently than recommended among low-risk persons (<10 % CVD risk) and with no individual risk factors. The table presents both unadjusted and adjusted relative risks. (The adjusted relative risks are adjusted for all of the other characteristics listed in the table.) For women, age was strongly associated with over-testing with low-risk women in all age categories being more likely than women aged 25–34 to be tested more frequently than guideline recommended (RR 2.04–3.16.) or men, age categories 35–44 and 45–54 were associated with lower likelihood of testing (RR 0.54–0.80) than for men aged 25–34. For both men and women, non-white race and averaging at least one primary care visits per year over the past five years were factors generally associated with a higher likelihood of testing in the multivariate models. While neighborhood education levels were not associated with over-testing among men or women, women in neighborhoods with higher median income had increased risk of over-testing. Significant comorbidity (RUB 3–5) was associated with over-testing among men but not women.

Table 4 Factors associated with lipid testing among adults with low cardiovascular risk (<10 %) and no CVD risk factors


Among persons at low-risk for CVD determined through the BMI-based Framingham calculations, no individual risk factors (obesity, tobacco use, hypertension, or diabetes), and under age 35 for men, a substantial proportion of men (35.8 %) and women (61.5 %) received cholesterol testing that is not recommended by the USPSTF. Similarly, among moderate- and high-risk individuals, 24.0 % and 21.6 % of these persons respectively had no lipid testing, reflecting under-screening as per guideline recommendations. Taken together, these findings suggest sizable gaps in targeting lipid screening across the risk spectrum that result in both missing prevention opportunities at one end and unnecessary screening at the other (particularly for women). While lipid testing is relatively inexpensive, there may be downstream consequences, particularly for those at low-risk, such as potential distress over an abnormal value [20], or the time clinicians use to explain results. Additionally provision of CVD risk information alone, does little to change risk [21]. Population identification of individuals likely to be at high-risk for CVD without lipid testing or not on statins would lead to more efficient and effective use of clinical resources. We were not able to determine CVD risk (with lab or BMI-based approach) on approximately 14 % of the study population suggesting that improvements in electronic vital sign data entry are needed to fully characterize risk and the need for cholesterol testing.

Many studies have explored factors related to underuse of lipid testing and CVD risk assessment. However less is known about the prevalence and factors associated with over use of lipid testing. Goodwin et al., in a Medicare population, found that exposure to health referral region and care by multiple different physicians was associated with overtesting independent of indication for testing, co-morbidities and total physician visits [11]. Virini et al. found that almost one third of Veteran’s Administration patients with coronary heart disease and who had attained LDL goals had more than one LDL test over an 11-month time period [22].

Our study included low risk and younger patients. Among low-risk persons, factors that are generally associated with over-testing include advancing age and more primary care visits. This finding suggests that care providers may be more inclined to order, or patients request, lipid testing if they are older and make frequent visits, independent of their low risk status. In other words, providers and patients may be inclined to overestimate CVD risk and need for lipid screening, particularly for women, based on age and visit frequency, leading to greater attention to early and more lipid screening. This finding suggests that many providers are not consistently using risk markers and scoring algorithms to guide lipid screening as recommended by the USPSTF. This is not unexpected given that barriers exist to using risk calculators (e.g., physicians often have to manually retrieve and enter the risk details) [2326] and they can be difficult for patients to understand [21, 27]. Furthermore, while the national Choosing Wisely campaign has gathered momentum on reducing overuse of many services [28], cholesterol overtesting is not currently a core measure.

Our study has some notable limitations. First, it is important to note however, because we excluded persons taking statins, we likely underestimated the proportion of persons at moderate or high-risk who were appropriately screened. Rather, our under-use estimates should be interpreted as the proportion of moderate or high risk persons not currently taking a statin who remain unscreened. Second, our study relied on BMI- rather than traditional lipid-based CVD risk estimates to classify individuals into risk categories. While this can create misclassification bias, we believe that bias to be conservative with respect to over testing in low-risk people since when the scores differ, the BMI-based scores are almost always higher [17]. Third, since family history [29] and socioeconomic risk [30] are independent CVD predictors but are not incorporated into traditional calculators, physicians may be appropriately screening low-risk people with positive family histories or who come from impoverished areas. However, we believe this limitation to be minor since research finds adding these factors only make slight improvements to population-based risk categorization [30, 31]. Finally, since the study takes place in an integrated delivery system with a history of applying evidence-based prevention guidelines [32], our results likely underestimate the degree of mismatch between CVD risk and lipid testing to be found in other practice settings. The study participants were also largely white and had health insurance which may limit out study’s generalizability.


Our study findings clearly highlight the opportunity to improve adherence to USPSTF screening guidelines.

In so doing, physicians may reduce unnecessary medical costs and burden for a significant subset of patients, while improving care for others.



American College of Cardiology-American Heart Association


Adjusted Clinical Group


Adult Treatment Panel – III


Body Mass Index


Cardiovascular Disease


High Density Lipoprotein


3-hydroxy-3-methylglutaryl-coenzyme A


Low Density Lipoprotein


Resource Utilization Band


Rural–urban Commuting Area


Total Cholesterol


US Preventive Services Task Force


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Financial support was provided funded by the National Heart, Lung and Blood Institute, NIH (RC1HL100590). The funder did not have any role in the design, in the collection, analysis and interpretation of data; in the writing of the manuscript; and in the decision to submit the manuscript for publication.


Support was provided funded by the National Heart, Lung and Blood Institute, NIH (RC1HL100590).

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Correspondence to Robert J. Reid.

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Dr. Reid declares that he is an employee/shareholder of Group Health Physicians, the physician group affiliated with Group Health Cooperative, the site of this study. The remaining authors declare that they have no competing interests.

Author contributions

RR contributed to the concept and design of the study, interpreting the data, drafting the manuscript and have given final approval of this version for publication. MA contributed to the concept and design of the study, analyzing and interpreting the data, revising the manuscript critically for important intellectual content and has given final approval of this version for publication. PF contributed to the concept and design of the study, revising the manuscript critically for important intellectual content and has given final approval of this version for publication. JM contributed to the concept and design of the study, revising the manuscript critically for important intellectual content and has given final approval of this version for publication. RJ contributed to analyzing the data, revising the manuscript critically for important intellectual content and has given final approval of this version for publication. SC contributed to the concept and design of the study, revising the manuscript critically for important intellectual content and has given final approval of this version for publication. BG contributed to the study by receiving funding to acquire the data, the concept and design of the study, revising the manuscript critically for important intellectual content and has given final approval of this version for publication.

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Reid, R.J., Anderson, M.L., Fishman, P.A. et al. Relationship between cardiovascular risk and lipid testing in one health care system: a retrospective cohort study. BMC Health Serv Res 15, 281 (2015).

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