Blennow K, Leon MJ de, Zetterberg H: Alzheimer's disease. Lancet. 2006, 368: 387-403. 10.1016/S0140-6736(06)69113-7.
Article
CAS
PubMed
Google Scholar
AKdÄ: Arzneimittelkommission der deutschen Ärzteschaft - Therapieempfehlungen Demenz. 2008
Google Scholar
Burns A, Iliffe S: Alzheimer's disease. BMJ. 2009, 338: b158-10.1136/bmj.b158.
Article
PubMed
Google Scholar
GEK Arzneimittelverordnungsreport. 2009
Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M: Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med. 2008, 148: 379-397.
Article
PubMed
Google Scholar
National service framework for older people. [http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4071283.pdf]
Kozma CM, Reeder CE, Schulz RM: Economic, clinical, and humanistic outcomes: a planning model for pharmacoeconomic research. Clin Ther. 1993, 15: 1121-1132.
CAS
PubMed
Google Scholar
Cramer JA, Roy A, Burrell A, Fairchild CJ, Fuldeore MJ, Ollendorf DA, Wong PK: Medication compliance and persistence: terminology and definitions. Value Health. 2008, 11: 44-47.
Article
PubMed
Google Scholar
WHO: Adherence to Long-Term Therapies - Evidence for action. Geneva. 2003
Google Scholar
Urquhart J: The electronic medication event monitor. Lessons for pharmacotherapy. Clin Pharmacokinet. 1997, 32: 345-356. 10.2165/00003088-199732050-00001.
Article
CAS
PubMed
Google Scholar
Cramer JA: Microelectronic systems for monitoring and enhancing patient compliance with medication regimens. Drugs. 1995, 49: 321-327. 10.2165/00003495-199549030-00001.
Article
CAS
PubMed
Google Scholar
Spilker B: Methods of assessing and improving compliance in clinical trials. Patient compliance in medical practice and clinical trials. Edited by: Cramer J, Spilker B. 1991, New York: Raven Press, 37-56.
Google Scholar
Bova CA, Fennie KP, Knafl GJ, Dieckhaus KD, Watrous E, Williams AB: Use of electronic monitoring devices to measure antiretroviral adherence: practical considerations. AIDS Behav. 2005, 9: 103-110. 10.1007/s10461-005-1685-0.
Article
PubMed
Google Scholar
Kogut SJ, El-Maouche D, Abughosh SM: Decreased persistence to cholinesterase inhibitor therapy with concomitant use of drugs that can impair cognition. Pharmacotherapy. 2005, 25: 1729-1735. 10.1592/phco.2005.25.12.1729.
Article
CAS
PubMed
Google Scholar
Mauskopf JA, Paramore C, Lee WC, Snyder EH: Drug persistency patterns for patients treated with rivastigmine or donepezil in usual care settings. J Manag Care Pharm. 2005, 11: 231-251.
PubMed
Google Scholar
Roe CM, Anderson MJ, Spivack B: How many patients complete an adequate trial of donepezil?. Alzheimer Dis Assoc Disord. 2002, 16: 49-51. 10.1097/00002093-200201000-00008.
Article
PubMed
Google Scholar
Suh DC, Thomas SK, Valiyeva E, Arcona S, Vo L: Drug persistency of two cholinesterase inhibitors: rivastigmine versus donepezil in elderly patients with Alzheimer's disease. Drugs Aging. 2005, 22: 695-707. 10.2165/00002512-200522080-00006.
Article
CAS
PubMed
Google Scholar
Rosen MI, Ryan CE, Rigsby MO: Motivational Enhancement and MEMS Review to Improve Medication Adherence. Behav Med. 2002, 19: 183-190.
Google Scholar
Shuter J: Forgiveness of non-adherence to HIV-1 antiretroviral therapy. J Antimicrob Chemother. 2008, 61: 769-773. 10.1093/jac/dkn020.
Article
CAS
PubMed
Google Scholar
Urquhart J: Pharmionics: research on what patients do with prescription drugs. Pharmacoepidemiol Drug Saf. 2004, 13: 587-590. 10.1002/pds.1004.
Article
PubMed
Google Scholar
Urquhart J: Defining the margins for errors in patient compliance with prescribed drug regimens. Pharmacoepidemiol Drug Saf. 2000, 9: 565-568. 10.1002/pds.540.
Article
CAS
PubMed
Google Scholar
Choo PW, Rand CS, Inui TS, Lee ML, Ma CC, Platt R: A pharmacodynamic assessment of the impact of antihypertensive non-adherence on blood pressure control. Pharmacoepidemiol Drug Saf. 2000, 9: 557-563. 10.1002/pds.539.
Article
CAS
PubMed
Google Scholar
Shuter J, Sarlo JA, Kanmaz TJ, Rode RA, Zingman BS: HIV-infected patients receiving lopinavir/ritonavir-based antiretroviral therapy achieve high rates of virologic suppression despite adherence rates less than 95%. J Acquir Immune Defic Syndr. 2007, 45: 4-8. 10.1097/QAI.0b013e318050d8c2.
Article
CAS
PubMed
Google Scholar
Nony P, Boissel JP: Use of sensitivity functions to characterise and compare the forgiveness of drugs. Clin Pharmacokinet. 2002, 41: 371-380. 10.2165/00003088-200241050-00004.
Article
CAS
PubMed
Google Scholar
Boissel JP, Nony P: Using pharmacokinetic-pharmacodynamic relationships to predict the effect of poor compliance. Clin Pharmacokinet. 2002, 41: 1-6. 10.2165/00003088-200241010-00001.
Article
CAS
PubMed
Google Scholar
Williams PJ, Ette EI: Pharmacometrics: Impacting Drug Development and Pharmacotherapy. Pharmacometrics - The Science of Quantitative Pharmacology. Edited by: Ette EI, Williams PJ. 2007, Hoboken: Wiley, 1-19.
Google Scholar
Jann MW, Shirley KL, Small GW: Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet. 2002, 41: 719-739. 10.2165/00003088-200241100-00003.
Article
CAS
PubMed
Google Scholar
Medical Research Council. MRC Health Services and Public Research Board. Framework for development and evaluation of RCTs for complex interventions to improve health. 2000, [http://www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC003372]
Apothekenbetriebsordnung (Ordinance on the Operation of Pharmacies) in the version of the publication of 26th September, 1995 (Federal Law Gazette I, page 1195) last amended pursuant to the Amendment Act for the Federal Pharmacists Regulation and other legislation dated 20st July 2007 (Federal Law Gazette I, page 1574).
Osterberg L, Blaschke T: Adherence to medication. N Engl J Med. 2005, 353: 487-497. 10.1056/NEJMra050100.
Article
CAS
PubMed
Google Scholar
Law AM: Simulation, Modeling and Analysis. 4th. 2007, New York: McGraw-Hill
Google Scholar
Mihara M, Ohnishi A, Tomono Y, Hasegawa J, Shimamura Y, Yamazaki K, Morishita N: Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers. Int J Clin Pharmacol Ther Toxicol. 1993, 31: 223-229.
CAS
PubMed
Google Scholar
Thron CD: Linearity and superposition in pharmacokinetics. Pharmacol Rev. 1974, 26: 3-31.
CAS
PubMed
Google Scholar
Rogers SL, Doody RS, Mohs RC, Friedhoff LT: Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group. Arch Intern Med. 1998, 158: 1021-1031. 10.1001/archinte.158.9.1021.
Article
CAS
PubMed
Google Scholar
Arnet I, Haefeli WE: Overconsumption detected by electronic drug monitoring requires subtle interpretation. Clin Pharmacol Ther. 2000, 67: 44-47. 10.1067/mcp.2000.103821.
Article
CAS
PubMed
Google Scholar
Denhaerynck K, Schafer-Keller P, Young J, Steiger J, Bock A, de Geest S: Examining assumptions regarding valid electronic monitoring of medication therapy: development of a validation framework and its application on a European sample of kidney transplant patients. BMC Med Res Methodol. 2008, 8: 5-10.1186/1471-2288-8-5.
Article
PubMed
PubMed Central
Google Scholar
Vrijens B, Tousset E, Rode R, Bertz R, Mayer S, Urquhart J: Successful projection of the time course of drug concentration in plasma during a 1-year period from electronically compiled dosing-time data used as input to individually parameterized pharmacokinetic models. J Clin Pharmacol. 2005, 45: 461-467. 10.1177/0091270004274433.
Article
CAS
PubMed
Google Scholar
Eisai: Aricept© summary of product characteristics. Eisai GmbH Frankfurt/Main Deutschland. 2007
Google Scholar
Sramek JJ, Cutler NR: RBC cholinesterase inhibition: a useful surrogate marker for cholinesterase inhibitor activity in Alzheimer disease therapy?. Alzheimer Dis Assoc Disord. 2000, 14: 216-227. 10.1097/00002093-200010000-00006.
Article
CAS
PubMed
Google Scholar
Piotrovsky V, van Peer A, van Osselaer N, Armstrong M, Aerssens J: Galantamine population pharmacokinetics in patients with Alzheimer's disease: modeling and simulations. J Clin Pharmacol. 2003, 43: 514-523.
Article
CAS
PubMed
Google Scholar
Gobburu JV, Tammara V, Lesko L, Jhee SS, Sramek JJ, Cutler NR, Yuan R: Pharmacokinetic-pharmacodynamic modeling of rivastigmine, a cholinesterase inhibitor, in patients with Alzheimer's disease. J Clin Pharmacol. 2001, 41: 1082-1090. 10.1177/00912700122012689.
Article
CAS
PubMed
Google Scholar
Urquhart J: How much compliance is enough?. Pharm Res. 1996, 13: 10-11. 10.1023/A:1016004611847.
Article
CAS
PubMed
Google Scholar
Urquhart J: Pharmacodynamics of variable patient compliance: implications for pharmaceutical value. Adv Drug Deliv Rev. 1998, 33: 207-219. 10.1016/S0169-409X(98)00029-5.
Article
CAS
PubMed
Google Scholar
McCann MF, Potter LS: Progestin-only oral contraception: a comprehensive review. Contraception. 1994, 50: S1-195. 10.1016/0010-7824(94)90076-0.
Article
CAS
PubMed
Google Scholar
Johnson BF, Whelton A: A Study Design for Comparing the Effects of Missing Daily Doses of Antihypertensive Drugs. Am J Ther. 1994, 1: 260-267. 10.1097/00045391-199412000-00003.
Article
PubMed
Google Scholar