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Table 1 Pharmacokinetic and pharmacodynamic models for donepezil.

From: Compliance assessment of ambulatory Alzheimer patients to aid therapeutic decisions by healthcare professionals

Model type (name) & equation Variables and parameters Reference
Pharmacokinetic model
(two compartment model)
   
C = D [ A e α ( t l a g t i m e ) + B e β ( t l a g t i m e ) ( A + B ) e k a ( t l a g t i m e ) ] for D = 5 mg:
A = 3.502 ng/mL
B = 1.209 ng/mL
α = 0.445 h-1
β = 0.014 h
ka = 1.319 h-1
lag time = 0.96 h
for D = 10 mg:
A = 4.536 ng/mL
B = 1.234 ng/mL
α = 0.542 h-1
β = 0.015 h-1
ka = 1.696 h-1
lag time = 0.68 h
[32]
Pharmacodynamic model
(Emax model)
Emax = 100.8%
EC50 = 15.6 ng/mL
  [34]
E = E max C E C 50 + C    
  1. Parameter values and reference to literature, utilised for the in silico simulation.
  2. C = total plasma drug concentration [ng/mL]
  3. t = time [h]
  4. D = dose
  5. A, B = intercepts of the two exponential terms
  6. α, β = macro (hybrid) rate constants
  7. ka = absorption rate constant
  8. E = effect, i.e. inhibition of peripheral cholinesterase, %
  9. Emax = maximum effect
  10. EC50 = drug concentration at half of maximum effect