- Research article
- Open Access
- Open Peer Review
A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severe thalassemic patients in Thailand
© Leelahavarong et al; licensee BioMed Central Ltd. 2010
- Received: 12 November 2009
- Accepted: 16 July 2010
- Published: 16 July 2010
Hematopoietic stem cell transplantation (HSCT) is the only curative treatment available to severe thalassemic patients. The treatment, however, is very costly, particularly in the context of low and middle income countries, and no studies have been carried out to explore its economic justifiability. This study aimed to estimate the cost-utility of HSCT compared with blood transfusions combined with iron chelating therapy (BT-ICT) for severe thalassemia in Thailand, and to investigate the affordability of HSCT using a budget impact analysis.
A Markov model was used to estimate the relevant costs and health outcomes over the patients' lifetimes taking a societal perspective as recommended by Thailand's health technology assessment guidelines. All future costs and outcomes were discounted at a rate of 3% per annum. Primary outcomes of interest were lifetime costs, quality adjusted life years (QALYs) gained, and the incremental cost-effectiveness ratio (ICER) in Thai baht (THB) per QALY gained.
Compared to BT-ICT, the incremental cost-effectiveness ratio increased with patient age from 80,700 to 183,000 THB per QALY gained for related HSCT and 209,000 to 953,000 THB per QALY gained for unrelated HSCT among patients aged 1 to 15 years (US$1= 34 THB). The governmental budget impact analysis showed that providing 200 related HSCT to patients aged 1 to 10 years, in accordance with the current infrastructure limitations, would initially require approximately 90 million additional THB per year.
At a societal willingness to pay of 100,000 THB per QALY gained, related HSCT was likely to be a cost-effective and affordable treatment for young children with severe thalassemia in Thailand.
- Hematopoietic Stem Cell Transplantation
- Thalassemic Patient
- Sibling Donor
- Capita Gross Domestic Product
Thalassemia is the most common gene-related hematological disease in Thailand. With a Thai population of 65 million, approximately 40% carry thalassemia traits and about 1% manifest the disease . The incidence of severe thalassemia (i.e. Hb Bart's hydrops fetalis, β-thalassemia, and β-thalassemia/Hb E) is estimated at 4,253 patients per year . Generally patients with severe thalassemia present with anemia at the first year of life. The provision of regular blood transfusion (BT) is standard practice for the treatment of severe thalassemia. Without ongoing BT, these individuals would have an expected life-span of only a few years. However, provision of BT is hampered by a shortage of blood donations, as well as the high cost of blood screening in order to reduce the residual risk of transmission of blood-borne viruses, including hepatitis and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) . Moreover, BT given over a long period of time can result in iron-overload causing heart failure and damage to other organs associated with high mortality. In order to reduce iron accumulation, iron chelating therapy (ICT) needs to be administered subcutaneously for 8 to 12 hours per day, 5 to 7 days per week. Effective provision of ICT is often compromised by poor compliance as the process itself can have a detrimental effect on quality of life (QoL), especially amongst children [3, 4].
Currently, hematopoietic stem cell transplantation (HSCT) is the only curative treatment available to severe thalassemic patients. Hematopoietic stem cells are usually extracted from bone marrow, peripheral blood, and umbilical cord blood. An allogeneic HSCT patient can obtain stem cells from a healthy human leukocyte antigen (HLA)-matched donor, being either a patient's relative (i.e. related HSCT) or from non-related donors (i.e. unrelated HSCT). HLA is determined by conventional serologic typing for class I and II antigen. DNA typing with high-resolution sequence-specific oligonucleotide probes for class I and II loci is undertaken for patients with matched and mismatched HLA-related or mismatched HLA-unrelated donors. Sibling donors are considered ideal as they can inherit identical HLA genes, reducing the probability of graft rejection and other complications. The formula for calculating the chances of a particular person having an HLA-matched sibling is 1 - (0.75) n , where n denotes the total number of siblings . The average Thai family has two children; therefore only 1 in 4 patients are likely to have an HLA-matched sibling donor , while only 3 out of 4 of these potential sibling-donors would themselves be without thalassemia. Thus the proportion of thalassemic patients that would have an HLA-matched sibling donor is approximately 19%. The remainder of the population must rely on unrelated donors. At present there is no local database in place for the identification of such donors, while reliance on foreign databases implies reduced donor availability and an increase in costs.
HSCT procedures are conditioning regimens to eradicate disease and facilitate persistent engraftment . Graft versus host disease (GVHD) prophylaxis is performed to prevent major complications related to severe immune incompetence. All HSCT patients are treated in positive-pressure isolation rooms and receive antibiotics for prevention of Pneumocystis carinii pneumonia, Cytomegalovirus, and Ebstein-Barr virus. The criteria of engraftment are an absolute neutrophil count more than 0.5 × 109/L within three consecutive days or a platelet count more than 20 × 109/L without transfusion within seven consecutive days [7–9]. If the patients have engraftment failure after receiving HSCT, a second round of HSCT may be provided to prevent thalassemia recurrence or irreversible aplasia.
As evident, HSCT is a resource-intense procedure requiring high financial expenditure especially at the first year of treatment. Moreover, patients receiving HSCT may experience poor quality of life due to its toxicity and complications. HSCT, however, is the only treatment to cure thalassemia at present, providing patients with longer life expectancy and potentially normal quality of life .
In Thailand, healthcare coverage for the provision of HSCT differs amongst the three health insurance schemes. HSCT is provided with full coverage to thalassemic patients who are government employees and their dependents enrolled under the Civil Servant Medical Benefit Scheme (9% of the Thai population) as well as employees enrolled under the Social Security Scheme (11% of the population). Provision of HSCT has not yet been included in the benefit package of the Universal Coverage (UC) scheme that applies to approximately 80% of the Thai population and is managed by the National Health Security Office (NHSO) .
An economic evaluation of HSCT for severe thalassemic patients was requested by the NHSO through a topic selection process facilitated by the Health Intervention and Technology Assessment Program (HITAP) , the institution responsible for appraising a wide range of health technologies including pharmaceuticals, medical devices, interventions, individual and community health promotion and prevention interventions. HITAP sent out an official letter dated December 27th, 2006 inviting public health agencies at the national level to submit their lists of interventions which they considered to require assessment. The representatives of these fifteen agencies were also invited to participate in a workshop which aimed at prioritizing the proposed health interventions in order to select the top ten most important items for the HITAP assessment process. The economic evaluation of HSCT was ranked as one out of five selected topics in 2007. This cost-utility analysis, therefore, was performed to evaluate and compare the costs and health outcomes for related and unrelated HSCT compared with BT-ICT.
The comparison of related HSCT and BT-ICT is aimed at those patients that have HLA-matched siblings. For the majority of the population however, for whom a matched donor is not readily available, the comparison is between unrelated HSCT and BT-ICT. A preliminary analysis based on the literature showed that when both interventions are available, related HSCT always dominated unrelated HSCT, since in addition to higher costs, the outcome of unrelated HSCT is often compromised by an increase in transplant-related complications including early and late toxicity, mortality and rejection [6, 7, 11, 12]. As a result, there is no head-to-head comparison of related and unrelated HSCT in this analysis, as it is clear that where related HSCT is viable, this would be the preferred option. In instances where HSCT was found to be cost-effective, the impact of including it in the UC package on the government budget was estimated.
The lifetime costs and health outcomes for severe thalassemic patients aged 1 to 28 years receiving either HSCT or BT-ICT were compared taking a societal perspective as recommended by the Thailand's health technology assessment guidelines . All future costs and outcomes were discounted at a rate of 3% per annum . Primary outcomes of interest were lifetime costs, quality adjusted life years (QALYs) gained, and the incremental cost-effectiveness ratio (ICER) in Thai baht (THB) per QALY gained. Based on the statement of the Subcommittee for Development of the National List of Essential Drugs and the Subcommittee for Development of the Health Benefit Package and Service Delivery of the NHSO in 2007, the societal willingness to pay (WTP) threshold for a QALY gained for the adoption of health interventions is between 100,000 THB (6,000 PPP$) to 300,000 THB (18,000 PPP$), approximating one to three times per capita Gross Domestic Product (GDP) . These values are in accordance with the recommendations of the Commission on Macroeconomics and Health, World Health Organization, suggesting that health technologies with ICERs below the per capita GDP are considered very cost-effective, those between one and three times per capita GDP being cost-effective, while ICERs above three times per capita GDP indicate that a health technology is not cost-effective .
The health states of both related and unrelated HSCT patients consisted of five states with different costs and QoL scores as follows: (i) the first year of HSCT where patients had the highest costs and worst QoL; (ii) the second year of HSCT, where patients had higher costs due to follow up visits and immunosuppressive therapy; (iii) following years after successful HSCT where QoL approximates that of the healthy population and costs were vastly reduced; (iv) HSCT failure resulting in a switch to BT-ICT; and (v) death. Blood transfusions-dependent patients had two health states (i.e. BT-ICT, characterized by low QoL, and the costs of ongoing care and death). The arrows represent the possible transitions from one state to another. Treatment complications were included within all health states as they typically took far less than one year to resolve.
Input parameters used in the model
References and type of data
Yearly discount rate (%)
Annual probability of death at age 0-1
Annual probability of death at age 2-5
Annual probability of death at age 6-10
Annual probability of death at age 11-15
Annual probability of death at age 16-20
Annual probability of death at age 21-30
Annual probability of death at age 31 and more
Parametric survival: death
Constant for baseline hazard
Age coefficient for baseline hazard
Ancillary parameter in Weibull distribution
Parametric survival: failure
Constant for baseline hazard
Type of HSCT coefficient for baseline hazard
Ancillary parameter in Weibull distribution
Resource cost parameters (THB)
Total direct medical cost of related HSCT in the 1st year
Total direct medical cost of related HSCT in the 2nd year
Total direct medical cost of related HSCT in the following years
Total direct medical cost of unrelated HSCT at the 1st year
Total direct medical cost of unrelated HSCT at the 2nd year
Total direct medical cost of unrelated HSCT in the following years
Total direct medical cost of BT-ICT per year
Total direct non-medical cost of HSCT at the 1st and 2nd year
Total direct non-medical cost of BT-ICT and the following year of HSCT
Total productivity loss of HSCT in the 1st and 2nd year
Total productivity loss of BT-ICT and the following years of HSCT
Utility of BT-ICT patients
Utility of HSCT patients in first and second year
Utility of HSCT patients from third year on
All costs were converted and reported in 2008 THB (US$1= 34 THB) using the consumer price index (CPI) . For international comparison, costs were converted to international dollars using a purchasing power parity (PPP) exchange rate (1 PPP$(2008) = 15.954 THB) . Direct medical costs were obtained from two data sources. First, the costs for blood transfusion-dependent patients were obtained from a cost analysis by Torcharus et al . The study population consisted of 124 severe thalassemia patients. Mean direct medical costs per year were 35,788 THB (SE = 4,156). The costs of patients receiving HSCT were retrieved from a hospital database at a teaching hospital between 1989 and 2007. The charges per patient per year were adjusted using a cost-to-charge ratio of 0.8 .
Both direct non-medical and indirect costs were collected by interviewing severe thalassemic patients and their caregivers at the teaching hospital after informed consent was obtained. Ethical approval for this study was granted by the Committee on Human Rights Related to Research Involving Human Subjects, Mahidol University for cost and clinical data collection. Two HSCT patients and twenty eight BT-ICT patients were interviewed by questionnaire. Mean age was 18 years (Range = 1-47 years). Direct non-medical costs including costs of transportation, meals, accommodation, facilities, and informal care were 37,384 THB (SE = 7,040) for BT-ICT patients and 259,994 THB (SE = 95,535) at the first and second year of HSCT . Indirect costs referred to productivity losses due to sick leave and were estimated at 19,171 THB (SE = 6,692) for BT-ICT and 77,468 THB (SE = 70,464) at the first and second year of HSCT . Since there were no data available on direct non-medical and indirect costs of HSCT patients after the first two years of treatment, it was assumed that these costs of HSCT patients were similar to those receiving BT-ICT in the following years. Resource cost parameters are presented in Table 1.
In addition, for patients receiving BT-ICT, the transition probabilities converted to annual probabilities of death were derived from available cohort studies [21–23]. Based on the cohort of 67 patients, no one received HSCT more than twice. Therefore, in the model it was assumed that if the HSCT patients had failed twice, patients would receive BT-ICT for the rest of their lives.
Quality of life variables
Utility measures for patients' quality of life were obtained from a systematic review of electronic databases. Two databases (PubMed and Center of Reviews and Dissemination) were searched using the following keywords: ("Quality of Life"[Mesh] OR "Quality-Adjusted Life Years"[Mesh] OR "Models, Economic"[Mesh]) AND ("Thalassemia"[Mesh] OR "beta-Thalassemia"[Mesh] OR thalassaemia) and (thalassemia OR thalassaemia) AND "quality of life", respectively. Inclusion criteria were where QoL is presented in a utility index (0=death and 1=full health) and measured by time trade-off (TTO), standard gamble (SG), or EQ-5D instruments. Two eligible studies reported that the mean utility indices of patients receiving BT-ICT were 0.61 and 0.66 [24, 25]. A Bayesian random effects meta-analysis using WinBUGS1.4 (Medical Research Council and Imperial College of Science, Technology and Medicine, United Kingdom) was used to obtain the pooled estimate of 0.61 (SE = 0.16). No studies relating to the QoL of severe thalassemic patients receiving HSCT were identified, therefore the utility of thalassemic patients receiving HSCT at the first and second years was assumed to be the same as that of thalassemic patients receiving BT-ICT for the worst case analysis. The utility of HSCT patients in the subsequent years was derived from the utility of HSCT patients in other diseases following HSCT (i.e. acute myeloid leukemia, multiple myeloma, non-Hodgkin lymphoma, and Hodgkin lymphoma) equal to 0.93 (SE 0.05) .
One-way sensitivity analysis was performed to examine the uncertainty surrounding each parameter individually and results were presented using a tornado diagram. In addition, a probabilistic sensitivity analysis (PSA) was conducted to examine the effect of all parameter uncertainty simultaneously using a second order Monte Carlo simulation performed by Microsoft Excel 2003 (Microsoft Corp., Redmond, WA) . Probability distributions were assigned as follows : (i) beta-distributions were assigned where parameter values ranged between zero and one, such as in probability and utility parameters, (ii) gamma-distributions were specified when parameter values were above zero and positively skewed, such as in costs, and (iii) a log-normal distribution was used for survival parameters. The mean, SE, and distribution of input parameters used in the model are shown in Table 1. A Monte Carlo simulation was run for 1,000 iterations to yield a range of probable values for total costs, health outcomes, and ICERs. In addition, the maximum expected net monetary benefit (NMB) was calculated for each ceiling ratio value (the value society would be WTP for a QALY gained). Results of the PSA were presented as cost-effectiveness acceptability curves.
Budget impact analysis
A Markov-based budget impact model was developed to evaluate direct medical costs for severe thalassemic patients based on a governmental perspective over 15 fiscal years. The model compared direct medical costs for BT-ICT to those of HSCT, where this was found to be a cost-effective option at a ceiling ratio of 100,000 THB per QALY gained , approximating the Thai GDP per capita . The actual number of additional HSCT procedures that could be carried out in practice is currently restricted to approximately 200 thalassemic patients as there are only four university hospitals that have the necessary specialists and suitable infrastructure to carry out HSCT (Suradej Hongeng, Vijj Kasemsup, Ramathibodi University Hospital, oral communication, March 24, 2009). Thus, the actual budget impact on the universal health insurance scheme was estimated for the maximum expected number of severe thalassemic patients that could receive HSCT at the four teaching hospitals, rather than the incidence of severe thalassemia.
ICER of related HSCT compared to BT-ICT, classified by patient age
ICERs of related HSCT
compared to BT-ICT
THB per QALY gained*
ICER of unrelated HSCT compared to BT-ICT, classified by patient age
ICER of unrelated HSCT
compared to BT-ICT
THB per QALY gained*
Budget impact analysis
Estimated budget impact during fiscal years 2008 to 2022 of provision of HSCT to 200 severe thalassemic patients (aged 1-10) per year
Estimated budget impact (million THB)
The costs shown in the table related to a cohort of patients that increases by 200 each year (minus fatalities), where in the BT-ICT column the cost consists of their ongoing treatments, while in the HSCT column the costs comprise of 200 treatments each year, the cost of BT-ICT for treatment failures, and the cost of follow-up procedures. It should be noted that the follow up costs were significantly reduced over time owing to the effect of discounting and reduction of costs of long-term care for HSCT patients. The rightmost column shows the actual impact of the government budget. Notwithstanding future possible changes in HSCT and BT-ICT costs, as the number of patients receiving BT-ICT increases continuously the difference in cost gradually decreases and over a longer time span would eventually become negative (i.e. HSCT would become the more affordable option).
This study is the first to compare the cost-effectiveness of related and unrelated HSCT to BT-ICT for severe thalassemic patients. Based on the WTP threshold of 100,000 THB per QALY gained [15, 28], this analysis shows that provision of HSCT to severe thalassemic patients with related or sibling donors was likely to be cost-effective only when provided to patients aged up to 10 years. Although we found that providing related HSCT to the youngest patients yields the maximum benefit, there are ethical and practical issues that require further consideration. For example, the availability of a sibling donor for a one year old patient will be more restricted than those for ten year old patients, as it is more likely that the 10 year old patients would have healthy siblings (having both elder and younger siblings that could act as donors). The majority of severe thalassemic patients, however, do not have the option of related HSCT, since most of them are either single children or they have no HLA-matched non-thalassemic relative or sibling donor. For these patients unrelated HSCT was the only alternative to BT-ICT. Although at a WTP of 300,000 THB per QALY gained unrelated HSCT was likely to be considered a cost-effective option for patients aged up to 10 years, it might not yet be appropriate within the Thai context, where the identification procedure for HLA-matched donors is very limited and expensive, as donors have to be identified from foreign sources such as the Tzu chi Taiwan Marrow Donor Registry . Furthermore, if unrelated HSCT procedure failed, the patients would be more likely to switch to standard therapy (BT-ICT) in the absence of another donor. The provision of HSCT only to younger patients for whom sibling donors are available, however, raises a substantial equity concern in that patients without a sibling donor or over the age of 10 would not be eligible to benefit from a potentially life-saving treatment.
The governmental budget impact demonstrated that the provision of related HSCT to patients for whom HSCT was found to be cost-effective could eventually result in lower government expenditure than ongoing BT-ICT. The budget impact analysis took a very practical perspective in calculating the costs for only 200 patients per year in accordance with the current available infrastructure and human resources, especially hematologists. If the Thai government were to provide additional budget to significantly expand HSCT services, it is likely that the cost-per case would fall due to economies of scale, improving the cost-effectiveness of HSCT. Such a scenario was considered unlikely in the near future therefore to ensure the relevance of the analysis to current policy making needs, the restriction to 200 patients a year was left in place. This restriction raises further equity concerns in deciding how to allocate these treatments.
Previous published studies suggested that allogeneic stem cell transplantation was more effective amongst younger severe thalassemic patients, as older patients had poorer outcomes and higher transplant-related mortality [29, 30]. This could be explained by the fact that older thalassemic patients had more progressive disease and prolonged iron overload having received blood transfusions for a longer period of time . This study also showed that the QALY gained among younger HSCT patients was higher than older ones.
This study had several limitations. First, due to the lack of survival data for patients treated with blood transfusions in Thailand, their transition probabilities were based on survival analysis studies in Iran [21–23]. The prevalence of thalassemia and its treatment in Iran were found to be similar to that of Thailand, in that severe thalassemia in Iran was the most prevalent genetic disease and its standard therapy was the provision of BT-ICT. Likewise, the survival data and transition probabilities for HSCT patients were obtained from a relatively small cohort; this area is a priority for future research. Second, the direct medical costs of the interventions were obtained from different sources. While both sources originate in the Thai context, the costs of blood transfusions were derived from a cost of illness study in three treatment centers in Thailand  whereas the costs of HSCT were estimated from a hospital database. Using a single hospital database could however underestimate the true costs of blood transfusions, as patients might receive these in a number of different hospitals. HSCT patients on the other hand, need to be followed up regularly at the same hospital so all costs could be collected in a single hospital database. Third, the sensitivity analysis indicated that the ICER per QALY gained was most sensitive to changes in the utility of BT-ICT patients which this study obtained from foreign data (i.e. Australia and UK). This is identified as an area where further studies using local data are needed. Fourth, no estimates were available for the utility parameter of patients receiving HSCT, so that the utility of HSCT patients with malignant diseases was used instead . Lastly, the utilities for all HSCT states were similar even though previous studies revealed that the QoL in the early post HSCT states would be poor due to possible complications (e.g. graft-versus-host-disease, infection, and graft failure); in subsequent states QoL was closer to the norm and better than patients receiving blood transfusions [6, 30–32].
The results of this study were twice presented to the Subcommittee for Development of the Health Benefit Package and Service Delivery of the NHSO. Although the analysis found that related HSCT for patients aged less than 10 years was the most cost-effective option in the Thai context, the currently limited infrastructure implies that this will only be available to a minority of patients, proving to be a major obstacle to policy formulation and implementation. This is indicative of a broader problem that is particularly acute in low and middle income countries, where life-saving and cost-effective technologies are becoming more readily accessible while the infrastructure and financial resources are not yet available to provide these on a large scale and in an equitable manner. There are immense challenges to rationing such services in deciding whether these should be allocated based on a "first come first serve", "severity of disease", "fair inning" or a "lottery principle" . As a result, the Subcommittee has not reached a consensus and provided any policy recommendations to the NHSO. This situation reiterates that economic analysis alone is insufficient in providing practical decision recommendations to policy makers where such pertinent equity concerns are present. There is an urgent need to carefully consider social, ethical and moral dimensions of this health technology beyond its immediate economic benefits.
The authors would like to thank the funding support provided through the Health Intervention and Technology Assessment Program (HITAP) from the Thai Health Promotion Foundation, the Health System Research Institute (HSRI), and the Bureau of Health Policy and Strategy, Ministry of Public Health. We would like to thank all staff and study participants at Ramathibodi Hospital, Mahidol University, who contributed to this study.
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