Parameters | Distribution | Mean | SE | References and type of data |
---|---|---|---|---|
Yearly discount rate (%) | Â | Â | Â | Â |
Costs (range) | Â | 3.00 (0-6.00) | - | [14] |
Outcomes (range) | Â | 3.00 (0-6.00) | - | [14] |
Transition probabilities | Â | Â | Â | Â |
BT-ICT | Â | Â | Â | Â |
   Annual probability of death at age 0-1 | Beta | 0.010 | - | [23] |
   Annual probability of death at age 2-5 | Beta | 0.003 | - | [23] |
   Annual probability of death at age 6-10 | Beta | 0.002 | - | [23] |
   Annual probability of death at age 11-15 | Beta | 0.010 | - | [23] |
   Annual probability of death at age 16-20 | Beta | 0.025 | - | [23] |
   Annual probability of death at age 21-30 | Beta | 0.015 | - | [22] |
   Annual probability of death at age 31 and more | Beta | 0.345 | - | [21] |
HSCT | Â | Â | Â | Â |
Parametric survival: death | Â | Â | Â | Â |
   Constant for baseline hazard | Lognormal | -8.07 | 2.00 | Cohort |
   Age coefficient for baseline hazard | Lognormal | 0.16 | 0.06 | Cohort |
   Ancillary parameter in Weibull distribution | Lognormal | -0.61 | 0.41 | Cohort |
Parametric survival: failure | Â | Â | Â | Â |
   Constant for baseline hazard | Lognormal | -7.18 | 1.55 | Cohort |
   Type of HSCT coefficient for baseline hazard | Lognormal | 2.60 | 1.08 | Cohort |
   Ancillary parameter in Weibull distribution | Lognormal | -0.74 | 0.34 | Cohort |
Resource cost parameters (THB) | Â | Â | Â | Â |
   Total direct medical cost of related HSCT in the 1st year | Gamma | 491,985 | 50,288 | Hospital database |
   Total direct medical cost of related HSCT in the 2nd year | Gamma | 42,694 | 15,535 | Hospital database |
   Total direct medical cost of related HSCT in the following years | Gamma | 11,638 | 3,240 | Hospital database |
   Total direct medical cost of unrelated HSCT at the 1st year | Gamma | 735,839 | 183,560 | Hospital database |
   Total direct medical cost of unrelated HSCT at the 2nd year | Gamma | 45,840 | 20,094 | Hospital database |
   Total direct medical cost of unrelated HSCT in the following years | Gamma | 6,385 | 1,037 | Hospital database |
   Total direct medical cost of BT-ICT per year | Gamma | 35,788 | 4,156 | [4] |
   Total direct non-medical cost of HSCT at the 1st and 2nd year | Gamma | 259,994 | 95,535 | Survey |
   Total direct non-medical cost of BT-ICT and the following year of HSCT | Gamma | 37,384 | 7,040 | Survey |
   Total productivity loss of HSCT in the 1st and 2nd year | Gamma | 77,468 | 70,464 | Survey |
   Total productivity loss of BT-ICT and the following years of HSCT | Gamma | 19,171 | 6,692 | Survey |
Utility parameters | Â | Â | Â | Â |
Utility of BT-ICT patients | Beta | 0.61 | 0.16 | |
Utility of HSCT patients in first and second year | Beta | 0.61 | 0.16 | |
Utility of HSCT patients from third year on | Beta | 0.93 | 0.05 | [26] |