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Table 1 Input parameters used in the model

From: A cost-utility and budget impact analysis of allogeneic hematopoietic stem cell transplantation for severe thalassemic patients in Thailand

Parameters

Distribution

Mean

SE

References and type of data

Yearly discount rate (%)

    

Costs (range)

 

3.00 (0-6.00)

-

[14]

Outcomes (range)

 

3.00 (0-6.00)

-

[14]

Transition probabilities

    

BT-ICT

    

   Annual probability of death at age 0-1

Beta

0.010

-

[23]

   Annual probability of death at age 2-5

Beta

0.003

-

[23]

   Annual probability of death at age 6-10

Beta

0.002

-

[23]

   Annual probability of death at age 11-15

Beta

0.010

-

[23]

   Annual probability of death at age 16-20

Beta

0.025

-

[23]

   Annual probability of death at age 21-30

Beta

0.015

-

[22]

   Annual probability of death at age 31 and more

Beta

0.345

-

[21]

HSCT

    

Parametric survival: death

    

   Constant for baseline hazard

Lognormal

-8.07

2.00

Cohort

   Age coefficient for baseline hazard

Lognormal

0.16

0.06

Cohort

   Ancillary parameter in Weibull distribution

Lognormal

-0.61

0.41

Cohort

Parametric survival: failure

    

   Constant for baseline hazard

Lognormal

-7.18

1.55

Cohort

   Type of HSCT coefficient for baseline hazard

Lognormal

2.60

1.08

Cohort

   Ancillary parameter in Weibull distribution

Lognormal

-0.74

0.34

Cohort

Resource cost parameters (THB)

    

   Total direct medical cost of related HSCT in the 1st year

Gamma

491,985

50,288

Hospital database

   Total direct medical cost of related HSCT in the 2nd year

Gamma

42,694

15,535

Hospital database

   Total direct medical cost of related HSCT in the following years

Gamma

11,638

3,240

Hospital database

   Total direct medical cost of unrelated HSCT at the 1st year

Gamma

735,839

183,560

Hospital database

   Total direct medical cost of unrelated HSCT at the 2nd year

Gamma

45,840

20,094

Hospital database

   Total direct medical cost of unrelated HSCT in the following years

Gamma

6,385

1,037

Hospital database

   Total direct medical cost of BT-ICT per year

Gamma

35,788

4,156

[4]

   Total direct non-medical cost of HSCT at the 1st and 2nd year

Gamma

259,994

95,535

Survey

   Total direct non-medical cost of BT-ICT and the following year of HSCT

Gamma

37,384

7,040

Survey

   Total productivity loss of HSCT in the 1st and 2nd year

Gamma

77,468

70,464

Survey

   Total productivity loss of BT-ICT and the following years of HSCT

Gamma

19,171

6,692

Survey

Utility parameters

    

Utility of BT-ICT patients

Beta

0.61

0.16

[24, 25]

Utility of HSCT patients in first and second year

Beta

0.61

0.16

[24, 25]

Utility of HSCT patients from third year on

Beta

0.93

0.05

[26]

  1. BT-ICT: blood transfusion combined with subcutaneous iron chelating therapy; HSCT: hematopoietic stem cell transplantation; and THB: Thai baht in 2008 value.