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Does health voucher intervention increase antenatal consultations and skilled birth attendances in Cameroon? Results from an interrupted time series analysis



Limited access to health services during the antenatal period and during childbirth, due to financial barriers, is an obstacle to reducing maternal and child mortality. To improve the use of health services in the three regions of Cameroon, which have the worst reproductive, maternal, neonatal, child and adolescent health indicators, a health voucher project aiming to reduce financial barriers has been progressively implemented since 2015 in these three regions. Our research aimed to assess the impact of the voucher scheme on first antenatal consultation (ANC) and skilled birth attendance (SBA).


Routine aggregated data by month over the period January 2013 to May 2018 for each of the 33 and 37 health facilities included in the study sample were used to measure the effect of the voucher project on the first ANC and SBA, respectively. We estimated changes attributable to the intervention in terms of the levels of outcome indicators immediately after the start of the project and over time using an interrupted time series regression. A meta-analysis was used to obtain the overall estimates.


Overall, the voucher project contributed to an immediate and statistically significant increase, one month after the start of the project, in the monthly number of ANCs (by 26%) and the monthly number of SBAs (by 57%). Compared to the period before the start of the project, a statistically significant monthly increase was observed during the project implementation for SBAs but not for the first ANCs. The results at the level of health facilities (HFs) were mixed. Some HFs experienced an improvement, while others were faced with the status quo or a decrease.


Unlike SBAs, the voucher project in Cameroon had mixed results in improving first ANCs. These limited effects were likely the consequence of poor design and implementation challenges.

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Reducing maternal, newborn, and child mortality is one of the world's top public health priorities. The third of the seventeen Sustainable Development Goals (SDGs) reflects the international commitment to improving maternal and child health. By 2030, the goals include reducing the global maternal mortality ratio to less than 70 per 100,000 live births, neonatal mortality to 12 per 1,000 live births at most, and under-five mortality to less than 25 per 1,000 live births [1].

However, despite considerable improvements in recent decades, maternal mortality has remained a major public health concern globally, with more than 295,000 maternal deaths in 2017 and sub-Saharan Africa (SSA) alone accounting for approximately 66% of this global picture [2]. On the other hand, despite dramatic reductions in child mortality over the last 30 years, the global burden of child deaths has remained immense, with a total of 5.2 million under-five deaths in 2019, representing an average of 14,000 deaths every day [3].

While from 2000 to 2017, the global maternal mortality ratio (MMR) decreased by 38% [2], Cameroon's MMR skyrocketed from 511 in 1998 to 782 in 2011 before declining to 467 in 2018 [4].

A priority toward ending preventable maternal and child deaths is to improve access to and use of quality health services and qualified nurses at birth [5, 6]. One of the basic elements is the presence of pregnant women at antenatal consultations. Previous studies have shown that performing prenatal consultations reduces the risk of neonatal mortality [7, 8].

However, women in developing countries encounter significant barriers to accessing conventional health services, including poor education, physical and financial barriers, and limited voice and decision-making power [9, 10]. The poor quality of available health services offers a further disincentive [6]. This translates to only half of parturient women receiving skilled assistance at delivery and many fewer receiving postpartum cares [6].

In Cameroon, the country’s comparatively slow reduction in maternal and child mortalities is likely due to insufficient coverage of reproductive, maternal, neonatal, child and adolescent health (RMNCAH) services; for instance, in 2018, an estimated 65% of women in Cameroon attended at least four antenatal consultations (ANC) visits, 69% gave birth with the assistance of qualified personnel, and 59% received postnatal care (PNC) [11]. In addition, these general estimates hide enormous disparities. Overall, 65% of the pregnant women who attended the four ANCs included more than 79% of those in urban areas but only 52% of those in rural areas. Moreover, while this rate was 91% in the richest quintile, only one-third (37%) of the poorest pregnant women attended the four ANCs [11].

The complexity of barriers to accessing care in developing countries indicates that any solution to improving maternal health service utilization must be comprehensive and address both supply- and demand-side health system constraints. This is particularly important in a context such as Cameroon where household out-of-pocket (OOP) spending was the single largest source of financing for the health sector, at 71 percent of total health spending in 2017, well above the WHO benchmark of 15-20 percent, and exceeding the average for SSA (33 percent) and countries of similar income such as Kenya (24 percent) and Ghana (40 percent) [12].

As ability to pay remains an important determinant of women’s access to healthcare, many countries have sought to improve coverage of maternal services by reducing financial barriers to seeking services [13, 14]. Strategies implemented at the country level include national health insurance and user fee removals/exemptions, and at the subnational level, community-based health insurance, health vouchers and conditional cash transfers [15].

Given that limited access to emergency obstetric and neonatal care (EmONC) is a major contributor to high maternal mortality [16], increasing pregnant women's use of health facilities for assisted delivery could help reduce maternal and new born morbidity and mortality, as previous studies have indicated [17, 18].

In recent years, there has been growing interest in the use of vouchers and other innovative financing mechanisms to increase access to EmONCs for low-income women [19,20,21,22,23,24,25]. By providing a financial or in-kind reward conditioned on the achievement of agreed-upon performance goals, vouchers are described as a promising holistic approach to foster the use of cost-effective services by the poor and other disadvantaged populations [22].

Vouchers can act on the demand side, the supply side, or both sides. Demand-side incentives encourage service use not only by reducing the financial burden but also by offering women a choice of providers and informing them of the benefits of using maternal health services. Supply-side incentives aim to improve the quality and responsiveness of service delivery.

To date, findings from the few assessments of reproductive health voucher programs suggest that, if implemented well, they have the potential to improve both assisted and facility-based deliveries [19, 20, 22, 24, 26]. Yet, there is a paucity of evidence based on rigorous evaluation studies, making it challenging to draw consistent conclusions about the impact of voucher initiatives and to make subsequent policy recommendations.

The current study evaluated a pilot voucher program in Cameroon, a country where approximately 39% of all deliveries took place at home at the time of the program’s inception [27]. The research aimed to assess the impact of the voucher scheme on first antenatal consultation and skilled birth attendance (SBA). In the following, we present a brief description of the Cameroon voucher program. We then present our data and methods, followed by the results. We end with a discussion of the study’s results, as well as the implications of these findings.

Voucher program in Cameroon

Results from the 2014 Multiple Indicator Cluster Survey (MICS) indicate an enormous disparity in health outcomes among Cameroon's ten regions, with the three northern regions (Adamawa, North, Far North) bearing the brunt of the disease burden [27]. For example, while the Far North and North regions represented 27.5% of the total population of children under five years in 2014, both regions accounted for 63% of the total excess mortality during the same period [27]. In addition, while 65% of women nationwide gave birth with the help of qualified personnel, only 29%, 36% and 53% in the Far North, North and Adamawa regions, respectively, gave birth in the same conditions. Moreover, these three regions featuring the lowest frequencies of ANCs and assisted deliveries, were home to more than 60% of the country’s poorest population [28].

Initiated in 2015, the voucher programme is a government programme, supported with funding from German and French partners, that aims to reduce financial barriers to maternal and neonatal care in the three northern regions of Cameroon.

Under the project, (poor) women can purchase subsidized vouchers for 6000 FCFA (≈$11), a co-payment of 10% of the actual cost of the service package estimated at 60,000 FCFA (approximately USD109), that covered the cost of a benefit package including services for pregnant women and their new-borns up to 42 days after delivery. In addition, beneficiaries are provided with transportation from their house to the nearest health facility and transportation from health centers to referral hospitals. Health facilities offering services for the voucher scheme are compensated for extra costs incurred. All pregnant women living within the 3 northern regions of Cameroon were eligible for the programme. To be included in the programme, health facilities are required to meet minimum quality standards based on national guidelines for the provision of maternal care. Women can redeem vouchers at any participating facility, and the contracted facilities submit claims to be reimbursed at standard rates for each service provided.

At its inception, the programme implementation was outsourced to the ‘Centre International de Développement et de Recherche’ (CIDR), an international organization. Since November 2018, the management of the scheme has been transferred to a national entity: the Regional Funds for Health Promotion (RFHP). A transfer protocol signed between the ministry of public health (MPH) and CIDR made provisions for the training of the RFHP personnel to take over the implementation.


Study design, data source and study sample

To achieve the study objectives, we used a quasi-experimental study design. Specifically, for each health facility (HF) that was enrolled in the health voucher project, the potential effect of the project was measured using an analysis of interrupted time series [29,30,31,32]. This method compares changes in the indicators of interest before and after the start of the intervention. It is based on the fundamental assumption that, in the absence of intervention, the trend of the interest indicator remains unchanged over time [31]. It is desirable to have at least 12 observation points for the indicator or variable of interest before and after the start of the intervention, respectively [29].

We used secondary data from the monitoring and evaluation system database populated by the three regional implementing agencies of the health voucher project, let by the CIDR-CARE prior to the transfer of the project to the RFHP that began in 2018. These databases were updated quarterly by trained research assistants after monthly data collection from the registries of all health facilities enrolled in the project. Data quality control was carried out jointly by the team from the MPH in charge of monitoring project implementation and by the project team. The data used in this study are monthly aggregates of the variables of interest over the period from January 2013 to May 2018 (i.e., 65 months of observation).

The database contains information on 42 health facilities (HFs) enrolled in the health voucher project, spread across three regions: 12 HFs in the Adamawa region, 15 in the North region and 14 in the Far North region. These HFs were sequentially enrolled in the health voucher project and not at the same time. In the Adamawa region, activities started in 9 HFs in May 2015 and in 3 HFs in March 2016. In the North region, the implementation of activities started in May 2015 in one HF, in June 2015 in 5 HFs and in July 2016 in 9 HFs. For the Far North region, the intervention started in 4 HFs in June 2015, in 3 HFs in March 2016 and in 7 HFs in July 2016. For the analysis of each outcome, HFs included in the sample were those with at least 90% data completeness over the selected period. Thus, the sample sizes for analysis of the outcomes associated with the first antenatal consultation and assisted deliveries were 33 and 37, respectively.

Study variables


Two dependent variables were considered for this evaluation: (i) the monthly number of first ANC visits in each HF and (ii) the monthly number of SBA in each HF.


  1. o

    Xit: a time-dependent dichotomous variable that takes the value 0 for the months before the start of the health voucher project in HF i and 1 after the start of the project.

  2. o

    Tt: time variable measured in months, with values ranging from 0 (January 2013) to 64 (May 2018).

  3. o

    Xit*(Tti): interaction variable between the variables Xit and Tt centered on the value corresponding to the month of project start in HF i (θi).

Statistical analysis

Descriptive analysis

To explore the outcomes, we used descriptive statistics (mean, median, standard deviation, interquartile range, absolute frequency, relative frequency) and trend curves.

Statistical modeling

For each HF and for each outcome, the estimation of the effects of the health voucher project was carried out using a negative binomial regression.

Since both outcomes are count variables, the choice of negative binomial regression instead of Poisson regression, which is the classic model for this type of variable, was considered to overcome the violation of the fundamental assumption underlying Poisson regression, which states that the mean is equal to the variance. Let Yit be the value of the considered outcome observed in HF i at time t. Yit follows a Poisson distribution with parameter μit (Yit ~Poisson (μit)). The general equation of the model used is shown below:

$$\log\ (\upmu_{\text{it}}) = \upbeta_{0} + \upbeta_{1} \text{T}_{\text{t}} + \upbeta_{2}\text{X}_{\text{it}} + \upbeta_{3}\text{X}_{\text{it}} \ast (\text{T}_{\text{t}} - \uptheta_{\text{i}}) + \upgamma_{\text{it}}$$

The other parameters of the model are described below.

  • β0= intercept (value of the dependent variable at month 1 of follow-up);

  • β1= slope of the outcome trajectory before the start of the health voucher project;

  • β2= change in the level of outcome at the end of the first month of implementation of the health voucher project;

  • β3= difference between the slope of the outcome trajectory after and before the start of the health voucher project;

  • variable γit is the term that differentiates Poisson regression from negative binomial regression. In other words, eγit follows a gamma distribution with mean 1 and variance α (eγit ~ gamma (1/α, α)), with α being the overdispersion parameter.

The coefficient β2 assesses the immediate effect of the project and β3 assesses the effect of the project over time.

The graphs used to explore the evolution of outcomes over time highlighted the presence of seasonality. Thus, 11 dichotomous variables were considered in the different models. Equation (1) becomes log (μit) = β0 + β1Tt + β2Xit + β3 Xit*(Tti) + ɸ1February + ɸ2March + ɸ3April + ɸ4May + ɸ5June + ɸ6July + ɸ7August + ɸ8September + ɸ9October + ɸ10November + ɸ11December + γit.

The variables February, March … December take the value 1 if the observation relates to this month and 0 otherwise. The month of January was considered a reference.

Because the project did not start at the same time in all HFs, to obtain estimates representing the overall situation, a meta-analysis was used [33]. Thus, the pooled estimates and their confidence intervals were obtained by combining the regression coefficients of each HF using the inverse variance method. Random effects models were used to consider the strong heterogeneity highlighted by the statistics I2=100*(Q-df)/Q (with Q the statistics of Cochran's Q-test of heterogeneity and df the number of degrees of freedom corresponding here to the number of HFs minus one). The values 0%, 25%, 50% and 75% of the I2 statistics represent the following levels of heterogeneity: absent, weak, moderate, and strong, respectively [33, 34]. The incidence-rate ratio (IRR) for each HF per month as well as the aggregate estimates were graphically represented using a "forest plot". The analysis was stratified by region.

The statistical significance threshold used for interpreting the results was 5%. All the statistical analyses were performed with Stata/SE software version 14.2.


Descriptive statistics

The results in Table 1 show that the overall level of data completeness is 98.9% for the monthly number of first ANC visits and 99.3% for the monthly number of SBAs. In all regions, better data completeness was observed in the post-start period of the intervention. For the descriptive statistics of the two variables of interest, overall, the average (respectively the median) of the monthly number of first ANC visits was 58.6 (respectively 50.0). For the monthly number of SBAs, the mean and median were 52.3 and 31.0, respectively. The observed differences between the means and medians illustrate the asymmetry of the distributions of these variables. We also found that the means and medians of these two variables appeared to be greater during the implementation period of the project than during the period prior to the intervention.

Table 1 Completeness of data and descriptive statistics of outcomes by region, before and during project implementation

Furthermore, Fig. 1 shows that there was an increasing trend over time for the monthly average of the first ANC and the monthly average of the SBA. It also emerged that the positive slope was more abrupt for SBA.

Fig. 1
figure 1

Evolution of the monthly averages of the number of first ANC visits and SBAs in the selected Health facilities between January 2013 and May 2018

Effects of the health voucher project

First antenatal consultation (ANC)

Table 2 and Figure S3 displays contrasting results. Overall, at the end of the first month of implementation of the project, controlling for other variables, a statistically significant increase of nearly 26% in the monthly number of first ANCs was observed in the 33 HFs considered in the study sample (IRR = 1.258 [95% CI: 1.075, 1.472]). A similar increase was recorded in the North region but was not statistically significant (IRR = 1.246 [95% CI: 0.976, 1.591]). In the Adamawa region, the increase was nearly 73% (IRR = 1.726 [95% CI: 1.117, 2.668]). Conversely, in the Far North region, a nonsignificant reduction of 0.2% was noted (IRR = 0.998 [95% CI: 0.882, 1.129]). These overall results hid disparities across facilities. In the Adamawa region, out of 10 HFs, there was a statistically significant increase in the monthly number of first ANCs at the end of the first month of project implementation in five HFs and a statistically significant decrease in one HF. In the Far North region, of the 10 HFs, a statistically significant increase was recorded in two HFs, and a statistically significant reduction was recorded in one HF. In the North region, of the 13 HFs, six exhibited a statistically significant increase in the aforementioned indicator and one exhibited a statistically significant decrease.

Table 2 Pooled regression coefficients obtained using Inverse-variance weighted random-effects meta-analysis of negative binomial regression coefficients estimated for each health facility, stratified by region

Moreover, regarding the difference between the slope of the trajectory of the first ANC after and before the start of the project, Table 2 and Figure S4 does not show statistically significant results, either overall or by region. However, in one HF in the Adamawa region, a statistically significant increase in the slope of the trajectory of the first ANC was observed during the project implementation period compared to the situation prior to the intervention. Conversely, a statistically significant decrease was recorded in one HF. In the Far North region, no HF exhibited a statistically significant increase, but a statistically significant decrease was observed in two HFs. In the North region, two HFs exhibited a statistically significant increase, and five HFs exhibited a statistically significant decrease.

Skilled birth attendance (SBA)

Table 2 and Figure S7 shows that by the end of the first month of implementation of the project, a statistically significant increase of nearly 57% in the monthly number of SBAs was recorded in the 37 HFs selected in the study sample, controlling for other variables (IRR = 1.566 [95% CI: 1.358, 1.806]).

A statistically significant increase in this indicator was also observed in each of the three regions. However, there were disparities between HFs. In the Adamawa region, out of 13 health facilities, there was a statistically significant increase in the monthly number of assisted deliveries at the end of the first month of project implementation in nine HFs and a statistically significant decrease in one HF. In the Far North region, of the 11 HFs, a statistically significant increase was recorded in eight HFs and a statistically significant decrease was recorded in two HFs. In the North region, of the 13 HFs, seven recorded a statistically significant increase and one a statistically significant decrease in the indicator of interest.

In addition, Table 2 and Figure S8 indicates that, overall, the intervention had a positive effect on SBAs (IRR = 1.009 [95% CI: 1.002, 1.016]). A similar finding is observed in the three regions, with the Far North region being the only region that was statistically significant. When considering the analysis of HFs, the results are mixed. In the Adamawa region, a positive and statistically significant result was recorded for four HFs while a negative and statistically significant result was observed for three HFs. In the Far North region, statistically significant results were recorded for five HFs and all these results were positive. In the North region, two HFs recorded a positive result and three recorded a negative result.

The high values of the I2 statistics reveal that a very large proportion of the total observed variance is due to a real difference in effect measures between HFs (Figure S1 to S8).


Our study explored the effect of the Health voucher Project on the use of health services. Overall, a statistically significant increase was observed in the number of first ANCs at the end of the first month of project implementation (success). However, this improvement was not sustained over time, with less than 10% of all HFs (3/33) experiencing an increase in ANCs.

For the SBAs, there was a statistically significant increase at the end of the first month of project implementation, with a sustained pattern over time. When looking at the individual HFs, 2/3 (65%) recorded success at the end of the first month of implementation, while 30% experienced overall improvement during the project implementation compared to the period before the start of the project.

These findings suggest that between the pre-intervention/roll-out and full implementation phases, the Cameroon voucher programme modestly increased the use of facility for ANC and SBA, consistent with previously reported results from evaluations of maternal health voucher programmes from other LMICs [21, 35,36,37,38].

Our results therefore indicate that in a country such as Cameroon, where progress toward universal health coverage is still to be achieved [39], reducing financial risk by providing subsidies to offset the costs of receiving RMNCAH services may be a good cost-effective intervention to improve service utilization.

Pregnant women were more likely to use the voucher system for SBAs than for the first ANC visits. One explanation could be the late attendance of pregnant women at health facilities, as more than 70% of pregnant women in these three regions are reported to have their first contact with a health facility after the first trimester of pregnancy [27], or the late acquisition of vouchers. In-depth discussions with health care providers and direct beneficiaries are needed to better understand the realities underlying these trends.

The decrease in first ANC and SBA over time in some HFs could be explained by the increasing expansion of service coverage, with the opening of new health facilities that were not yet included in the project and that were used by some pregnant women. On the other hand, the context of growing insecurity linked to Boko Haram and other rebel groups in neighboring countries could also constitute a barrier to the use of health facilities in these regions.

It is also important to note that the voucher program is conceptually designed to target the poorest populations. In Cameroon, however, the project covers all women of reproductive age in the intervention areas, regardless of socioeconomic status. We suspect that the contribution of the 6,000 FCFA ($11 US) remains a major barrier to the use of health services for the poorest women, especially since the project covers mostly urban areas, raising the question of program equity as reported elsewhere [13, 14, 16]. This challenge was also highlighted in an unpublished qualitative study.

Focusing on strategies that prioritize the poorest women and strengthen community engagement can ensure equity and achieve sustainable results over time. For example, in Bangladesh and Cambodia, the voucher programme focused on those most in need and reimbursed care givers in facilities to motivate them [40, 41]. Moreover, both countries have successfully partnered with recipient communities to improve the targeting of the poor [40,41,42].

In addition to stimulating demand, voucher schemes are often proposed as a way to improve the quality of care, as is the case in Cameroon, where health facility accreditation mechanisms are used, alongside the performance-based financing scheme implemented nationwide. However, experiences show that providers may find reimbursement rates to be unattractive and engage in practices such as providing inconsistent quality of care or ‘skimming’ programme users who require minimal intervention. Moreover, as reported in other voucher programs, the most significant problem faced by the voucher scheme in Cameroon was the delay in paying for health facilities, which led to staff demotivation and mistrust between the managers of the scheme and the beneficiaries [41] and suggested a need for greater attention to issues related to implementation in such a program [26].

This study helps to extend the body of knowledge generated by previous research on health voucher programmes in LMICs. However, in interpreting our findings, the strengths and limitations of the study design should be considered.

First, most studies on voucher programmes to date have examined the immediate or shorter-term impact of the intervention on service utilization [21]. Our study examined the immediate to longer-term effects of the intervention and used a quasi-experimental design, known as a reliable approach, to provide robust estimates of the effect of an intervention when a randomized controlled trial cannot be conducted or when a control group is lacking [29, 31]. Unlike in cross-sectional observational studies, interrupted time series analysis allows us to estimate the dynamics of change driven by the intervention, controlling for secular changes that might have occurred in the absence of the intervention [29, 43]. This approach thus makes it possible to observe whether the intervention has an immediate or delayed, sudden or gradual effect and whether this effect persists or is temporary. Furthermore, there is no real consensus on the number of observation points needed to use the interrupted time series method. However, the statistical power increases with the number of time points [30]. Some authors recommend 12 observation points before and after the start of the intervention [29]. In our study, only one HF had 10 observation points before the start of the project, and the others had observation points ranging from 14 and 42. During the project implementation period, the number of observations varied between 23 and 37.

At the time of the study, 81 facilities had already enrolled in the voucher project. We limited ourselves to 33 HFs for the first ANC and to 37 HFs for the SBA analysis because the data prior to the project were either unavailable or insufficient. Therefore, the results presented in this study may be a fragmented view of the project’s effect. In addition, analysis that could provide insight into the RMNCAH continuum of care was not possible due to the limited quality of data (high frequency of missing data) for some key indicators, such as the fourth ANC and postnatal consultation, as reported with other voucher programs [22, 44,45,46].

In identifying the impact of an intervention, it is important that there are no exogenous factors influencing the results. During the implementation of the voucher program in Cameroon, there were no closures of health facilities that could have an impact on the two selected indicators. Population growth naturally leads to an increase in the number of pregnant women in absolute terms, and consequently to an increase in the number of SBAs. Because demographic data were only available for each health district and not for each health facility, estimates of expected populations or pregnant women were not included into the various negative binomial regression models as a control variable. As a result, the estimates obtained may be biased.

It is also important to point out that due to its fragility, the northern part of the country is a convergence zone of several programs and projects, including those of health. Therefore, other interventions may have also contributed to the achievement of these outcome levels. One of the most important programmes is the National Multi-sector Program to Combat Maternal, Newborn and Child Mortality, which was created in 2013.

Finally, we would like to underline that the fidelity of the program's implementation was hampered by deviations, leading for instance to extending the intervention to all women of childbearing age. At present, the program is more akin to an obstetric risk insurance system, as described for example in Mauritania [47].


This study provided important insight into the Cameroon voucher scheme. The intervention had a significant early effect on the first ANC and SBA but failed to effectively sustain these results over time for the first indicator. These mixed effects were likely the consequence of poor design and implementation challenges, including the fact that the programme did not include specific equity measures to facilitate uptake by the poorest people. This suggests that for a complex intervention such as a voucher, it is critical to properly implement practice strategies that can sustain the long-term impact of the programme.

Availability of data and materials

The data that support the findings of this study are available from the Ministry of Public Health (MPH) of Cameroon, but restrictions apply due to the terms of our contract with the MPH, and so, data are not publicly available. The corresponding author should be contacted for the process to request data access.



Antenatal consultation


Centre International de Développement et de Recherche


Emergency obstetric and neonatal care


Communauté financière africaine


Health facility


Low- and middle-income country


Maternal mortality ratio


Multiple Indicator Cluster Survey


Ministry of public health




Post-natal care


Regional Funds for Health Promotion


Reproductive, maternal, neonatal, child and adolescent health


Skilled birth attendance


Sustainable Development Goals


Sub Saharan Africa


United States dollar


World health organization


  1. Nations Unies. Développement durable. 2021. Objectif de Développement Durable - Santé et Bien-Être pour tous. 2021. Available at: Accessed 3 June 2023.

  2. WHO, UNICEF, UNFPA, World Bank Group, United Nations Population Division. Trends in maternal mortality: 2000 to 2017. Geneva, Switzerland: World Health Organization; 2019. p. 119. Available at: Accessed 10 May 2023.

  3. UN Inter-agency Group for Child Mortality Estimation. Levels & Trends in Child Mortality. New York, NY 10017 États-Unis: United Nations Children’s Fund; 2020 p. 56. Available at: Accessed 2 Jul 2023.

  4. Institut National de la Statistique (INS). Enquête Démographique et de Santé et à Indicateurs Multiples EDS-MICS 2011. 2011. Available at: Accessed 2 Feb 2023.

  5. Donnay F. Maternal survival in developing countries: what has been done, what can be achieved in the next decade. Int J Gynecol Obstet. 2000;70(1):89–97.

    Article  CAS  Google Scholar 

  6. Singh S, Darroch JE, Ashford LS, Vlassoff M. Adding It Up: The costs and Benefits of Investing in family Planning and maternal and new born health. GUTTMACHER INSTITUTE; 2009. Available at: Accessed 20 April 2023.

  7. Tekelab T, Chojenta C, Smith R, Loxton D. The impact of antenatal care on neonatal mortality in sub-Saharan Africa: a systematic review and meta-analysis. PLOS One. 2019;14(9):e0222566.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wondemagegn AT, Alebel A, Tesema C, Abie W. The effect of antenatal care follow-up on neonatal health outcomes: a systematic review and meta-analysis. Public Health Rev. 2018;39(1):33.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Matsuoka S, Aiga H, Rasmey LC, Rathavy T, Okitsu A. Perceived barriers to utilization of maternal health services in rural Cambodia. Health Policy. 2010;95(2):255–63.

    Article  PubMed  Google Scholar 

  10. Sharma S, Smith S, Sonneveldt E, Pine M, Dayaratna V, Sanders R. Formal and Informal Fees for Maternal Health Care Services in Five Countries. USAID; 2005. Available at: Accessed 30 Jan 2023.

  11. Institut National de la Statistique (INS) and IFC. Enquête Démographique et de Santé EDS 2018. INS et IFC 2020. Available at: Accessed 4 Jan 2023.

  12. WHO. World Health Organization. 2020. Global Health Expenditure Database. Available at: Accessed 13 Feb 2023.

  13. Gabrysch S, Campbell OM. Still too far to walk: Literature review of the determinants of delivery service use. BMC Pregnancy Childbirth. 2009;11(9):34.

    Article  Google Scholar 

  14. Dzakpasu S, Powell-Jackson T, Campbell OMR. Impact of user fees on maternal health service utilization and related health outcomes: a systematic review. Health Policy Plan. 2014;29(2):137–50.

    Article  PubMed  Google Scholar 

  15. Ensor T, Ronoh J. Effective financing of maternal health services: a review of the literature. Health Policy. 2005;75(1):49–58.

    Article  PubMed  Google Scholar 

  16. Richard F, Witter S, de Brouwere V. Innovative approaches to reducing financial barriers to obstetric care in low-income countries. Am J Public Health. 2010;100(10):1845–52.

    Article  PubMed  PubMed Central  Google Scholar 

  17. World Health Organization. Making pregnancy safer: the critical role of the skilled attendant: a joint statement by WHO, ICM and FIGO. Geneva: WHO; 2004. 24 p. Available at: Accessed 15 April 2023.

  18. Baral YR, Lyons K, Skinner J, van Teijlingen ER. Determinants of skilled birth attendants for delivery in Nepal. Kathmandu Univ Med J. 2010;8(3):325–32.

    Article  CAS  Google Scholar 

  19. Bellows NM, Bellows BW, Warren C. Systematic review: the use of vouchers for reproductive health services in developing countries: systematic review. Trop Med Int Health TM IH. 2011;16(1):84–96.

    Article  PubMed  Google Scholar 

  20. Brody CM, Bellows N, Campbell M, Potts M. The impact of vouchers on the use and quality of health care in developing countries: a systematic review. Glob Public Health. 2013;8(4):363–88.

    Article  PubMed  Google Scholar 

  21. Hunter BM, Harrison S, Portela A, Bick D. The effects of cash transfers and vouchers on the use and quality of maternity care services: a systematic review. PLOS One. 2017;12(3):e0173068.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Nguyen HTH, Hatt L, Islam M, Sloan NL, Chowdhury J, Schmidt JO, et al. Encouraging maternal health service utilization: an evaluation of the Bangladesh voucher program. Soc Sci Med. 2012;74(7):989–96.

    Article  PubMed  Google Scholar 

  23. Azmat SK, Ali M, Rahman MdM. Assessing the sustainability of two independent voucher-based family planning programs in Pakistan: a 24-months post-intervention evaluation. Contracept Reprod Med. 2023;8(1):43.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Nandi A, Charters TJ, Quamruzzaman A, Strumpf EC, Kaufman JS, Heymann J, et al. Health care services use, stillbirth, and neonatal and infant survival following implementation of the Maternal Health Voucher Scheme in Bangladesh: A difference-in-differences analysis of Bangladesh Demographic and Health Survey data, 2000 to 2016. PLOS Med. 2022;19(8):e1004022.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Sultana N, Hossain A, Das H, Pallikadavath S, Koeryaman M, Rahman M, et al. Is the maternal health voucher scheme associated with increasing routine immunization coverage? Experience from Bangladesh. Front Public Health. 2023;2(11):963162.

    Article  Google Scholar 

  26. Hunter BM, Murray SF. Demand-side financing for maternal and newborn health: what do we know about factors that affect implementation of cash transfers and voucher programmes? BMC Pregnancy Childbirth. 2017;17(1):262.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Institut National de la Statistique. Cameroon - Enquête par Grappes à Indicateurs Multiples 2014. Yaoundé, Cameroun: Institut National de la Statistique; 2015; p. 504. Available at: Accessed 22 Jan 2023

  28. Institut National de la Statistique. Annuaire statistique 2017. 2018. Available at: Accessed May 10, 2023.

  29. Wagner AK, Soumerai SB, Zhang F, Ross-Degnan D. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther. 2002;27(4):299–309.

    Article  CAS  PubMed  Google Scholar 

  30. Bernal JL, Cummins S, Gasparrini A. Interrupted time series regression for the evaluation of public health interventions: a tutorial. Int J Epidemiol. 2017;46(1):348–55.

    Article  PubMed  Google Scholar 

  31. Linden A. ITSA: Stata module to perform interrupted time series analysis for single and multiple groups. Statistical Software Components. Boston College Department of Economics; 2021. Available at: Accessed 21Oct 2023.

  32. Ramsay CR, Matowe L, Grilli R, Grimshaw JM, Thomas RE. Interrupted time series designs in health technology assessment: Lessons from two systematic reviews of behavior change strategies. Int J Technol Assess Health Care. 2003;19(4):613–23.

    Article  PubMed  Google Scholar 

  33. Gebski V, Ellingson K, Edwards J, Jernigan J, Kleinbaum D. Modelling interrupted time series to evaluate prevention and control of infection in healthcare. Epidemiol Infect. 2012;140(12):2131–41.

    Article  CAS  PubMed  Google Scholar 

  34. Borenstein M, Hedges LV, Higgins J, Rothstein HR. Introduction to Meta-Analysis. 2nd ed. Hoboken: Wiley; 2021. p. 500.

    Book  Google Scholar 

  35. Obare F., Warren C., Abuya T., Askew I., Bellows B. Assessing the population-level impact of vouchers on access to health facility delivery for women in Kenya. Soc Sci Med. 2014;183–9.

  36. Obare F, Warren C, Kanya L, Abuya T, Bellows B. Community-level effect of the reproductive health vouchers program on out-of-pocket spending on family planning and safe motherhood services in Kenya. BMC Health Serv Res. 2015;15(1):343.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Bellows B, Kyobutungi C, Mutua MK, Warren C, Ezeh A. Increase in facility-based deliveries associated with a maternal health voucher programme in informal settlements in Nairobi Kenya. Health Policy Plan. 2013;28(2):134–42.

    Article  PubMed  Google Scholar 

  38. Amendah DD, Mutua MK, Kyobutungi C, Buliva E, Bellows B. Reproductive health voucher program and facility based delivery in informal settlements in nairobi: a longitudinal analysis. PLOS One. 2013;8(11):e80582.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Sieleunou I, Tamga DM, Maabo Tankwa J, Aseh Munteh P, Longang Tchatchouang EV. Strategic health purchasing progress mapping in cameroon: a scoping review. Health Syst Reform. 2021;10(7):1.

    Article  Google Scholar 

  40. Ir P, Horemans D, Souk N, Van Damme W. Using targeted vouchers and health equity funds to improve access to skilled birth attendants for poor women: a case study in three rural health districts in Cambodia. BMC Pregnancy Childbirth. 2010;10(1):1.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Ahmed S, Khan MM. A maternal health voucher scheme: what have we learned from the demand-side financing scheme in Bangladesh? Health Policy Plan. 2011;26(1):25–32.

    Article  PubMed  Google Scholar 

  42. Ridde V, Yaogo M, Kafando Y, Sanfo O, Coulibaly N, Nitiema PA, et al. A community-based targeting approach to exempt the worst-off from user fees in Burkina Faso. J Epidemiol Community Health. 2010;64(01):10–5.

    Article  CAS  PubMed  Google Scholar 

  43. Eccles M, Grimshaw J, Campbell M, Ramsay C. Research designs for studies evaluating the effectiveness of change and improvement strategies. BMJ Qual Saf. 2003;12(1):47–52.

    Article  CAS  Google Scholar 

  44. Ahmed S, Khan MM. Is demand-side financing equity enhancing? Lessons from a maternal health voucher scheme in Bangladesh. Soc Sci Med. 2011;72(10):1704–10.

    Article  PubMed  Google Scholar 

  45. Agha S. Impact of a maternal health voucher scheme on institutional delivery among low income women in Pakistan. Reprod Health. 2011;8(1):10.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Van de Poel E, Flores G, Ir P, O’Donnell O, Van Doorslaer E. Can vouchers deliver? An evaluation of subsidies for maternal health care in Cambodia. Bull World Health Organ. 2014;92(5):331–9.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Philibert A, Ravit M, Ridde V, Dossa I, Bonnet E, Bedecarrats F, Dumont A. Maternal and neonatal health impact of obstetrical risk insurance scheme in Mauritania: a quasi experimental before-and-after study. Health Policy Plan. 2017;32(3):405–17.

    Article  PubMed  Google Scholar 

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We would like to thank Dr Bassirou Bouba and Dr Okala from the voucher project, Dr Yumo Habakkuk and Bashirou Ndindumouh from Research for Development International, Dr Denise Tamga from the Worlb Bank Office, and Dr Aubin Baleba from UNFPA. We are much indebted to the SPARC team for continuously reviewed our work and provided valuable comments. Finally, the authors would also like to acknowledge the work of the anonymous reviewers who provided us with extremely helpful comments and feedback.


This work was supported by the Bill & Melinda Gates Foundation [Grant number: OPP1179622].

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Authors and Affiliations



IS and RPEB conceived and designed the study. RPEB managed the data, including quality control, provided statistical advice on study design and analyzed the data. IS drafted the manuscript, and all authors contributed substantially to its revision. All authors agreed to the final approval of the version to be published. All authors agreed to be accountable for all aspects of the work.

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Correspondence to Isidore Sieleunou.

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Ethics approval and consent to participate

Ethical approval for the study was obtained from the Cameroon National Ethics Committee for Human Health Research (CNECHHR) (N0 2020/07/1274/CE/CNERSH/SP). Administrative authorization was granted by the Cameroonian Ministry of Health (D30-607/N/MINSANTE/SG/DROS/CRSPE/BBM, N0 631-32-20). All methods were performed in accordance with the relevant guidelines and regulations. The CNECHHR waived the need for participants’ informed consent in this retrospective study because the data used were fully anonymised and aggregated.

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The authors declare no competing interests.

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Sieleunou, I., Enok Bonong, R.P. Does health voucher intervention increase antenatal consultations and skilled birth attendances in Cameroon? Results from an interrupted time series analysis. BMC Health Serv Res 24, 602 (2024).

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