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System-level policies on appropriate opioid use, a multi-stakeholder consensus

Abstract

Background

This consensus statement was developed because there are concerns about the appropriate use of opioids for acute pain management, with opposing views in the literature. Consensus statement on policies for system-level interventions may help inform organisations such as management structures, government agencies and funding bodies.

Methods

We conducted a multi-stakeholder survey using a modified Delphi methodology focusing on policies, at the system level, rather than at the prescriber or patient level. We aimed to provide consensus statements for current developments and priorities for future developments.

Results

Twenty-five experts from a variety of fields with experience in acute pain management were invited to join a review panel, of whom 23 completed a modified Delphi survey of policies designed to improve the safety and quality of opioids prescribing for acute pain in the secondary care setting. Strong agreement, defined as consistent among> 75% of panellists, was observed for ten statements.

Conclusions

Using a modified Delphi study, we found agreement among a multidisciplinary panel, including patient representation, on prioritisation of policies for system-level interventions, to improve governance, pain management, patient/consumers care, safety and engagement.

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Introduction

Scientific understanding of opioid pharmacology and of the neurophysiology of pain has been a success story of the twentieth century. In the face of gross global inequalities in access to opioid medications, over the last 30 years, there has been increasingly liberal prescribing of opioids in some parts of the world, both for acute and for persistent or chronic pain [1].

In some countries more than in others, over-supply and overuse resulted in unwanted adverse effects, dependence, addiction, opioid use disorders and overdose-related deaths, which have reached epidemic proportions [2,3,4]. At the same time, there are problems of access to pain relief in general, including opioids and non-opioids, in many lower income countries.

These issues are relevant at an individual, as well as societal levels, involving public, healthcare professionals and industry, because they find their origins at different levels [5,6,7,8,9,10]. Unfortunately, although there is increasing recognition of problems occurring with opioid prescribing, as well as the unclear analgesic benefit, even in the acute pain setting, there continues to be high rates of harm from opioid prescribing and no universal policy orientation [11, 12].

Therefore, consensus is needed, not only on the prescribing of opioids, but also on policies for system-level interventions, including governance, pain management, patient care and patient engagement [13, 14].

Such a consensus requires collaboration between different disciplines: pain specialists, anaesthesiologists, surgeons, general practitioners, nurses, psychologists, pharmacists, addiction specialists and educators. In addition, healthcare organisations and governmental bodies will need to support the development of a culture of more rational and safe prescribing. This may include prescribing guidelines such as limitations on medication types, dosage, and duration, as well as patient education, provider training, clear referral mechanisms, and other public health initiatives such as real-time monitoring of prescribing. The public and patients should be involved in the context of informed consent and shared decision-making.

Whilst a review of clinical practices has recently been undertaken [15], policies at institutional and societal (governmental and healthcare system) levels have not. The current work aims to identify where there is consensus regarding these policies.

Methods

Methodology model

A modified Delphi method was used. This technique was selected because it has been used widely to generate robust consensus in healthcare research and does not require face-to-face contact. It has proven very useful in related projects [16].

Panellist recruitment

The steering committee recruited panellists by inviting members of major scientific societies (European Pain Federation EFIC, International Association for the Study of Pain IASP, International Society of Addiction Medicine ISAM, Pain Alliance Europe PAE, European Federation of Addiction Societies EUFAS, European Psychiatric Association EPA) and their networks. This ensured all relevant profiles were represented i.e. involved in pain and/or in addiction problematics. Along with healthcare representation (different medical disciplines namely anaesthesia/pain medicine, addiction medicine/psychiatry, surgery, nursing, physiotherapy and pharmacy) consumers (patient representatives) were also included in the panel (Table 1).

Table 1 Participant profiles

Given the range of perspectives on pain and its management in different social, professional and geographical settings, we also invited, and included participants from Europe, Asia, Africa, Oceania and America.

Policies on appropriate opioids use

Policies were developed by the steering group, based on the current literature on quality improvement using Pain Management Stewardship groups [17, 18]. A first version of the statement was drafted by the steering committee, and then presented at International Society of Addiction Medicine—Canadian.

Society of Addiction Medicine Joint Conference 2020 (12th to 14th November 2020), Victoria, BC, Canada. All statements were presented and comments were taken into account to finalize the proposed statements in the first round.

Governance policies, pain management policies and policies regarding patient care and consumer engagement are detailed, in their final version, in the Table 2.

Table 2 Results of the Delphi survey. Statements are in their final version

Data collection structure

After compiling a group representing all the desired expertise, 25 panellists in total were invited using a secured web-based platform. The responses were collected and managed using REDCap (Research Electronic Data Capture) electronic data capture tools [19]. REDCap is a secure, web-based application designed to support data capture for research studies, providing 1) an intuitive interface for validated data entry; 2) audit trails for tracking data manipulation and export procedures; 3) automated export procedures for seamless data downloads to common statistical packages; and 4) procedures for importing data from external sources. This ensured the anonymity of data collection, the structuring and controlling the data capture and providing feedback to the panellists (namely the automatization of the report of the response from one round to the subsequent one).

Data collection process

In round 1 the participants were asked to rate the 12 statements drafted by the steering committee, based on a scoping review of the literature using a five-levels Likert scale. They also had the opportunity to propose new statements.

In subsequent rounds, participants had the option to change their rating after seeing their selection with regard to the (aggregated and anonymised) selections of the other voters agreeing/disagreeing. In rounds 3 and 4 the items for which an agreement had been reached were presented to determine whether or not this should be prioritised (yes/no).

Data analysis

An aggregation of responses was semi-automated using REDCap and available for the participants in total. For the final report presented here, an aggregate of strongly agreed and agreed was used to determine if 75% threshold for agreement was met. A high stability was defined as < 10% changes in absolute proportions between the last round and the previous one (looking at the construct or at the prioritisation of it).

Ethical review

Aligned with United Kingdom (UK) Policy Framework for Health and Social Care Research, this study has been granted an exemption from requiring ethics approval (Name of the ethics committee: NHS Research Ethics Committee, REC), according to the Central Office for Research Ethics Committees (COREC) and the National Research Ethics Service (NRES) guidance. Written informed consent was obtained from all participants.

Results

Round 1

Twenty-three of the 25 invited panellists participated in the Delphi survey. Two who initially accepted the invitation to be part of the study did not respond to subsequent emails. Participants, with varied professional background and roles, came from primary, secondary care and academia, from secondary and tertiary referral hospitals (Table 1).

Other than the 2 consumer representatives, all participants were regularly involved in providing direct patient care.

Twelve items were proposed to the participants. All 23 participants completed the 12 items survey and 12 added comments.

Round 2

All 23 participants from round 1 participated in round 2.

Based on the panellists feedback in round 1 six of the 12 items were modified according to the participant’s suggestions in round 1 and a 13th statement (item) was added: ‘Information from drug intelligence and law enforcement agencies as well as from overdoses and deaths related to prescribed drugs should be fed back to prescribers’ . The modifications are detailed in Table 2. All were discussed by the steering committee.

All 13 statements reached the predefined agreement threshold (75%) and only one statement did not meet the definition of high stability (< 10%) changes, but as this change was + 11% of additional agreement, we decided to proceed to Round 3 (Table 2). The final versions are presented in this document.

Rounds 3 and 4

All 23 panellists completed the prioritisation questionnaires in due time. The 75% threshold for agreement was reached to prioritise the statements for all but for three: Processes should be developed to facilitate and monitor the return of any unused or expired analgesic medications (52%); Public opinion and societal attitudes should be explored on the implications of ‘Pain relief as a human right’ (59%); Feedback from drug intelligence and law enforcement agencies (65%).

Stability was high for all but for one: The health system should have policies in place which outline the safe and accountable use (closed-loop) of drugs (+ 11%).

Where an agreement was reached, it related to statements (Table 2) grouped afterwards in themes. This related to information, coordination and implementation tasks by regulatory authorities; promotion, monitoring and support of safe and appropriate prescribing; 2. Better understanding of prescribing practices; 3. Communication, follow-up, referral and patient-centredness. The agreement varied between 76 and 100% with a percentage change between the last two rounds ranging from − 6% to + 11%. Concrete propositions were made (Table 2).

Discussion

This Delphi survey reached a robust agreement on thirteen system-level policy statements on the appropriate use of opioids. Ten of them were considered priorities by the panellists. These statements related to improving governance, pain management, patient/consumers care, safety and engagement.

What are the priorities in terms of governance policies?

This work highlights the needs for developing Pain and Opioid Stewardship Steering Committees. These committees could facilitate the implementation of policies and best practices for the safe and responsible use of opioids or other drugs that could lead to dependence. According to the panellists, this should be sensitive to the country and could be implemented at both national levels and hospital/healthcare system levels. Such a committee may supervise Opioid Stewardship programmes.

The Institute for Safe Medication Practice Canada describes Opioid Stewardship as “coordinated interventions designed to improve, monitor, and evaluate the use of opioids in order to support and protect human health”. By an interprofessional, multidisciplinary approach, the goal is to optimise opioid prescribing while minimizing unintended consequences. This could be elegantly integrated into metrics as quality indicators, rather than just looking at the number of prescriptions. But this steering committee could also look at other solutions that have been proposed for chronic or persistent pain, like:

  • Education: Increasing the importance of pain management education [20].

  • Individualised prescribing: Rather than indiscriminately reducing supply, perhaps the focus should be on tailoring pain medication prescriptions to the individual, such as tailoring the number of pills to need.

  • Monitoring prescriptions: continuing prescriptions and repeat prescribing after surgery have been shown to be a significant factor in persistent opioid use. Reviewing the effectiveness of analgesia and the ongoing need should be recognised as a normal part of good medical practice.

  • Reducing risk; identification of risk factors for predicting the development opioid use disorders are limited in their accuracy [21] but must be part of the prescription process, with an appropriate informed consent [22].

  • Opioid reduction programmes: helping patients to gradually reduce opioids has been shown to be achievable and to not lead to worsening of pain. Indeed, patient quality of life has been found to be improved [23].

However, in addition to the complexity of deprescribing, the committee recognizes that there is a risk that overreaction and regulation of opioid prescribing could cause the pendulum to tip too far in the other direction, with the possibility that patients may suffer needlessly [24, 25].

How to improve pain management (policies)?

As opioids play a critical role in pain management, especially after surgery and trauma, it is necessary to achieve a balance between providing adequate analgesia while minimising the risk of medication related harm. Evidence shows that the risk of long-term opioid use increases with each additional day of the initial prescription supply, [26] particularly if more than 5 days of therapy is prescribed [27]. This supports the development of strategies aiming to manage persistent pain in the weeks after surgery, as well as persistent opioid use, stewarding the patient by a careful tailored approach.

Further research is also needed. Even after decades of investigations, the transition from acute to chronic pain remains poorly understood [28,29,30,31,32]. One important factor that has become evident is the potential for opioids to cause acute opioid-induced hyperalgesia (playing a potential role in the sensitization to pain of the central nervous system), and persistent postoperative opioid use, associated with a significant risk for the patient, with unclear and inconsistent evidence for benefit in relieving pain [33].

Patient care and consumer engagement

Clearly, anaesthetic, analgesic and surgical plans should be constantly questioned, and integrated into a holistic vision; patient-centred optimisation of pre- and perioperative management, including screening for vulnerability factors, not only physical, but also psychosocial factors. Reinforcing and structuring communication plans during the perioperative phase, between secondary care prescribers, acute pain services and primary care is clearly highlighted by this consensus. The Faculty of Pain Medicine UK Best Practice Guidelines on Opioids and Surgery [34] recommend assessment and management by chronic as well as acute pain management services, for patients undergoing surgery to facilitate specific measures, such as reducing opioid use in the preoperative period, assessing the appropriateness of gabapentinoid prescription and addressing psychosocial factors which are associated with increased risk of poorly controlled postoperative pain, persistent postoperative pain and opioid use. Good practices should be facilitated such as the return of unused medicines and, in general, provide specific and appropriate information and trigger patient and consumer engagement. Improving communication (verbal and written) will enhance patients understanding of pain. Pre-operative information and education that incorporate a health literacy sensitive approach (use of plain language, talk back strategy – asking patient to repeat back what has been said to them to ensure understanding) would ensure a patient centred approach to pain management. Informed consent to treatment could improve patient experience, reduce risks and harms – to the patient and within society [35]. Finally, links with addiction services to inform assessment and risk management would contribute to minimising the likelihood of patients developing problematic drug use. There should be a referral process for high-risk patients and access to pain and dependency services.

What can we learn from current practices, guidelines and policies?

In the last 10 years, prescription rates of strong opioids have more than doubled in most developed countries. North America, Europe and Australasia have seen the greatest increases. The widespread use of opioids and its association with premature mortality demonstrate that this is a major public health issue. Guidelines, mostly at the intention of prescribers have been developed, for instance in the UK, as there is a need to develop consistent evidence on effective and safe prescription strategies [3, 28, 36,37,38]. But evidence is lacking regarding the effect, at the system level, of policies on prescriptions and the different strategies adopted internationally.

Prescription patterns are best described in North America and Australia, including specific, potentially modifiable, factors [39]. But little is known about the optimal pathways (acute, episodic and chronic; after surgery; risky co-prescriptions; relationships with socio-economic factors and mortality). This could be addressed by the development of real-time prescription monitoring, permitting us to study and to identify sources of variability and opportunities for improvement. This would allow us to identify where problems may exist while protecting patients from a blind approach based solely on reducing prescription rates. Concrete propositions are made in Table 2.

The findings in this research reflect the views of this multi-stakeholder panel. As a result, their specific perspectives and experiences are a limitation of a Delphi-based consensus. However, the panel was recruited to represent a breadth of perspectives to improve the robustness of the work. Additionally, the strength of the consensus suggests that the final statements are at least partially, if not fully, translatable to most contexts. Finally, although the Delphi method is good for reaching consensus, it may also moderate the findings.

Conclusion

The opioid epidemic has been a wake-up call for medicine to take stock of how pain is managed. Unintended consequences of persistent opioid use and related harm have been observed. When putting system-level policies in place to improve pain management, we must also design safeguards that will reduce the risk of overprescribing, while encouraging a more biopsychosocial approach.

In this Delphi study, we have identified themes and priorities relating to concrete actions for regulatory authorities. We have found agreement to prioritize policies for system level interventions, to improve governance, pain management, patient / consumer care, safety and engagement. In terms of governance, this includes projects to promote, monitor and support the safe and appropriate prescribing of drugs which often lead to dependence, such as opioids. For pain management policies, a better understanding of prescribing practices and future programs could include guidelines and educational activities to implement them, but also communication, monitoring and referral between 1st and 2nd line caregivers. Finally, patients must be well informed and provided structured/integrated support, including pain management and/or opioid stewardship, in addition to addiction management, when required.

The problem is global, even if the solutions may be different, depending on context and country specific factors. However, common denominators may exist, such as monitoring of practices and improved observational studies.

Availability of data and materials

All the data generated and analysed during the current study are available in the manuscript.

References

  1. Torrance N, Mansoor R, Wang H, Gilbert S, Macfarlane G, Serpell M, et al. Association of opioid prescribing practices with chronic pain and benzodiazepine co-prescription: a primary care data linkage study. Br J Anaesth. 2018;120(6):1345–55.

    CAS  Article  PubMed  Google Scholar 

  2. Hooten W, St Sauver J, McGree M, Jacobson D, Warner D. Incidence and risk factors for progression from short-term to episodic or long-term opioid prescribing: a population-based study. Mayo Clin Proc. 2015;90(7):850–6.

    Article  PubMed  Google Scholar 

  3. Macfarlane GJ, Beasley M, Jones GT, Stannard C. The epidemiology of regular opioid use and its association with mortality: Prospective cohort study of 466 486 UK biobank participants. eClinicalMedicine. 2020;21:100321.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Häuser W, Schubert T, Scherbaum N, Tölle T. Guideline-recommended vs. high-dose long-term opioid therapy for chronic non-cancer pain is associated with better health outcomes: data from representative sample of the German population. Pain. 2018;159:85–91.

    Article  PubMed  Google Scholar 

  5. Melzack R. The tragedy of needless pain. Sci Am. 1990;262(2):27–33.

    CAS  Article  PubMed  Google Scholar 

  6. Cousins M, Brennan F, Carr D. Pain relief: a universal human right. Pain. 2004;112(1):1–4.

    Article  PubMed  Google Scholar 

  7. Campbell J. APS 1995 Presidential Address. Pain Forum. 1995;5(1):85–8.

    Article  Google Scholar 

  8. Niv D, Devor M. Chronic pain as a disease in its own right. Pain Practice. 2004;4(3):179–81.

    Article  PubMed  Google Scholar 

  9. Ballantyne J. Opioids for chronic pain: taking stock. Pain. 2006;125:3–4.

    Article  PubMed  Google Scholar 

  10. Haffajee RNL, Mello MM. Drug companies’ liability for the opioid epidemic. N Engl J Med. 2017;377(24):2301–5.

    Article  PubMed  PubMed Central  Google Scholar 

  11. NIH National Institute on Drug Abuse., “Opioid Overdose Crisis,” 2021. Available: https://www.drugabuse.gov/drug-topics/opioids/opioid-overdose-crisis. [Accessed 10 Mar 2021].

    Google Scholar 

  12. Penington Institute, “Australia’s Annual Overdose Report 2020,” 2020. Available: https://www.penington.org.au/publications/2020-overdose-report/. [Accessed 10 mar 2021].

    Google Scholar 

  13. Chou R, Gordon D, de Leon-Casasola OA, Rosenberg J, Bickler S, Brennan T, et al. Management of Postoperative Pain: a clinical practice guideline from the American pain society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists. J Pain. 2016;17(2):131–57.

    Article  PubMed  Google Scholar 

  14. Sandbrink F, Uppal R. The time for opioid stewardship is now. Jt Comm J Qual Patient Saf. 2019;45:1–2.

    PubMed  Google Scholar 

  15. Levy N, Quinlan J, El-Boghdadly K, Fawcett WJ, Agarwal V, Bastable RB, et al. An international multidisciplinary consensus statement on the prevention of opioid-related harm in adult surgical patients. Anaesthesia. 2021;76(4):520–36.

    CAS  Article  PubMed  Google Scholar 

  16. Hasson F, Keeney S, McKenna H. Research guidelines for the Delphi survey technique. J Adv Nurs. 2000;32(4):1008–15.

    CAS  PubMed  Google Scholar 

  17. Rizk E, Swan J, Cheon O, Colavecchia A, Bui L, Kash B, et al. Quality indicators to measure the effect of opioid stewardship interventions in hospital and emergency department settings. Am J Health Syst Pharm. 2019;76(4):225–35.

    Article  PubMed  Google Scholar 

  18. Uritsky T, Busch M, Chae S, Genord C. Opioid stewardship: building on antibiotic stewardship principles. J Pain Palliat Care Pharmacother. 2020;34:181–3.

    Article  PubMed  Google Scholar 

  19. Harris P, Taylor R, Thielke R, Payne J, Gonzalez N, Conde J. Research electronic data capture (REDCap) – a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009;42(2):377–81.

    Article  PubMed  Google Scholar 

  20. Fishman SM, Young HM, Arwood EL, Chou R, Herr K, Murinson BB, et al. Core competencies for pain management: results of an interprofessional consensus summit. Pain Med. 2013;14(7):971–81.

    Article  PubMed  Google Scholar 

  21. Klimas J, Gorfinkel L, Fairbairn L, Amato LA, Nolan S. Strategies to identify patient risks of prescription opioid addiction when initiating opioids for pain; a systematic review. JAMA Open. 2019;2(5):e193365.

    Article  Google Scholar 

  22. FPM, “Faculty of pain medicine opioids aware,”2020. Available: https://www.fpm.ac.uk/opioids-aware. [Accessed 22 March 2021].

    Google Scholar 

  23. Darnall B, Mackey S, Lorig K, Kao M, Mardian A, Stieg R, et al. Comparative effectiveness of cognitive behavioral therapy for chronic pain and chronic pain self-management within the context of voluntary patient-centered prescription opioid tapering: the EMPOWER study protocol. Pain Med. 2020;21(8):1523–31.

    Article  PubMed  Google Scholar 

  24. Forget P. Opioid treatment for non-cancer pain: we need a comprehensive approach. BMJ. 2021;375:n3045.

    Article  PubMed  Google Scholar 

  25. Forget P. Prescribing and Deprescribing opioids. Pain. 2021. https://doi.org/10.1097/j.pain.0000000000002299.

  26. Sugai D, Deptula P, Parsa A, Parsa FD. The importance of communication in the management of postoperative pain. Hawaii J Med Public Health. 2013;72(6):180–4.

    PubMed  PubMed Central  Google Scholar 

  27. Holman J, Stoddard G, Horwitz D, Higgins T. The effect of preoperative counseling on duration of postoperative opiate use in orthopaedic trauma surgery: a surgeon-based comparative cohort study. J Orthop Trauma. 2014;28(9):502–6.

    Article  PubMed  Google Scholar 

  28. Glare P, Aubrey K, Myles P. Transition from acute to chronic pain after surgery. Lancet. 2019;393(10180):1537–46.

    Article  PubMed  Google Scholar 

  29. Deumens R, Steyaert A, Forget P, Schubert M, Lavand'homme P, Hermans EDKM. Prevention of chronic postoperative pain: cellular, molecular, and clinical insights for mechanism-based treatment approaches. Prog Neurobiol. 2013;104:1–37.

    CAS  Article  PubMed  Google Scholar 

  30. Albrecht E, Grape S, Frauenknecht J, Kilchoer L, Kirkham K. Low- versus high-dose intraoperative opioids: a systematic review with meta-analyses and trial sequential analyses. Acta Anaesthesiol Scand. 2019;64(1):6–22.

    Article  PubMed  Google Scholar 

  31. Neuman M, Bateman B, Wunsch H. Inappropriate opioid prescription after surgery. Lancet. 2019;393:1547–57.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Kent M, Hurley R, Oderda G, Gordon D, Sun E, Mythen M, et al. POQI-4 working group. American Society for Enhanced Recovery and Perioperative Quality Initiative-4 joint consensus statement on persistent postoperative opioid use: definition, incidence, risk Factorsand healthcare systems initiatives. Anaesth Analg. 2019;129(2):543–52.

    Article  Google Scholar 

  33. Colvin L, Bull F, Hales T. Perioperative opioid analgesia-when is enough too much? A review of opioid-induced tolerance and hyperalgesia. Lancet. 2019;393(10180):1558–68.

    Article  PubMed  Google Scholar 

  34. P. Wilkinson, D. Srivastava, R. Bastable, S. Carty, W. Harrop-Griffiths, S. Hill, N. Levy and M. Rockett, “Surgery and Opioids: Best practice Guidelines 2021,” 2020. Available: https://fpm.ac.uk/sites/fpm/files/documents/2021-03/surgery-and-opioids-2021_4.pdf.

    Google Scholar 

  35. Horn A, Kaneshiro K, Tsui B. Preemptive and preventive pain Psychoeducation and its potential application as a multimodal perioperative pain control option: a systematic review. Anesth Analg. 2020;130(3):559–73.

    Article  PubMed  Google Scholar 

  36. Levy N, Lord LJ, Lobo DN. UK recommendations on opioid stewardship. Br Med J. 2021;372:m490.

    Google Scholar 

  37. Häuser W, Morlion B, Vowles K, Bannister K, Buchser E, Casale R, et al. European* clinical practice recommendations on opioids for chronic noncancer pain - part 1: role of opioids in the management of chronic noncancer pain. Eur J Pain. 2021;25:949–68.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Krcevski-Škvarc N, Morlion B, Vowles K, Bannister K, Buchsner E, Casale R, et al. European clinical practice recommendations on opioids for chronic noncancer pain - part 2: special situations. Eur J Pain. 2021;25:969–85.

    Article  PubMed  Google Scholar 

  39. Donovan P, Arroyo D, Pattullo C, Bell A. Trends in opioid prescribing in Australia: a systematic review. Aust Health Rev. 2020;44(2):277–87.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

Authors

Contributions

The steering committee, composed by PF, CP, DH and SG conceptualized the work, participated to the data acquisition, analysed and interpreted the data, wrote the first version of the manuscript, approved the final version of this article and have read, and confirmed meeting the ICMJE criteria for authorship. The writing committee was composed by these authors and all the others. All these authors participated to the data acquisition, data interpretation, reviewed critically and edited the manuscript, approved the final version of this article and have read, and confirmed meeting the ICMJE criteria for authorship.

Corresponding author

Correspondence to Patrice Forget.

Ethics declarations

Ethics approval and consent to participate

The study was conducted according to the relevant law, guidelines, and aligned with UK Policy Framework for Health and Social Care Research, this study has been granted an exemption from requiring ethics approval (Name of the ethics committee: NHS Research Ethics Committee, REC), according to the Central Office for Research Ethics Committees (COREC) and the National Research Ethics Service (NRES) guidance. Written informed consent was obtained from all participants.

Consent for publication

Not applicable.

Competing interests

The following authors declare the potential conflict of interest:

HDDB is Board Member and Treasurer of the ERAS® Society and president of the Dutch ERAS®​ Society, member of the global Advisory board of Merck, member of the Scientific Advisory Board of Senzime, member of the global Advisory Board of NMD Pharma, member of the Research Committee and Scientific (SI) Committee of the European Society of Anaesthesiology and Intensive Care.

BMF has received an honorarium (speaker and manuscript) for unrelated work from Pfizer-Lily.

DNL has received a speaker’s honorarium for unrelated work from Fresenius Kabi in the last 36 months.

NS received honoraria for several activities (advisory boards, lectures, manuscripts) by the factories AbbVie, Camurus, Hexal, Janssen-Cilag, MSD, Medice, Mundipharma, Reckitt-Benckiser/Indivior, and Sanofi-Aventis. During the last 3 years he participated in clinical trials financed by the pharmaceutical industry.

The other authors did not have any conflict of interest.

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Forget, P., Patullo, C., Hill, D. et al. System-level policies on appropriate opioid use, a multi-stakeholder consensus. BMC Health Serv Res 22, 329 (2022). https://doi.org/10.1186/s12913-022-07696-x

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