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Radiation oncologists’ attitudes and beliefs about intensity-modulated radiation therapy and stereotactic body radiation therapy for prostate cancer
BMC Health Services Research volume 20, Article number: 796 (2020)
Abstract
Background
To better understand how radiation oncologists perceive intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) for prostate cancer and how these perceptions may influence treatment decisions.
Methods
We conducted semi-structured interviews of radiation oncologists between January–May, 2016. We used a purposeful sampling technique to select participants across a wide range of experience, regions, and practice types. Two trained qualitative researchers used an inductive, iterative approach to code transcripts and identify themes. We then used content analysis and thematic analysis of the coded transcripts to understand radiation oncologists’ attitudes and beliefs about IMRT and SBRT.
Results
Thematic saturation was achieved after 20 interviews. Participants were affiliated with academic (n = 13; 65%), private (n = 5; 25%), and mixed (n = 2; 10%) practices and had a wide range of clinical experience (median 19 years; range 4–49 years). Analysis of interview transcripts revealed four general themes: 1) most radiation oncologists offered surgery, brachytherapy, IMRT, and active surveillance for low-risk patients; 2) there was no consensus on the comparative effectiveness of IMRT and SBRT; 3) key barriers to adopting SBRT included issues related to insurance, reimbursement, and practice inertia; and 4) despite these barriers, most participants envisioned SBRT use increasing over the next 5–10 years.
Conclusions
In the absence of strong opinions about effectiveness, nonclinical factors influence the choice of radiation treatment. Despite a lack of consensus, most participants agreed SBRT may become a standard of care in the future.
Background
Intensity-modulated radiation therapy (IMRT) and stereotactic body radiation therapy (SBRT) are two relatively novel radiation treatments for prostate cancer. Both these treatments demonstrate encouraging initial outcomes, including good cancer control and minimal toxicity [1, 2]. Yet these treatments exhibit varying utilization patterns [3]. When IMRT emerged around 2001, it was rapidly adopted [4]. In contrast, SBRT’s initial adoption around 2007 was more variable—generally slow with some areas of rapid uptake [3]. In addition, there is wide regional variation in the use of these two treatments, with greater use of SBRT among patients residing in urban areas and by those living in the northeast [3].
A key source of this variation may be the attitudes and beliefs of the physicians who prescribe these treatments and therefore play an essential role in their adoption. To date, at least two surveys have queried physicians about their use of IMRT or SBRT [5, 6]. These studies found that physicians using SBRT worked more frequently in academic settings and completed training more recently [6]. However, these studies did not specifically investigate why providers preferred one treatment over another. Further, they focused on the treatment of all cancers rather than just prostate cancer, and, at the time, SBRT for prostate cancer was only used by 8% of responding physicians [6]. As a result, there is a persistent knowledge gap about how physicians make decisions regarding the use of IMRT and SBRT for prostate cancer. A better understanding of the decision making process will elucidate potentially modifiable factors that policymakers and other interested stakeholders can focus their attention on to either accelerate or decelerate SBRT use depending on the latest scientific evidence and, perhaps more importantly, help refine the health care environment to maximize the chance that new prostate cancer technologies are adopted at appropriate rates.
For these reasons, we conducted semi-structured interviews of 20 radiation oncologists to better understand their attitudes and beliefs about IMRT and SBRT. We sought to use qualitative insights to develop hypotheses regarding barriers and facilitators of the adoption of new radiation technologies to offer insights into potential intervention targets for technology adoption and the provision of high value care for prostate cancer.
Methods
Study design
We used a qualitative description approach, which is frequently employed in the health sciences when the goal is a description or understanding of a particular phenomenon, but without describing a culture (as in ethnography), individual lived experience (as in phenomenology), or to build theory (as in grounded theory). Using qualitative interviews, this approach allowed us to inductively investigate radiation oncologists’ experiences with and perspectives of IMRT and SBRT for prostate cancer [7]. Our objective was not to quantify these attitudes, but rather to better understand what factors influence the physicians’ decision making regarding these two treatments. By using a qualitative approach, we sought to uncover new insights and novel hypotheses about this decision-making process for which little is currently known.
Interview guide
We developed an interview guide, which was created through an iterative process and refined through 5 pilot interviews and multiple discussions with a multidisciplinary research team that included urologists, radiation oncologists, and qualitative research experts (Supplementary File). The final interview guide addresses the following domains: 1) spectrum of treatments offered for patients with low-risk disease; 2) comparative effectiveness of IMRT and SBRT; 3) barriers to adopting IMRT and/or SBRT; and 4) future treatment landscape for prostate cancer.
Interviewee selection process
To select interviewees, we used a purposeful sampling technique [8] to identify a diverse group of radiation oncologists who treat prostate cancer. To ensure that we obtained a diverse sample, we selected candidates across a wide range of experience (i.e., years in practice), geographic regions, and types of practice (i.e., private practice, academic, mix). We identified potential interviewees by asking the previous interviewee to recommend another individual to participate, a practice known as “snowball sampling” [9]. No more than one physician was interviewed from a practice. We continued to interview subjects until we interviewed individuals from varying experience levels, geographic regions, and types of practices, and until we achieved thematic saturation, which we defined as three consecutive interviews in which no new information was generated [10]. We anticipated reaching thematic saturation after 15 to 20 interviews, as is typical in samples of homogenous informants [11, 12].
Interviews
All interviews were conducted by a physician who treats prostate cancer. Before starting the interview process, the interviewer received coaching and performed practice interviews with non-study radiation oncologists to maximize the ability to elicit the respondent’s complete response to open-ended questions. Verbal consent was obtained prior to each interview. The interviewer conducted audio-recorded phone interviews designed to last 30 min. The “grand tour” question to begin the conversation was: “Tell me about the treatments you generally consider for patients with low-risk prostate cancer?” We focused on low-risk disease since active surveillance, surgery, and radiation are all reasonable options [13]. Open-ended questions were then asked about why they chose or did not choose IMRT or SBRT. Interviewers were conducted from January 2016 through May 2016.
Analyses and rigor
All interviews were transcribed verbatim with identifiers removed. The interviewer reviewed a sample of transcripts to ensure that transcribed interviews were consistent with the recalled conversation. Two trained qualitative research specialists developed the codebook through an iterative process known as “editing” where the semi-structured interview transcripts were reviewed for important topics that emerged [14]. After the codebook was completed and agreed upon, the primary coder coded all 20 transcripts while the secondary coder coded 10 transcripts, both with the assistance of Atlas.ti software (Berlin, Germany). Kappa statistics were calculated to measure the inter-coder reliability with a result of 0.78, which Landis and Koch describe as “substantial” agreement [15]. Following the coding, the two coders performed a thematic analysis in which researchers identify topics, patterns, and ideas that were present in the data in order to identify themes that succinctly describe them [16, 17]. The themes derived by the coders were then shared with the qualitative expert and principal investigator as a form of investigator triangulation [18]. In addition to thematic analysis, constant comparative analysis was used to determine similarities and differences between the participants’ responses [19].
Our institution’s institutional review board deemed this study ethical and exempt from review.
Results
Participant characteristics
We conducted 20 interviews of radiation oncologists, including 19 men and 1 woman (Table 1). Physicians were affiliated with academic (n = 13; 65%), private (n = 5; 25%), and mixed (n = 2; 10%) practices. Physicians were evenly distributed across regions of the country and had a wide range of clinical experience (median 19 years; range 4–49 years).
Of those who mentioned where radiation equipment was located, they all mentioned it resided at a hospital. Most participants mentioned that the equipment for performing IMRT could be used to perform SBRT, but some clarified that there were some differences in equipment, especially Cyberknife (Accuray Inc., Sunnyvale CA, USA) to perform SBRT. Participants received variable training for IMRT and SBRT. The majority of physicians had training in one or both of these modalities. Among those who lacked formal training, some were not trained because it was not available while they were residents while others were involved in the creation of the technique and thus had no training in it, per se. Some participants believed that formal training should be available for everyone and that clinicians should be certified, while others thought that they were relatively straightforward modalities that did not require formal training. Among those who used SBRT, most mentioned that the transition from delivering IMRT to SBRT was not difficult.
General themes
Four general themes emerged from the qualitative analysis of the semi-structured interviews, including 1) treatment selection; 2) comparative effectiveness; 3) barriers; and 4) future treatment use. Themes and sub-themes are summarized below and relevant quotes are in Table 2.
Treatment selection
The most common treatments discussed included surgery, active surveillance, brachytherapy, and IMRT (Table 3).
Comparative effectiveness
Participants discussed what they considered before determining which treatments to provide for their patients, which included the following factors:
Clinical factors
These factors included the patient’s prostate-specific antigen (PSA) level and Gleason score, the biopsy results, the prostate size and volume, the magnetic resonance imaging results, and whether or not there was extra-glandular involvement, patient motivation in the setting of organ-confined disease, patient age, comorbidities, and urinary function.
Lack of randomized control trial data
One of the factors mentioned the most about whether to offer patients IMRT or SBRT was the lack of randomized control trial data supporting SBRT as a safe and effective alternative to IMRT. Those who favored using IMRT were concerned about SBRT’s toxicity and disease control. Provided the lack of randomized control trial data, some participants did not feel comfortable treating patients with SBRT.
Preliminary evidence
Others felt that even though there was not a vast amount of scientific literature, there was enough for them to feel comfortable treating patients with SBRT. Some participants believed that SBRT had lower toxicity and better disease control than IMRT and other therapies. They preferred SBRT because of its shorter duration and cost-effectiveness.
Barriers
Barriers mentioned included health insurance coverage, reimbursement, and practice traditions (e.g., harder to adopt a new technology in a work culture that favors using traditional treatments).
Health insurance coverage
Although most participants raised health insurance coverage as an issue, only some mentioned IMRT not being covered by insurers, while most mentioned SBRT was not covered by insurers. A participant mentioned that SBRT’s coverage has improved over time. Most insurance companies still did not cover SBRT because of a lack of evidence in terms of its long-term effects, since it is a relatively new treatment. In a fee-for-service payment model, the financial reimbursement for SBRT could be less, which can act as a disincentive.
Reimbursement differences
Some participants felt that the lower reimbursement for SBRT as compared with IMRT was a barrier to its adoption.
Practice inertia
Some participants mentioned that the practice culture and lack of training at some institutions could negatively impact the adoption of a new technology, such as SBRT.
Future treatment use
Participants were asked about the landscape of treatments for low-risk prostate cancer in 5–10 years. There seemed to be consensus that technology will improve, which will allow for creating better decision-making tools in terms of patient treatment selection, such as the use of molecular diagnostics. They also mentioned that more data will be available for SBRT, including effectiveness and long-term toxicity (which is the main concern for most participants), and the cost for SBRT will be further reduced. Participants also believed that more health insurances will cover SBRT. Some participants considered that health insurance companies will begin using bundled payments to pay for these treatments. Many participants who use IMRT hope to provide SBRT in the future once there is more concrete data on its long-term effects. Most agreed that SBRT may become a standard of care for prostate cancer.
Discussion
Radiation oncologists consider several treatments for patients with low-risk prostate cancer, most commonly active surveillance, surgery, brachytherapy, and IMRT. In regards to IMRT and SBRT specifically, most participants used IMRT, however there was a wide range of opinions regarding the comparative effectiveness of IMRT and SBRT. Barriers to adoption, which more often pertained to SBRT, included lack of data, insurance coverage, reimbursement, and training. Most participants felt that SBRT would be a standard of care in the next 5–10 years.
Although SBRT is currently not a commonly used modality, many participants felt it would become more of a standard of care in the future. This will likely hinge on the results of prospective studies with longer term follow up and the results of ongoing randomized clinical trials [20, 21]. If the findings from these studies are favorable, clinicians will have fewer concerns regarding the risks of long-term toxicity and cancer control, payers will support a treatment that costs less, and patients will prefer spending less time getting radiation [22].
In addition to the lack of long-term data and data from randomized trials, there were other factors thought to impede the adoption of SBRT, including insurance coverage and reimbursement. Some insurance companies do not cover SBRT for prostate cancer due to lack of evidence. For example, Medicare’s coverage of SBRT varies by region in the form of local coverage determinations, which represent a determination as to whether a service is reasonable and necessary [23, 24]. Medicare administrative contractors evaluate whether a claim complies with a local coverage determination policy provision in deciding whether or not to pay for it [25]. The lack of coverage for SBRT has dissipated over time, but is still an issue to some degree.
Another barrier to SBRT use pertains to reimbursement. Since SBRT is delivered in five sessions instead of the traditional 40–45 sessions, reimbursement is often lower for SBRT in a fee-for-service environment. However, as alternative payment models such as bundled payments gain traction, there will be a greater incentive to deliver SBRT since it is less expensive.
In contemplating the various barriers to SBRT use, it is helpful to consider the Technology Acceptance Model, developed by Davis and colleagues [26]. This model, which was designed to provide an explanation of the determinants of computer acceptance in the 1980’s, focuses on the impact of external factors on internal beliefs, attitudes, and intentions; two beliefs in particular that are relevant to behavior are “perceived ease of use” and “perceived usefulness” [26]. Many of the participants’ comments regarding SBRT pertain to these two beliefs. For example, opinions regarding the need for additional training, the ability to use the same or different equipment, and insurance coverage relate to perceived ease of use whereas opinions pertaining to data, toxicity, and clinical effectiveness relate to perceived usefulness.
There was a wide range of opinions regarding the comparative effectiveness of IMRT and SBRT, which suggests that the existing evidence does not clearly support one treatment over the other. This highlights the importance of getting patients enrolled in clinical trials and registries to generate more data in a timely manner. Some policies encourage this practice by requiring enrollment to qualify for insurance coverage. For example, some local coverage determinations will only endorse SBRT if patients enroll in a clinical trial or registry [27]. Such a registry currently exists in Florida—the Multi-Institutional Registry for Prostate Cancer Radiosurgery (NCT01226004) [28]. Coverage with evidence development represents another policy that encourages enrollment by only offering coverage if patients participate in research (i.e., a clinical trial or registry) [29]. This generates evidence to help determine whether a treatment has a net benefit [30].
In discussing the treatment selection process, participants did not mention a lot about patient goals or preferences. Admittedly, this was not explicitly asked about in the interviews. Nonetheless, given the variety of acceptable treatment options for low-risk prostate cancer, an opportunity for shared decision-making among providers and patients exists. Providers generally discuss risk and benefits of treatments well, but infrequently engage patients in shared-decision making processes or have patient preferences guide the treatment plan [31].
Our findings should be interpreted in the context of several limitations. First, opinions are based on interviews with 20 radiation oncologists, which could limit generalizability. However, we purposefully selected participants from all regions of the country, from different types of practices, and among physicians with a wide range of experience. Further, we followed rigorous qualitative methodologies that required interviewing participants until we reached thematic saturation, which is typically achieved by 15–20 interviews [12]. Second, the majority of participants interviewed were male (95%). This is in part due to the low proportion of women in the radiation oncology workforce (29%) [32]. In designing the study, we did not seek to purposefully select participants based on gender since we felt attitudes towards IMRT and SBRT were unlikely to differ based on gender. Third, these interviews occurred in 2016 and more evidence has accumulated since then supporting hypofractionated radiation [33]. Nonetheless, SBRT is still sparingly used and, in the absence of randomized controlled data, these views are still very relevant today.
Conclusions
This study is the first to our knowledge to use qualitative analyses to examine the attitudes and beliefs of radiation oncologists about different prostate cancer treatment modalities, namely IMRT and SBRT. This uncovered several knowledge gaps not addressable with traditional quantitative research methods. There were a wide range of opinions regarding the barriers to adopting SBRT, including the need for specific training, and the comparative effectiveness of IMRT and SBRT, highlighting the lack of clarity with existing data and the importance of enrolling patients in existing registries or ongoing clinical trials. Along these lines, most participants are optimistic that SBRT will be a standard of care in the next 5–10 years once longer term data matures.
Availability of data and materials
The de-identified datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. The data are stored at our institution in a secure environment with multiple firewalls and physical security measures.
Abbreviations
- IMRT:
-
Intensity-modulated radiation therapy
- SBRT:
-
Stereotactic body radiation therapy
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Acknowledgments
None.
Funding
Bruce Jacobs is supported in part by the National Institutes of Health Institutional KL2 award (KL2TR001856), University of Pittsburgh Physicians Academic Foundation, P30CA047904 from the National Cancer Institute, and the Henry L. Hillman Foundation. Jeremy Kahn is supported in part by a career development award from the National Institutes of Health (K24HL133444). Amber Barnato is supported in part by the Levy Cluster in Health Care Delivery at Dartmouth. The funding sources had no role in the design, implementation, analysis, or decision to publish this research.
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Contributions
BLJ contributed to study conception and design, performed the interviews, analyzed the qualitative data, interpreted the results, and drafted the manuscript. MH analyzed the qualitative data and critically revised the manuscript for important content. FAC transcribed the data, analyzed the data, and critically revised the manuscript for important content. JLH transcribed the data, analyzed the data, and critically revised the manuscript for important content. DEH contributed to study conception and design, interpreted the results, and critically revised the manuscript for important content. JMK contributed to study conception and design, interpreted the results, and critically revised the manuscript for important content. AEB contributed to study conception and design, interpreted the results, and critically revised the manuscript for important content. All authors have read and approved the manuscript.
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Ethics approval and consent to participate
The University of Pittsburgh’s institutional review board deemed this study exempt from review (PRO15080475). Verbal, as opposed to written, consent was obtained since interviews were performed by telephone. Verbal consent was approved by our institutional review board.
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Not applicable.
Competing interests
The authors declare that they have no competing interests.
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Supplementary information
Additional file 1:
Interview Guide.
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Jacobs, B.L., Hamm, M., de Abril Cameron, F. et al. Radiation oncologists’ attitudes and beliefs about intensity-modulated radiation therapy and stereotactic body radiation therapy for prostate cancer. BMC Health Serv Res 20, 796 (2020). https://doi.org/10.1186/s12913-020-05656-x
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DOI: https://doi.org/10.1186/s12913-020-05656-x