Skip to main content

E-learning as valuable caregivers’ support for people with dementia – A systematic review



Present demographic trends show a considerable rise in elderly populations with aging disorders, such as dementia. The current article focused on the exploitation of e-learning as an informal support for caregivers of people with dementia and considered its benefits and limitations to provide proper and relevant care for this target group of people as well as maintain the quality of life of their caregivers.


The methodology of this study is based on a literature review of accessible peer-review articles from three recognized databases: Web of Science, Scopus, and PubMed. The findings of the selected studies were compared and evaluated.


The findings showed that e-learning educational programs/courses helped caregivers feel more confident about dementia care, reduced their perceived stress and enhanced their feelings of empathy, understanding and concern.


The findings of this study reveal that the exploitation of e-learning as a support tool, especially for informal caregivers, in the management of dementia may be a promising method, but its implementation requires professional training of informal caregivers in the use of this technology. More evidence-based studies are needed on this topic.

Peer Review reports


Dementia affects 58 million people worldwide, and the forecasts indicate that this number will be three times higher by 2050 [1]. One of the foremost and striking symptoms of dementia is cognitive impairment [2], but people with dementia also have problems with concentration, orientation, finding the right words, and planning. They may be prone to rapid mood changes, and they may suffer from depressive symptoms or apathy and exhibit signs of aggression against other people, especially their loved ones [3, 4]. These symptoms generally worsen over time, and people with dementia lose their capability of performing tasks of daily life. Therefore, they are necessarily reliant on the help of other people, in most cases, on their relatives, who become their caregivers [5].

There is a current tendency to shift institutional care to community care [6]. For example, the results of the SHARE project revealed that the non-institutionalized care in Europe of people aged 65 years and over ranged between 21 and 43% [7]. Informal care heavily depends on the help of family members, and the percentage of these informal caregivers has reached 80%. However, the assistance of informal caregivers generally results in a worsening their quality of life [8]. Informal caregivers generally spend between five and 20 h per day taking care of family members with dementia [9]. Informal caregivers, like formal caregivers, also suffer from a gradually increasing physical, mental and economic burden [10,11,12]. Therefore, there is an urgent need and effort to alleviate this burden for informal caregivers and provide them with some professional help. Technology may be one solution. The World Health Organization supports this initiative, and finds it urgent to seek different ways of providing support to people who take care of individuals with dementia [13].

Technology is ubiquitous, and it penetrates all spheres of human life, including education, where information and communication technologies (ICT) are used in electronic education (i.e., e-learning), which is particularly used for distant education and as a support to traditional, face-to-face teaching for full-time students. E-learning is learner-centred to develop the student’s autonomy and independence while learning and make him/her responsible or his/her learning while providing him/her with needed skills and strategies for learning. Students can use it at any place and time and collaborate with other students. Learning has also become more interactive [14].

E-learning is primarily used as a component of traditional, face-to-face classes. This combined form of learning is called blended learning (BL), and it is widely used in healthcare in developed countries. L’Engle, Raney, & D’Adamo [15] claimed that e-learning enhanced provisions of health care and its services worldwide, and it enabled its delivery to remote regions and developing countries in particular.

Nine Lanterns [16] found that the use of e-learning in health care was primarily suitable for the training of future healthcare professionals in different regions and countries, and it was more cost-effective. The findings of their survey showed that 95% of subjects used online courses, and 80% used them as support for their face-to-face classes. Other research indicated the significance of the role of e-learning in knowledge retention, the understanding of particular health issues, continuous education, and the educating of future healthcare professionals [17,18,19,20]. Recent trends illustrate that e-learning courses also play important roles in inter-professional education and collaboration [21, 22]. E-learning courses may enhance inter-professional care in the sense of improved communication between healthcare staff and achieving desirable outcomes for people [23]. In case of informal caregivers, Official healthcare organizations, such as the Alzheimer’s Association, municipalities or healthcare staff, generally distribute e-learning programs [24]. These programs are mostly available for free or at reasonable cost, as in the case of iCare Stress Management e-Training Program, which focuses on reducing stress and depression of family caregivers [25].

Government and independent organizations also leverage e-learning to provide health information to the public of diseases awareness, such as HIV, and dietary and lifestyle advice [26]. The European Commission aims to fund projects that focus on improving digital health literacy [27].

The present article focused on the exploitation of e-learning as a support for informal caregivers of people with dementia and considered its benefits and limitations to provide proper and relevant care for this target group of people and maintain the quality of life of their caregivers.


The topic of e-learning and its exploitation as a valuable support for caregivers of people with dementia was searched in three recognized databases, Web of Science, Scopus, and PubMed, from 2010 to 2018. The search period started in 2010 when e-learning began to appear widely [14]. Reference lists of the detected studies were checked to avoid omitting other important studies on the research topic. The authors used the following keywords: e-learning AND caregivers, e-learning AND carers, e-learning AND dementia, e-learning AND dementia AND carers, e-learning AND dementia AND caregivers. Two authors (BK, JM) detected 248 peer-review journal articles written in English. The largest share of these articles was identified in Scopus (91), followed by PubMed (82) and Web of Science (75). The titles and abstracts were thoroughly reviewed (61) and screened for duplication (16). Forty-five studies were screened, and 30 studies remained for full-text analyses.

The full-text articles were analysed and evaluated using the following inclusion and exclusion criteria. The following inclusion criteria were based on PICOS guidelines:

  • The articles were published between January 1, 2010, and December 31, 2018.

  • Only peer-reviewed journal articles written in English were included.

  • Articles that involved older people with dementia and their informal caregivers were included.

  • Only randomized controlled trials, experimental studies, or survey quality studies were included.

  • The primary outcome concentrated on the use of e-learning as a support tool for informal caregivers.

The following exclusion criteria were used:

  • Studies that focused on a different target group and disease were excluded, such as [13, 17,18,19,20, 23, 28,29,30,31,32,33,34,35].

  • Descriptive studies that depicted the e-learning course for dementia caregivers, such as empirical studies [36,37,38], posters [39], or protocol trials [40].

  • Review articles on the research topic [9, 41,42,43,44].

A backward search was also performed, i.e., references of detected studies were evaluated for relevant research studies that authors may have missed during their search, which identified another article. Therefore, six research articles were eventually analysed and evaluated.

Figure 1 below describes the selection procedure of the detected studies.

Fig. 1
figure 1

An overview of the selection procedure


Six studies on the research topic were detected. Three studies were randomized controlled trials [24, 25, 45], two were survey quality studies [46, 48], and one was an experimental study [47]. The main topic in most studies concentrated on the use of e-learning in the improvement of psychological and emotional distress when caring for people with dementia, dissemination of knowledge about the disease itself and its management, enhancement of caregiver’s skills (social, behavioural, cognitive, or reflective), and the development a forum for their social network. E-learning support was primarily Internet based in the form of an educational training portal/program/course, and there was also a virtual simulation movie in one study [48]. These programs consisted of several modules or lessons and included different topics that focused on caregiver’s needs, such as Cognitive Decline, Daily Tasks, Behavioral Changes, Social Activities, or You as a Caregiver. For example, the virtual reality intervention Through the D’mentia Lens (TDL) enabled caregivers to see what dementia is like and how people with dementia feel [48].

Common methods were used to assess outcome measures, e.g., pre- and post-tests, online questionnaires, and statistical analyses. The detected articles lacked large subject samples. The number of participants was between 35 and 279 people. The period of assessment generally lasted from 3 weeks to 3–4 months without a follow-up period. Four studies [24, 45, 47, 48] were of multi-national origin (Australia, Denmark, the Netherlands, UK, Spain, and Poland), one study was a Chinese study [46], and one study was performed in USA [25]. The detected articles satisfied the basic quality criteria [49].

The results revealed that participants in all detected studies [24, 25, 45,46,47,48] were satisfied with the e-learning platforms, programs, and courses because the content helped them reduce their perceived stress and increase their empathy. The flexibility of these e-learning programs [24, 46] and their ease of accessibility from anywhere at any time [24, 25, 45,46,47], which meant less travelling, were other factors that motivated caregivers to participate in the intervention. Other benefits of e-learning support involved the personalized approach [45,46,47], the user-friendliness of e-learning programs [45,46,47,48], avoidance of stigmatized professional (psychiatric) help [46], development of a social network of informal caregivers [24], and the cost-effectiveness of the e-learning programs [25, 46]. In contrast, a high drop-out rate revealed the need to stimulate informal caregivers to participate in e-learning programs [25, 47]. One study [45] reported a reduction in self-reported sense of caring competence.

The findings of the detected studies are summarized in alphabetical order of their first author in Table 1 below.

Table 1 An overview of the findings of the selected studies


The findings of the detected studies showed that e-learning portals/programs/courses helped caregivers feel more confident about dementia care, enhanced their knowledge and skills, reduced their perceived stress, and enhanced their feelings of empathy, understandings and concern. These results are consistent with recent review studies on this topic [9, 41,42,43,44]. The results indicate that e-learning programs are feasible and acceptable for informal carers of people with dementia because these caregivers considered them useful, especially in improving their confidence about their care qualities [47, 48].

Kurz et al. [32] stated that the e-learning, especially web-based courses, was a new form of providing better healthcare learning, counselling, and assistance. Notably, learners studied according to their usual tempo. Therefore, this approach to learning enabled greater access to personalized learning and autonomy, which was reflected in the learners’ enhanced motivation [50]. Walsh [37] noted that e-learning courses should aim to meet the learner’s needs to be effective in providing relevant care for the target population groups. Nunez-Naveira et al. [24] also highlighted this goal in their study in which low scores were obtained for satisfaction and required modification to meet the informal caregivers’ needs in national, social, and cultural contexts.

The Chinese study [46] revealed that informal caregivers needed appropriate training because generally only younger caregivers and caregivers with a higher education level were willing to use the e-learning programs. Surr et al. [41] listed several key features that must be followed to achieve an effective training/educational program in dementia care. Some of these features may be applied in e-learning programs, such as tailored-made materials developed by a professional, the activities or tasks are realistic and based on experience, or use of different teaching methods. Moniz-Cook et al. [3] reported that without ongoing review of implementation of recommended action plans, e-learning interventions are not effective in reducing challenging behaviour in dementia compared to usual care.

There are several ongoing initiatives for e-learning programs, such as the RHAPSODY (Research to Assess Policies and Strategies for Dementia in the Young) program, which aims to provide informal caregivers with relevant skills and knowledge to help them overcome and deal with possible problems [32]. Moreno et al. [40] developed another project to reduce informal caregiver’s physical and mental burden and enhance their quality of life.

The demand for e-learning programs and resources is increasing because there is a need to guarantee an adequate quality of healthcare services and in this sense to provide professional and informal caregivers with relevant information and skills (cf. [34]). To assess the effectiveness of these e-learning programs, researchers should follow the model of Ruggeri, Farrington, & Brayne [35] for the assessment of e-learning courses in health care. The key performance indicators of this model are purpose, demographics of participants, acquired knowledge, resources, attitude and behaviour of the participants towards the e-learning program, their performance, time spent, quality assessment, audit, benefits, changes, and future use.

The limitations of this systematic review article are the lack of research studies on the research topic and the different methodologies, follow-up observations and assessment periods of the included studies. Surr et al. [41] also confirmed the small number of studies on family carers of people with dementia. Nevertheless, these inconsistencies may lead to an overestimation of the results on the exploitation of e-learning as a valuable support tool for caregivers of people with dementia, which may shed a negative light on the validity of the findings of these research studies (cf. [51, 52]).


The findings of this study show that e-learning educational programs/courses help caregivers feel more confident about dementia care, reduce their stress and enhance their feelings of empathy, understanding and concern [53]. The results of this systematic review also show that the exploitation of e-learning as a support tool, especially for informal caregivers, in the management of dementia may be a promising method, but its implementation requires professional training of informal caregivers in the use of this technology.

Availability of data and materials

The search strategies used in this systematic review are included in the Methods, and all of the manuscripts informing this systematic review are listed in Table 1.



blended learning


Education/Information-Only Condition


iCare Condition


Information and Communication Technologies


Mastery over Dementia


the European Skills Training and Reskilling


Through D’mentia Lens


  1. WHO. Accessed 18 May 2017.

  2. Corbett A, Husebo BS, Achterberg WP, Aarsland D, Erdal A, Flo E. The importance of pain management in older people with dementia. Br Med Bull 2014;111(1):139–148.

  3. Craik F, Salthouse T. The handbook of aging and cognition. 2nd edition. Mahwah, NJ: Lawrence Erlbaum; 2002.

  4. Salthouse T. Consequences of age-related cognitive declines. Annu Rev Psychol. 2012;63:201–26.

    Article  Google Scholar 

  5. Hahn EA, Andel R. Non-pharmacological therapies for behavioral and cognitive symptoms of mild cognitive impairment. J Aging Health. 2011;23(8):1223–45.

    Article  Google Scholar 

  6. De Vliegher K, Aertgeerts B, Declercq A, Milisen K, Sermeus W, Moons P. Shifting care from hospital to home: a qualitative study. Prim Health Care. 2015;25(9):24–31.

    Google Scholar 

  7. Riedel M, Kraus M. Informal care provision in Europe: Regulation and profile of providers. ENEPRI Research Report no. 96. Accessed 8 Sept 2017.

  8. Alzheimer’s Association. Alzheimer’s association report 2015. Alzheimer’s disease facts and figures. Alzheimers Dement. 2015;11:332–84.

    Article  Google Scholar 

  9. Wasilewski MB, Stinson JN, Cameron JI. Web-based health interventions for family caregivers of elderly individuals: a scoping review. Int J Med Inform Accessed 14 Sept 2017.

  10. Klimova B, Valis M, Kuca K. Potential of mobile technologies and applications in the detection of mild cognitive impairment among older generation groups. Soc Work Health Care. 2017;56(7):588–99.

    Article  Google Scholar 

  11. Klimova B, Maresova P, Kuca K. Non-pharmacological approaches to the prevention and treatment of Alzheimer’s disease with respect to the rising treatment costs. Curr Alzheimer Res. 2016;13(11):1249–58.

    Article  CAS  Google Scholar 

  12. Klimova B, Maresova P, Valis M, Hort J, Kuca K. Alzheimer’s disease and language impairments: social intervention and medical treatment. Clin Interv Aging. 2015;10:1401–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Prince M, Prina M, Guerchet M. World Alzheimer Report 2013. Journey of caring. An analysis of long-term care for dementia. text. Accessed 8 Sept 2017.

  14. Klimova B, Simonova I, Poulova P. Blended learning in the university English courses: case study. In: Cheung S., Kwok L., ma W., lee LK., Yang H. (eds) blended learning. New challenges and innovative practices. ICBL 2017. Lect Notes Comput Sci 2017;10309:53–64.

  15. L’Engle K, Raney L, D’Adamo M. mHealth resources to strengthen health programs. Glob Health Sci Pract. 2014;2(1):130–1.

    Article  Google Scholar 

  16. Nine Lanterns. Accessed 8 Sept 2017.

  17. Chong MC, Francis K, Cooper S, Abdullah KL, Thin N, Hmwe T, et al. Access to, interest in and attitude toward e-learning for continuous education among Malaysian nurses. Nurse Educ Today. 2016;36:370–4.

    Article  Google Scholar 

  18. Delf P. Designing effective eLearning for healthcare professionals. Radiography. 2013;19(4):315–20.

    Article  Google Scholar 

  19. Kelly C, Reid E, Lohan M, Alderdice F, Spence D. Creating an eLearning resource to improve knowledge and understanding of pregnancy in the context of HIV infection. Int J Environ Res Public Health. 2014;11(10):10504–17.

    Article  Google Scholar 

  20. Rider BB, Lier SC, Johnson TK, Hu DJ. Interactive web-based learning: translating health policy into improved diabetes care. Am J Prev Med. 2016;50(1):122–8.

    Article  Google Scholar 

  21. Menard P, Varpio L. Selecting an interprofessional education model for a tertiary health care setting. J Interprof Care. 2015;28(4):311–6.

    Article  Google Scholar 

  22. Schwartz A, Young R, Hicks PJ. Medical education practice-based research networks: facilitating collaborative research. Med Teach. 2016;38(1):67–74.

    Article  Google Scholar 

  23. Casimiro L, MacDonald CJ, Thompson TL, Stodel E. Grounding theories of W(e)learn: a framework for online interprofessional education. J Interprof Care. 2009;23(4):390–400.

    Article  Google Scholar 

  24. Nunez-Naveira L, Alonso-Bua B, de Labra C, Gregersen R, Maibom K, Mojs E, et al. UnderstAID, an ICT platform to help informal caregivers of people with dementia: a pilot randomized controlled study. Biomed Res Int. 2016;2016:5726465.

    Article  Google Scholar 

  25. Kajiyama B, Thompson LW, Eto-Iwase T, Yamashita M, Di Mario J, Marian Tzuang Y, et al. Exploring the effectiveness of an internet-based program for reducing caregiver distress using the iCare stress management e-training program. Aging Ment Health. 2013;17(5):544–54.

    Article  Google Scholar 

  26. Andriotis N. E-learning in the healthcare industry. Accessed 8 Sept 2017.

  27. EU. Research and innovation. Accessed 10 Sept 2017.

  28. Andersson S, Magnusson L, Hanson E. The use of information and communication technologies to support working carers of older people – a qualitative secondary analysis. Int J Older People Nursing. 2015;11:32–43.

    Article  Google Scholar 

  29. Ghazisaeedi M, Safari A, Sheikhtaheri A, Dalvand H. The effect of an android-based application on the knowledge of the caregivers of children with cerebral palsy. Med J Islam Repub Iran. 2016;30:456.

    PubMed  PubMed Central  Google Scholar 

  30. Trae G. E-learning course for Norwegian caregivers. Orphanet J Rare Dis. 2014;9(Suppl 1):12.

    Article  Google Scholar 

  31. Moniz-Cook E, Hart C, Woods B, Whitaker C, James I, Russell I, et al. Challenge Demcare: management of challenging behaviour in dementia at home and in care homes – development, evaluation and implementation of an online individualised intervention for care homes; and a cohort study of specialist community mental health care for families. Programme Grants for Applied Research. 2017;5(15):doi:

  32. Kurz A, Bakker C, Böhm M, Diehl-Schmid J, Dubois B, Ferreira C, et al. RHAPSODY – internet-based support for caregivers of people with young onset dementia: program design and methods of a pilot study. Int Psychogeriatr. 2016;28(12):2091–9.

    Article  Google Scholar 

  33. Lazzari C. Ecological momentary assessments and interventions in Alzheimer's caregiving. Curr Alzheimer Res. 2018;15(11):1027–31.

    Article  CAS  Google Scholar 

  34. MacDonald CJ, Walton R. E-learning education solutions for caregivers in long-term care (LTC) facilities: new possibilities. Educ Health (Abingdon). 2007;20(3):85.

    CAS  Google Scholar 

  35. Ruggeri K, Farrington C, Brayne C. A global model for effective use and evaluation of e-learning in health. Telemed J E Health. 2013;19(4):312–21.

    Article  Google Scholar 

  36. Xenakis N. Creating a professional development platform to transform social work clinical practice in health care. Soc Work Health Care. 2018;57(6):440–64.

    Article  Google Scholar 

  37. Walsh K. The future of e-learning in healthcare professional education: some possible directions. Ann Ist Super Sanita. 2014;50(4):309–10.

    PubMed  Google Scholar 

  38. Tannebek K, Hultberg P, Refsgaard E, Hansen BH, Waldemar G. The Danish ABC dementia: new e-learning for professional caregivers. Alzheimers Dement 2014;10(4):P180-P181.

  39. Van Asch I, Prins M, Willemse B. Development of an e-learning for caregivers to manage challenging behavior of people with dementia. The Gerontologist. 2016;56(Suppl. 3):538.

    Google Scholar 

  40. Moreno PA, Garcia-Pacheco JL, Charvill J, Lofti A, Langensiepen C, Saunders A, et al. iCarer: AAL for the informal carers of the elderly. Stud Health Technol Inform. 2015;210:678–80.

    CAS  PubMed  Google Scholar 

  41. Surr CA, Gates C, Irving D, Oyebode J, Smith SJ, Parveen S, et al. Effective dementia education and training for the health and social care workforce: a systematic review of the literature. Rev Educ Res. 2017;87(5):966–1002.

    Article  Google Scholar 

  42. Boots LMM, Vugt ME, Knippenberg RJM, Kempen GIJM, Verhey FRJ. A systematic review of internet-based supportive interventions for caregivers of patients with dementia. Int J Geriatr Psychiatry. 2014;29(4):331–44.

    Article  CAS  Google Scholar 

  43. Dam AE, de Vugt ME, Klinkenberg IP, Verhey FR, van Boxtel MP. A systematic review of social support interventions for caregivers of people with dementia: are they doing what they promise? Maturitas. 2016;85:117–30.

    Article  Google Scholar 

  44. Jackson D, Roberts G, Wu ML, Ford R, Doyle C. A systematic review of the effect of telephone, internet or combined support for carers of people living with Alzheimer’s, vascular or mixed dementia in the community. Arch Gerontol Geriatr. 2016;66:218–36.

    Article  Google Scholar 

  45. Hattink B, Meiland F, van der Roest H, Kevern P, Abiuso F, Bengtsson J, et al. Web-based STAR e-learning course increases empathy and understanding in dementia caregivers: results from a randomized controlled trial in the Netherlands and the United Kingdom. J Med Internet Res. 2015;17(10):e241.

    Article  Google Scholar 

  46. Ho DWH, Maka V, Kwokab TCY, Au A, Ho FKY. Development of a web-based training program for dementia caregivers in Hong Kong. Clin Gerontol. 2015;38:211–23.

    Article  Google Scholar 

  47. Pot AM, Blom MM, Willemse BM. Acceptability of a guided self-help internet intervention for family caregivers: mastery over dementia. Int Psychogeriatr. 2015;27(8):1343–54.

    Article  Google Scholar 

  48. Wijma EM, Veerbeek MA, Prins M, Pot AM, Willemse BM. A virtual reality intervention to improve the understanding and empathy for people with dementia in informal caregivers: results of a pilot study. Aging Ment Health. 2018;22(9):1115–23.

    Article  Google Scholar 

  49. Health Evidence Quality Assessment Tool for review articles. 2005. Accessed 10 April 2019.

  50. Klimova B, Poulova P. Personalized learning environment - a case study. Adv Sci Lett. 2016;22(5/6):1129–32.

    Article  Google Scholar 

  51. Melby-Lervag M, Hulme C. There is no convincing evidence that working memory training is effective: a reply to Au et al. (2014) and Karbach and Verhaeghen (2014). Psychon Bull Rev. 2016;23(1):324–30.

    Article  Google Scholar 

  52. Melby-Lervag M, Hulme C. Is working memory training effective? A meta-analytic review. Dev Psychol. 2013;49(2):270–91.

    Article  Google Scholar 

  53. Klimova B. Exploring eLearning for dementia care. In: Park J, Yang L, Jeong YS, Hao F (eds), Advanced Multimedia and Ubiquitous Engineering. MUE 2019, FutureTech 2019. LNCS. 2020;590:265–270.

Download references


The authors acknowledge that this study reflects some of the findings of the following article: Klimova B. Exploring eLearning for dementia care. In: Park J, Yang L, Jeong YS, Hao F (eds), Advanced Multimedia and Ubiquitous Engineering. MUE 2019, FutureTech 2019. LNCS. 2020;590:265-270.


This study was supported by the Ministry of Education, Youth and Sports of Czech Republic (project ERDF no. CZ.02.1.01/0.0/0.0/18_069/0010054), whose researchers (authors of this systematic review) performed the design of the study and collection, analysis, and interpretation of data and writing the manuscript.

Author information

Authors and Affiliations



BK, MV, KK, and JM equally contributed to the drafting, analyses and final version of the entire manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Kamil Kuca.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Klimova, B., Valis, M., Kuca, K. et al. E-learning as valuable caregivers’ support for people with dementia – A systematic review. BMC Health Serv Res 19, 781 (2019).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: