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The impact of web-based and face-to-face simulation on patient deterioration and patient safety: protocol for a multi-site multi-method design
© The Author(s). 2016
Received: 1 March 2016
Accepted: 17 August 2016
Published: 7 September 2016
There are international concerns in relation to the management of patient deterioration which has led to a body of evidence known as the ‘failure to rescue’ literature. Nursing staff are known to miss cues of deterioration and often fail to call for assistance. Medical Emergency Teams (Rapid Response Teams) do improve the management of acutely deteriorating patients, but first responders need the requisite skills to impact on patient safety.
In this study we aim to address these issues in a mixed methods interventional trial with the objective of measuring and comparing the cost and clinical impact of face-to-face and web-based simulation programs on the management of patient deterioration and related patient outcomes. The education programs, known as ‘FIRST2ACT’, have been found to have an impact on education and will be tested in four hospitals in the State of Victoria, Australia. Nursing staff will be trained in primary (the first 8 min) responses to emergencies in two medical wards using a face-to-face approach and in two medical wards using a web-based version FIRST2ACTWeb. The impact of these interventions will be determined through quantitative and qualitative approaches, cost analyses and patient notes review (time series analyses) to measure quality of care and patient outcomes.
In this 18 month study it is hypothesised that both simulation programs will improve the detection and management of deteriorating patients but that the web-based program will have lower total costs. The study will also add to our overall understanding of the utility of simulation approaches in the preparation of nurses working in hospital wards. (ACTRN12616000468426, retrospectively registered 8.4.2016).
The quality of patient care and patient safety are organisational, individual, and international responsibilities that require an appreciation of adverse events and medical errors [1–3]. In Australia, the Australian Commission on Safety and Quality in Healthcare has prescribed national standards with the objective of improving the quality of clinical care . Health service providers are required to report compliance with these standards, including recognition and response to patients’ ‘severe clinical deterioration’ which is listed as Standard 9 – ‘Clinical Deterioration in Acute Health Care’ . Thus, a key responsibility of providers of acute hospital care, and elsewhere, is to ensure that systems are in place to enable patients with severe clinical deterioration to receive immediate and appropriate assistance . This includes the empowerment of clinicians to activate a ‘Medical Emergency Team’ (MET) (also known as a ‘Rapid Response Team’) whose members are skilled in the management of medical emergencies [7, 8].
Definitions of what constitutes a deteriorating patient or clinical deterioration are lacking, [9, 10] however there is a considerable body of evidence from the ‘failure to rescue’ literature indicating that the management of deterioration can be improved. This includes disturbed physiological variables in the general ward population , poorer patient outcomes for mismanaged patient deterioration [12–15], delays in team activation , missed indicators of deterioration in rural hospitals , a lack of knowledge as to when to call for assistance , and a failure to appreciate clinical urgency .
Efforts to improve recognition and response to clinical deterioration in Australia include the introduction of a National Patient Observation and Response Chart for recording of patient vital signs and observations . Such standardised reports enable recording of core physiological observations as specified in the National Consensus Statement 1.6 (i.e. respiratory rate, oxygen saturation, heart rate, blood pressure, temperature and level of consciousness). Similarly, in the United Kingdom, physiological track and trigger systems are recommended to monitor all adult patients in acute hospital settings . These charts utilise colour-coded graphed observation and vital sign documentation to designate the level of factors that should trigger an escalation of care. In Australia, the use of one of five available charts is mandatory except for the state of New South Wales where an alternative ‘Between the Flags’ - Standard Adult General Observation Chart is required in most public facilities [19, 21].
In relation to the management of emergencies it is known that the management of deteriorating patients can be enhanced through educative approaches [4, 5, 22–24] and through clinical and simulated experience [25, 26]. Education approaches emphasize the need for active learning in simulated environments that offer authentic learning experiences without risk to real patients [27, 28]. Clinical staff do benefit from simulation-based education in settings which have high fidelity (believability) [26, 29] with consequential reductions in medical errors .
This paper describes the protocol for a study that aims to address patient safety in relation to first responders’ ‘failure to rescue’ deteriorating patients, with a focus on enhancing the nursing assessment and management of clinical deterioration. Hospital registered nurse participants will be trained in the requisite primary responses to patient emergencies using two simulation approaches. Participants will participate in either in-situ face-to-face simulation or a web based simulation version of a valid clinical training package: FIRST2ACT (Feedback Incorporating Review and Simulation Techniques to Act on Clinical Trends) . A cost benefit analyses will be performed and the clinical impact of training will be determined through a multi-method evaluation that will include quality of care evaluations, primarily achieved through pre-post intervention patient notes review with time series analyses.
This multi-method study will utilize both qualitative and quantitative research techniques to evaluate the impact of FIRST2ACT on the quality of nursing care and patient outcomes. The design is a mixed methods interventional cohort trial comparing the impact of a web-based (Group 1) and face-to-face (Group 2) education program within and between groups.
Aim and hypothesis
Both the face-to-face and web-based models of simulation education will improve the detection and management of patient deterioration and patient outcomes.
The web-based program will have lower total costs in improving the detection and management of patient deterioration and patient outcomes.
Description of the intervention resource: FIRST2ACT
This study commenced data collection in February 2016, to be completed by November 2016.
Sample selection and recruitment
Registered nurses will be recruited from a medical ward in one of four Victorian acute care hospitals. Both Division 1 Registered nurses and Enrolled nurses will be included. Two medical wards will be assigned as Group 1 (web-based intervention), while another two will be assigned as Group 2 (face-to-face intervention). This approach ensures that there is no contamination between homogeneous groups. There are approximately 160 nurses employed at the larger hospitals and 85 at the remaining two sites. In pilot hospital-based studies we have achieved a participation rate of 82 % and anticipate similar participation for this study (n = >200). Maximising staff attendance is important in order to have the greatest effect on clinical outcomes.
Nurses in each group will be recruited by a member of the research team who will provide a brief explanation of the study and invite nurses to participate in the study. Participant information sheets and consent forms will be made available and written consent obtained.
Clinical impact measures
The impact of the interventions will be assessed on the proportion of patients that progress from early to late signs of deterioration and the quality of nursing care (primary measures). As per our previous studies we will use validated data extraction tools to mine data from patient observation charts. Appropriate frequency of vital signs and evidence-based responses to deterioration will be proxies for the quality of nursing care. Secondary measures include in-hospital mortality and admissions to ICU, and cost of provision of face-to-face versus web based education. We will also investigate stakeholder views and attitudes through semi-structured interviews with three key stakeholder groups at each site.
Patient sample size: Pilot data from an earlier rural study indicated that early signs of deterioration were present in 28 % of patients while late signs were present in 10 %, and that the total sample size required to detect a 5 % reduction in late signs of deterioration with a level of significance of 5 % and a power of 0.8 is 434 patients (217 before and 217 after the intervention) at each site .
Training procedure: participants’ journey
Flow chart of participants’ journey in web-based simulation and face-to-face high fidelity clinical learning environment scenarios
FIRST2ACT In-situ face-to-face
Short written introduction with explanation.
Short verbal introduction with explanation.
Demographics and Pre-course MCQ
A demographics form and an 12-item multiple choice questionnaire (MCQ).
As in web-based.
An animated slide show – with voice over from an educator.
As in web-based.
Scenario (i) – Cardiac scenario
Scenario (ii) – Shock scenario
Scenario (iii) – Respiratory scenario
Total score and feedback provided. Each scenario runs for 8 min with acute deterioration at the mid-point.
As in web–based. Video recorded scenarios are rated by attending researchers.
The software gathers all performance data for automated feedback at the end of each scenario.
Face-to-face feedback will be conducted with an educator using video and performance records.
Repeat of the MCQ.
As in web-based.
A course evaluation and reflective review of educational impact
As in web-based.
Download a course participation certificate
Issued with a course participation certificate.
Download the course manual for reflection and review
Issued with the course manual for reflection and review
Patient medical records.
A multiple choice knowledge questionnaire (MCQ).
Standardized performance measurement forms.
Costs derived from patient records and inventory of resources.
Qualitative data will be captured in six stakeholder focus groups (three at each site) at the end of the study. Participants will include those who attended training and their line managers in order to elicit the impact of the two programs of education.
Data collection tools
Patient medical records review
Early and late signs of patient deterioration [Adapted from Harrison et al. 
Systolic blood pressure (mmHg)
80–100 or 181–240
<80 or >240
40–49 or 121–140
<40 or >140
5–9 or 31–40
<5 or >40
Glasgow coma scale
>2 point drop
A validated Multiple Choice Questionnaire (pre-post) [42–44] will be completed by participants before and after the program in order to measure patient deterioration knowledge. This measure will enable identification of knowledge in relation to skill performance and changes in knowledge based on program participation.
Skill performance measurements
All participants will complete three contrasting simulation exercises that are either recorded as interactive web-based versions or completed face-to-face with a patient actor. Each scenario will be based on common presenting conditions (e.g. acute myocardial infarction, shock and a respiratory case). Standardized patients (actors) will simulate the clinical scenarios. During the simulation exercises, information will be presented in a manner that most clearly reflects the real world requiring participants to be an active searcher . This approach will enhance the ecological validity of the simulation  allowing the participant to experience clinical thinking in a more dynamic manner. Levels of relevant information and levels of uncertainty will be taken into account  and incorporated into the scenarios.
Debriefing and feedback
The web-based version collects performance data for feedback at the end of each scenario, producing a score and written feedback. In the face-to-face version a video recording of the participants’ performance during the simulation exercise enables comprehensive verbal feedback. Written participant evaluations will be sought by survey after the training activities as an evaluation of the educational impact of each program.
We will conduct a cost analysis [48, 49] to assess total costs of training. The primary outcome of the cost analysis will be comparison of total costs between web-based versus face-to-face simulation education interventions. Secondary outcomes will include comparison of the costs associated with each intervention (e.g. software development, educator staffing costs, staff release costs, patient actors, etc.). In addition, hospitalization costs will be estimated using the Australian Refined Diagnosis Related Groups (AR-DRGs, Version 7) [50, 51] model, adjusting for ICU admissions and mortality.
Patient notes review: a pre-post intervention analysis through time series analyses. The appropriateness of observations, incidence of late signs of deterioration, in-hospital mortality and admissions to ICU will be used as the primary measures of patient management. Successful intervention will be identified by a statistically significant increase in applicable actions and a reduction in the proportion of late signs, in-hospital mortality and admissions to ICU.
Knowledge and skill performance ratings
Participant demographics, questionnaire, and simulation performance will be described with the use of descriptive and inferential statistics. Measures of dispersion (means, medians, etc.) will be reported. There will be a range of nominal, ordinal and interval data (paired and unpaired) requiring tests such as Chi-square; McNemar; Mann Whitney U; and t-tests. Multivariate analysis (linear and logistic regression) will be used to identify predictors of performance. Simulation exercises will be rated by two researchers for inter-rater reliability. A significance level of p < .05 will be applied throughout.
Based upon a Generic Qualitative Design eight stakeholder focus groups will be completed (two at each site) in order to identify the perceived impact of the program(s) . Core themes and outcomes will be identified using Miles and Huberman’s stages of data analysis . Analysts will attribute nominal codes to narrative segments and group narrative segments to identify key themes. Emergent themes will be shared and collaboratively refined to achieve a consensus for reporting. The reporting of findings will by guided by the COREQ guidelines for reporting qualitative research.
The program is designed to run for 18 months with a seven month lead-in, to enable literature reviews, ethical approval, access arrangements and refinement of data collection tools. The training intervention will be compressed into a four month period and subsequent patient notes review, data analyses and report writing will take a further seven months.
This project will add to the body of knowledge in relation to the ‘failure to rescue’ literature with a concern for measuring and improving the management of deteriorating patients. This is a contemporary international issue and one that the project funder – The Victorian Government – is keen to address.
In this mixed methods interventional trial we will investigate the clinical and financial impact of two forms of simulation education. Whilst many studies have identified the educational impact of simulation approaches few have identified how such approaches impact on clinical care and patient outcomes in combination with a cost benefit analyses. Importantly, the reader should note here that it is our intention to compare program impact rather than draw direct comparisons between the web-based and face-to-face versions of the program, as they are quite different forms of delivery.
In testing educational interventions Sullivan  suggests that there is a need to understand practice and patient safety issues in the real world through ‘pragmatic trials’. These may be cross sectional studies (data from a specified time), longitudinal approaches (exposures over time), cluster randomised trials, quasi (non-randomised) experimental approaches or a range of mixed methods approaches . Individual randomisation of subjects in education trials is problematic as cross-contamination is likely, the dynamics within existing groups will be changed and ethical concerns are raised when individuals are given no choice relating to learning methods . Further, control of such trials is difficult as educational delivery style will differ, participants will attend at different times, and comparison groups are often dissimilar (e.g. comparing lectures with simulation). Randomisation is therefore not the gold standard in education [54, 55].
In large and complex trials of this sort there are a number of issues with a need for effective leadership and management. In this study we have allowed seven months or more to gain ethical approval, access to clinical sites and to develop collaborative networks. The delivery of the simulation interventions will also take time and require careful roll-out in relation to the potentially stressful nature of the training which is designed to elicit the true nature of patient deterioration. Time series analyses and patient notes review is also complex commencing with the challenge of producing a valid and reliable audit tool .
However, the project findings will add significantly to our knowledge of organisational systems, adverse events and medical errors. Further, as a result of this multi-method evaluation, we will produce rigorous evidence to inform the development of simulation-based training programs with resultant improvements in patient safety.
The Patient Deterioration and Patient Safety Simulation Project was supported by the Victorian Government, Australia. The authors wish to acknowledge the research team that developed the foundation education program FIRST2Act, enabled by grants from the Australian Government Office of Learning and Teaching.
The trial is supported by the Victorian Government (Australia). The funding body did not influence the study design or the collection, analysis, and interpretation of data, nor writing of the manuscript.
Availability of data and materials
The datasets generated or analysed during the current study are not available due to confidentiality arrangements. A summary results report will be available on request from the primary author. The e-simulation training intervention including background information is available on the website: FIRST2ACTWeb (http://first2actweb.com/). The face-to-face simulation intervention and evaluation technique is publicly available: Cooper S, Porter J, Bogossian F, Cant R and the First2Act team: Development and Evaluation of a web-based Patient Deterioration Management Program. (2014) [Final report] Australian Government Office of Learning and Teaching, Sydney, Australia. ISBN: 978-1-74361-581-2. Available at: http://www.olt.gov.au/project-managing-patient-deterioration-enhancing-student-nursesapos-competence-through-web-based-sim Other related publications from this research group are cited in the reference list.
The study was designed by SC and LK. RC and SC drafted the paper with critical input from LK, TR, and CC. All authors (SJC, LK, CC, RC, JB, LB, AC, CLC, JAK, AMK, KN, EP, TR) reviewed and approved the draft paper for publication.
Professor Cooper of Federation University Australia, is Professor of Acute Care and Research Development. As a registered nurse, he is a leading researcher in the development of evidence-based simulation education projects, and has published widely in the emergency nursing and education fields.
Professor Kinsman of University of Tasmania, Australia, is Professor of Healthcare Improvement, and has a strong record of research that aims to reduce the gap between evidence and clinical practice.
Professor Rotter of University of Saskatchewan, Canada, Chair in Health Quality Improvement Science, is involved research that aims to improve the quality of patient care.
The authors declare that they have no competing interests.
Consent for publication
All participants in the web-based simulation (video) provided informed consent during development and the program is already published, openly available, and used as a simulation training program on a dedicated website.
Ethics approval and consent to participate
Approval was given by Monash Health Human Research Ethics Committee (approval No. 15414 L), the St John of God Health Care Human Ethics Committee (approval No.874) and Federation University Australia Human Ethics Committee (approval No. 15–10195). Nurses will provide informed consent to participate in the study.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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