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Influence of hospitalization on prescribing safety across the continuum of care: an exploratory study
© von Klüchtzner and Grandt; licensee BioMed Central. 2015
Received: 15 February 2014
Accepted: 24 April 2015
Published: 13 May 2015
Transitions between different levels of healthcare, such as hospital admission and discharge, pose a considerable threat to the quality and continuity of drug therapy. This study aims to further explore the current role of hospitalization in prescribing error exposure and medication-related communication as patients are transferred from and back to ambulatory care.
Assisted by electronic decision support, pre-admission and discharge medication regimens of 187 adult patients in a German university hospital were comparatively screened for clinically relevant categories of potentially inadequate prescribing. Binary logistic regression analyses were conducted to identify risk factors predisposing individuals to prescribing errors as a result of hospitalization. Additionally, it was established to what extent medication changes and potentially inappropriate prescribing decisions originating from inpatient treatment were communicated in discharge letters.
94.7% of the patients are subjected to differences between pre-admission and discharge prescriptions occurring at a rate of 461 per 100 hospitalizations. However, these modifications in drug therapy do not have a significant effect on the total number of potential prescribing errors per patient (p = 0.135) even though a large potential for improvement exists throughout the care continuum. For instance, almost a quarter of study participants with impaired kidney function lacks appropriate dose adjustment for one or more drugs before onset and at the end of inpatient treatment alike (22.5% [95% CI: 13.5%-34.0%] vs. 22.8% [95% CI: 14.1%-33.6%]). Overall, the probability of error exposure following hospitalization rises with an increasing number of prescribed drugs per patient, while individuals treated on surgical wards are four times more likely to be discharged with a prescribing-related safety hazard than their counterparts from medical departments (OR: 4.069 [95% CI: 1.126-14.703]; p = 0.032). In the study population’s discharge summaries only 14.8% of medication changes and none of the potentially inappropriate prescribing decisions made during inpatient care are addressed, despite the latter occurring at a rate of 91 per 100 hospitalizations.
There is urgent need for standardized and evidence-based measures contributing to patient safety across sectorial interfaces of drug therapy. Our findings provide useful orientation for the targeted and rational design of such improvement strategies.
Transitions between different levels of healthcare, such as hospital admission and discharge, pose a considerable threat to the quality and continuity of drug therapy. This is primarily due to poor management and transfer of information both between health professionals and in relation to their patients [1,2]. These shortcomings gain significance as increasingly complex medication regimens tend to be under fragmented control of various specialized caregivers with limited resources for coordination and documentation of treatment plans. Moreover, differing drug formularies as well as unsteady and vulnerable patient conditions are typical phenomena at care interfaces that further add to the challenge. In line with this, a prospective, observational cohort study from Denmark has found medication data retrieved from the patient, the general practitioner and the hospital to show complete consistency for only 8% (95% CI: 3%-17%) of consecutive medical cases throughout the continuum of care .
Despite the aforementioned problems, a hospital stay allows for intensive medical assessment and monitoring, thus providing an opportunity to adjust and coordinate all medication-related aspects for the benefit of cross-sectorial patient safety. With a view to determining to what extent current hospital practice lives up to this potential, the present study explores the role of hospitalization in prescribing error exposure and medication-related communication as patients transition from and back to ambulatory care. This may consequently assist in informing the rational development of targeted improvement strategies.
Calculation of study power
Difference of the means
Prospective data collection comprised systematic and integrative collation of comprehensive medication profiles across the transitions to and from hospital including corresponding patient and morbidity characteristics. Following a standardized protocolb, we initially obtained best-possible home medication histories by interviewing patients, their families and/or carers. Medication plans and/or supplies carried by the interviewees were also taken into account. In addition, we sought any existing referral letters from community care physicians as well as routine admission notes and other relevant medical records from present or past hospitalizations. Hospital laboratory test results required for prescribing safety appraisal (e.g. MDRD estimates of glomerular filtration rates ) were accessed electronically. On a regular basis, we contacted health professionals involved in the ambulatory care of study participants in order to resolve perceived gaps or inconsistencies in collected information. Finally, we retrieved electronic copies of the discharge summaries including recommendations on how to resume outpatient drug therapy.
Inappropriate dosing (e.g. with respect to impaired kidney function)
Adverse or redundant combination of drugs
Contraindicated drug choice
Unjustified omission of an indicated drug
Medication without indication
Inappropriate drug choice for the therapeutic goal
Medication for a patient aged 65 or older which is acknowledged as potentially inappropriate in this age group 
Prescription of inappropriate tablet fractions
Each drug prescribed to a given patient could be possibly associated with more than one kind of inadequacy simultaneously. In case of potential uncertainties of classification consensus between the study authors was sought.
Moreover, for each study participant the number of discrepancies between pre-admission and discharge medication (i.e. temporary or permanent introduction or withdrawal of a drug, alteration of dose and/or frequency including switching between regular and pro re nata application schemes, therapeutic drug substitutions) was determined. It was established to which extent such medication changes as well as potentially inappropriate prescribing decisions (see categorization above) originating from hospital care were communicated in the discharge letter.
95% confidence intervals were calculated according to Clopper-Pearson assuming binomial distributions. Gender allocation of the study sample was tested for agreement between observed and hypothesized binary probability. Depending on the scale of measure, the following tests were used for longitudinal comparisons of patient characteristics and prescribing error exposure at admission versus discharge: McNemar’s test for dichotomous variables, Marginal Homogeneity test for multinomial criteria and Wilcoxon matched-pair signed-rank test for metric parameters. To identify risk factors for potentially inadequate prescribing as a result of hospitalization, binary logistic regression analyses were conducted using a stepwise approach. In all adopted statistical procedures a significance level of α = 0.05 was applied.
The study population comprises both genders in comparable proportions (47.6% [95% CI: 40.3%-55.0%] women vs. 52.4% [95% CI: 45.0%-59.7%] men; p = 0.559). Both at admission and discharge two out of five patients (38.0% [95% CI: 31.0%-45.3%] vs. 42.2% [95% CI: 35.1%-49.7%]; p = 0.077) suffer from impaired kidney function (GFR < 60 ml/min/1.73 m2). More than one third (36.9%) of the participants is 65 years of age or older. Throughout the hospital stay a statistically significant increase of patients with more than 5 prescribed drugs is observed (52.9% [95% CI: 45.5%-60.3%] vs. 59.9% [95% CI: 52.5%-67.0%]; p = 0.043).
Influence of hospitalization on prescribing safety across the care continuum
Only 1 out of 19 (5.3%) patients receives the same medication regimen both before entering and upon leaving the hospital. The predominant rest of the patients is exposed to differences between pre-admission and discharge prescriptions occurring at a rate of 461 per 100 hospitalizations. Nearly 9 out of 10 (89.3%) affected patients encounter multiple (up to 14) medication changes.
Overall burden of potentially inadequate prescribing at hospital admission and discharge
Median (IQR) of potential prescribing errors per patient
Number of patients with prescribing error exposure
Binary logistic regression analysis
Odds ratio (95% CI)
Odds ratio (95% CI)
Age (years) at discharge
GFR (ml/min/1.73 m2) at discharge
Prescribed drugs per patient at discharge
Length of stay (days)
Finally, medication-related communication in the discharge letters of the study population has been found to be highly incomplete in that only 1 out of 7 (14.8%) alterations to the pre-admission medication regimen and none of the potentially inappropriate prescribing decisions made during inpatient treatment are pointed out or justified even though the latter occur at a rate of 91 per 100 hospitalizations.
In line with findings of an investigation conducted in Northern Ireland , the present study reveals no statistically significant improvement in overall prescribing safety as a result of routine inpatient treatment even though a large potential for error reduction is apparent throughout the care continuum. While the total extent of potentially inadequate prescribing is shown to remain constant between admission and discharge, our analyses convey marked alterations in the pattern of patient-level error exposure, thereby expanding the evidence published so far. For example, the prevalence of patients whose medication regimen lacks at least one indicated drug increases significantly by eight per cent until the end of the hospital stay. In nearly one out of four discharge prescriptions such an unjustified omission has been identified. Similarly, in their assessment of discharge summaries from an internal medicine department within a Swiss teaching hospital Perren and colleagues have found over a quarter of patients to be affected by this type of prescribing error .
Our findings further reveal that surgical patients are four times more likely to be discharged with potentially inadequate prescriptions than their counterparts from medical wards. This independent risk factor might reflect that surgical hospitalizations are primarily focused on acute interventions as opposed to the on-going pharmacotherapeutic management of comorbidities. This can be particularly problematic as surgery and follow-up care themselves regularly require (temporary) modification and/or expansion of usual home medication with additional implications for prescribing safety. In this regard, Boeker and colleagues note that the relative risk for post-operative complications is elevated almost by factor three (2.7; 95% CI: 1.8-4.0) in those patients taking co-medication beyond the context of their surgical treatment .
Our findings also confirm that medication-related information included in discharge letters of study participants is insufficient to ensure safety and continuity of drug therapy across different care settings. Identified shortcomings in communication concern both medication changes [10,11] and, as this study has additionally revealed, potentially inadequate prescribing decisions. Importantly, this impairs the ability of ambulatory care professionals to provide for an appropriate continuation of post-hospital drug treatment and latently facilitates occurrence and perpetuation of secondary prescribing errors . Consequentially, these inadequacies are in stark contrast to community care providers’ informational demands as reported in the literature. For example, almost nine out of ten general practitioners anonymously responding to a survey in the catchment area of a Dutch urban teaching hospital wish to know whether and why inpatient medication changes have been introduced, and also appreciate clinical advice pertaining to prescribing safety .
Our study has a number of limitations. Representativeness and generalizability of our findings are limited by the study setting. Patients treated in a university hospital like ours tend to have more advanced healthcare needs than inpatients in general, which will likely affect the complexity of prescribing patterns and by extension may result in increased manifestation of related inadequacies . There are also limiting implications of our study being monocentric, which may have been mitigated to only some extent by the broad range and diversity of patient cases recruited from various medical and surgical disciplines regardless of any morbidity specific restrictions. Meanwhile, patient recruitment has been compromised by the time and effort required for collecting scientifically sound data in an environment of clinical routine practice. Thus, it has not been possible to approach each and every admitted patient for inclusion in the study. We believe, however, that this has not led to a systematic distortion of our findings because on each occasion any given study ward was visited patients were recruited consecutively in their order of admission. Finally, our approach to pre-define targeted categories of inadequate prescribing, while lending itself to computational operationalization of measurement and enhancing objectivity and reproducibility of obtained results, will not be able to account for each and every form of insufficient prescribing safety despite the context sensitivity of the assessment criteria applied. However, this limitation may be deemed acceptable in the light of observations made by a systematic review of the medication error literature challenging the assumption of an automatically given association between the number of error types considered on the one hand and the overall error prevalence detected on the other .
Our findings highlight the urgent requirement to develop and implement standardized and evidence-based measures contributing to patient safety across sectorial interfaces of drug therapy. At admission, a best-possible medication history matching drugs and corresponding diagnoses should routinely be obtained and made centrally available in order to review quality and coherence of the underlying prescribing decisions with regard to the current healthcare needs of the individual patient. This may subsequently inform inter-professional coordination of further inpatient medication management, paying particular attention to poly-medicated and/or surgically treated patients as a possible means to rationalize improvement efforts. At discharge, detailed recommendations for continued drug treatment including insights on medication changes and/or prescribing-related safety hazards possibly requiring special follow-up monitoring ought to be transmitted to subsequent health care providers through appropriate means of communication. Given restrictions in time and staff resources, the intelligent use of IT solutions holds promise to support and control implementation of the aforementioned approaches for the benefit of trans-sectorial prescribing safety.
aCommittee of the Medical Faculty of the University of Duisburg-Essen
bThe standardized protocol was based on a structured data collection form detailing demographic, clinical and medication-related information required for each patient from pre-admission through to discharge. Conceptual development of this tool relied on a comprehensive review of the pertinent literature and of outputs from publicly advocated initiatives pursuing seamless medication safety (e.g. resources from the Safer Healthcare Now! campaign, the Institute for Healthcare Improvement, the Agency for Healthcare Research and Quality, etc.). Prior to implementation in this study, practicability and functionality of the resulting procedure were tested and refined following a stepwise approach in a sample of 100 patients.
cThe tool used is a component of the software product RpDoc® (version 2.4.2) and as such provides informational support for medication prescribing and review with a particular focus on dosing, interactions and redundancies, contraindications and galenical issues (e.g. breakability of tablets). The user is automatically alerted to potential prescribing errors of clinical relevance and can access evidence-based explanations and recommendations for optimized use of each drug. All information provided is tailored to the specific therapeutic context by accounting for individual patient and morbidity related characteristics (e.g. age, sex, body weight, lab results, indications). The mentioned functionalities are based on regularly updated databases comprising contents extracted from the summaries of product characteristics, publications from regulatory and other healthcare related authorities, guidelines from medical and pharmaceutical associations and societies or their respective drug commissions, etc.
This publication is based on an analysis of data collected as part of a larger research project on medication safety across health care sectors, carried out under the direction of DG and funded by the German Federal Ministry of Health (grant #: 2509 ATS 002). The article-processing charge for this paper has been covered by an allowance from the Open Access Publishing programme of the German Research Foundation.
The authors appreciate Hubert Schneemann’s and Karl-Heinz Jöckel’s contribution to the overall coordination of the study and are grateful to (junior) pharmacy staff of Essen University Hospital assisting with electronic data entry and maintenance. They also wish to thank Elizabeth Holt for proofreading the first draft of the manuscript.
- Gleason K, McDaniel M, Feinglass J, Baker D, Lindquist L, Liss D, et al. Results of the medications at transitions and clinical handoffs (MATCH) study: an analysis of medication reconciliation errors and risk factors at hospital admission. J Gen Intern Med. 2010;25:441–7.View ArticlePubMedPubMed CentralGoogle Scholar
- Witherington EM, Pirzada OM, Avery AJ. Communication gaps and readmissions to hospital for patients aged 75 years and older: observational study. Qual Saf Health Care. 2008;17:71–5.View ArticlePubMedGoogle Scholar
- Foss S, Schmidt JR, Andersen T, Rasmussen JJ, Damsgaard J, Schaefer K, et al. Congruence on medication between patients and physicians involved in patient course. Eur J Clin Pharmacol. 2004;59:841–7.View ArticlePubMedGoogle Scholar
- Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW, et al. Expressing the modification of diet in renal disease study equation for estimating glomerular filtration rate with standardized serum creatinine values. Clin Chem. 2007;53:766–72.View ArticlePubMedGoogle Scholar
- Kaufmann C, Tremp R, Hersberger K, Lampert M. Inappropriate prescribing: a systematic overview of published assessment tools. Eur J Clin Pharmacol. 2014;70:1–11.View ArticlePubMedGoogle Scholar
- Holt S, Schmiedl S, Thurmann PA. Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arztebl Int. 2010;107:543–51.PubMedPubMed CentralGoogle Scholar
- Burnett KM, Scott MG, Fleming GF, Clark CM, Mcelnay JC. Effects of an integrated medicines management program on medication appropriateness in hospitalized patients. Am J Health Syst Pharm. 2009;66:854–9.View ArticlePubMedGoogle Scholar
- Perren A, Previsdomini M, Cerutti B, Soldini D, Donghi D, Marone C. Omitted and unjustified medications in the discharge summary. Qual Saf Health Care. 2009;18:205–8.View ArticlePubMedGoogle Scholar
- Boeker E, de Boer M, Kiewiet J, Lie AH, Dijkgraaf M, Boermeester M. Occurrence and preventability of adverse drug events in surgical patients: a systematic review of literature. BMC Health Serv Res. 2013;13:364.View ArticlePubMedPubMed CentralGoogle Scholar
- Frydenberg K, Brekke M. [Communication about drug use in referrals, acute admissions and discharge letters]. Tidsskr Nor Laegeforen. 2011;131:942–5.View ArticlePubMedGoogle Scholar
- Roth-Isigkeit A, Harder S. Reporting the discharge medication in the discharge letter. Med Klin. 2005;100:87–93.View ArticleGoogle Scholar
- Sexton J, Brown A. Problems with medicines following hospital discharge: Not always the patient's fault? J Soc Adm Pharm. 1999;16:199–207.Google Scholar
- Karapinar F, van den Bemt P, Zoer J, Nijpels G, Borgsteede S. Informational needs of general practitioners regarding discharge medication: content, timing and pharmacotherapeutic advices. Pharm World Sci. 2010;32:172–8.View ArticlePubMedPubMed CentralGoogle Scholar
- Cano FG, Rozenfeld S. Adverse drug events in hospitals: a systematic review. Cad Saude Publica. 2009;25:S360–72.View ArticlePubMedGoogle Scholar
- Lisby M, Nielsen LP, Brock B, Mainz J. How are medication errors defined? A systematic literature review of definitions and characteristics. Int J Qual Health Care. 2010;22:507–18.View ArticlePubMedGoogle Scholar
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