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Comparative study of paediatric prescription drug utilization between the spanish and immigrant population



The immigrant population has increased greatly in Spain in recent years to the point where immigrants made up 12% of the infant population in 2008. There is little information available on the profile of this group with regard to prescription drug utilization in universal public health care systems such as that operating in Spain. This work studies the overall and specific differences in prescription drug utilization between the immigrant and Spanish population.


Use was made of the Aragonese Health Service databases for 2006. The studied population comprises 159,908 children aged 0-14 years, 13.6% of whom are foreign nationals. Different utilization variables were calculated for each group. Prescription-drug consumption is measured in Defined Daily Doses (DDD) and DDD/1000 persons/day/(DID).


A total of 833,223 prescriptions were studied. Utilization is lower for immigrant children than in Spanish children for both DID (66.27 v. 113.67) and average annual expense (€21.55 v. €41.14). Immigrant children consume fewer prescription drugs than Spanish children in all of the therapy groups, with the most prescribed (in DID) being: respiratory system, anti-infectives for systemic use, nervous system, sensory organs. Significant differences were observed in relation to the type of drugs and the geographical background of immigrants.


Prescription drug utilization is much greater in Spanish children than in immigrant children, particularly with reference to bronchodilators (montelukast and terbutaline) and attention-disorder hyperactivity drugs such as methylphenidate. There are important differences regarding drug type and depending on immigrants' geographical backgrounds that suggest there are social, cultural and access factors underlying these disparities.

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We have witnessed a profound transformation in Spanish society in recent years resulting from the large increase in the immigrant population, most of whom have come from low-income countries [14]. Contrary to the situation a number of decades back, Spain is now considered a destination country for migratory flow.

According to Spanish National Institute of Statistics data taken from the Spanish Population Register on 1 January 2008, immigrants make up 12.7% of the total population of Spain. Immigrants comprise 12.46% of the child (≤14 years of age) population in Spain. In 2008, immigrants in the region of Aragon, where the study was made, accounted for 13.14% of the total population and 13.38% of the paediatric population

Spain is the European Union country that received the largest number of immigrants in 2007. The number of resident foreign nationals has multiplied by 3 in the last 6 years. It is clear that an increase of this scale in the immigrant population in such a short period of time involves adapting and reorganizing a number of aspects of the host society. This occurrence requires the destination society to undertake preparations in many aspects, among which are the public health service and health care. Awareness of the habits and needs of this population group is therefore of great interest so that resources may be planned and the necessary measures taken in order to for them to be faced in the best possible conditions [1, 49].

Health care for non-EU foreign nationals in Spain is regulated by law and is guaranteed for foreign nationals, regardless of their residency status, in the same conditions as Spaniards [10]. Therefore, all children with foreign national status are covered by public health care, which is the same as that of the Spanish population.

Health care professionals and the public at large are generally unaware of the health care needs of, and services provided to, the immigrant population [5, 7, 11]. However, immigrants are believed to contribute to greater utilization of health care resources resulting in overcrowded health centres and accident and emergency services, and they are believed to have higher utilization of prescription drugs [1215].

Despite the increase in recent years in the number of studies directed at analysing the health of immigrants, these studies tend to focus on medical aspects such as the prevalence of different diseases and conditions among foreign nationals, care procedures to be applied and mortality rates, among others [2, 3, 1620]. However, there are very few studies aiming to discover the repercussions of providing health care to immigrants inside the health service, with a view to directing health policies and improving care. These studies additionally do not tend to focus on the paediatric population [57, 11, 2125].

Pharmaceutical expense is one of the fastest growing components of the Spanish National Health Service budget. Subsidies for prescriptions dispensed in community pharmacies account for approximately 25% of total health care spending [26]. The expenditure generated by the immigrant population is therefore an important aspect to study when analysing the repercussions the immigration phenomenon is having on the public health system, given that the available information is very scarce. Additionally, as pharmaceutical expense is the result of prescriptions made by public health service doctors, this information is a good indication of the health care delivered.

In 2006, the population of Aragon (an autonomous region in northeastern Spain), all with access to public health care, was 1,273,662, of which 116,677 (9.16%) were foreign nationals. In the same year, 24,400,843 prescriptions were dispensed and billed to the Aragonese Public Health Service (SALUD) for a total value of €377,262,671. Public health system subsidies accounted for €341,731,076 of this amount.

Our study aims to provide insight into one of the least known aspects of the impact produced by the immigrant population on the Spanish health system - prescription drug utilization - compared to the Spanish population. The objectives of our work were:

  1. 1.

    to study the overall and specific differences in prescription drug utilization between the immigrant and Spanish paediatric population residing in a Spanish region; and 2. to understand the profile of drugs prescribed to both population groups, with regard to the main therapeutic groups prescribed and to the active ingredients that generate the greatest expense.


This is a descriptive observational study on prescription drug utilization comparing the two different populations residing in Aragon: Spaniards and immigrants. In order to give an operational definition of immigrant, we have used the legal category of foreign national. This article makes use of both terms indistinctly [27]. Study population was the whole paediatric population of Aragon, both Spaniards and foreign nationals, with access to health care provided by SALUD accredited by their corresponding personal health insurance card. The period covered by the study was 1 January to 31 December 2006. This research has been aproved by Ethic Committe of Clinic Research of Aragon.

Pharmaceutical expense was analysed from the SALUD Pharmacy Service pharmaceutical billing database statistics for 2006 covering all publicly subsidised prescription drugs dispensed by pharmacies. These do not include drugs prescribed by private practices or those dispensed without prescription. Nor do they include drugs utilized in hospitals or dispensed there to outpatients (very specific treatments for particular diseases and conditions). Drugs corresponding to immunization campaigns are also excluded from this study. The data collected are cross-sectional. Long-term drug utilization patterns were not studied.

In order for their bills to be settled by the Pharmacy Service, pharmacists must use the computerized data-collection system to record the details of the prescribed drug (national drug formulary code), those of the prescribing doctor (health area identification code and registration number) and those of the patient for whom the drug is prescribed (personal identification code), among others.

By matching the personal identification code with the information from the health insurance card, which provides information on users' age, sex, country of birth and status (Spanish or foreign national), data can be obtained on utilization by age and sex of the local Spanish and immigrant population.

By matching the drug code with the drug formulary database, Digitalis, information can be obtained regarding the active ingredient, Anatomical Therapeutic Chemical (ATC) classification therapeutic main group and subgroup, the content in DDDs in each package needed to calculate the DID and whether it is a generic drug [28].

Statistical Analysis: Prescription drug utilization is compared by age, sex and foreign national or Spanish in the health card database. We applied the central limit theorem for large samples. The DID variable has a normal distribution and we were therefore able to use Student's t-test to compare these values between the immigrant and Spanish populations. P-values < 0.05 were considered statistically significant.

For each patient: DID, prescriptions, packages, health system subsidy, retail price of prescription drugs, utilization rate (patients utilizing the drug/drugs in 2006 compared to the total population by age at year's end) and percentage of generics utilized compared to total DDD.

Analysis was performed on anatomical groups, therapeutic groups and active ingredients with the purpose of ascertaining whether the differences in utilization occur in a similar manner in all prescription drug groups or whether, on the contrary, there is a different utilization profile. All of the prescribed and dispensed drugs and healthcare products were grouped according to the ATC classification system by anatomical main group, therapeutic main group, pharmacological and chemical subgroups, and active ingredients.

Inferential data analysis, which attempts to compare mean utilization per age and sex group, was performed using Student's t-test for independent samples. In order to be able to use this parametric contrast, we defined the central limit theorem, because this allowed us to work with a normal distribution when analysing the mean of a variable and, consequently, with parametric inference. The DID variable has a normal distribution and we were therefore able to use Student's t-test to compare these values between the immigrant and Spanish populations. P-values < 0.05 were considered statistically significant.


A total of 833 223 prescriptions made to children between the ages of 0 and 14 years were analysed. The reference population was 159 908 children residing in Aragon in 2006 of whom 13.6 (19 231) were foreign nationals. 24% of these foreign national children were born in Spain. The distribution by geographical background is as follows: 40% from South and Central America; 32% from Non EU- Europe; 21% from Africa; 8% of other origin.

Figure 1 shows the differences in DID between children, with regard to age and sex.

Figure 1
figure 1

Distribution by sex and age of the DID prescription. Aragón, 2006

Table 1 provides general information on prescription drug utilization for Spanish and foreign national children in Aragon regarding: DID, packages/person, expense/person, retail price/person, % co-payment - (retail price-expense/retail price) and utilization rate (percentage of the population that utilized at least one prescription in the year).

Table 1 Main indicators for prescription-drug utilization in spanish and foreign national children.

In all of the measurement units used - DDD, DID, packages, expense and retail price per person, prescription drug utilization by the Spanish population is far higher than that of the immigrant population (between 51% and 100%), with a great degree of significance.

Foreign nationals pay a higher co-payment percentage, no doubt owing to the lower value of their utilization of drugs for chronic conditions (with lower co-payment) than Spaniards. The prescription drug utilization rate for foreign nationals is only 16% lower than that of Spaniards, which means that the fundamental difference lies in the number of drugs consumed per person and the value of those drugs, rather than the number of children who utilized them.

Table 2 provides the percentage difference of Spaniards v. foreign nationals in the 18 anatomical and therapeutic groups studied, together with the general DID data previously presented.

Table 2 Difference in DID utilization between spaniards and foreign nationals by different anatomical and therapeutic groups.

It can be observed that the differences in utilization are not homogeneous in the different drug groups. While the differences are relatively slight and below the mean for groups such as analgesics (N02) and anti-inflammatories (M01), there are very wide disparities in other groups such as bronchodilators (R03), decongestants (R01) and particularly psychoanaleptics (N06) and psycholeptics (N05).

Table 3 shows the analysis of active ingredients for which the active ingredients with the largest difference in utilization have been chosen, with a minimum utilization of 1 DID.

Table 3 Main active ingredients with highest DID and largest differences in utilization between spaniards and foreign nationals.

Drugs for problems of Attention-disorder hyperactivity such as methylphenidate show extremely significant differences in utilization. In the bronchodilator group, montelukast and terbutaline show differences in utilization that are higher than the group as a whole (385% and 238% compared to 142% for the R03 group). Within the antibiotics group, cefuroxime, cefaclor and clarythromicine show differences of 147%, 138% and 134%, respectively, compared to 72% for the J01 group.

Within the immigrant population, important differences are seen in utilization according to the geographical background and place of birth of the children, as shown in Table 4.

Table 4 Differences in DID prescription-drug utilization by place of birth of foreign national children. Aragón 2006.

Certain heterogeneity was detected among immigrants themselves; children born in their countries of origin utilize fewer prescription drugs than those born in Spain. Children from western countries, Asia and Latin America have lower utilization rates than sub-Saharan and North Africans, although it will be necessary to study their qualitative utilization in greater depth in order to understand this phenomenon.


The results presented in this study are quite clear and consistent: prescription drug utilization is much greater in Spanish children than in immigrant children. In a National Health Service with universal child cover, despite what is thought, conveyed [29], and often appears in different media, our study shows that the utilization of prescription drugs by the immigrant paediatric population is far lower than that of the Spanish population. This has been demonstrated in the measurement of DID, total expense and number of packages consumed. Other studies had demonstrated this low utilization of services, although not all of them had given in depth study to drug utilization [5, 7, 22, 3033]. It has also been shown that this difference occurred in all therapeutic groups and main active ingredients although with huge variability.

Because the characteristics of Aragon are similar to Spain in distribution of resources, health system management, immigration population frequency, and social and demographic characteristics, our data may be generalizable for the entire country.

If we assume that the immigrant population has a socio-economic level that is lower than the Spanish population, it would seem that immigrants should have lower levels of health [3436]. The low drug utilization found in our study could respond to the classic "Inverse Care Law" described by Hart in 1971 (patients receive medical care in inverse proportion to their need) or to their level of health being higher than expected, or to a combination of both [37]. There are a number of hypotheses explaining such striking differences.

One example is accessibility. There may be lower access for immigrant children, meaning they go to the doctor less regularly. However, there is no legal reason for this because the law guarantees their right to be attended in equal conditions. The Rivera Study concluded that there were no significant problems of access in Spain [7], but other authors have concluded that there are different barriers of culture, language, legal status, lack of familiarity with the health care system, and others that are related to work and timetables [38].

In order to explain this further, it would be of great use to have information on the utilization of the different health services by these patients. Data on frequency of consultations are disputed and new studies would be necessary to prove this point, but it would seem that immigrants make fewer consultations than Spaniards [5, 7, 11, 32, 33, 39, 40].

This factor would justify the lower overall prescription drug utilization, but not the important differences existing in the utilization profile.

This study only evaluates drugs prescribed by the public health services and does not include those dispensed with private medical prescriptions or those acquired over the counter without prescription, a situation that is quite common in paediatrics. It is estimated that of the total Spanish pharmaceutical market handled through the Pharmacy Service in 2006, 75.4% corresponded to the Spaninh National Health Service [41]. If this private utilization were taken into account, it would widen even further the differences between the two population groups, given that it is likely that immigrants would make less use of these services.

The cost of co-payment in Spain is very low and we do not consider this to be a reason that justifies the differences. In the analysis of utilization shown in Table 3, it could be suspected that the part to be paid by patients for some active ingredients influences patients with lower purchasing power to not accept having to pay a higher proportion of the price of a drug, therefore dissuading the doctor to prescribe it.

However, methylphenidate, the most utilized brand, has an extremely low price to be paid by patients, and both montelukast and terbutaline have a reduced co-payment scale - 10% of the total - with a maximum of €2.64 per package. In the case of the antibiotics cefuroxime, cefaclor and clarythromicine, the part to be paid by the patient is higher than for most drugs routinely prescribed in paediatrics such as amoxicillin and amoxicillin with clavulanic acid, with a lower cost per treatment, although these are acute treatments with a total cost that can never be high. Other factors may also be present in their being prescribed.

There are numerous studies pointing out that immigrants usually have a better level of health than their host populations because the healthiest are more likely to migrate ("healthy migration effect") and this population group has better lifestyles. These studies have been made on general populations and it is doubtful whether they can be applied to the paediatric population that has not undergone the selection process involved in emigrating to another country [5, 7, 39, 4247].

Some cultural and sociological issues arise when we analyse the enormous differences in the utilization of bronchodilators and Attention-disorder hyperactivity drugs (Table 3): Should we be considering that there is lower incidence of Asthma or Hyperactivity disorders in the immigrant population? Are we confirming the hygienist theories regarding the origin of asthma? Do immigrants with these conditions not receive treatment? Are Spanish children being overdiagnosed or overtreated for these conditions? Are these drugs being put to the correct use for which they were approved? Why do Spanish children utilize the latest Asthma treatments?

Prescription drug utilization does not only obey factors of health or illness. There are important sociological factors that influence it. The concept of and attitudes toward health and illness may be different in both groups. Our society is medicalized and seeks the solution to many of its problems in drugs. Different studies have confirmed that the self perception of good health is higher among immigrants than among locals [5, 7, 42].

Health care in most of the countries of origin of immigrants have shortcomings that often means medical treatment is given those processes considered most pressing, while people geneally turn to home remedies for different ailments. Over time, immigrants adapt and are assimilated into the culture of greater health-resource utilization of the host country, which would justify the differences found between children of immigrants born in Spain and those born in their countries of origin.

Likewise, we should also look at the concept of health and illness held by the immigrant population and the culture of health-resource utilization in their countries of origin that might justify a differential pattern of "felt morbidity". Health and illness are socially-constructed concepts and they vary in relation to the social and cultural context in which they are produced.

Taking into account a more biological concept, perhaps another motive could be health and the scale of needs. Consultations with immigrants tend to relate to more acute events; follow up is much more complex once the event for which the consultation was made has been overcome. Immigrants are very often unaccustomed to their children making regular visits to the doctor if they feel well. Adherence to chronic treatments is difficult. Preventive activities do not form a part of their requirements because they are not seen to be necessary, at least during their first years in Spain [4850].

The finding that the differences are lower between drugs treating "acute" conditions (analgesics, anti-inflammatories and antibiotics) than drugs treating chronic conditions (Asthma and Hyperactivity) support this hypothesis.


In conclusion, prescription drug utilization is much greater in Spanish children than in immigrant children, particularly with reference to bronchodilators (montelukast and terbutaline) and Attention-disorder hyperactivity drugs such as methylphenidate.

Prescription drug utilization by the immigrant paediatric population is much lower than for the Spanish population. Probably, cultural, sociological and accesibility factors are the factors that contribute more to these differences. Other studies will be needed to further analyse the disparities shown by drug subgroups, the idealness and suitability of prescription, the background of the immigrant population and frequency of consultations, among others, in order to assist us in ascertaining the causes of this situation.


What is already known about this topic?

There is not enough information about consumption of health resources from the immigrant paediatric population. Population studies could highlight disparities and explain variability in clinical practice.

What this study adds?

Pharmaceutical consumption from immigrant children in a public health system such as Spain's, with universal health care, is very much lower than for native-born children. There are many differences, depending on country of origin and drug type. This fact entails relevant implications for the health planning and opens new research lines.

The Corresponding Author has the right to grant on behalf of all authors and does grant on behalf of all authors, an exclusive licence (or non-exclusive for government employees) on a worldwide basis to the BMJ Publishing Group Ltd and its Licensees to permit this article (if accepted) to be published in Journal of Epidemiology and Community Health and any other BMJPGL products to exploit all subsidiary rights, as set out in our licence



Defined Daily Doses


DDD/1000 persons/day


Aragonese Public Health Service


Anatomical Therapeutic Chemical.


  1. Jansa JM, Garcia de Olalla P: Salud e inmigración: nuevas realidades y nuevos retos. Gac Sanit. 2004, 18 (Suppl 1): 207-13. 10.1157/13062528.

    Article  PubMed  Google Scholar 

  2. Manzardo C, Treviño B, Gómez i, Prat J, Cabezos J, Mongui E, Clavería I, et al: Communicable diseases in the immigrant population attended to in a tropical medicine unit: epidemiological aspects and public health issues. Travel Med Infect Dis. 2008, 6 (1-2): 4-11.

    Article  PubMed  Google Scholar 

  3. Salazar A, Navarro-Calderón E, Abad I, Alberola V, Almela F, Borras R, et al: Diagnós ticos al alta hospitalaria de las personas inmigrantes en la ciudad de Valencia (2001-2002). Rev Esp Salud Publica. 2003, 77 (6): 713-23. 10.1590/S1135-57272003000600005.

    Article  PubMed  Google Scholar 

  4. Vázquez Villegas J: Inmigración y salud: ¿un nuevo modelo de atención primaria para un nuevo modelo de sociedad?. Atención Primaria. 2006, 37 (5): 249-10.1157/13086302.

    Article  PubMed  Google Scholar 

  5. Carrasco-Garrido P, De Miguel AG, Barrera VH, Jimenez-Garcia R: Health profiles, lifestyles and use of health resources by the immigrant population resident in Spain. Eur J Public Health. 2007, 17 (5): 503-7. 10.1093/eurpub/ckl279.

    Article  CAS  PubMed  Google Scholar 

  6. Jansa JM: Inmigración y envejecimiento, nuevos retos en salud pública. Gaceta Sanitaria. 2006, 20 (Supl 1): 10-4.

    Article  PubMed  Google Scholar 

  7. Rivera B, Casal B, Cantarero D, Pascual M: Adaptación de los servicios de salud a las características especificas y de utilización de los nuevos españoles. Informe SESPAS 2008. Gac Sanit. 2008, 22 (Suppl 1): 86-95. 10.1016/S0213-9111(08)76079-5.

    Article  Google Scholar 

  8. Borrell C, Muntaner C, Sola J, Artazcoz L, Puigpinos R, Benach J, et al: Immigration and self-reported health status by social class and gender: the importance of material deprivation, work organisation and household labour. J Epidemiol Community Health. 2008, 62 (5): e7-10.1136/jech.2006.055269.

    Article  CAS  PubMed  Google Scholar 

  9. Adams KM, Gardiner LD, Assefi N: Healthcare challenges from the developing world: post-immigration refugee medicine. BMJ. 2004, 328 (7455): 1548-52. 10.1136/bmj.328.7455.1548.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Vázquez Villegas J: Atención sanitaria a inmigrantes. Legislación. 2004, [updated 2004; cited 25-03-2007;], []

    Google Scholar 

  11. López Lázaro L: Inmigración, estado de salud y uso de servicios de atencion primaria. Aten Primaria. 2008, 40 (5): 232-3. 10.1157/13120589.

    Article  PubMed  Google Scholar 

  12. Esteva M, Cabrera S, Remartinez D, Díaz A, March S: Percepción de las dificultades en la atencion sanitaria al inmigrante económico en medicina de familia. Aten Primaria. 2006, 37 (3): 154-9. 10.1157/13085348.

    Article  CAS  PubMed  Google Scholar 

  13. Jansa JM: Salud e inmigración, en qué punto nos encontramos. Enf Emerg. 2007, 9 (2): 59-60.

    Google Scholar 

  14. Martin Laso M: El paciente inmigrante en atencion primaria. ¿Estamos preparados?. Aten Primaria. 2001, 28 (2): 89-90.

    Article  CAS  PubMed  Google Scholar 

  15. López-Vélez R, Gimeno Feliu LA: La migración: una perspectiva desde la Atención Primaria de Salud. Medifam. 1994, 4 (3): 109-12.

    Google Scholar 

  16. Bruguera M, Sanchez Tapias JM: Hepatitis viral en población inmigrada y en niños adoptados. Un problema de magnitud desconocida en España. Med Clin (Barc). 2001, 117 (15): 595-6.

    Article  CAS  Google Scholar 

  17. Cabezos J, Durán E, Treviño B, Bada JL: Paludismo importado por inmigrantes en Cataluña. Med Clin (Barc). 1995, 104 (2): 45-8.

    CAS  Google Scholar 

  18. Chirveches Perez E, Peleato Catalán MD, Cabello Diaz MS, Torne Cachot J: Enfermedad tuberculosa en inmigrantes de la comarca de Garraf. Aten Primaria. 2001, 28 (7): 508-9.

    Article  CAS  PubMed  Google Scholar 

  19. Díaz J, Igual R, Alonso MC, Moreno MJ: Estudio del parasitismo intestinal en inmigrantes de la comarca de La Safor (Comunidad Valenciana). Med Clin (Barc). 2002, 119 (1): 36.

    Article  Google Scholar 

  20. Garcia-Samaniego J, Soriano V, Enríquez A, Lago M, Martinez ML, Muno F: Hepatitis B and C virus infections among African immigrants in Spain. Am J Gastroenterol. 1994, 89 (10): 1918-9.

    CAS  PubMed  Google Scholar 

  21. Serra-Sutton V, Hausmann S, Bartomeu N, Berra S, Elorza-Ricart JM, Rajmil L: Experiencias de investigación y políticas de salud relacionadas con inmigración en otros países europeos. El caso de los Países Bajos, el Reino Unido y Suiza. Barcelona: Agència d'Avaluació de Tecnologia i Recerca Mèdiques. CatSalut. Departament de Sanitat i Seguretat Social. Generalitat de Catalunya. Junio de. 2004

    Google Scholar 

  22. Cots F, Castells X, Garcia O, Riu M, Felipe A, Vall O: Impact of immigration on the cost of emergency visits in Barcelona (Spain). BMC Health Serv Res. 2007, 7: 9-10.1186/1472-6963-7-9.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Cots F, Xastells X, Ollé C, Manzanera R, Varela J, Vall O: Perfil de la casuística hospitalaria de la población inmigrante en Barcelona. Gac Sanit. 2002, 16 (5): 376-84.

    Article  CAS  PubMed  Google Scholar 

  24. Martinez AM, Tejedor ED: Análisis de la demanda asistencial de la población inmigrante en la atencion neurológica ambulatoria. Neurología. 2008, 23 (6): 361-6.

    PubMed  Google Scholar 

  25. Albares Tendero MP, Ramos Riñón JM, Belinchon Romero I, Betlloch Mas I, Pastor Tomas N, Botella Antón R: Análisis de la demanda asistencial en dermatologías de la población inmigrante. Gac Sanit. 2008, 22 (2): 133-6. 10.1157/13119322.

    Article  PubMed  Google Scholar 

  26. Lopez Bastida J: El mercado farmacéutico español: una panorámica. Gestión sanitaria Innovaciones y desafíos. Madrid: Masson. Edited by: del Llano Señaris J, Ortún Rubio V, Martín Moreno J, Millán Núñez-Cortés J, Gené Badía J. 2000, 105-24.

    Google Scholar 

  27. Malmusi D, Jansa JM, del Vallado L: Recomendaciones para la investigación e información en salud sobre definiciones y variables para el estudio de la población inmigrante de origen extranjero. Rev Esp Salud Publica. 2007, 81 (4): 399-409. 10.1590/S1135-57272007000400007.

    Article  PubMed  Google Scholar 

  28. ATC/DDD system. []

  29. Barbero J: Inmigración, salud y bioética. Consideraciones éticas en la atención al inmigrante. Guía de atención al inmigrante. Edited by: Alonso A, Huerga H, Morera J. 2006, Madrid: Ergon, 33-44. 2

    Google Scholar 

  30. Turrientes M, Huerga H, López-Vélez R: Coste económico y carga asistencial en el laboratorio de parasitología derivados de la atención al inmigrante. Enferm Infecc Microbiol Clin. 2003, 21 (4): 188-92. 10.1157/13045449.

    Article  Google Scholar 

  31. Muennig P, Fahs MC: Health status and hospital utilization of recent immigrants to New York City. Prev Med. 2002, 35 (3): 225-31. 10.1006/pmed.2002.1072.

    Article  PubMed  Google Scholar 

  32. Goldman DP, Smith JP, Sood N: Immigrants and the cost of medical care. Health Aff (Millwood). 2006, 25 (6): 1700-11. 10.1377/hlthaff.25.6.1700.

    Article  Google Scholar 

  33. Stronks K, Ravelli AC, Reijneveld SA: Immigrants in the Netherlands: equal access for equal needs?. J Epidemiol Community Health. 2001, 55 (10): 701-7. 10.1136/jech.55.10.701.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Lynch JW, Kaplan GA, Pamuk ER, Cohen RD, Heck KE, Balfour JL, et al: Income inequality and mortality in metropolitan areas of the United States. Am J Public Health. 1998, 88 (7): 1074-80. 10.2105/AJPH.88.7.1074.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Pantzer K, Rajmil L, Tebe C, Codina F, Serra-Sutton V, Ferrer M, et al: Health related quality of life in immigrants and native school aged adolescents in Spain. J Epidemiol Community Health. 2006, 60 (8): 694-8. 10.1136/jech.2005.044073.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Reijneveld SA: Reported health, lifestyles, and use of health care of first generation immigrants in The Netherlands: do socioeconomic factors explain their adverse position?. J Epidemiol Community Health. 1998, 52 (5): 298-304. 10.1136/jech.52.5.298.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Hart JT: The inverse care law. Lancet. 1971, 1 (7696): 405-12.

    Article  CAS  PubMed  Google Scholar 

  38. Ramos M, García R, Prieto M, March J: Problemas y propuestas de mejora en la atención sanitaria a los inmigrantes económicos. Gac Sanit. 2001, 15 (4): 320-6.

    Article  CAS  PubMed  Google Scholar 

  39. DesMeules M, Gold J, Kazanjian A, Manuel D, Payne J, Vissandee B, et al: New approaches to immigrant health assessment. Can J Public Health. 2004, 95 (3): I22-6.

    PubMed  Google Scholar 

  40. Pearce N, Foliaki S, Sporle A, Cunningham C: Genetics, race, ethnicity, and health. BMJ. 2004, 328 (7447): 1070-2. 10.1136/bmj.328.7447.1070.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Medicamento y farmacia en cifras 2006. 2007, [updated 2007; cited 28/10/2008];, [$File/07.pdf]

  42. Singh GK, Hiatt RA: Trends and disparities in socioeconomic and behavioural characteristics, life expectancy, and cause-specific mortality of native-born and foreign-born populations in the United States, 1979-2003. Int J Epidemiol. 2006, 35 (4): 903-19. 10.1093/ije/dyl089.

    Article  PubMed  Google Scholar 

  43. Ali JS, McDermott S, Gravel RG: Recent research on immigrant health from statistics Canada's population surveys. Can J Public Health. 2004, 95 (3): I9-13.

    PubMed  Google Scholar 

  44. Hyman I: Setting the stage: reviewing current knowledge on the health of Canadian immigrants: what is the evidence and where are the gaps?. Can J Public Health. 2004, 95 (3): I4-8.

    PubMed  Google Scholar 

  45. Razum O: Commentary: of salmon and time travellers--musing on the mystery of migrant mortality. Int J Epidemiol. 2006, 35 (4): 919-21. 10.1093/ije/dyl143.

    Article  PubMed  Google Scholar 

  46. Razum O, Twardella D: Time travel with Oliver Twist--towards an explanation for a paradoxically low mortality among recent immigrants. Trop Med Int Health. 2002, 7 (1): 4-10. 10.1046/j.1365-3156.2002.00833.x.

    Article  PubMed  Google Scholar 

  47. Razum O, Zeeb H, Akgun HS, Yilmaz S: Low overall mortality of Turkish residents in Germany persists and extends into a second generation: merely a healthy migrant effect?. Trop Med Int Health. 1998, 3 (4): 297-303. 10.1046/j.1365-3156.1998.00233.x.

    Article  CAS  PubMed  Google Scholar 

  48. Vázquez Villegas J: Asistencia al inmigrante desde el equipo de atención primaria (aspectos organizativos, formativos y de planificación). Cuadernos de Gestión. 2002, 8 (2): 16-22.

    Google Scholar 

  49. Jansa JM, Villalbi JR: La salud de los inmigrantes y la atención primaria. Aten Primaria. 1995, 15 (5): 320-7.

    CAS  PubMed  Google Scholar 

  50. Berra S, Elorza-Ricart JM, Bartomeu N, Hausmann S, Serra-Sutton V, Rajmil L: Necesidades en salud y utilización de los servicios sanitarios en la población inmigrante en Cataluña. Revisión exhaustiva de la literatura científica. Barcelona: Agència d'Avaluació de Tecnologia i Recerca Mèdiques. CatSalut. Departament de Sanitat i Seguretat Social. Generalitat de Catalunya. 2004

    Google Scholar 

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This work has been possible thanks to the Red de Investigación en Actividades de Prevención y Promoción de la Salud (REDIAPP-06/018), nodo de Aragón, from Instituto de Salud Carlos III, Madrid, Spain.

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Correspondence to Luís A Gimeno-Feliu.

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LAGF: conceived of the study, and participated in its design and coordination section. JAG: participated in the design of the study and performed the statistical analysis. RMC: participed in data analysis. RMB: participed in the design, and prepared the manuscript. All authors read and approved the final manuscript.

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Gimeno-Feliu, L.A., Armesto-Gómez, J., Macipe-Costa, R. et al. Comparative study of paediatric prescription drug utilization between the spanish and immigrant population. BMC Health Serv Res 9, 225 (2009).

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