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A framework for assessing Health Economic Evaluation (HEE) quality appraisal instruments
BMC Health Services Research volume 12, Article number: 253 (2012)
Health economic evaluations support the health care decision-making process by providing information on costs and consequences of health interventions. The quality of such studies is assessed by health economic evaluation (HEE) quality appraisal instruments. At present, there is no instrument for measuring and improving the quality of such HEE quality appraisal instruments. Therefore, the objectives of this study are to establish a framework for assessing the quality of HEE quality appraisal instruments to support and improve their quality, and to apply this framework to those HEE quality appraisal instruments which have been subject to more scrutiny than others, in order to test the framework and to demonstrate the shortcomings of existing HEE quality appraisal instruments.
To develop the quality assessment framework for HEE quality appraisal instruments, the experiences of using appraisal tools for clinical guidelines are used. Based on a deductive iterative process, clinical guideline appraisal instruments identified through literature search are reviewed, consolidated, and adapted to produce the final quality assessment framework for HEE quality appraisal instruments.
The final quality assessment framework for HEE quality appraisal instruments consists of 36 items organized within 7 dimensions, each of which captures a specific domain of quality. Applying the quality assessment framework to four existing HEE quality appraisal instruments, it is found that these four quality appraisal instruments are of variable quality.
The framework described in this study should be regarded as a starting point for appraising the quality of HEE quality appraisal instruments. This framework can be used by HEE quality appraisal instrument producers to support and improve the quality and acceptance of existing and future HEE quality appraisal instruments. By applying this framework, users of HEE quality appraisal instruments can become aware of methodological deficiencies inherent in existing HEE quality appraisal instruments. These shortcomings of existing HEE quality appraisal instruments are illustrated by the pilot test.
The optimal allocation of scarce resources for the production of health benefits to society requires best evidence of cost-effectiveness, and is relevant to any decision in health care. Health economic evaluations support the health care decision-making process by providing information on costs and consequences of health interventions. For example, the NHS Economic Evaluation Database currently contains over 11,000 quality assessed economic evaluations, the results of which are increasingly used for pricing and reimbursement decisions.
To be useful, health economic evaluation studies should be methodologically comparable, of high quality (e.g., in terms of transparency, quality of data sources, completeness of documentation), and relevant for the health care decision context. However, the quality of the conduct and reporting in such studies varies . Health economic evaluation studies are heterogeneous with respect to purposes, conceptual and measurement issues, and value judgments leading to problems with comparability and suboptimal delivery of care. To ensure the scientific quality of such studies, and to facilitate the comparison and transferability of economic evaluation results, methodological standards for health economic evaluations have been established . Besides the purposes of setting methodological and ethical standards, such standards are also used as a formal requirement prior to reimbursement .
There are different instruments to guide the quality assessment of health economic evaluations. Among these health economic evaluation (HEE) quality appraisal instruments, considerable agreement exists on the terminology of economic evaluation, the importance of considering alternatives, the need for specifying the analytical viewpoint, the superiority of incremental analysis, the principal need for discounting costs and benefits, and the importance of conducting a sensitivity analysis . Besides particular methodological issues such as inclusion of indirect costs or choice of discount rate, differences between these HEE quality appraisal instruments refer to the level of aggregation. For instance, the International Society for Pharmacoeconomics and Outcomes Research (ISPOR) has set up several task forces for specific elements of an economic evaluation, e.g., the ISPOR Task Force on Good Research Practices for Modeling Studies .
As methods of health economic evaluation mature over time, it is also important to appraise and monitor the quality of these HEE quality appraisal instruments which are used by researchers, journals, institutions and governments throughout the world to assess new health technologies and allocate resources. To date, tools for comparing, measuring, and improving the quality of HEE quality appraisal instruments have not been developed. Therefore, the objectives of this study are to: establish a framework for assessing the quality of HEE quality appraisal instruments in order to support and improve their quality; apply this quality assessment framework to those HEE quality appraisal instruments which have been subject to relatively more scrutiny than others, in order to test the framework and to demonstrate the shortcomings of existing HEE quality appraisal instruments.
Before developing a framework for quality assessment of HEE quality appraisal instruments, it might be prudent to review experiences regarding other applications of quality appraisal instruments. The obvious locus for such a review is appraisal tools for clinical guidelines.
To identify potentially relevant clinical guideline appraisal instruments, the following electronic databases were searched from inception to October 2010: PubMed, RePEc, and Web of Science. The literature search used the following search terms (including synonyms and closely related words): “clinical guidelines” combined with “appraisal”, “instrument”, and “quality”. Only publications in English, French, or German were considered. Further publications were retrieved by citation tracking, using the “related citations” function in PubMed and Web of Science, hand searching the journals “International Journal of Technology Assessment in Health Care”, “International Journal for Quality in Health Care”, and “Quality & Safety in Health Care” from 2000 to 2010, and searching relevant websites. A total of 14 relevant guideline appraisal instruments were retrieved by the search process (see Additional file 1), which are described in Table 1.
However, it was not intended to provide a systematic review of appraisal tools for clinical practice guideline evaluation. Therefore, the interested reader is referred to the reviews by Vlayen et al.  and Graham et al. , which were identified by the literature search on clinical guideline appraisal instruments and provide a detailed description and comparison of clinical practice guideline appraisal instruments. These systematic reviews were used to inform the framework development.
Based on a deductive iterative process, the clinical guideline appraisal instruments identified were reviewed, consolidated, and adapted. For this purpose, all questions/statements included in these instruments were listed to exclude double counting. For inclusion in the final framework, the questions/statements were required to have the following characteristics:
○ Generally and internationally accepted
○ Relevant to the realm of health economic evaluation
○ Distinguishable from other questions/statements (i.e., the questions/statements selected for final inclusion should overlap as little as possible)
The questions/statements identified by this method were thematically grouped to devise the final quality assessment framework for HEE quality appraisal instruments.
In order to test the framework and demonstrate the shortcomings of existing HEE quality appraisal instruments, the framework developed was applied to those HEE quality appraisal instruments which have been subject to relatively more scrutiny than others. Using a similar search process, HEE quality appraisal instruments were determined possibly relevant if they provided explicit criteria against which the quality of economic evaluations could be appraised. Because of regional, cultural, institutional, or political preferences and interests, country-specific guidelines were not considered for inclusion. Instruments assessing the transferability of health economic evaluations were also beyond the scope of this study.
Framework for quality assessment of HEE quality appraisal instruments
The framework consists of 36 items organized within 7 dimensions, each of which captures a specific domain of quality: Dimension A (“purpose and scope”, items A1-A5), Dimension B (“stakeholder involvement”, items B1-B3), Dimension C (“rigor of development process/validity”, items C1-C8c), Dimension D (“reliability/ reproducibility”, items D1-D4d), Dimension E (“clarity of presentation”, items E1-4), Dimension F (“applicability”, items F1-F5), Dimension G (“evaluation”, items G1-G2). The quality assessment framework is presented in Table 2.
Application of the quality assessment framework
To test the established framework and to demonstrate the shortcomings of existing HEE quality appraisal instruments, four well-known, often-cited, and widely-used HEE quality appraisal instruments, which have been subject to relatively more scrutiny than most others, were selected: the Quality of Health Economic Studies (QHES) instrument developed by Chiou et al. , the British Medical Journal (BMJ) guidelines for economic submissions established by Drummond and Jefferson on behalf of the BMJ Economic Evaluation Working Party , the Consensus on Health Economic Criteria (CHEC) list devised by Evers et al. , and the Good Practice Guidelines for Decision-Analytic Modeling accomplished by Philips et al. .
The BMJ list, the CHEC list, and the Philips list were chosen because they are recommended by the Cochrane Handbook for Systematic Reviews of Interventions  for critical appraisal of the methodological quality of health economic evaluation studies. In the chapter related to systematic reviews of economic evaluations, the Centre for Reviews and Dissemination’s guidance for undertaking reviews in health care  also refers to the BMJ list and the Philips list as instruments to assess the quality of economic evaluations. The QHES instrument was selected because it is an example of a quality scoring system which has been the subject of controversy in the literature.
As can be seen in Table 3, the BMJ list and the QHES instrument are broader and more comprehensive than the other two quality appraisal instruments: this is because the Philips list is solely designed for model-based economic evaluations and the CHEC list is only intended for undertaking systematic reviews of trial-based economic evaluations. In Table 4, the main characteristics of the HEE quality appraisal instruments are provided.
Pilot review of the quality assessment framework
The experiences of applying the quality assessment framework to the HEE quality appraisal instruments are presented in Table 5.
The quality dimension of “purpose and scope” (dimension A) is fulfilled by all HEE quality appraisal instruments, even though not all items are explicitly described. In terms of the quality dimension of “stakeholder involvement” (dimension B), only Evers et al. (CHEC list, ) do not declare whether they have any conflicts of interest. Furthermore, at none of the different HEE quality appraisal instrument development stages were all the key professionals (e.g., economists, clinicians, epidemiologists, and statisticians) involved. However, all the quality appraisal instruments used methods to ensure that the perspectives of the target audience informed the development process (e.g., by participation on the development group, or by external review of drafts of the appraisal instruments). The main differences in the quality of the four HEE quality appraisal instruments relate to the quality dimension of “rigor of development process/validity” (dimension C). Especially with the BMJ list, the different stages of the development process are not reported. Moreover, as methodology advances, the date for updating the appraisal instrument should be stated. Only Philips et al.  refer to the need for periodic updates, but when these should take place remains unclear. The lack of formal validity is one of the main limitations of all four quality appraisal instruments. Only the QHES instrument was formally validated in terms of construct validity . Other limitations refer to the quality dimension of “reliability/reproducibility” (dimension D). As mentioned before, the development process of the BMJ list is not documented. All four HEE quality appraisal instruments were published in peer-reviewed journals and, hence, external reviewers were involved in appraisal instrument development during the generic review process. However, in order to develop the BMJ list and the Philips list, additional external experts were convened to discuss drafts of these quality appraisal instruments. In addition, provided that external reviewers should not have been involved in developing the appraisal instrument, the QHES instrument and the CHEC list have not been externally reviewed before their publication (certainly, except for the review process). For the appraisal instrument to be effective with regard to reliability and reproducibility, it also needs to be piloted/pretested among the target audience. Only the QHES instrument was pretested among 60 experts in the field of health economics, who evaluated the methodological quality of three health economic analyses, first on a visual analog scale, and then using the grading system. In respect of the quality dimension of “clarity of presentation” (dimension E), the appraisal instruments established by Philips et al.  and the grading system developed by Chiou et al. (QHES instrument, ) do not provide specific and unambiguous items in those cases where more than one question refers to the same criterion, resulting in ambivalent assessments. Additionally, on account of the rather technical nature of the questions provided by Philips et al. , these are only suitable for specialist readers with expertise in the field of decision-analytic modelling and with knowledge of the disease area. Philips et al.  state that without that knowledge, it is a complex matter to decide whether all structural assumptions are justified, or whether all feasible and practical options have been evaluated. Further, because of the problem with the interpretation of the term “justified” or “appropriate”, it might be difficult to use these four quality appraisal instruments in a straightforward manner. Some items/questions are highly dependent on the judgment of the respective user and thus have an unavoidable element of subjectivity. For example, based on a comparison of three instruments for appraising the quality of health economic evaluations (BMJ list, CHEC list, and QHES instrument) Gerkens et al.  found that the reviewer has a greater influence on the results of the quality assessment than the appraisal instrument itself. Another problem within this dimension concerns the operationalization of the questions. Chiou et al. (QHES instrument, ) and Evers et al. (CHEC list, ) provide questions in a yes/no format, but in specific circumstances some questions may not be applicable to the study context. Because of the weighting of the criteria, only the key items of the QHES instrument can be easily identified. Regarding the quality dimension of “applicability” (dimension F), all appraisal instruments provide a standard reporting format and present items of methodological quality and transparency. All but the QHES instrument give detailed assessment instructions (to a greater or lesser extent) and all appraisal instruments except for the BMJ list specify their strengths and limitations. The QHES instrument is the only quality appraisal instrument to use a quality score. Concerning the quality dimension of “evaluation” (dimension G), all but the QHES instrument describe the evaluation methods. However, none of the instruments describes the extent of adherence by the target audience.
At present, there is no common instrument for measuring and improving the quality of HEE quality appraisal instruments. A quality assessment framework for HEE quality appraisal instruments was developed to support and improve their quality. It permits not only the assessment of their quality but also the recognition of the most urgent adjustments needed to improve their quality. Applying the quality assessment framework to four existing HEE quality appraisal instruments, it was found that these quality appraisal instruments are of variable quality.
Moreover, the HEE quality appraisal instruments have other limitations. The CHEC list established by Evers et al.  consists of a minimum set of items and is intended only for full economic evaluations based on clinical trials. In order to appraise the overall methodological quality of trial-based economic evaluations, the authors point out that their list should be used in combination with existing instruments for assessing the quality of clinical trials . In systematic reviews including trial-based and model-based economic evaluations, the CHEC list should be combined with issues relevant to modelling studies such as structural assumptions. Therefore, in a systematic review , the appraisal instruments developed by Philips et al.  were used as a complement to the CHEC list. Another limitation concerns the items included in the CHEC list. As these items should deliver insight into the quality of economic evaluation studies, most of them are rather subjective, which is a challenge for the inter-rater reliability . However, formularies and HTAs would in fact need some flexibility to make their own best decisions for their patients. The subjective judgment generally inherent in quality assessment is a particularly fundamental problem for the Philips guidelines . Additionally, because of the combination of transparency and quality aspects in the same question, the Philips guidelines produce ambivalent quality assessments. By contrast, other research groups provide quality appraisal instruments that differentiate between these two issues . Furthermore, because of the scope of the Philips list, it should be used in conjunction with more general quality assessment instruments for health economic evaluation (e.g., the BMJ list) . The quality appraisal instrument devised by Philips et al.  include dimensions of methodological quality corresponding to rationales for structure, structural assumptions, disease states/pathways, cycle length, and internal consistency. This is due to the fact that this HEE quality appraisal instrument is specific for decision-analytic models, and, thus, has a more technical character than the other three HEE quality appraisal instruments. Therefore, the Philips list does not highlight the importance of discounting, the superiority of incremental analysis, and the measurement and valuation of costs. However, in their version published in 2004, Philips et al.  point out that “costing and discounting methods should accord with standard guidelines for economic evaluation”. Due to limitations in reporting, the quality of the BMJ list in particular was difficult to assess. In contrast to the other three quality appraisal instruments, the QHES instrument provides a grading system, but the advantage of scoring methods is questionable.
To date, relatively little empirical research has been undertaken in order to investigate the influence of decisions to include only economic evaluations of high quality on the results of a critical assessment of health economic evaluations. However, such lessons can be obtained from the experiences made with quality scores for clinical studies. Using 25 different quality assessment scales to identify high-quality clinical trials, Jüni et al.  show that the conclusions of meta-analytic studies of randomized clinical trials might be affected by the type of quality assessment scale used. They consider the use of grading systems to be problematic, and thus they recommend that relevant methodological issues should be appraised individually. In a review, Moher et al.  use the same 25 scales to show differences in scale development. As these differences can result in important differences in quality assessment, they recommend that meta-analyses of randomized clinical trials should be undertaken with and without assessing quality. Based on these experiences, it is not recommended to select economic evaluations on the basis of their quality scores, as proposed by Chiou et al. (QHES instrument, . In general, a corresponding NHS EED structured abstract  consisting of “subject of study”, “key elements of study”, “details about clinical evidence”, “economic analysis”, “results”, “critical commentary”, “implications”, and “other publications of related interest” might enhance quality assessment of all types of full health economic evaluation informed by HEE quality appraisal instruments, because these abstracts provide critical appraisal of methodological quality on the basis of the same quality dimensions as included in the quality appraisal instruments . In their study, Thurston et al.  found that decision-makers in health care need an initial screen of economic evaluation results provided by a critical descriptive summary or a score, plus a short abstract to gather more information on the quality and relevance of economic evaluation results. However, how to condense information provided by critical appraisal of methodological quality is an unresolved issue which requires further research.
The framework described in this study should be regarded as a starting point for assessing the quality of HEE quality appraisal instruments. This framework can be used by quality appraisal instrument producers to support and improve the quality and acceptance of existing and future HEE quality appraisal instruments. By applying this framework, users of HEE quality appraisal instruments can become aware of methodological deficiencies inherent in existing quality appraisal instruments, as illustrated by the pilot test. As the development of HEE quality appraisal instruments is a dynamic and interactive process, and as methodology advances, a continual update of existing quality appraisal instruments is needed.
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The author is grateful to Prof. Dr. Reiner Leidl for valuable comments on earlier versions of this paper.
The author declares that she has no competing interests.
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Additional file 1: Flow chart for study selection for clinical practice guideline evaluation. Flow chart showing the records identified through database searching and other sources during the literature search for clinical practice guideline evaluation. (DOC 27 KB)
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Langer, A. A framework for assessing Health Economic Evaluation (HEE) quality appraisal instruments. BMC Health Serv Res 12, 253 (2012). https://doi.org/10.1186/1472-6963-12-253
- Economic Evaluation
- Methodological Quality
- Quality Dimension
- Health Economic Evaluation
- Appraisal Tool