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The Effect of Using Assessment Instruments on Substance-abuse Outpatients' Adherence to Treatment: a Multi-centre Randomised Controlled Trial
© Raes et al; licensee BioMed Central Ltd. 2011
Received: 10 December 2010
Accepted: 25 May 2011
Published: 25 May 2011
Drop-out is an important problem in the treatment of substance use disorder. The focus of this study was to investigate the effectiveness of within treatment assessment with feedback directly to patients with multiple substance use disorder on outpatient individual treatment adherence. Feedback consisted of personal resources' and readiness to change status and progress that facilitate or hinder change, thereby using graphical representation.
Informed consent was obtained from both the control and experimental groups to be involved in research and follow-up. Following Zelen's single consent design, baseline participants (n = 280) were randomised (sample-size-estimation: 80%power, p=.05, 2-sided) and treatment consent was obtained from those allocated to the experiment (n = 142). In both groups, equal numbers of patients did not attend sessions after allocation. So, 227 persons were analyzed according to intention-to-treat analysis (ITT: experiment n = 116;control n = 111). Excluding refusals 211 participants remained for per-protocol analysis (PP: experiment n = 100; control n = 111), The study was conducted in five outpatient treatment-centres of a large network (De Sleutel) in Belgium. Participants were people with multiple substance use disorder -abuse and dependence- who had asked for treatment and who had been advised to start individual treatment after a standardised admission assessment with the European Addiction Severity Index.
The experimental condition consisted of informing the patient about the intervention and of subsequent assessments plus feedback following a protocol within the first seven sessions. Assessments were made with the Readiness to Change Questionnaire and the Personal Resources Diagnostic System. The control group received the usual treatment without within treatment assessment with feedback. The most important outcome measure in this analysis of the study was the level of adherence to treatment at and beyond eight sessions.
Individual treatment that included assessment with feedback increased adherence to treatment at and beyond eight sessions (RR = 1.6,95%CI:1.2-2.2). Benefit was also found at and beyond twelve sessions, which was the number of sessions required to complete 90% of the assessments with feedback in practice (RR = 1.6,95%CI:1.2-2.5).
Assessment with feedback in routine practice improved adherence to treatment. More research is needed to evaluate progress in social functioning and motivation to change in outpatient treatment of substance use disorder, thereby using objective measures
Current Controlled Trials ISRCTN65456186
Drop-out is an important problem in the treatment of people with multiple substance use disorder. There is growing agreement for substance abuse and dependence, being a chronic and relapsing condition [1–3]. The effectiveness of treatment to stabilize or overcome a chronic condition is strongly related to treatment compliance . Among alcohol-dependent people, diabetics or persons with hypertension it is common to find a compliance rate below 50% .
In a therapeutic community environment for drug addicted people, evidence has been found that family-[5, 6], social network- [7, 8], and staff-involvement [9, 10], improve retention levels. In the broader area of health care, patient-based measures in routine practice combined with feedback were found to improve significantly the process and outcome of patient care . In mental healthcare, feedback to clinicians about patients' progress based on routine outcome monitoring affected outcome and even the number of sessions in psychological interventions [12, 13].
In the realm of outpatient treatment of substance use disorder, compliance is also associated with session attendance a/o adherence to treatment. Regular treatment often relies on assessment, but outside its use in planning, monitoring, and evaluating interventions, assessment and feedback as part of the treatment itself and its positive effect on patient adherence is under-investigated. Kypri et al. focused on this issue, related to contamination of clinical trials , and found that routine screening and minimal assessment themselves may produce some benefit . In line with the studies based on routine outcome monitoring in psychotherapy [12, 16], Hawkins et al.  developed a similar approach in the treatment of substance use disorder. Their focus was on feedback to clinicians about lack of progress in order to reduce the risk of patient drop-out.
In this study, assessment and feedback is introduced as part of the treatment process itself. It is aimed to offer opportunities to support counselling by establishing a collaborative relationship and a patient-centred focus [18, 19]. This therapeutic method of assessment  seeks to integrate key features of therapeutic alliance between clinician and patient in assessment and feedback sessions. Feedback is given to the patient each time at the next session after assessment. It consists of communicating the status of substance use, readiness to change, and personal resources that may facilitate or hinder change. Repeated assessment and graphical representation is considered to provide opportunities for feeding back of progress, treatment recommendation, and further action. It is also providing the patient with new ways of thinking and feelings about self and others.
This study addresses the question whether continuing rounds of assessment with personal feedback to patients that replace a number of regular outpatient sessions in the treatment of people with multiple substance use disorder, improves adherence, compared to an outpatient approach without such within treatment assessment and feedback. It is the most important aim of this study to investigate the effectiveness of within treatment assessment and personal feedback to patients on outpatients' adherence to treatment. The reporting follows the CONSORT-guidelines [21–23].
In an attempt to determine whether enhanced adherence could be demonstrated by the introduction of within treatment assessment and personal feedback in outpatient treatment of substance use disorder, we set up an experimental study. This study was a multi-centre randomised controlled trial registered in the ISRCTN-database (ISRCTN65456186). It was embedded within an already existing system to ask informed consent to all patients for the use of admission assessment and treatment data for research purposes, and for follow-up. To minimize problems associated with the clinicians' resistance to enter patients into a clinical trial, Zelen's single consent design was chosen [24–26]. The key characteristic of this method is that participants were randomised and treatment consent was obtained from participants who were allocated to the experimental intervention, while controls did not receive the experimental treatment but get the best usual care. In such an open trial, statistical power can be affected by a high proportion of participants getting usual care. Therefore, Adamson et al.  advised performing sample-size-estimation before the start of the project and an intention-to-treat analysis.
Setting and Participants
All persons who entered one of the five outpatient drug-treatment centres of the treatment network 'De Sleutel' in Belgium between March 2007 and March 2009 were candidates for inclusion in the study. Based upon yearly reports, patient characteristics in the five centres were assumed to be very comparable. To be taken in charge for treatment in one of these centres, patients should be diagnosed DSM IV substance abuse or dependence for at least one substance, exclusive single alcohol abuse or dependence. The inclusion criteria for the trial were that the patient: (1) gave informed consent about the use of data and being contacted for follow-up, (2) sufficiently understood the Dutch language, (3) passed the full admission assessment, consisting of at least a first contact session, the EuropASI-interview and a feedback session, and (4) was advised to start individual treatment. The study was approved by the Central Ethics Board for the Mental Health Sector of the n.p.o. Provincialat of the Brothers of Charity (ref. OG054-2006-19).
EuropASI and feedback form
Admission assessment was based upon the European version of the Addiction Severity Index (EuropASI) . The Dutch version of EuropASI (Cronbach's alphas > =.70, except for employment status) , adapted for Flanders, was used. This semi-structured interview offers an inventory of problems in seven potential problem areas (physical health, education-work-income, alcohol use, drug use, judicial, relations, psycho-emotional). The information from ASI is synthesized on a two-sided feedback form, placing positive aspects of the patient's experience against the problems in each life area. The feedback form helps clinicians to communicate findings from EuropASI with the patient and to suggest and support treatment options .
Readiness to Change Questionnaire (RCQ)
The RCQ was used for within treatment assessment and feedback. Originally, the RCQ was a self-rating questionnaire  used to assess the first three stages of change, which are pre-contemplation, contemplation and action. The Dutch version of this instrument  has been adapted for poly-drug abusers. For each substance separately, being in action could be distinguished from not being in action (Cronbach's alphas > = .70, except for pre-contemplation) . Feedback was based on the principles from the trans-theoretic model approach. For each substance that was used in the last 30 days, the clinician commented on whether the person was in pre-, contemplation or in action. The information about stage of change was further elaborated, making use of the number and type of used substances, and the number of use-days.
Personal Resources Diagnostic system (PREDI)
Two scales were used within treatment from PREDI , originally a German instrument consisting of three scales: personal resources and wish to change. The personal resources scale provided the appreciation of both the clinician and the patient, the wish to change scale only the patient's appreciation in 16 important life-areas, which were: every day life situation, living situation, financial situation, legal situation, work situation, health status, health behaviour, substance use, self-esteem, self-realization, self-control, contact with reality, partner relation, family relations, social relations, social cultural situation. It was translated into Dutch, using common rules for cross-cultural adaptations of health measurements . Preliminary to this study, the system was validated in a small sample of patients with substance use disorder (personal resources' Cronbach's alpha=.81; wish to change's Cronbach's alpha=.83) . Feedback consisted of the synthesis of a patient's particular personal resources and a focus on the life areas where the person clearly indicated a wish to change.
The trial was presented in the centres during the first quarter of 2007. Clinicians were mainly social, educational, and/or psychological workers or psycho-therapists. Their basic training was completed with EuropASI-assessment and feedback, and with motivational interviewing. They had at least one year of training or experience. Inspired by Del Boca & Darkes' guidelines  for enhancing validity and utility of randomised controlled trials, a manual was devised that included a training DVD for the experimental sessions. Extra training for supplementary assessment (RCQ and PREDI) with feedback took place in the centres between April and June 2007.
The admission assessment was similar in all centres for all patients. This study focused on the individual treatment after admission, where the treatment length usually was open-ended. Regular treatment consisted of non-manualized individual counselling sessions of about one hour, principally aimed at changes in drug-use behaviour. The expected treatment duration, number or intensity of counselling sessions were defined only by the clinicians' subjective judgment about progress towards goals and life changes, although such progress was not measured objectively.
Scheduling of planned assessment and feedback sessions
experimental group planned assessment and feedback
information plus consent
First Readiness to Change Questionnaire (RCQ)
First RCQ (1)
Feedback on first RCQ
Personal Resources Diagnostic system (PREDI), part one
PREDI, part two
Feedback on PREDI
Second RCQ (± 30 days after first RCQ)
Feedback on second RCQ
Unlike those in the control group, people in the experimental group were informed in the first session about further sessions dealing with continued assessment and feedback and asked for consent. During session three (Table 1), the clinician provided the patient with feedback on RCQ using the trans-theoretic model, graphical representation of change and worksheets . For feedback on PREDI a standardised form was used that showed a time-schedule and the personal resources on which to focus further actions. Planning for repeated measurement with feedback using the same instruments was left to the clinicians, with about 30 days in between as a guideline. The researcher closely followed up the clinicians' adherence to the manual.
Data-collection on patients' attendance at counselling sessions was part of the routine-administration in the central database of the De Sleutel-network. The start and end date as well as the clinicians' evaluation at the end of the whole treatment was also documented, but the most important outcome measure in this study was the adherence to individual counselling treatment. Adherence was measured by counting the total number of sessions between the date of the first session after admission and the last session date. Therefore, the initial assessment sessions being part of the admission assessment did not count towards sessions in the outcome measure. Since the first five trial related assessment and feedback sessions in the experimental group take approximately seven sessions (Table 1), completing at least eight individual counselling sessions after admission was set as a first outcome measure. In reality, however, 90% of the assessment and feedback activities took place within the first twelve sessions, so completion of at least twelve sessions was set as a second outcome measure.
Sample size and power
Randomisation and enrolment
The researcher distributed five closed envelopes to each outpatient centre each month - two experimental/three controls or three experimental/two controls. Each of the closed envelopes was assigned to an eligible patient by the clinical supervisor, and only after the assignment was made the envelope was opened to determine whether the patient was assigned to the control group or the experimental group. The researcher evaluated monthly the enrolment process and confirmed whether the patients assigned met or did not meet all eligibility criteria.
320 patients were assessed for eligibility, of which 40 were excluded because they did not meet the inclusion criteria, so at baseline 280 persons were randomly assigned to the experimental group (n = 142) and to the control group (n = 138) (Figure 1). 26 eligible patients assigned to the experimental group and 27 patients assigned to the control group and being referred to individual treatment did not attend any sessions after admission assessment. They were excluded from further analyses. Thus, the intention-to-treat analysis is based on 116 patients in the experimental group and 111 patients in the control group. Of them who attended their first individual counselling session, 16 patients in the experimental group refused participation and were excluded for per-protocol analysis.
The Pearson Chi-square test and the independent samples T-test were used to test for differences in patient characteristics between both allocations at baseline. A p-value of .05 or less was considered to indicate statistical significance. The outcome measure was adherence to treatment at and beyond eight and twelve sessions. Risk-ratios (RR) with accompanying 95% confidence intervals were calculated to evaluate adherence to the individual treatment that included psychological assessment and feedback. In this study, the word "risk" referred to a desired effect. Risk ratios of 1 indicate a null-finding, while 95% confidence intervals (CI) should not include 1 to be statistically significant. Risk ratios > 1 are indicating enhanced likelihood of the desired effect. All analyses were performed using SPSS for Windows (release 16.0).
Baseline characteristics by allocation
Sample characteristics at baseline by allocation
Experimental (n = 142)
Control (n = 138)
Pearson Chi2 or T-value
Mean age ± SD,y
27.4 ± 7.1
26.9 ± 6.6
Men, n (%)
Country of birth, n (%)
Relationship, n (%)
Never been Married
Living situation, n(%)
Partner & children
Partner no children
Educational level, n (%)
< = vocational until 2nd degree
Vocational & 3rd or 4th degree
Employment status, n (%)
Employed full-time or part-time
Other or missing
Primary substance, n (%)
Mean years of drug use ± SD
4.6 ± 5.0
3.3 ± 3.1
8.0 ± 5.8
7.9 ± 5.4
3.1 ± 3.7
3.1 ± 3.7
3.8 ± 4.1
3.0 ± 2.3
Mean n of drugs ever used ± SD
3.9 ± 2.0
3.7 ± 1.9
Mean n of treatments drugs ± SD
1.0 ± 1.3
0.9 ± 1.3
EASI-severity > = 4, n (%)
Education, Work, Income
Mean EASI Severity Indexes ± SD
2.0 ± 1.6
1.9 ± 1.6
Education, Work, Income
2.5 ± 1.5
2.5 ± 1.8
2.3 ± 1.7
2.2 ± 1.9
5.0 ± 1.1
4.6 ± 1.1
2.4 ± 1.7
2.4 ± 2.0
3.8 ± 1.5
3.6 ± 1.6
3.5 ± 1.8
3.4 ± 1.9
Adherence to treatment
The primary outcome measure for this study was treatment adherence at and beyond eight sessions. The results confirmed enhanced likelihood of this desired effect in patients allocated to the experimental condition.
Adherence at and beyond eight and twelve sessions in intention-to-treat and per-protocol analysis
> = 8 sessions
> = 12 sessions
Intention-to-treat (n = 227)
Risk ratio (RR)
Per-protocol (n = 211)
Risk ratio (RR)
A second outcome measure was also set for adherence to treatment at and beyond twelve sessions. Yet, 90% of the assessment and feedback sessions (Table 1) took place within the first twelve sessions. In intention-to-treat analysis, the results showed again statistically significant improved adherence at and beyond twelve sessions, where continued assessment and feedback took place (RR = 1.6, 95%CI:1.0-2.5, n = 227). In per-protocol analysis, the results even showed 70% more persons that adhered to individual treatment for at least twelve sessions (RR = 1.7, 95%CI:1.1-2.7, n = 211).
Adherence in addiction treatment and studies is an important issue . The results indicate that counselling sessions which included assessment with feedback directly to patients increased adherence to outpatient session-based treatment of substance use disorder, compared to an approach without assessment with feedback. Our results can be compared with findings in general health care  and in psychotherapy , although not 1:1. The nature of this trial was different in several aspects: (1) structuring treatment and continuing assessment was part of the intervention itself; (2) the trial - a non-medical intervention - was conducted in a population with multiple substance use disorder, where drop-out with low adherence and attendance rates are common , and (3) the design provided the inclusion of experienced therapists themselves to realise the intervention.
As a consequence, this study had limitations. Conducting a well-structured randomized controlled trial in a natural setting, where no manuals or protocols are used, does limit the conditions in the control group, because of possible contamination [15, 14]. To keep the design pure, further structuring and assessments in the control group were not designated. Therefore, the primary outcome measure was limited to adherence at and beyond eight sessions and no other outcome measures were included. Studies in psychotherapy have found that 25% of patients reach clinically significant change in subjective discomfort, interpersonal relationships and social role functioning after five sessions, 50% reach clinically significant change after nine sessions, and 75% do so after 17 sessions . In this study, most of the benefit was expected next to the first seven sessions, during which patients in the experiment were exposed to the assessment with feedback sessions. Application of a cut-point at twelve sessions also showed significant differences between the control group and the experimental group.
The strengths of this trial included its being built upon an already existing monitoring system, the use of well evaluated instruments and that it is associated with the real-world context where the intervention took place. Other than establishing protocols and providing a manual and continued training and supervision, the researcher had no influence on common processes in each centre in terms of managing capacity limitations on the unpredictable behaviour of patients. In all likelihood, the realised randomization and the participation level in a natural setting was the highest that could be reached in a trial where the trial's focus itself could lead to an increased workload without the benefit of additional clinical staff . Moreover, the intervention took place within a real clinician-patient relationship, where good communication should consist of both instrumental (here, the trial intervention), and affective behaviours. Both elements, although unfavourable to meeting the internal validity benchmark, certainly enhanced external validity, and thus contributed to contextual evidence, favouring the probability of adoption in clinical settings [44, 45]. The results may also have significance in the broader area of health care, where low compliance rates are of concern in case of preventive advice and/or chronic conditions to cope with.
The use of assessment instruments with feedback directly to patients provided evidence to enhance adherence in routine practice in the treatment of substance use disorder. This finding may inspire the broader field of health care, especially in the care of chronic conditions and mental health to further elaborate continued measurement and outcome-feedback in daily practice. More research is needed to evaluate progress in social functioning and motivation to change in the treatment of substance use disorder, thereby using objective measures.
Acknowledgements and Funding
The project was conducted with financial support of De Sleutel, n.p.o. Provincialat of the Brothers of Charity and the Department of Family Medicine and Primary Health Care of Ghent University. Scientific supervision was provided by the co-authors. The study received ethical approval OG054-2006-19. The authors wish to thank staff, patients and management of De Sleutel, who made it possible to conduct this project in the centres. A special thanks goes also to Lieve Coudeville for her support with the database. The participating centres and their management had no further role in the conduct or interpretation of this study.
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