Table 4 Fixed effects estimates for patient-reported outcome measures

Pain

 Intensity

  Time 1^a

-.132 ± .122

.281

-.372

.107

-.103

  Time 2^b

.109 ± 0.153

.477

-.191

.409

.092

  EVP Dose

-.018 ± .010

.075

-.039

.002

 Interference

  Time 1

-.864 ± .439

.050

-1.724

-.004

-.256

  Time 2

-.447 ± .561

.427

-1.546

.653

-.102

  EVP Dose

-.034 ± .035

.335

-.101

.034

 Catastrophizing

  Time 1

-1.009 ± .275

 < .001^*

-1.548

-.470

-.345

  Time 2

-.686 ± .434

.116

-1.536

.165

-.204

  EVP Dose

-.036 ± .020

.083

-.076

.004

 Kinesiophobia

  Time 1

-.204 ± .332

.538

-.854

.446

-.059

  Time 2

-.455 ± .462

.326

-1.360

.451

-.127

  EVP Dose

.008 ± .023

.734

-.037

.052

Physical

 Physical Function

  Time 1

-.690 ± .256

.009^*

-1.199

-.180

-.249

  Time 2

-.262 ± .398

.511

-1.042

.518

-.086

  EVP Dose

-.027 ± .024

.261

-.074

.020

 Sleep Disturbance

  Time 1

.103 ± .140

.464

-.172

.377

.070

  Time 2

-.189 ± .140

.178

-.462

.085

-.171

  EVP Dose

-.007 ± .007

.340

-.021

.007

Psychological

 Anxiety

  Time 1

-.446 ± .167

.008^*

-.773

-0.118

-.256

  Time 2

-.273 ± .246

.269

-.756

0.210

-.143

  EVP Dose

-.021 ± .013

.116

-.047

0.005

 Depression

  Time 1

-.534 ± .173

.002^*

-.872

-0.196

-.296

  Time 2

-.322 ± .235

.172

-.783

0.139

-.175

  EVP Dose

-.013 ± .013

.313

-.038

0.012

 Motivation

  Time 1

-.465 ± .308

.133

-1.069

0.139

-.146

  Time 2

.019 ± .343

.752

-.564

0.782

.042

  EVP Dose

-.013 ± .017

.451

-.021

0.046

 Self-Efficacy

  Time 1

.138 ± .327

.673

-.503

0.779

.041

  Time 2

.019 ± .399

.962

-.762

0.801

.007

  EVP Dose

.048 ± .019

.103

.012

0.085

Acceptance

 Activity Engagement

  Time 1

1.977 ± .524

 < .001^*

.950

3.004

.364

  Time 2

1.915 ± .658

 < .001^*

.626

3.204

.376

  EVP Dose

-.034 ± .039

.378

-.110

0.042

 Pain Willingness

  Time 1

-1.041 ± .749

.032

-1.985

-0.098

-.209

  Time 2

-.400 ± .481

.413

-1.355

0.556

-.106

  EVP Dose

-.061 ± .030

.047

-.120

-0.001

Social

 Social Isolation

  Time 1

-.850 ± .438

.054

-1.707

0.008

-.183

  Time 2

-.421 ± .558

.452

-1.515

0.674

-.096

  EVP Dose

-.052 ± .034

.134

-.119

0.016