Cost of implementing CAR-T activity and managing CAR-T patients: an exploratory study

Table 3 Mean and total cost of the CAR-T clinical pathway

Mean cost of CAR-T clinical pathway		Activities which are not remunerated through a fee-for-service/episode		Activities which are remunerated through a fee-for-service/episode	Total mean cost	Total costs
Mean cost of CAR-T clinical pathway		General activities*	Activities provided to individual patients
IRCCS AOU BO Orsola	Patients alive at follow-up (four months) (21 patients)	€ 1,334	€ 1,884	€ 92,815	€ 96,033	€ 2,837,511
	Patients alive at follow-up (four months) (21 patients)	1.4%	2.0%	96.6%	100.0%
	Patients considered eligible by the referral centre (59 patients)	€ 1,334	€ 1,884	€ 44,876	€ 48,093
		2.8%	3.9%	93.3%	100.0%
AOU Careggi	Patients alive at follow-up (one year) (5 patients)	€ 20,181	€ 3,928	€ 81,952	€ 106,061	€ 1,542,023
	Patients alive at follow-up (one year) (5 patients)	19.0%	3.7%	77.3%	100.0%
	Patients considered eligible by the referral centre (27 patients)	€ 20,181	€ 3,928	€ 33,003	€ 57,112
		35.3%	6.9%	57.8%	100.0%

*Coordination / SOP, Protocols and Check list updates / Quality Assurance, Audits
Source: Primary data (interviews with the CAR-T coordinators) and secondary data (e.g. personnel costs, fee-for-episode and service) collected at the IRCCS AOU BO Orsola and AOU Careggi

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