Outpatient visits before and after Lyme disease diagnosis in a Maryland employer-based health plan

Rebman, Alison W.; Yang, Ting; Wang, Lin; Marsteller, Jill A.; Murphy, Shannon M. E.; Uriyo, Maria; Aucott, John N.

doi:10.1186/s12913-023-09909-3

BMC Health Services Research

Table 2 Generalized linear mixed effects regression models with number of all Lyme disease-relevant outpatient care visits as the outcome. Models were run on the overall sample [1], as well as on adult [2] and children [3] strata only. Additional models [4, 5, and 6] were run with a gender and Lyme disease diagnosis period (pre vs. post) interaction term included

From: Outpatient visits before and after Lyme disease diagnosis in a Maryland employer-based health plan

	Overall Sample N^a=317		Children Only N = 70^b		Adults Only N = 247^b
Models with no interaction terms	Model 1		Model 2		Model 3
	RR ^c	p -value	RR	p -value	RR	p -value
Pre-Lyme disease diagnosis period	REF	REF	REF	REF	REF	REF
Post-Lyme disease diagnosis period	1.26 [1.18, 1.36]	< 0.001	1.17 [0.99, 1.38]	0.068	1.31 [1.21, 1.42]	< 0.001
Men	REF	REF	REF	REF	REF	REF
Women	1.34 [1.05, 1.70]	0.016	0.95 [0.66, 1.35]	0.764	1.44 [1.08, 1.92]	0.013
Age (10 years)	1.09 [1.02, 1.16]	0.007	0.70 [0.48, 1.02]	0.060	1.13 [1.01, 1.25]	0.029
Winter	REF	REF	REF	REF	REF	REF
Spring	1.08 [0.99, 1.19]	0.080	1.19 [0.97, 1.46]	0.099	1.07 [0.96, 1.18]	0.214
Summer	1.15 [1.05, 1.26]	0.002	1.03 [0.83, 1.28]	0.781	1.18 [1.06, 1.30]	0.002
Fall	1.06 [0.97, 1.16]	0.191	1.31 [1.07, 1.61]	0.008	1.01 [0.91, 1.12]	0.877
Models with a gender interaction term	Model 4		Model 5		Model 6
	RR	p -value	RR	p -value	RR	p -value
Pre-Lyme disease diagnosis period	REF	REF	REF	REF	REF	REF
Post-Lyme disease diagnosis period	1.14 [1.02, 1.27]	0.017	1.27 [1.03, 1.55]	0.023	1.13 [0.99, 1.28]	0.068
Men	REF	REF	REF	REF	REF	REF
Women	1.22 [0.95, 1.56]	0.118	1.06 [0.71, 1.56]	0.783	1.27 [0.94, 1.71]	0.119
Women: Post-Lyme disease diagnosis period (interaction)	1.20 [1.04, 1.38]	0.013	0.80 [0.58, 1.10]	0.169	1.27 [1.08, 1.49]	0.004
Age (10 years)	1.09 [1.02, 1.16]	0.006	0.69 [0.47, 1.01]	0.055	1.13 [1.01, 1.25]	0.026
Winter	REF	REF	REF	REF	REF	REF
Spring	1.08 [0.99, 1.19]	0.085	1.19 [0.97, 1.46]	0.097	1.06 [0.96, 1.18]	0.228
Summer	1.15 [1.05, 1.26]	0.002	1.03 [0.83, 1.28]	0.769	1.18 [1.06, 1.30]	0.002
Fall	1.06 [0.97, 1.16]	0.195	1.31 [1.08, 1.61]	0.008	1.01 [0.91, 1.12]	0.879

^aN Number of unique members
^bFor multi-variate analyses, we defined adult status based on age at the last available month of data to keep adult status unique for each member. Therefore, the numbers of children and adults do not exactly match Table 1, in which adult status was defined based on age at the time of Lyme disease diagnosis; there were 5 members who were < 18 years of age (children) at the time of Lyme disease diagnosis who were subsequently ≥ 18 years of age (adults) when they contributed their last month of data
^cRR rate ratio. All but the interaction terms are rate ratios. The interaction terms in Models 4, 5, and 6 are ratios of rate ratios

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ISSN: 1472-6963

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