Cost of exome analysis in patients with intellectual disability: a micro-costing study in a French setting

Table 1 Unit cost (€) per ES diagnostic test for ID

Resources	- 1 - Preparation of the pre-analytical step	- 2 - Pre-analytical step	- 3 - Analytical step			- 4 - Bioinformatics step	- 5 - Biological step	Total
			a.Sample preparation	b. Production	c. Quality control and primary bioinformatics analysis
Disposable materials and reagents	€ 0.80	€ 15.59	€ 8.52	€ 515.67	-	-	-	€ 540.58
Reusable materials	-	€ 0.35	€ 0.01	€ 0.22	-	-	-	€ 0.59
Equipment	-	€ 3.42	€ 0.91	€ 44.52	€ 30.17	€ 3.15	-	€ 82.18
Maintenance	-	€ 0.72	€ 0.65	€ 21.79	-	€ 16.69	-	€ 39.86
Labor	€ 29.21	€ 47.30^b	€ 166.13	€ 643.55	€ 57.74	€ 10.35	€ 69.71^b	€ 1,023.99
Overheads^a	€ 6.00	€ 13.33	€ 35.12	€ 240.79	€ 17.58	€ 5.41	€ 13.94	€ 332.18
Total	€ 36.00	€ 80.72	€ 211.35	€ 1,466.56	€ 105.50	€ 35.60	€ 83.65	€ 2,019.39

^aOverheads (20% rate) applied on all resources of steps 1,2,3 and 5 excepted the maintenance. At step 4, overheads were applied on a part of equipment cost (€0.03 over the €3,15, corresponding to computer cost) and on the totality of the maintenance because it is realized by an bioinformatics engineer
^bLabor cost for the pre-analytical step was estimated from the time spent by two biological technicians separately during a typical working day to analyze 5 index cases each, allowing the calculation of an average cost. Concerning the biological step, the cost of labor was estimated from the mean time mobilized for interpretation of data, the preparation of the meeting, the presentation and the discussion

ISSN: 1472-6963