Table 1 The manufacturer information for drugs with a frequency ≥ 5 in the provincial lists of drug shortages in China, 2018–2021
Ranking | Name | Dosage form | Frequency in the provincial shortage lists* | Number of API manufacturers | Number of drug manufacturers | Whether in the national list of drug shortages |
|---|---|---|---|---|---|---|
1 | Methotrexate | Injection | 26 | 5 | 12 | YES |
2 | Vitamin K | Injection | 22 | 4 | 20 | YES |
3 | Posterior pituitary | Injection | 21 | 2 | 2 | YES |
4 | Urokinase | Injection | 21 | 2 | 8 | YES |
5 | Protamine | Injection | 21 | 5 | 29 | YES |
6 | Atropine | Injection | 20 | 3 | 84 | YES |
7 | Lobeline | Injection | 19 | 0 | 10 | YES |
8 | Bleomycin | Injection | 18 | 2 | 3 | YES |
9 | Deslanoside | Injection | 18 | 1 | 2 | YES |
10 | Nikethamide | Injection | 17 | 5 | 5 | YES |
11 | Nitroglycerin | Injection | 17 | 2 | 3 | YES |
12 | Neostigmine | Injection | 17 | 2 | 28 | YES |
13 | Pyridostigmine Bromide | Tablet | 17 | 7 | 6 | YES |
14 | Nitroglycerin | Tablet | 17 | 7 | 13 | YES |
15 | Ethacridine | Injection | 17 | 2 | 5 | YES |
16 | Noradrenaline/Norepinephrine | Injection | 16 | 2 | 7 | YES |
17 | Isoprenaline | Injection | 16 | 1 | 3 | YES |
18 | Cytarabine | Injection | 15 | 3 | 8 | YES |
19 | Allopurinol | Tablet | 15 | 2 | 21 | YES |
20 | Calcium gluconate | Injection | 15 | 3 | 14 | YES |
21 | Propafenone | Injection | 15 | 4 | 43 | YES |
22 | Adrenaline | Injection | 15 | 13 | 5 | YES |
23 | Dobutamine | Injection | 14 | 3 | 8 | YES |
24 | Mitoxantrone | Injection | 14 | 3 | 7 | YES |
25 | Benzathine Benzylpenicillin | Injection | 14 | 3 | 25 | YES |
26 | Pralidoxime Chloride | Injection | 14 | 4 | 4 | YES |
27 | Phentolamine | Injection | 13 | 5 | 9 | YES |
28 | Mitomycin | Injection | 13 | 1 | 4 | YES |
29 | Ketamine | Injection | 13 | 2 | 8 | NO |
30 | Bleomycin A5 | Injection | 13 | 1 | 3 | YES |
31 | Phenobarbital | Injection | 12 | 3 | 6 | YES |
32 | Sodium Thiosulfate | Injection | 12 | 0 | 4 | YES |
33 | Oxytocin | Injection | 12 | 4 | 21 | YES |
34 | Verapamil | Injection | 12 | 2 | 7 | YES |
35 | Metaraminol | Injection | 12 | 1 | 12 | NO |
36 | Adrenocorticotropine | Injection | 11 | 1 | 2 | YES |
37 | Diazepam | Injection | 11 | 4 | 20 | YES |
38 | Dopamine | Injection | 11 | 2 | 9 | YES |
39 | Furosemide | Injection | 11 | 3 | 58 | YES |
40 | Magnesium Sulfate | Injection | 11 | 5 | 19 | YES |
41 | Vincristine | Injection | 11 | 3 | 10 | YES |
42 | Thiamazole | Tablet | 10 | 1 | 16 | YES |
43 | Arginine | Injection | 10 | 12 | 13 | YES |
44 | Acetamide | Injection | 10 | 0 | 1 | YES |
45 | Oryzanol | Tablet | 10 | 3 | 200 | NO |
46 | Tetanus antitoxin | Injection | 10 | 0 | 2 | NO |
47 | Hydroxycarbamide | Tablet | 10 | 1 | 5 | NO |
48 | Cyclophosphamide | Injection | 9 | 5 | 4 | YES |
49 | Methylene Blue | Injection | 9 | 1 | 3 | YES |
50 | Pralidoxime Iodide | Injection | 9 | 2 | 7 | NO |
51 | Chlorpromazine | Injection | 9 | 4 | 28 | NO |
52 | Phenylephrine | Injection | 9 | 1 | 2 | NO |
53 | Nystatin | Tablet | 9 | 2 | 15 | NO |
54 | Sodium Dimercaptopropane Sulfonate | Injection | 8 | 1 | 3 | YES |
55 | Hydrocortisone | Injection | 8 | 7 | 43 | YES |
56 | Mercaptopurine | Tablet | 8 | 3 | 5 | YES |
57 | Iodinated Oil | Injection | 8 | 2 | 3 | NO |
58 | Scopolamine | Injection | 8 | 2 | 9 | NO |
59 | Promethazine | Injection | 8 | 4 | 24 | NO |
60 | Penicillamine | Tablet | 7 | 2 | 4 | YES |
61 | Amiodarone | Injection | 7 | 2 | 4 | YES |
62 | Digoxin | Oral liquid | 7 | 0 | 1 | YES |
63 | Etoposide | Injection | 7 | 3 | 14 | YES |
64 | Haloperidol | Injection | 7 | 2 | 6 | NO |
65 | Heparin | Injection | 7 | 12 | 18 | NO |
66 | Suxamethonium Chloride | Injection | 7 | 2 | 3 | NO |
67 | Chymotrypsin | Injection | 7 | 1 | 4 | NO |
68 | Chorionic Gonadotrophin | Injection | 7 | 4 | 14 | NO |
69 | Sodium Bicarbonate | Tablet | 7 | 4 | 124 | NO |
70 | Clofazimine | Capsule | 6 | 1 | 1 | YES |
71 | Thrombin | Lyophilizing Powder | 6 | 2 | 20 | YES |
72 | Sodium Nitroprusside | Injection | 6 | 5 | 12 | YES |
73 | Aminophylline | Injection | 6 | 7 | 45 | NO |
74 | Bupivacaine | Injection | 6 | 2 | 9 | NO |
75 | Estriol | Cream | 6 | 0 | 1 | NO |
76 | Etamsylate | Injection | 6 | 5 | 57 | NO |
77 | Metoclopramide | Injection | 6 | 2 | 15 | NO |
78 | Labetalol | Injection | 6 | 2 | 2 | NO |
79 | Propranolol | Tablet | 6 | 4 | 58 | NO |
80 | Human albumin | Injection | 6 | 0 | 44 | NO |
81 | Isoniazid | Injection | 6 | 4 | 18 | NO |
82 | Testosterone Undecanoate | Capsule | 6 | 1 | 2 | NO |
83 | Stanozolol | Tablet | 6 | 2 | 4 | NO |
84 | Aminophylline | Tablet | 5 | 7 | 135 | NO |
85 | Testosterone Propionate | Injection | 5 | 3 | 4 | NO |
86 | Progesterone | Injection | 5 | 11 | 12 | NO |
87 | Metoclopramide | Tablet | 5 | 2 | 71 | NO |
88 | Carbidopa and Levodopa | Controlled/Sustained-release Tablet | 5 | 0 | 1 | NO |
89 | Rifapentine | Capsule | 5 | 2 | 6 | NO |
90 | Procaine | Injection | 5 | 5 | 95 | NO |
91 | Anisodamine | Tablet | 5 | 1 | 2 | NO |
92 | Folic acid | Tablet | 5 | 3 | 29 | NO |
93 | Dextran 40 Sodium Chloride | Injection | 5 | 0 | 26 | NO |
94 | Aminomethylbenzoic Acid | Injection | 5 | 5 | 36 | NO |
95 | Menadione Sodium Bisulfite | Injection | 5 | 5 | 23 | NO |