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Table 4 Utilities associated with the health states of the model [Source: in the notes]

From: Cost-effectiveness analysis of gemtuzumab ozogamicin for the treatment of de novo CD33-positive Acute Myeloid Leukaemia (AML) in Italy

Health states

EQ-5D (Default)a

Chemotherapy treatmentb

0.6574

Consolidation therapy

0.6574c

HSCT procedure

0.6574c

GVHD (post HSCT)

0.6700c

CR o CRp

0.7400

Relapse

0.5680

Refractory

0.5680d

Functionnaly cured

0.8199e

Dead

0.0000

  1. CR = complete remission, CRp = complete remission with incomplete platelet recovery, EQ-5D = European quality of life 5 dimensions, GVHD = graft versus host disease, HSCT = hematopoietic stem-cell transplant
  2. aValues from TA399 of NICE [21], using the mapping algorithm by McKenzie and Van der Pol (2009) [22]
  3. bIncludes patients who are receiving induction or salvage chemotherapy
  4. cValue from Kurosawa et al. (2016) [23]
  5. dAssumed equal to relapse
  6. eCalculated using baseline patient characteristics for all patients in the ALFA-0701 study [11]