Table 1 Treatment regimens of study interventions [Source: [11]]

GO + DA (intervention)

Induction, course 1:

GO = 3 mg/m² per day (max = 5 mg), on days 1–3 (2-h IV infusion)

DNR = 60 mg/m² per day, on days 1–3 (30-min IV infusion)

AraC = 200 mg/m² per day, on days 1–7 (continuous IV infusion)

Induction, course 2:

DNR = 35 mg/m² per day, on days 1–3 (30-min IV infusion)

AraC = 1,000 mg/m² per 12 h, on days 1–3 (12-h IV infusion)

Consolidation, course 1^a:

GO = 3 mg/m² per day (maximum = 5 mg), on day 1 (2-h IV infusion)

DNR = 60 mg/m² per day, on day 1 (30-min IV infusion)

AraC = 1,000 mg/m² per 12 h, on days 1–4 (2-h IV infusion)

Consolidation, course 2^a:

GO = 3 mg/m² per day (maximum = 5 mg), on day 1 (2-h IV infusion)

DNR = 60 mg/m² per day, on days 1 and 2 (30-min IV infusion)

AraC = 1,000 mg/m² per 12 h, on days 1–4 (2-h IV infusion)

DA (comparator)

Induction, course 1:

DNR = 60 mg/m² per day, on days 1–3 (30-min IV infusion)

AraC = 200 mg/m² per day, on days 1–7 (continuous IV infusion)

Induction, course 2:

DNR = 35 mg/m² per day, on days 1–3 (30-min IV infusion)

AraC = 1,000 mg/m² per 12 h, on days 1–3 (2-h IV infusion)

Consolidation, course 1^a:

DNR = 60 mg/m² per day, on day 1 (30-min IV infusion)

AraC = 1,000 mg/m² per 12 h, on days 1–4 (2-h IV infusion)

Consolidation, course 2^a:

DNR = 60 mg/m² per day, on day 1 and 2 (30-min IV infusion)

AraC = 1,000 mg/m² per 12 h, on days 1–4 (2-h IV infusion)