Table 1 MeTree conditions and associated clinical decision support
Condition | Guideline-based risk management recommendation |
|---|---|
Monogenic RISK | |
 • Hereditary cancer syndromes (N = 20) | • Genetic counseling for comprehensive cancer risk assessment & management |
 • Hereditary cardiovascular syndromes (N = 9) | • Genetic counseling for comprehensive inherited cardiac disease risk assessment & management |
 • Familial hypercholesterolemia | • Genetic testing to screen for Familial Hypercholesterolemia |
 • Thrombosis | • Genetic testing for inherited thrombophilia • Genetic counseling for comprehensive inherited thrombophilia risk assessment & management |
Familial risk | |
 • Breast cancer | • Breast cancer surveillance via annual breast MRI and mammography • Discuss chemoprevention for breast cancer (tamoxifen or raloxifene) • Discuss chemoprevention for breast cancer (tamoxifen) |
 • Colon cancer | • Colonoscopy, with frequency based on number, size and histology of polyps • Colonoscopy every 1–2 yrs with biopsies for dysplasia, beginning 8 yrs after onset of pancolitis, or 12–15 yrs after onset of left-sided colitis • Early colorectal cancer surveillance (beginning at age 40) • Early colorectal cancer surveillance (beginning at age 45) • Early and more frequent colonoscopies (every 5 years beginning at age 40 or 10 yrs younger than the earliest diagnosis in the family, whichever comes first) |