Direct medical costs of young-onset colorectal cancer: a worldwide systematic review

Garg, Ria; Cheng, Vicki; Ellis, Ursula; Verma, Vanay; McTaggart-Cowan, Helen; Peacock, Stuart; Loree, Jonathan M.; Sadatsafavi, Mohsen; De Vera, Mary A.

doi:10.1186/s12913-022-08481-6

BMC Health Services Research

Table 1 Characteristics of included studies on direct medical costs of yCRC

From: Direct medical costs of young-onset colorectal cancer: a worldwide systematic review

Study	Country	Data Source	Sample size	Female (%)	Age (mean)	Follow-up (years)	Cancer Information			Modified CHEERS score^a
Study	Country	Data Source	Sample size	Female (%)	Age (mean)	Follow-up (years)	Site	Definition	Stage	Modified CHEERS score^a
Studies estimating costs of prevalent disease
Byun, 2014 [10]	Korea	Claims Health Insurance Review and Assessment Service	83,594	40.7	Not stated	1	Colon Rectal	ICD-10	Not stated	13
Zheng, 2016 [11]	USA	Medical Expenditure Panel Survey	540	55.8	Not stated	1	Colon Rectal	self-report	Not stated	12
Huang, 2017 [12]	China	Hospital medical records; patient survey	2,356	42.9	57.4	Not specified	Colon Rectal	self-report	I-IV	14
Tran, 2020 [13]	Vietnam	Hospital medical records	531	41.4	55.9	1	Colon Rectal	ICD-18,19,20	I-IV	11
Gigli, 2021 [14]	Italy	National Health Service Databases: Cancer registry, Outpatient services, Drug prescriptions, Hospital discharges	9,358	43.0	Not stated	1	Rectal	ICD9-CM	I-IV	14
Studies estimating costs of incident disease
Taplin, 1995 [17]	USA	Health Electronic Records from Cancer Research Network’s Virtual Data Warehouse	1,315	Not stated	Not stated	1	Colon	ICD-O	CIS – distant	12
Clerc, 2008 [16]	France	Public healthcare plan enrollees and health insurance database	204	49.4	Not stated	1	Colon Rectal	ICD-O	I-IV	10
Hall, 2015 [15]	England	Patient Level Information and Costing Systems	146	49.0	65.0	1.5	Colon Rectal	medical records	Dukes staging (A-D)	14
Laudicella, 2016 [18]	England	National Cancer Data Repository; Hospital Episode Statistics; National Schedules of Reference Costs	275, 985	41.5	55.6	9	Colon Rectal	ICD-10	I-IV	14
Ritzwoller, 2018 [19]	USA	Health Electronic Records from Cancer Research Network’s Virtual Data Warehouse	De novo^b: 1,072 Recurrent^c: 542	De-Novo^b: 49.0 Recurrent^c: 46.0	De-Novo^b: 66.1 Recurrent^c: 68.2	1	Colon Rectal	ICD-9,10	De-Novo^b: IV Recurrent^c:I-IV	15
Shi, 2019 [20]	China	Hospital medical records	14,536	42.7	58.2	Not specified	Colon Rectal	medical records	I-IV	15
Goldsbury, 2021 [21]	Australia	Sax Institute’s NSW 45 and Up Study questionnaire data linked with administrative datasets, including Admitted Patient Data Collection, Emergency Department Data Collection, NSW Cancer Registry, Pharmaceutical Benefits Scheme and Medicare Benefits Schedule	1,747	Colon: 52.0 Rectal: 35.0	Median age: Colon: 72 Rectal: 68	1	Colon Rectal	ICD-10	Localized, regional, distant metastases	16
Paszat, 2021 [22]	Canada	ICES database	9,977	40.5	Not stated	1	Colon Rectal	ICD-10	I-IV	14
Utsumi, 2021 [23]	Japan	National health insurance claims data	Endoscopic^d: 267 Surgical^e: 175 Palliative^f: 161	Endoscopic^d: 42.7 Surgical^e: 39.4 Palliative^f: 34.8	Median age: Endoscopic^d: 67 Surgical^e: 67 Palliative^f: 66	3	Colon Rectal	ICD-10	I-IV	14

^aModified Consolidated health economic evaluation reporting standards (CHEERS) checklist
^bDe novo CRC patient defined as those without a prior cancer diagnosis
^cReccurent CRC patient defined as those previously treated for early-stage (I-III) CRC
^dPatients who received endoscopic treatment only
^ePatients who received radical surgery for resection of the primary tumor with or without adjuvant chemotherapy
^fPatients who were considered to have non-curable CRC

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