Table 2 Summary of screening approaches included in the Cervical Precancer Planning Tool (CPPT)

1

VIA alone

A woman in the selected screening age range is screened with a naked eye VIA test. If she screens positive, she is referred to treatment. If a newer approach to visualization becomes available, data specific to this approach can be used in the CPPT instead.

2

HPV alone

A woman in the selected screening age range is screened with an HPV test (physician or self-collected sample, polymerase chain reaction [PCR] or hybrid capture method). If she screens positive for HPV, she is referred to treatment.

3

HPV + VIA triage^a

A woman in the selected screening age range is screened with an HPV test (physician or self-collected sample, PCR or hybrid capture method). If she screens positive for HPV, she is referred to a VIA triage test. If she screens positive for the triage test (there is a visual suspicion of cervical precancer), she is referred to treatment. Though not factored into this model, women who are HPV + but do not have suspicion of cervical cancer lesions in the triage test should be monitored for persistent infection.

4

HPV + enhanced triage^a

A woman in the selected screening age range is screened with an HPV test (physician or self-collected sample, PCR or hybrid capture method). If she screens positive for HPV, she is referred to an enhanced triage test. In this Tool, an enhanced triage test refers to a triage test that has an improved performance compared to a traditional triage test (e.g., VIA, colposcopy, or Pap). This improvement should lead to a sensitivity and specificity of at least 80% and/or improvement of 20% over a traditional triage approach. If she screens positive for the enhanced triage test (there is further evidence of cervical precancer), she is referred to treatment. Though not factored into this model, women who are HPV + but do not have further evidence of cervical lesions in the triage test should be monitored for persistent infection.