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Table 3 Best-evidence synthesis

From: Effectiveness comparison of inpatient vs. outpatient pulmonary rehabilitation: a systematic review

Outcomes

Significant differences in favor of inPR:

Study (Outcome) [Risk of Bias]

Significant differences in favor of outPR

Study (Outcome) [Risk of Bias]

No difference between inPR and outPR

Study (Outcome) [Risk of Bias]

Best-evidence synthesis

Health-related quality of life

Braeken et al. (CAT) [HR]

Braeken et al. (SGRQ-C) [HR]

Braeken et al. (CCQ) [HR]

Stoffels et al. (CAT) [HR]

none

none

MODERATE EVIDENCE with four outcomes (100%) in favor of inPR

Exercise tolerance

Braeken et al. (6MWD) [HR]

Guler et al. (6MWD) [HR]

Stoffels et al. (6MWD) [HR]

Stoffels et al. (CWRT TTE) [HR]

Stoffels et al. (4MGS) [HR]

none

Braeken et al. (CWRT) [HR]

Clini et al. (peak workload) [HR]

Stoffels et al. (5STS) [HR]

CONFLICTING EVIDENCE with five outcomes (63%) in favor of inPR and three outcomes (37%) in favor of no difference between the two modalities

Muscle Strength

none

none

Stoffels et al. (isokinetic quadriceps peak) [HR]

LIMITED EVIDENCE with one outcome (100%) in favor of no difference between the two modalities

Dyspnea

Stoffels et al. (mMRC) [HR]

none

Clini et al. (Borg scale) [HR]

CONFLICTING EVIDENCE with one outcome (50%) in favor of inPR and one outcome (50%) in favor of no difference between the two modalities

Psychological status

Braeken et al. (HADS-anxiety) [HR]

Braeken et al. (HADS-depression) [HR]

Stoffels et al. (HADS-anxiety) [HR]

Stoffels et al. (HADS-depression) [HR]

none

none

MODERATE EVIDENCE with four outcomes (100%) in favor of inPR

Healthcare burden

none

none

none

NO EVIDENCE

Refusals

none

none

none

NO EVIDENCE

Dropouts/Adherence

none

none

Braeken et al. [HR]

Stoffels et al. [HR]

MODERATE EVIDENCE with two outcomes in favor of no difference between the two modalities

Economic costs

Clini et al. (total per program) [HR]

Clini et al. (grand total) [HR]

Clini et al. (total per session) [HR]

none

CONFLICTING EVIDENCE with two outcomes (67%) in favor of inPR and one outcome (33%) in favor of outPR

Survival status

none

none

Bowen et al. [HR]

Hjalmarsern et al. [HR]

MODERATE EVIDENCE with two outcomes (100%) in favor of no difference between the two modalities

  1. NOTE: PR Pulmonary rehabilitation, outPR outpatient PR, inPR Inpatient PR, HRQoL Health-related quality of life, 6MWD 6-MinuteWwalk Distance, CWRT Constant Work Rate Test, CWRT TTE Constant Work Rate Test Time-to-exhaustion, CAT COPD Assessment Test, SGRQ-C St. Georges Respiratory questionnaire for COPD patients, CCQ Clinical COPD Questionnaire, HADS Hospital Anxiety and Depression Scale, 5STS Five Times Sit to Stand Test, 4MGS Four-meter gait speed, HR High risk