Authors, Year | Type of Analysis/ | Type of Costs | Costs | Type of effectiveness outcome | Effectiveness | ICER (definition); | ICER (results) | Sensitivity Analysis (definitions) | Sensitivity analysis (results) | Authors conclude (Reviewer comments where these differ from authors) |
---|---|---|---|---|---|---|---|---|---|---|
Hersey et al. 2012 [51*] | CUA | Mean cost per participant | Group 1: $145; Group 2: $160. Group 3: $390 | Mean weight loss (%) | Group 1: 4.1%, Group 2: 3.9%, Group 3: 5.3%. | ICER (cost per 1% weight loss) vs “do nothing” approach; Group 3 vs Group 1 & 2. | Group1: $30, Group 2: $40, Group 3: £70; $200. | Cost-effective “Extrapolation of savings for the entire TRICARE population would significantly reduce direct medical costs” | ||
Mean life year gain | Group 1: 0.17, Group 2: 0.16, Group 3: 0.21. | ICER (cost per life year gained) vs “do nothing” approach; Group 3 vs Group 1 & 2. | Group 1: $900, Group 2: $1000, Group 3: $1800; $4200–$5300. | |||||||
ICER (cost per QALY gained) vs “do nothing approach”; Group 3 vs Group 1 & 2. | Group 1: $900, Group 2: $1100, Group 3: $1900; $4400–$5600. | |||||||||
Mean QALY gain | Group 1: 0.16; Group 2: 0.15; Group 3: 0.20. | |||||||||
Perri 2014 [86*] | CEA (kg decrease in weight) | Total costs | Intervention: (Low dose): $16,351, (Moderate) $19,426, (High): $26,630; Control: $13,233; | Mean % initial body weight lost (kg) at 6 months | Intervention: Low dose: 7.2% (95%CI 6.1, 8.3), Moderate: 9.3% (95%CI 8.2, 10.3) High dose: 10.9% (9.8,11.9); Control: 4.1% (95% CI:3.1, 5.1) | ICER Cost per kg lost per participant | Low $33; Moderate: $22; High: $25; Control:$28 | Low-dose treatment is less effective and less cost-efficient than moderate-dose. A moderate dose can produce clinically meaningful, two-year reductions in body weight comparable to high-dose treatment, at a lower cost. (Unclear. ICER estimate for 2 years is lower for high dose than moderate. At six months there is a dose-response relationship between the interventions compared to control). | ||
Cost per participant | Intervention (Low dose): $111, (Moderate): $145, (High): $165 Control: $78. | Mean % initial body weight lost (kg) at 24 months: | Intervention: Low dose: 3.5% (95%CI 2.0, 4.8), Moderate: 6.7% (95%CI 5.3, 7.9) High: 6.8% (5.5,8.1); Control: 2.9% (95% CI: 1.7, 4.3) at 24 months |