Table 5 Results of ITS analysis for the change of volume, expenditures, and DDDc of policy-related antihypertensive drugs

Coef.

95 % CI

Coef.

95 % CI

Coef.

95 % CI

Bid-winning drugs

Baseline change, β₀

0.24

(-0.35, 0.83)

0.47

(0.18, 0.77)**

2.04

(1.96, 2.12)***

Baseline trend, β₁

0.01

(-0.07, 0.09)

0.02

(-0.02, 0.06)

-0.02

(-0.03, -0.01)**

Level change, β₂

3.12

(2.14, 4.10)***

0.93

(0.45, 1.42)**

-1.30

(-1.43, -1.18)***

Trend change, β₃

0.13

(-0.02, 0.28)

0.01

(-0.06, 0.09)

0.01

(-0.01, 0.03)

R²

0.94

0.85

0.99

Durbin-Watson d

2.12

2.11

1.91

Non-winning drugs

Baseline change, β₀

1.66

(1.36, 1.96)***

5.39

(4.40, 6.38)***

3.20

(3.09, 3.30)***

Baseline trend, β₁

0.09

(0.05, 0.13)***

0.26

(0.13, 0.39)***

-0.004

(-0.02, 0.01)

Level change, β₂

-2.33

(-2.83, -1.82)***

-6.92

(-8.57, -5.28)***

0.28

(0.11, 0.46)**

Trend change, β₃

-0.11

(-0.19, -0.03)**

-0.34

(-0.59, -0.09)*

0.01

(-0.02, 0.03)

R²

0.92

0.91

0.65

Durbin-Watson d

2.20

2.11

2.00

“4 + 7” List drugs

Baseline change, β₀

1.97

(1.19, 2.74)***

5.88

(4.73, 7.02)***

3.06

(2.89, 3.24)***

Baseline trend, β₁

0.09

(-0.01, 0.19)

0.28

(0.13, 0.43)**

-0.01

(-0.03, 0.02)

Level change, β₂

0.95

(-0.33, 2.23)

-5.96

(-7.87, -4.04)***

-1.94

(-2.21, -1.66)***

Trend change, β₃

0.02

(-0.18, 0.22)

-0.33

(-0.62, -0.04)*

-0.04

(-0.09, 0.002)

R²

0.74

0.84

0.98

Durbin-Watson d

2.15

2.15

1.96

Alternative drugs

Baseline change, β₀

3.91

(3.11, 4.71)***

12.76

(10.36, 15.17)***

3.24

(3.18, 3.31)***

Baseline trend, β₁

0.16

(0.05, 0.26)**

0.41

(0.10, 0.73)*

-0.02

(-0.02, -0.01)**

Level change, β₂

-0.91

(-2.24, 0.42)

-1.99

(-5.99, 2.02)

0.14

(0.03, 0.25)*

Trend change, β₃

0.01

(-0.20, 0.21)

-0.01

(-0.62, 0.60)

0.00

(-0.02, 0.01)

R²

0.62

0.56

0.59

Durbin-Watson d

2.25

2.18

2.03

Overall policy-related

antihypertensive drugs

Baseline change, β₀

5.85

(4.49, 7.20)***

18.59

(15.28, 21.90)***

3.18

(3.09, 3.27)***

Baseline trend, β₁

0.25

(0.07, 0.43)**

0.70

(0.26, 1.13)**

-0.01

(-0.02, 0.00)*

Level change, β₂

-0.01

(-2.26, 2.25)

-8.02

(-13.54, -2.51)**

-0.78

(-0.92, -0.63)***

Trend change, β₃

0.02

(-0.33, 0.36)

-0.35

(-1.19, 0.49)

-0.02

(-0.04, 0.004)

R²

0.74

0.47

0.98

Durbin-Watson d

2.36

2.24

2.35