Table 1 Government-recommended alternatives
From: Effects of the cefazolin shortage on the sales, cost, and appropriate use of other antimicrobials
Treatment | ||
Disease | Parenteral antimicrobial | Oral antimicrobial |
Sepsis caused by methicillin-sensitive Staphylococcus aureus | Ampicillin and sulbactam | |
Cefotaxime | ||
Ceftriaxone | ||
Vancomycin | ||
Daptomycin | ||
Soft tissue infection (e.g., cellulitis,erysipelas) | Ampicillin and sulbactam | Amoxicillin and clavulanate |
Cefotaxime | Cephalexin | |
Ceftriaxone | Clindamycin | |
Clindamycin | ||
Acute osteomyelitis / septic arthritis | Ampicillin and sulbactam | |
Cefotaxime | ||
Ceftriaxone | ||
Vancomycin | ||
Daptomycin | ||
Urinary infection (acute pyelonephritis) | Cefotiam | Ciprofloxacin |
Cefmetazole | Levofloxacin | |
Flomoxef | Sulfamethoxazole and trimethoprim | |
Cefotaxime | ||
Ceftriaxone | ||
Aminoglycosides | ||
Prophylaxis | ||
Surgical cite / bacteria | Parenteral antimicrobial | Oral antimicrobial |
Neuro surgery/Staphylococcus aureus, Streptococcus | Cefotiam | |
Cefotaxime | ||
Ceftriaxone | ||
Clindamycin | ||
Vancomycin | ||
Otorhinolaryngology/Staphylococcus aureus, Oral anaerobic bacteria, Streptococcus | Ampicillin and sulbactam | |
Cefotiam | ||
Clindamycin | ||
Cardiovascular surgical procedure (heart, vessel)/Staphylococcus aureus, Streptococcus | Cefotiam | |
Cefotaxime | ||
Ceftriaxone | ||
Clindamycin | ||
Vancomycin | ||
thoracic surgery (lung, trachea)/Oral anaerobic bacteria, Streptococcus | Ampicillin and sulbactam | |
Cefotiam | ||
Clindamycin | ||
Breast surgery/Staphylococcus aureus, Streptococcus | Cefotiam | |
Clindamycin | ||
Upper Gastrointestinal Tract Surgery (esophagus, stomach, jejunum) /Escherichia coli, Klebsiella pneumoniae | Ampicillin and sulbactam | |
Cefotiam | ||
Gastrointestinal surgery (liver, gallbladder, bile duct, pancreas)/Enterobacteriaceae | Ampicillin and sulbactam | |
Cefotiam | ||
Cefmetazole | ||
Flomoxef | ||
Gynecology/Enterobacteriaceae, Group of Bacteroides fragilis | Ampicillin and sulbactam | |
Cefotiam | ||
Cefmetazole | ||
Flomoxef | ||
Urology/Enterobacteriaceae | Ampicillin and sulbactam | Ciprofloxacin |
Cefotiam | Levofloxacin | |
Aminoglycoside | ||
Ciprofloxacin | ||
Levofloxacin | ||
Orthopedic surgery (Spinal Surgery, Artificial Bone Replacement, etc)/Staphylococcus aureus, Streptococcus | Cefotiam | |
Cefmetazole | ||
Flomoxef | ||
Clindamycin | ||
Vancomycin | ||