Table 2 Cost input included in the analysis

Main procedures

Glaucoma + cataract surgery cost (€)

€2294.20

iStent acquisition cost + procedures cost [34,35,36,37]

Cataract surgery cost (€)

€994.00

DH 39 [38]

Subsequent procedures

Trabeculectomy cost (€)

€1969.10

Code 12.64 [35, 39, 40]

Medications

Bimatoprost cost (€)

€20.23

Generic ex-factory price [41]

Bimatoprost + timolol cost (€)

€27.25

Branded ex-factory price [42]

Brinzolamide + timolol cost (€)

€16.88

Branded ex-factory price [42]

Dorzolamide + timolol cost (€)

€7.33

Generic ex-factory price [41]

Travoprost + timolol cost (€)

€18.26

Generic ex-factory price [41]

Timolol cost (€)

€5.70

Generic ex-factory price [41]

Tafluprost cost (€)

€25.94

Branded ex-factory price [42]

Bimatoprost MS (%)

15.6%

[43]

Bimatoprost + timolol MS (%)

11.5%

Brinzolamide + timolol MS (%)

13.9%

Dorzolamide + timolol MS (%)

16.4%

Travoprost + timolol MS (%)

6.6%

Timolol MS (%)

25.4%

Tafluprost MS (%)

10.7%

Disease monitoring

Ophthalmologist consultation cost (€)

€20.66

Code 95.02 [44]

Gonioscopy cost (€)

€7.75

Code 95.26 [44]

VF defect test cost (€)

€16.78

Code 95.05 [44]

Optic disc imaging cost (€)

€90.00

Code: 95.17 [36]

Incidence ophthalmologist consultation (n/month), mild glaucoma

0.17

[26]

Incidence ophthalmologist consultation (n/month), moderate glaucoma

0.25

Incidence ophthalmologist consultation (n/month), advanced glaucoma

0.33

Incidence ophthalmologist consultation (n/month), severe/blind glaucoma

0.25

Incidence gonioscopy (n/month), mild glaucoma

0.08

Incidence gonioscopy (n/month), moderate glaucoma

0.08

Incidence gonioscopy (n/month), advanced glaucoma

0.08

Incidence gonioscopy (n/month), severe/blind glaucoma

0.08

Incidence VF defect test (n/month), mild glaucoma

0.17

Incidence VF defect test (n/month), moderate glaucoma

0.17

Incidence VF defect test (n/month), advanced glaucoma

0.25

Incidence VF defect test (n/month), severe/blind glaucoma

0.17

Incidence optic disc imaging (n/month), mild glaucoma

0.17

Incidence optic disc imaging (n/month), moderate glaucoma

0.17

Incidence optic disc imaging (n/month), advanced glaucoma

0.33

Incidence optic disc imaging (n/month), severe/blind glaucoma

0.17

Adverse events

Hyperaemia unit cost (€)

€20.66

Code 89.07 [44]

Stent obstruction unit cost (€)

€1522.00

DH 42 [38]

Incidence hyperaemia, iStent + cataract group (%)

0.8%

[45]

Incidence stent obstruction, iStent + cataract group (%)

6.2%

Incidence hyperaemia, cataract surgery only group (%)

5.9%

Incidence stent obstruction, cataract surgery only group (%)

0.0%