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Table 2 Adverse Drug Event (ADE) Rates, by Definition and Data Source

From: Detection of adverse drug events in e-prescribing and administrative health data: a validation study

Data Source ADE in all Study Patients
(N = 688)
ADE in Patients Prescribed an Antidepressant
(N = 302)
ADE in Patients Prescribed an Antihypertensive
(N = 386)
Gold Standarda 114 (16.6%) 74 (24.5%) 40 (10.4%)
Electronic Prescribing Data, Treatment Change Ordersb 40 (5.8%) 20 (6.6%) 20 (5.2%)
Administrative Health Data, Expanded ICD Code Setc 62 (9.0%) 11 (3.6%) 51 (13.2%)
Administrative Health Data,
Standard ICD Code setd
19 (2.8%) 3 (1.0%) 16 (4.1%)
  1. aGold standard assessment of ADEs was based on patient interview data, adjudicated by a clinical expert to assess causality based on the Naranjo criteria. bPotential ADEs in electronic prescribing data were defined as study drug discontinuations or dose changes due to safety or effectiveness reasons. cPotential ADEs in administrative health data using the expanded ICD code set were defined as a physician visit, ED visit, or hospital admission during follow-up for which the recorded ICD code was (1) a relevant external cause code or (2) an adverse effect of the study drug. dPotential ADEs in administrative health data using the standard ICD code set were defined as a physician visit, ED visit, or hospital admission during follow-up for which the recorded ICD code was (1) a relevant external cause code or (2) an adverse effect of the study drug and (3) was included in previously validated code sets.