Direct medical costs of end-stage kidney disease and renal replacement therapy: a cohort study in Guangzhou City, southern China

Table 4 Unadjusted annual medical costs per patient by types of renal replacement therapies, in Chinese Yuan (CNY)

	Overall HD	Overall PD	Difference (99.17%CI)	P value	KT (first year)	KT (second year)	Difference (99.17%CI)	P value
Composition of total costs	3765	1237			117	41
Total annual medical costs
Mean	94,674.7	80,734.6	13,940.1 (10,825.5–17,054.7)	0.000^a	132,345.4	93,316.2	39,029.2 (22,547.6–55,510.8)	0.000^a
SD	45,034.2	32,459.0			39,385.0	31,350.6
Laboratory and diagnostic costs
Percentage of total cost (%)	0.8	0.4			1.8	0.2
Mean	730.1	307.7	422.4 (258.7–586.2)	0.000^a	2324.9	187.3	2137.6 (1730.8–2544.5)	0.000^a
SD	2870.4	1432.1			1337.5	567.2
Non-medication treatment costs
Percentage of total cost (%)	77.9	12.9			27.5	6.4
Mean	73,747.8	10,377.7	63,370.1 (61,632.0–65,108.1)	0.000^a	36,421.5	5996.1	30,425.4 (27,096.7–33,754.1)	0.000^a
SD	27,286.9	17,060.3			12,483.6	2969.6
Medication costs
Percentage of total cost (%)	20.6	86.2			67.8	93.4
Mean	19,498.0	69,633.0	−50,135.1 (−52,198.9 - -48,071.3)	0.000^a	89,668.5	87,130.6	2537.9 (−12,788.2–17,863.9)	0.654^a
SD	18,190.4	25,409.8			32,098.5	30,766.0
Bed Fees
Percentage of total cost (%)	0.4	0.3			1.7	0.0
Mean	349.4	265.6	83.8 (−1.3–168.9)	0.009^a	2235.5	0.0	2235.5 (1619.5–2851.4)	0.000^a
SD	1406.7	795.6			2480.8	0.0
Other fees
Percentage of total cost (%)	0.4	0.2			1.3	0.0
Mean	354.1	150.6	203.5 (116.7–290.4)	0.000^a	1695.0	2.2	1692.8 (1519.3–1866.3)	0.000^a
SD	1166.2	943.2			698.5	13.2
Out-of-pocket spending
Percentage of total cost (%)	13.0	14.3	−1.1 (−2.0 - -0.3)	0.000^b	23.7	16.8	6.9 (3.2–10.8)	0.000^b
Mean	12,323.9	11,516.7	807.2 (−49.2–1663.5)	0.013^a	31,378.6	15,703.6	15,675 (9026.7–22,323.3)	0.000^a
SD	11,461.9	9318.3			17,453.4	11,971.4

HD Haemodialysis, PD Peritoneal Dialysis, KT Kidney Transplantation
UEBMI, Urban Employee-based Basic Medical Insurance scheme; URBMI, Urban Resident-based Basic Medical Insurance scheme;
^ap-values were based on the independent two-sample T-test; ^bp-values were based on the two-proportion Z-test. A Bonferroni adjustment was applied: the adjusted alpha level was 0.0083 (alpha = 0.05/6) and 99.17% Confidence Intervals (CI) were presented

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