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Table 6 Point of Care Testing Regime: Home HIVST Setting (Funded by Consumer)

From: Economic evaluation of alternative testing regimes and settings to detect undiagnosed HIV in Australia

 

True HIV Positive (PHIV)

True HIV Negative (1 − PHIV)

Outcomes

HIVST+, EIA+, WB+

HIVST -

HIVST +, EIA-

HIVST+, EIA+, WB-

HIVST+ EIA-

HIVST -

Probability of result

(PHIV ∗ SenHIVST ∗ SenEIA ∗ SenWB )

PHIV ∗ (1 − SenHIVST)

(PHIV ∗ SenHIVST ∗ (1 − SenEIA))

((1 − PHIV) ∗ (1 − SpecHIVST) ∗ (1 − SpecEIA) + SpecWB )

((1 − PHIV) ∗ (1 − SpecHIVST) ∗ SpecEIA )

(1 − PHIV) ∗ SpecHIVST

Inputs

 Visit 1: Initial Screening

  Staffing

Self

Self

Self

Self

Self

Self

  OraQuick® In-Home HIV Test

$54.75

$54.75

$54.75

$54.75

$54.75

$54.75

  Postage

$7.50

$7.50

$7.50

$7.50

$7.50

$7.50

Confirmatory Testing conducted at Bulk Billing GP

 Visit 1: Initial Screening

  Consult time

20 min

 

20 min

20 min

20 min

 

  Medicare Rebate

$71.701

 

$71.701

$71.701

$71.701

 

  Staffing

GP

 

GP

GP

GP

 

 Pathology costs

  EIA test

$15.652

 

$15.652

$15.652

$15.652

 

  WB confirmatory

$29.003

  

$29.003

  

 Visit 2: Test Results

  Consult time

40 min

 

20 min

20 min

20 min

 

  Medicare Rebate

$105.554

 

$71.701

$71.701

$71.701

 

  Staffing

GP

 

GP

GP

GP

 

Total Cost of Each Outcome

$284.15

$62.25

$221.30

$250.30

$221.30

$62.25

Total Cost of Each Outcome (excluding private costs)

$221.90

$0

$159.05

$188.05

$159.05

$0

Average cost per person tested

=(PHIV ∗ SenHIVST ∗ SenEIA ∗ SenWB) ∗ AC per True PositiveHIVST + , EIA + , WB+ + (PHIV ∗ (1 − SenHIVST)) ∗ AC per False NegativeHIVST− + (PHIV ∗ SenHIVST ∗ (1 − SenEIA)) ∗ AC per False NegativeHIVST + , EIA− + ((1 − PHIV) ∗ SpecHIVST) ∗ AC True NegativeHIVST− + ((1 − PHIV) ∗ (1 − SpecHIVST) ∗ SpecEIA) ∗ False PositiveHIVST + , EIA− + ((1 − PHIV) ∗ (1 − SpecHIVST) ∗ (1 − SpecEIA) ∗ SpecWB) ∗ False PositiveHIVST + , EIA + , WB−

Average number of tests for a positive diagnosis

\( =\frac{1}{P_{HIV}\ast Se{n}_{HIV ST}\ast Se{n}_{EIA}\ast Se{n}_{WB}} \)

  1. Note: AC Average Cost, DHC Alere Determine™ HIV-1/2 Ag/Ab Combo Test, EIA fourth generation enzyme immunoassay test, GP General Practitioner, P Probability, Sen Sensitivity, Spec Specificity, WB Western Blot Test, + reactive test result, − nonreactive test result. 1 = Medicare Rebate Item 36; 2 = Medicare Rebate Item 69,384; 3 = Medicare Rebate Item 69,387; 4 = Medicare Rebate Item 44