Table 1 Epidemiologic data of a typical HNSCC cohort, subdivided due to the insurance status. CUP: Cancer of unknown primary; C-/RT: Chemo-radiation

n

925

129

Age (years)

0.06

 Median

60

62

 Mean ± SD

60 ± 10

62 ± 11

Sex, n (%)

0.19

 Male

731 (79)

108 (84)

 Female

194 (21)

21 (16)

Location, n (%)

0.52

 Sinonasal

32 (4)

3 (2)

 Nasopharynx

14 (2)

5 (4)

 Oropharynx

363 (39)

52 (40)

 Hypopharynx

192 (21)

27 (21)

 Larynx

180 (20)

27 (21)

 Oral cavity

140 (15)

14 (11)

 CUP

4 (< 1)

1 (1)

T stage, n (%)

0.002

 T1/2

503 (54)

87 (67)

 T3/4

418 (45)

41 (32)

N stage, n (%)

0.86

 N0

366 (40)

50 (39)

 N+

559 (60)

79 (61)

M stage, n (%)

0.76

 M0

886 (96)

127 (98)

 M1

39 (4)

2 (2)

Grading, n (%)

0.20

 G1

39 (4)

5 (4)

 G2

452 (49)

53 (41)

 G3

407 (44)

62 (48)

 G4

27 (3)

5 (7)

R status, n (%)

0.24

 R0

510 (83)

78 (80)

 R1

52 (9)

6 (6)

 R2

11 (2)

3 (3)

 Rx

40 (7)

10 (10)

UICC stage, n (%)

0.14

 UICC I

136 (15)

21 (16)

 UICC II

117 (13)

17 (13)

 UICC III

152 (16)

26 (20)

 UICC IV

513 (56)

63 (49)

Therapy, n (%)

0.31

 Surgery

164 (18)

23 (18)

 Surgery + C/RT

433 (47)

69 (54)

 pC/RT

328 (35)

37(29)