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Table 1 Overview of the active substances investigated, with INN, brand name (in the Netherlands), EU reference date, average yearly drug switches, average yearly number of repeat dispenses (not switching), and percentage of drug switches of consecutive dispenses per month (median, range) from June 2009 to December 2016. Active substances are tabulated in descending order by median drug switch percentage

From: Drug switching in the Netherlands: a cohort study of 20 active substances

INN Brand name EU reference date Average yearly drug switches Average yearly repeat dispenses (not switching) % drug switches median (range per month)
ethinylestradiol/
levonorgestrel
Microgynon® April 1965 63,824 331,419 15.8% (7.44–48.9)
atorvastatin Lipitor® November 1996 264,776 1,297,895 15.0% (4.71–68.1)
salmeterol/
fluticasone
Seretide® October 1990 104,663 689,450 14.4% (3.10–26.2)
perindopril Coversyl® June 1988 161,155 890,803 14.0% (4.31–34.2)
losartan Cozaar® September 1994 118,979 735,195 12.0% (3.94–63.6)
simvastatin Zocor® April 1988 559,303 3,220,461 11.8% (3.24–47.4)
paroxetine Seroxat® December 1990 112,555 754,569 11.8% (4.63–38.2)
pantoprazole Pantozol® Augustus 1994 289,171 1,897,439 10.7% (4.06–63.2)
irbesartan Aprovel® Augustus 1997 58,854 398,297 9.93% (0.00–60.8)
venlafaxine Efexor® September 1993 55,719 416,314 9.61% (5.78–39.9)
metformin Glucophage® March 1959 252,557 2,231,914 9.41% (2.82–32.3)
omeprazole Losec® April 1987 361,669 2,977,064 9.39% (3.38–28.7)
esomeprazole Nexium® March 2000 94,460 761,959 8.98% (4.40–48.6)
methotrexate (immunosuppressant) Metoject® July 2003 21,310 171,876 8.70% (4.05–35.8)
enalapril Renitec® January 1985 102,387 1,027,850 7.69% (2.82–23.1)
metoprolol Lopresor® February 1975 359,131 3,479,555 7.41% (3.58–29.9)
salbutamol Ventolin® January 1969 65,047 789,636 7.29% (4.24–13.7)
methylphenidate Ritalin® October 1954 29,472 529,279 4.81% (2.59–15.7)
rivastigmine Exelon® May 1998 4051 53,243 4.02% (0.00–20.3)
methotrexate (antineoplastic agent) Ledertrexate® September 1974 2090 60,219 2.21% (0.00–46.4)
levothyroxine Thyrax Duotab® January 1952 66,909 1,252,976 1.75% (0.281–26.0)