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Table 2 Overview of the Cirrhosis Care Alberta (CCAB) evaluation methods

From: The cirrhosis care Alberta (CCAB) protocol: implementing an evidence-based best practice order set for the management of liver cirrhosis - a hybrid type I effectiveness-implementation trial

RE-AIM Domains Outcomes Measures Data sources/ tools Analytic Methods Study Phase
1 2 3
Reach Uptake Proportion of care providers who participate in education interventions for the order set, Program data, Administrative data, Descriptive statistics   X X
Proportion of cirrhosis patients being managed using the CCAB order set Chart reviews
Effectiveness Clinical and Cost-Utility I.e.. Cumulative hospital LOS and readmission rates per patient year, Administrative data, Interrupted time series, X   X
Chart reviews Incremental Cost-Effectiveness Ratio
Cost of care (health system perspective) QALYs gained
Patient reported outcome measures (PROMs) Health-related quality of life, Post-discharge phone surveys, EQ-5D and CTM questionnaires, Descriptive and inferential statistics, X   X
Patient/family and provider experience
Framework and thematic analyses
Qualitative interviews
Quality Measures Quality of care (eg. appropriate prescribing of rifaximin, screening for frailty, time to post discharge follow up) Chart reviews Interrupted time series X   X
Adoption Utilization Number of hospital sites that use the orders sets/Number of hospital sites enrolled, Administrative data, Descriptive statistics,    X
Qualitative interviews Framework and thematic analyses guided by NPT and CFIR
Processes and determinants of adoption
Implementation Feasibility Processes and determinants of feasibility and acceptability from patients, caregivers and health care providers’ perspectives Qualitative interviews Framework and thematic analyses guided by NPT and CFIR X X X
Fidelity Proportion of order sets prescribed that adhere to the three core-components of the standardized CCAB order set Administrative data Descriptive statistics    X
Maintenance Sustainability Proportion of cirrhosis patients being managed using the CCAB order set 6 months after the research team has completed supported rollout CCAB program implementation data, Descriptive statistics,    X
Framework and thematic analyses guided by NPT and CFIR
Qualitative interviews
  1. CCAB Cirrhosis Care Alberta, CFIR Consolidated Framework for Implementation Research, EQ-5D EuroQol- 5 Dimension, NPT Normalization Process Theory, Study Phases: 1 = Engagement, 2 = Preparation, 3 = Implementation