Table 4 Reduced incidence of complications for the Spanish type 2 diabetes population with starting HbA1c > 48 mmol/mol (per 1000 population)
> 48 to ≤ 58 mmol/mol | 5 years | 10 years | 15 years | 20 years | 25 years |
Eye disease | |||||
BDR | 5.5 | 22.8 | 33.1 | 38.8 | 36.0 |
PDR | 0.3 | 1.7 | 3.0 | 3.9 | 4.1 |
ME | 5.1 | 20.7 | 30.7 | 36.0 | 33.5 |
SVL | 0.1 | 2.4 | 5.7 | 8.7 | 10.6 |
Cataract | 1.8 | 6.3 | 8.8 | 10.2 | 9.3 |
TOTAL | 12.7 | 54.0 | 81.3 | 97.6 | 93.5 |
Renal disease | |||||
MA | 8.0 | 31.0 | 45.0 | 52.0 | 47.3 |
GRP | 1.3 | 7.7 | 13.9 | 19.0 | 19.2 |
ESRD | 0.2 | 1.4 | 2.9 | 4.5 | 5.3 |
TOTAL | 9.5 | 40.1 | 61.9 | 75.5 | 71.8 |
Diabetic foot | |||||
Ulcer | 3.5 | 23.2 | 42.0 | 53.5 | 52.9 |
Recurrent ulcer | 0.5 | 9.1 | 30.7 | 56.0 | 75.0 |
Amputation ulcer | 0.2 | 3.2 | 8.9 | 14.5 | 17.8 |
Amputation recurrent ulcer | 0 | 0.4 | 1.6 | 3.5 | 5.3 |
Neuropathy | 26.8 | 85.6 | 106.9 | 110.1 | 94.5 |
TOTAL | 31.0 | 121.6 | 190.2 | 237.5 | 245.4 |
Cardiovascular disease | |||||
CHF onset | 0.5 | 5.2 | 7.7 | 8.8 | 8.4 |
PVD onset | 2.4 | 9.2 | 13.7 | 16.5 | 15.5 |
Angina | 0.5 | 6.0 | 9.0 | 10.1 | 9.7 |
Diabetes mortality | 0 | 0.9 | 3.0 | 5.7 | 8.0 |
Stroke event | −0.1 | 4.9 | 6.8 | 7.2 | 6.5 |
Event fatality | 1.4 | 17.4 | 27.8 | 32.7 | 32.9 |
MI event | 0.9 | 16.7 | 26.8 | 31.3 | 31.3 |
TOTAL | 5.7 | 59.7 | 94.8 | 112.3 | 112.2 |
58 to ≤ 64 mmol/mol | 5 years | 10 years | 15 years | 20 years | 25 years |
Eye disease | |||||
BDR | 3.4 | 8.0 | 10.9 | 11.4 | 9.5 |
PDR | 0.3 | 0.8 | 1.3 | 1.5 | 1.3 |
ME | 3.1 | 7.7 | 10.6 | 11.2 | 9.3 |
SVL | 0.1 | 1.1 | 2.2 | 3.1 | 3.4 |
Cataract | 0.9 | 2.1 | 2.8 | 2.9 | 2.5 |
TOTAL | 7.8 | 19.7 | 27.7 | 30.01 | 26.1 |
Renal disease | |||||
MA | 4.6 | 11.2 | 15.2 | 15.7 | 12.6 |
GRP | 0.9 | 3.1 | 5.1 | 6.3 | 5.5 |
ESRD | 0.1 | 0.6 | 1.1 | 1.5 | 1.5 |
TOTAL | 5.7 | 14.8 | 21.5 | 23.5 | 19.6 |
Diabetic foot | |||||
Ulcer | 2.4 | 8.9 | 14.5 | 16.7 | 15.4 |
Recurrent ulcer | 0.4 | 4.5 | 12.0 | 19.9 | 24.7 |
Amputation ulcer | 0.2 | 1.5 | 3.3 | 5.0 | 5.6 |
Amputation recurrent ulcer | 0 | 0.2 | 0.7 | 1.3 | 1.9 |
Neuropathy | 14.7 | 29.4 | 34.7 | 32.3 | 26.4 |
TOTAL | 17.7 | 44.5 | 65.02 | 75.2 | 74.0 |
Cardiovascular disease | |||||
CHF onset | 0.5 | 1.8 | 2.4 | 2.5 | 2.0 |
PVD onset | 1.3 | 3.1 | 4.4 | 4.5 | 3.8 |
Angina | 0.5 | 2.0 | 2.8 | 2.8 | 2.4 |
Diabetes mortality | 0 | 0.4 | 1.0 | 1.7 | 2.4 |
Stroke event | 0.4 | 1.7 | 2.1 | 2.1 | 1.7 |
Event fatality | 1.6 | 6.3 | 8.7 | 9.5 | 8.6 |
MI event | 1.6 | 6.2 | 8.4 | 8.9 | 8.2 |
TOTAL | 6.0 | 21.6 | 29.9 | 32.1 | 29.2 |
64 to ≤ 75 mmol/mol | 5 years | 10 years | 15 years | 20 years | 25 years |
Eye disease | |||||
BDR | 6.9 | 11.5 | 14.5 | 16.3 | 15.4 |
PDR | 0.7 | 1.3 | 1.9 | 2.3 | 2.3 |
ME | 6.7 | 11.4 | 14.6 | 16.5 | 15.7 |
SVL | 0.6 | 1.9 | 3.4 | 4.8 | 5.6 |
Cataract | 1.9 | 3.2 | 3.9 | 4.4 | 4.1 |
TOTAL | 16.9 | 29.3 | 38.4 | 44.2 | 43.1 |
Renal disease | |||||
MA | 9.8 | 16.2 | 20.4 | 22.8 | 21.2 |
GRP | 2.3 | 4.8 | 7.3 | 9.4 | 9.7 |
ESRD | 0.4 | 1.1 | 1.8 | 2.5 | 2.9 |
TOTAL | 12.5 | 22.1 | 29.5 | 34.7 | 33.8 |
Diabetic foot | |||||
Ulcer | 5.9 | 14.3 | 20.9 | 24.8 | 24.6 |
Recurrent ulcer | 1.6 | 8.9 | 20.1 | 31.3 | 39.5 |
Amputation ulcer | 0.7 | 2.7 | 5.3 | 7.6 | 9.1 |
Amputation recurrent ulcer | 0.1 | 0.5 | 1.3 | 2.3 | 3.4 |
Neuropathy | 31.0 | 43.2 | 47.2 | 47.2 | 41.1 |
TOTAL | 39.3 | 69.6 | 94.7 | 113.3 | 117.8 |
Cardiovascular disease | |||||
CHF onset | 1.9 | 3.0 | 3.6 | 3,8 | 3.6 |
PVD onset | 2.4 | 4.3 | 5.7 | 6.6 | 6.2 |
Angina | 2.1 | 3.3 | 4.0 | 4.3 | 4.0 |
Diabetes mortality | 0.2 | 0.7 | 1.7 | 2.7 | 3.8 |
Stroke event | 1.8 | 2.7 | 3.0 | 3.1 | 2.9 |
Event fatality | 5.6 | 9.5 | 11.6 | 12.7 | 12.5 |
MI event | 5.2 | 8.7 | 10.4 | 11.2 | 10.8 |
TOTAL | 19.1 | 32.2 | 40.0 | 44.4 | 43.8 |
> 75 mmol/mol | 5 years | 10 years | 15 years | 20 years | 25 years |
Eye disease | |||||
BDR | 6.5 | 10.7 | 13.8 | 15.7 | 14.6 |
PDR | 0.7 | 1.3 | 1.8 | 2.3 | 2.3 |
ME | 6.4 | 10.6 | 13.8 | 15.9 | 14.9 |
SVL | 0.5 | 1.9 | 3.4 | 4.9 | 5.7 |
Cataract | 1.8 | 2.9 | 3.7 | 4.2 | 3.9 |
TOTAL | 15.8 | 27.3 | 36.6 | 43.1 | 41.4 |
Renal disease | |||||
MA | 8.9 | 14.7 | 18.8 | 21.3 | 19.4 |
GRP | 5.1 | 10.0 | 14.9 | 19.3 | 22.9 |
ESRD | 0.5 | 1.2 | 2.1 | 3.0 | 3.4 |
TOTAL | 14.5 | 25.9 | 35.8 | 43.5 | 45.6 |
Diabetic foot | |||||
Ulcer | 5.6 | 13.5 | 20.2 | 24.5 | 24.1 |
Recurrent ulcer | 1.4 | 8.4 | 19.8 | 32.0 | 41.3 |
Amputation ulcer | 0.6 | 2.6 | 5.2 | 7.7 | 9.4 |
Amputation recurrent ulcer | 0.1 | 0.4 | 1.3 | 2.5 | 3.7 |
Neuropathy | 28.5 | 39.7 | 43.7 | 43.8 | 37.0 |
TOTAL | 36.0 | 64.6 | 90.2 | 110.5 | 115.5 |
Cardiovascular disease | |||||
CHF onset | 1.5 | 2.4 | 3.0 | 3.2 | 2.9 |
PVD onset | 2.1 | 3.8 | 5.3 | 6.4 | 5.9 |
Angina | 1.9 | 3.3 | 4.0 | 4.5 | 4.1 |
Diabetes mortality | 0 | 0.5 | 1.6 | 2.8 | 4.2 |
Stroke event | 1.4 | 2.4 | 2.8 | 2.9 | 2.7 |
Event fatality | 4.5 | 8.1 | 10.1 | 11.4 | 11.1 |
MI event | 4.4 | 7.7 | 9.6 | 10.5 | 10.0 |
TOTAL | 15.8 | 28.3 | 36.4 | 41.6 | 41.0 |