Variable | local Median [Q1-Q3] | Imported Median [Q1-Q3] | P value | Fold difference in medians |
---|---|---|---|---|
Therapeutic class | 2.60 [2.00–4.50] | 4.00 [4.00–8.50] | 0.026 | 1.53 |
Mechanism of action | 0.00 [0.00–4.25] | 0.00 [0.00–17.00] | 0.713 | 1 |
Indications | 30.60 [19.50–42.75] | 39.80 [18.50–74.50] | 0.566 | 1.30 |
Drug dose | 21.50 [12.50–51.25] | 44.30 [28.30–65.25] | 0.233 | 2.06 |
Duration of using | 1.60 [0.00–5.25] | 20.00 [2.35–27.60] | 0.059 | 12.5 |
Missing dose | 21.00 [16.65–32.75] | 22.50 [0.00–28.40] | 0.507 | 1.07 |
Maximum dose | 6.00 [1.00–9.25] | 7.00 [6.00–28.80] | 0.169 | 1.16 |
Directions for use | 33.50 [31.00–52.00] | 30.00 [22.75–45.85] | 0.200 | 1.11 |
Overdose and management | 36.00 [35.80–41.80] | 55.00 [36.80–93.75] | 0.144 | 1.52 |
Warning and precautions | 66.00 [31.00–92.30] | 261.00 [183.00–425.50] | 0.002 | 3.95 |
Effect on ability to drive and use machines | 11.00 [0.00–14.80] | 33.00 [20.00–61.50] | 0.002 | 3.00 |
Contraindications | 29.00 [19.00–84.00] | 132.00 [100.00–152.75] | 0.005 | 4.55 |
Adverse drug reactions | 76.50 [60.25–104.50] | 327.00 [213.20–503.75] | 0.001 | 4.27 |
Drug-drug interactions | 53.00 [49.00–67.05] | 180.00 [118.25–257.85] | 0.001 | 3.39 |
Drug-food interactions | 4.30 [0.00–7.50] | 18.50 [4.35–30.50] | 0.053 | 4.30 |
Pregnancy considerations | 19.00 [13.75–27.25] | 45.00 [11.25–88.55] | 0.170 | 2.36 |
Lactation considerations | 13.00 [11.65–24.25] | 9.00 [8.75–28.15] | 0.595 | 1.44 |
Pediatric considerations | 48.00 [35.65–64.75] | 87.00 [56.25–120.95] | 0.024 | 1.81 |
Geriatric considerations | 0.00 [0.00–4.15] | 42.40 [21.50–71.85] | 0.002 | > 42.40 |
Possibility of tablet splitting | 0.00 [0.00–0.00] | 5.00 [0.00–13.00] | 0.010 | > 5.00 |
Possibility of crushing and mixing with food or beverages | 2.60 [1.50–3.15] | 4.40 [3.00–6.10] | 0.030 | 1.69 |
Shelf life | 15.00 [10.60–16.00] | 21.00 [16.35–27.00] | 0.012 | 1.40 |
Storage | 18.00 [14.50–32.00] | 58.00 [43.85–78.05] | 0.005 | 3.22 |