Table 1 Fixed Modelling Assumptions
Data | Assumption |
|---|---|
Primary Stoke Centres (PSC) in addition to CSCs | FIXED at 50 in both scenarios |
Stroke incidence in England | FIXED at 80,800 For compatibility with model predicting optimal number of CSCs centres [6, 19] |
Early presenters presentation times | FIXED to the distribution of those moderate and severe (NIHSS ≥6) confirmed LAO strokes presenting to a large Hospital in North East Englanda. |
Stroke patient characteristics | FIXED to those of the HERMES Meta-Analysis cohort [18] |
Distances | FIXED road distances calculated by Geographic Information System (GIS) from geographic population weighted centroid of Local Super Output Area of patients home or between locations of PSU and CSC [6] |
Time dependent outcomes of EVT | FIXED to those of the HERMES Meta-Analysis cohort [18] |
Early presenters | FIXED at those initially presenting to either a PSU or an EVT CSC within 270 min of stroke onset [19]. |
Stroke mimics | No mimics are included in the simulation |
Death | Is determined only by mRS at 90 days or following subsequent deterioration |
Deterioration | Only occurs within 5 years and is determined only by mRS at 90 days and is FIXED at a two point increase in mRS to a maximum of 5. |
Door in Door Out | FIXED at 60 min, determined by optimisation [6] |
Door to EVT time | FIXED at 90 min, determined by optimisation [6] |
Maximum Lifetime | FIXED at 100 years |