Table 1 Summary of the primary screening performance for fetal Down syndrome
Final Risk | N (%) | Down Syndrome | Sensitivity | False Positive | |
|---|---|---|---|---|---|
Maternal Serum Screening Based on Caucasian Reference Ranges | |||||
Contingent screen (C-S) | LR | 25,580 (86.2%) | 7 | 86.8% | 13.7% |
HR | 4112 (13.8%) | 46 | |||
Total | 29,692 (100%) | 53 | |||
Second trimester serum screen (STS) alone | LR | 10,877 (88.9%) | 5 | 76.2% | 11.0% |
HR | 1355 (11.1%) | 16 | |||
Total | 12,232 (100.0%) | 21 | |||
C-S plus STS | LR | 36,457 (87.0%) | 12 | 83.8% | 12.9% |
HR | 5467 (13.0%) | 62 | |||
Total | 41,924 (100%) | 74 | |||
Maternal Serum Screening Based on Thai Reference Ranges | |||||
Contingent screen (C-S) | LR | 27,361 (92.1%) | 8 | 84.9% | 7.7% |
HR | 2331 (7.9%) | 45 | |||
Total | 29,692 (100%) | 53 | |||
Second trimester serum screen (STS) alone | LR | 11,093 (90.7%) | 5 | 76.2% | 9.2% |
HR | 1139 (9.3%) | 16 | |||
Total | 12,232 (100%) | 21 | |||
C-S plus STS | LR | 38,454 (91.7%) | 13 | 82.4% | 8.1% |
HR | 3470 (8.3%) | 61 | |||
Total | 41,924 (100%) | 74 | |||
First trimester serum screen (FTS) alone | LR | 27,627 (93.0%) | 11 | 79.2% | 6.8% |
HR | 2065 (7.0%) | 42 | |||
Total | 29,692 (100%) | 53 | |||
I-S (Independently combined first and second trimester) | LR | 38,720 (92.4%) | 16 | 78.4% | 7.5% |
HR | 3204 (7.6%) | 58 | |||
Total | 41,924 (100%) | 74 | |||
Age-based Screening | |||||
Combined First and Second Trimester | LR | 36,967 (88.2%) | 52 | 29.7% | 11.8% |
HR | 4957 (11.8%) | 22 | |||
Total | 41,924 (100%) | 74 | |||