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Table 3 Rates and rate ratios with 95%CIs for antibacterial therapy by drug class

From: Is antibacterial treatment intensity lower in elderly patients? A retrospective cohort study in a German surgical intensive care unit

Drug class Observed rate (whole ICU cohort) a Observed rate patients aged < 80 yearsa Observed rate patients aged ≥ 80 yearsa Unadjusted rate ratio ≥ 80 vs. < 80b Adjusted rate ratio ≥ 80 vs. < 80c
All Antibacterials 38.70 (38.26–39.15) 39.73 (39.25–40.21) 30.97 (29.84–32.15) 0.99 (0.94–1.03) 1.02 (0.98–1.07)
All antibacterials except erythromycin 32.81 (32.41–33.22) 33.49 (33.05–33.93) 27.69 (26.63–28.81) 1.05 (1.00–1.10) 1.07 (1.02–1.12)
Tetracyclines 0.87 (0.81–0.94) 0.94 (0.86–1.01) 0.41 (0.30–0.57) 2.26 (1.59–3.22) 1.87 (1.25–2.81)
Penicillins 8.43 (8.23–8.64) 8.36 (8.14–8.58) 9.01 (8.41–9.66) 1.41 (1.29–1.53) 1.37 (1.26–1.48)
Cephalosporins 9.02 (8.81–9.24) 9.20 (8.97–9.43) 7.70 (7.15–8.30) 1.22 (1.11–1.34) 1.20 (1.09–1.31)
Carbapenems 8.08 (7.88–8.28) 8.58 (8.36–8.80) 4.32 (3.91–4.77) 1.29 (1.15–1.44) 1.35 (1.20–1.50)
Macrolides 14.52 (14.26–14.80) 15.36 (15.07–15.66) 8.21 (7.63–9.82) 0.96 (0.88–1.04) 0.97 (0.90–1.06)
Clarithromycin 0.18 (0.16–0.22) 0.18 (0.15–0.22) 0.19 (0.12–0.31) 1.17 (0.64–2.14) 1.02 (0.51–2.04)
Lincosamides 0.73 (0.67–0.80) 0.69 (0.63–0.75) 1.06 (0.87–1.30) 1.41 (1.08–1.83) 1.40 (1.05–1.86)
Aminoglycosides 0.49 (0.45–0.55) 0.53 (0.48–0.59) 0.18 (0.11–0.29) 1.12 (0.61–2.04) 1.11 (0.61–2.02)
Fluoroquinolones 7.20 (7.02–7.40) 7.34 (7.13–7.54) 6.22 (5.72–6.76) 1.24 (1.12–1.37) 1.17 (1.05–1.30)
Glycopeptides 0.41 (0.37–0.46) 0.44 (0.39–0.49) 0.19 (0.12–0.31) 2.16 (1.14–4.10) 1.69 (0.90–3.20)
Imidazoles 7.94 (7.74–8.14) 7.85 (7.64–8.06) 8.59 (8.00–9.22) 1.36 (1.25–1.48) 1.34 (1.23–1.46)
Oxazolidinones 4.33 (4.19–4.48) 4.69 (4.53–4.85) 1.64 (1.40–1.93) 1.22 (1.02–1.47) 1.30 (1.08–1.56)
  1. aExposed patient days per 100 patient days
  2. bZero-inflated Poisson-regression
  3. cZero-inflated Poisson-regression adjusted for mean SAPS II- and TISS-scores, sex, and year of treatment