Table 6 Most frequent reasons for using the NGS mention for 18 therapeutic classes
Drug | Most frequent reasons for using the NGSa mention | |||||
|---|---|---|---|---|---|---|
Patient request | Benign adverse drug reaction | Severe adverse drug reaction | Biological or clinical inequivalence to the brand-name drug | Class with increased risk (inter-individual variations, interactions, narrow therapeutic range …) | Compliance with specialist prescription | |
Antiplatelet agents - n, % | 64(27.6) | 11 (4.7) | 8 (3.4) | 28 (12.1) | 41 (17.7) | 80 (34.5) |
Thyroid hormones - n, % | 29 (11.3) | 7 (2.7) | 3 (1.2) | 105 (41.0) | 73 (28.5) | 39 (15.2) |
Antiepileptic drugs - n, % | 41 (16.7) | 2 (0.8) | 3 (1.2) | 55 (22.4) | 91 (37.0) | 54 (22.0) |
Antiacids - n, % | 112 (55.2) | 31 (15.3) | 3 (1.5) | 47 (23.2) | 6 (3.0) | 4 (2.0) |
Antispasmodic drugs - n, % | 106 (76.8) | 14 (10.1) | 1 (0.7) | 14 (10.1) | 2 (1.4) | 1 (0.7) |
Step I analgesics - n, % | 107 (77.0) | 14 (10.1) | 1 (0.7) | 9 (6.5) | 6 (4.3) | 2 (1.4) |
Step II/III analgesics - n, % | 104 (60.8) | 30 (17.5) | 3 (1.8) | 24 (14.0) | 7 (4.1) | 3 (1.8) |
Anti-inflammatory drugs - n, % | 89 (56.0) | 34 (21.4) | 8 (5.0) | 17 (10.7) | 10 (6.3) | 1 (0.6) |
Antibiotics - n, % | 86 (50.3) | 45 (26.3) | 6 (3.5) | 24 (14.0) | 8 (4.7) | 1 (0.6) |
Antidepressants - n, % | 110 (54.2) | 28 (13.8) | 2 (1.0) | 33 (16.3) | 17 (8.4) | 13 (6.4) |
Hypnotics/Benzodiazepines - n, % | 143 (72.6) | 15 (7.6) | 1 (0.5) | 23 (11.7) | 10 (5.1) | 5 (2.5) |
Neuroleptics - n, % | 94 (51.6) | 20 (11.0) | 2 (1.1) | 18 (9.9) | 26 (14.3) | 22 (12.1) |
Statins - n, % | 105 (55.6) | 42 (22.2) | 8 (4.2) | 16 (8.5) | 10 (5.3) | 8 (4.2) |
Oral anti-diabetic drugs - n, % | 83 (43.2) | 55 (28.6) | 2 (1.0) | 30 (15.6) | 14 (7.3) | 8 (4.2) |
Diuretics - n, % | 102 (59.6) | 22 (12.9) | 2 (1.2) | 20 (11.7) | 14 (8.2) | 11 (6.4) |
Beta blockers - n, % | 94 (49.7) | 25 (13.2) | 3 (1.6) | 29 (15.3) | 19 (10.1) | 19 (10.1) |
Angiotensin-converting-enzyme inhibitors/ Angiotensin II receptor blockers - n, % | 100 (51.0) | 35 (17.9) | 1 (0.5) | 25 (12.8) | 13 (6.6) | 22 (11.2) |
Oral contraceptives - n, % | 110 (68.3) | 19 (11.8) | 2 (1.2) | 16 (9.9) | 12 (7.5) | 2 (1.2) |