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Table 6 Most frequent reasons for using the NGS mention for 18 therapeutic classes

From: Factors influencing the use of the “not for generic substitution” mention for prescriptions in primary care: a survey with general practitioners

Drug Most frequent reasons for using the NGSa mention
Patient request Benign adverse drug reaction Severe adverse drug reaction Biological or clinical inequivalence to the brand-name drug Class with increased risk (inter-individual variations, interactions, narrow therapeutic range …) Compliance with specialist prescription
Antiplatelet agents - n, % 64(27.6) 11 (4.7) 8 (3.4) 28 (12.1) 41 (17.7) 80 (34.5)
Thyroid hormones - n, % 29 (11.3) 7 (2.7) 3 (1.2) 105 (41.0) 73 (28.5) 39 (15.2)
Antiepileptic drugs - n, % 41 (16.7) 2 (0.8) 3 (1.2) 55 (22.4) 91 (37.0) 54 (22.0)
Antiacids - n, % 112 (55.2) 31 (15.3) 3 (1.5) 47 (23.2) 6 (3.0) 4 (2.0)
Antispasmodic drugs - n, % 106 (76.8) 14 (10.1) 1 (0.7) 14 (10.1) 2 (1.4) 1 (0.7)
Step I analgesics - n, % 107 (77.0) 14 (10.1) 1 (0.7) 9 (6.5) 6 (4.3) 2 (1.4)
Step II/III analgesics - n, % 104 (60.8) 30 (17.5) 3 (1.8) 24 (14.0) 7 (4.1) 3 (1.8)
Anti-inflammatory drugs - n, % 89 (56.0) 34 (21.4) 8 (5.0) 17 (10.7) 10 (6.3) 1 (0.6)
Antibiotics - n, % 86 (50.3) 45 (26.3) 6 (3.5) 24 (14.0) 8 (4.7) 1 (0.6)
Antidepressants - n, % 110 (54.2) 28 (13.8) 2 (1.0) 33 (16.3) 17 (8.4) 13 (6.4)
Hypnotics/Benzodiazepines - n, % 143 (72.6) 15 (7.6) 1 (0.5) 23 (11.7) 10 (5.1) 5 (2.5)
Neuroleptics - n, % 94 (51.6) 20 (11.0) 2 (1.1) 18 (9.9) 26 (14.3) 22 (12.1)
Statins - n, % 105 (55.6) 42 (22.2) 8 (4.2) 16 (8.5) 10 (5.3) 8 (4.2)
Oral anti-diabetic drugs - n, % 83 (43.2) 55 (28.6) 2 (1.0) 30 (15.6) 14 (7.3) 8 (4.2)
Diuretics - n, % 102 (59.6) 22 (12.9) 2 (1.2) 20 (11.7) 14 (8.2) 11 (6.4)
Beta blockers - n, % 94 (49.7) 25 (13.2) 3 (1.6) 29 (15.3) 19 (10.1) 19 (10.1)
Angiotensin-converting-enzyme inhibitors/ Angiotensin II receptor blockers - n, % 100 (51.0) 35 (17.9) 1 (0.5) 25 (12.8) 13 (6.6) 22 (11.2)
Oral contraceptives - n, % 110 (68.3) 19 (11.8) 2 (1.2) 16 (9.9) 12 (7.5) 2 (1.2)
  1. aNGS Not for Generic Substitution