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Table 1 Participating Healthcare Systems and Lynch Syndrome Screening by Clinical Site

From: Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts

  Lynch Syndrome Screening Program Typea
  CRC Tumor Screeningb EC Tumor Screeningc
Healthcare System Clinical Site (State) No Program CRC age cutoff BRAF Reflex PHM Reflex EC age cutoff PHM Reflex
Geisinger Geisinger (PA)   All ages X X All ages X
Kaiser Permanente (KP) KP-Colorado (CO) X      
KP-Northwest (OR/WA)   All ages X X All ages X
Sutter Health (SH) SH-Palo Alto Medical Foundation (CA) X      
Meyers Primary Care Institute (MCPI) Reliant Medical Group (MA)   All ages     
HealthPartners HealthPartners (MN)   All ages X X All ages X
Harvard Pilgrim Healthcare Harvard Pilgrim (MA) X      
Catholic Health Initiatives (CHI) Franciscan (WA)   All ages X X All ages X
Tri Health (OH)   All ages X X All ages X
Mercy Des Moines (IA)   All ages X X All ages  
Kentucky One (KY)   All ages     
Chattanooga (TN)   All ages X X All ages X
Good Samaritan (NE) X      
Lincoln (NE)   < 70 years X    
St. Francis (NE) X      
St. Joes Bryan (TX) X      
St. Vincent (AR) X      
Centura (CO)   < 70 years    < 60 years  
Alegent Creighton (OH) X      
St. Alexius (ND) X      
Mercy (ND) X      
  1. aRecommendation: screen all Colorectal cancer (CRC) and Endometrial Cancer (EC) tumors for mismatch repair deficiency
  2. bRecommendation: reflex test positive screens for BRAFV600E point mutation and MLH1 Promoter Hypermethylation (PHM) testing to rule out somatic loss of function (sporadic cancer)
  3. cRecommendation: reflex test positive screens for PHM to rule out somatic loss of function (sporadic cancer)