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Table 2 PPV and 95% CI of serious hypocalcemia and serious dermatologic adverse event claims from emergency departments or inpatient facilities within the PMO study population

From: Predictive values of diagnostic codes for identifying serious hypocalcemia and dermatologic adverse events among women with postmenopausal osteoporosis in a commercial health plan database

Event of interest

Charts requested

Charts obtained

Confirmed cases

N

N

n

PPV %a

95% CIb

Hypocalcemia

 Overall

55

40

16

 

(24.9–56.7)

 By site of care

  Emergency department

12

11

9

81.8

(48.2–97.7)

  Hospital

43

29

7

24.1

(10.3–43.5)

 By provider specialtyc

  Emergency medicine

31

24

13

54.2

(32.8–74.4)

  Internal medicine

33

21

5

23.8

(8.2–47.2)

  Cardiology

26

16

3

18.8

(4.0–45.6)

  Other specialtiesd

44

30

8

26.7

(12.3–45.9)

 With inclusion of incidental casese

55

40

28

70.0

(54.6–81.9)

Dermatologic adverse events

 Overall

265f

184

128

69.6

(62.4–76.1)

  Bullous dermatoses

6

3

1

33.3

(0.8–90.6)

  Erythematous event

15

9

5

55.6

(21.2–86.3)

  Urticaria or rash

247

173

122

70.5

(63.1–77.2)

 By site of care

  Emergency department

   Overall

214

148

114

77.0

(69.4–83.5)

    Bullous dermatoses

1

0

0

    Erythematous event

7

3

2

66.7

(9.4–99.2)

    Urticaria or rash

207

145

112

77.2

(69.5–83.8)

  Hospital

   Overall

51

36

14

38.9

(23.1–56.5)

    Bullous dermatoses

5

3

1

33.3

(0.8–90.6)

    Erythematous event

8

6

3

50.0

(11.8–88.2)

    Urticaria or rash

40

28

10

35.7

(18.6–55.9)

 By provider specialtyc

  Emergency medicine

   Overall

192

137

107

78.1

(70.2–84.7)

    Bullous dermatoses

9

6

4

66.7

(22.3–95.7)

    Erythematous event

3

2

1

50.0

(1.3–98.7)

    Urticaria or rash

181

129

102

79.1

(71.0–85.7)

  Internal medicine

   Overall

43

30

14

46.7

(28.3–65.7)

    Bullous dermatoses

5

4

2

50.0

(6.8–93.2)

    Erythematous event

3

2

1

50.0

(1.3–98.7)

    Urticaria or rash

37

25

11

44.0

(24.4–65.1)

  Dermatology

   Overall

21

13

5

38.5

(13.9–68.4)

    Bullous dermatoses

7

6

3

50.0

(11.8–88.2)

    Erythematous event

3

1

0

0.0

(0.0–97.5)

    Urticaria or rash

13

7

2

28.6

(3.7–71.0)

  Family/general practice

   Overall

34

22

11

50.0

(28.2–71.8)

    Bullous dermatoses

3

1

1

100

(2.5–100)

    Erythematous event

1

1

1

100

(2.5–100)

    Urticaria or rash

30

20

9

45.0

(23.1–68.5)

  Other specialtiesd

   Overall

56

40

17

42.5

(27.0–59.1)

    Bullous dermatoses

8

6

3

50.0

(11.8–88.2)

    Erythematous event

5

3

1

33.3

(0.8–90.6)

    Urticaria or rash

45

32

13

40.6

(23.7–59.4)

 With inclusion of incidental casesg

  Overall

265f

184

137

74.5

(67.7–80.2)

   Bullous dermatoses

6

3

1

33.3

(0–70.8)

   Erythematous event

15

9

6

66.7

(35.4–87.9)

   Urticaria or rash

247

173

131

75.7

(68.8–81.5)

  1. Abbreviations: PMO Post-Menopausal Osteoporosis, PPV positive predictive value, CI confidence interval
  2. aNumber of confirmed cases divided by number of obtained charts
  3. bCI calculated using binomial exact method
  4. cTreating providers may have more than one specialties. Thus, each potential case may be counted under multiple provider specialties.
  5. dOther outpatient specialties were grouped due to small sample sizes
  6. eIncluded cases of medical record confirmed hypocalcemia which were listed in the record as a secondary reason for the emergency department or hospital visit
  7. fThree potential dermatologic adverse events had qualifying codes for multiple dermatologic subtypes.
  8. gIncluded cases of medical record confirmed dermatologic adverse events which were listed in the record as a secondary reason for the emergency department or hospital visit