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Table 2 PPV and 95% CI of serious hypocalcemia and serious dermatologic adverse event claims from emergency departments or inpatient facilities within the PMO study population

From: Predictive values of diagnostic codes for identifying serious hypocalcemia and dermatologic adverse events among women with postmenopausal osteoporosis in a commercial health plan database

Event of interest Charts requested Charts obtained Confirmed cases
N N n PPV %a 95% CIb
Hypocalcemia
 Overall 55 40 16   (24.9–56.7)
 By site of care
  Emergency department 12 11 9 81.8 (48.2–97.7)
  Hospital 43 29 7 24.1 (10.3–43.5)
 By provider specialtyc
  Emergency medicine 31 24 13 54.2 (32.8–74.4)
  Internal medicine 33 21 5 23.8 (8.2–47.2)
  Cardiology 26 16 3 18.8 (4.0–45.6)
  Other specialtiesd 44 30 8 26.7 (12.3–45.9)
 With inclusion of incidental casese 55 40 28 70.0 (54.6–81.9)
Dermatologic adverse events
 Overall 265f 184 128 69.6 (62.4–76.1)
  Bullous dermatoses 6 3 1 33.3 (0.8–90.6)
  Erythematous event 15 9 5 55.6 (21.2–86.3)
  Urticaria or rash 247 173 122 70.5 (63.1–77.2)
 By site of care
  Emergency department
   Overall 214 148 114 77.0 (69.4–83.5)
    Bullous dermatoses 1 0 0
    Erythematous event 7 3 2 66.7 (9.4–99.2)
    Urticaria or rash 207 145 112 77.2 (69.5–83.8)
  Hospital
   Overall 51 36 14 38.9 (23.1–56.5)
    Bullous dermatoses 5 3 1 33.3 (0.8–90.6)
    Erythematous event 8 6 3 50.0 (11.8–88.2)
    Urticaria or rash 40 28 10 35.7 (18.6–55.9)
 By provider specialtyc
  Emergency medicine
   Overall 192 137 107 78.1 (70.2–84.7)
    Bullous dermatoses 9 6 4 66.7 (22.3–95.7)
    Erythematous event 3 2 1 50.0 (1.3–98.7)
    Urticaria or rash 181 129 102 79.1 (71.0–85.7)
  Internal medicine
   Overall 43 30 14 46.7 (28.3–65.7)
    Bullous dermatoses 5 4 2 50.0 (6.8–93.2)
    Erythematous event 3 2 1 50.0 (1.3–98.7)
    Urticaria or rash 37 25 11 44.0 (24.4–65.1)
  Dermatology
   Overall 21 13 5 38.5 (13.9–68.4)
    Bullous dermatoses 7 6 3 50.0 (11.8–88.2)
    Erythematous event 3 1 0 0.0 (0.0–97.5)
    Urticaria or rash 13 7 2 28.6 (3.7–71.0)
  Family/general practice
   Overall 34 22 11 50.0 (28.2–71.8)
    Bullous dermatoses 3 1 1 100 (2.5–100)
    Erythematous event 1 1 1 100 (2.5–100)
    Urticaria or rash 30 20 9 45.0 (23.1–68.5)
  Other specialtiesd
   Overall 56 40 17 42.5 (27.0–59.1)
    Bullous dermatoses 8 6 3 50.0 (11.8–88.2)
    Erythematous event 5 3 1 33.3 (0.8–90.6)
    Urticaria or rash 45 32 13 40.6 (23.7–59.4)
 With inclusion of incidental casesg
  Overall 265f 184 137 74.5 (67.7–80.2)
   Bullous dermatoses 6 3 1 33.3 (0–70.8)
   Erythematous event 15 9 6 66.7 (35.4–87.9)
   Urticaria or rash 247 173 131 75.7 (68.8–81.5)
  1. Abbreviations: PMO Post-Menopausal Osteoporosis, PPV positive predictive value, CI confidence interval
  2. aNumber of confirmed cases divided by number of obtained charts
  3. bCI calculated using binomial exact method
  4. cTreating providers may have more than one specialties. Thus, each potential case may be counted under multiple provider specialties.
  5. dOther outpatient specialties were grouped due to small sample sizes
  6. eIncluded cases of medical record confirmed hypocalcemia which were listed in the record as a secondary reason for the emergency department or hospital visit
  7. fThree potential dermatologic adverse events had qualifying codes for multiple dermatologic subtypes.
  8. gIncluded cases of medical record confirmed dermatologic adverse events which were listed in the record as a secondary reason for the emergency department or hospital visit
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