Table 3 Genetic testing completion, results and use of information
From: Impact of a genetic counseling requirement prior to genetic testing
GC Requirement Policy | ||||
|---|---|---|---|---|
Total N (%) | Before N (%) | After N (%) | P-value | |
BRCA1/2 Testing Completion | n = 1247 | n = 297 | n = 940 | |
Yes | 966 (77.5%) | 243 (81.5%) | 723 (76.2%) | 0.13 |
No | 271 (21.7%) | 54 (18.1%) | 217 (22.9%) | |
Unknown/Missing/Declined | 10 (0.8%) | 1 (0.3%) | 9 (1%) | |
BRCA1/2 Test Results | n = 966 | n = 243 | n = 723 | |
Mutation | 89 (9.2%) | 26 (10.7%) | 63 (8.7%) | 0.55 |
No Mutation | 821 (85.0%) | 204 (84.0%) | 615 (85.3%) | |
Results Uncertain | 19 (2.0%) | 6 (2.5%) | 13 (1.8%) | |
Do not Understand Results | 8 (0.8%) | 0 (0.0%) | 8 (1.1%) | |
Unknown | 8 (0.8%) | 2 (0.8%) | 6 (0.8%) | |
Missing/Declined | 21 (2.2%) | 5 (2.1%) | 16 (2.2%) | |
Most commonly reported use of genetic testing resultsa | n = 966 | n = 243 | n = 723 | |
Talked with Family Members about Results | 590 (47.3%) | 147 (60.5%) | 443 (61.3%) | 0.42 |
Routine Breast Cancer Screenings | 329 (26.4%) | 71 (29.2%) | 258 (35.7%) | 0.25 |
Plan Cancer Treatment | 173 (13.9%) | 42 (17.3%) | 131 (18.1%) | 0.90 |
Additional Breast Cancer Screening with MRI utilized | 53 (4.3%) | 10 (4.1%) | 43 (6.0%) | 0.38 |
Surgery to Remove Breast or Ovaries to prevent Cancer | 40 (3.2%) | 11 (4.5%) | 29 (4.0%) | 0.59 |
Other | 39 (3.1%) | 17 (7.0%) | 22 (3.0%) | 0.003 |
Most commonly reported reasons for why BRCA1/2 testing was not completeda | n = 271 | n = 54 | n = 217 | |
Insurance issues/requirements | 165 (60.9%) | 39 (72.2%) | 126 (58.1%) | 0.06 |
Costs | 129 (47.6%) | 38 (70.4%) | 91 (41.9%) | 0.0002 |
Testing not recommended by GC | 56 (20.7%) | 3 (5.6%) | 53 (24.4%) | 0.002 |
Testing recommended for another family member | 24 (8.9%) | 4 (7.4%) | 20 (9.2%) | 0.79 |
Likelihood low so decided against testing | 18 (6.6%) | 1 (1.9%) | 17 (7.8%) | 0.14 |