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Table 1 Demographic and clinical features and genetic testing rationale

From: Impact of a genetic counseling requirement prior to genetic testing

  Total N (%) GC Requirement Policy BRCA1/2 Testing
Before N (%) After N (%) P-value Tested N (%) Not Tested N (%) P-value
Total 1247 297 (23.8) 940 (75.4) n/a 966 (77.5) 271 (21.7) n/a
Gender (F) 1227 (98.4) 293 (98.3) 934 (98.4) 0.99 950 (98.3) 267 (98.5) 0.29
Ethnicity
 Caucasian 1028 (82.4) 250 (83.9) 778 (82.0) 0.27 801 (82.9) 219 (80.8) 0.26
 Hispanic/Latino 83 (6.7) 13 (4.4) 70 (7.4) 58 (6.0) 24 (8.9)
 Black or African American 69 (5.5) 18 (6.0) 51 (5.4) 54 (5.6) 15 (5.5)
 Other 64 (5.1) 17 (5.7) 47 (5.0) 50 (5.2) 13 (4.8)
Age Range (years)
 18–35 165 (13.2) 26 (8.7) 139 (14.7) 0.01 125 (12.9) 36 (13.3) 0.47
 36–45 347 (27.8) 78 (26.2) 269 (28.4) 269 (27.8) 77 (28.4)
 46–55 412 (33.0) 98 (32.9) 314 (33.1) 323 (33.4) 87 (32.1)
 56+ 318 (25.5) 94 (31.5) 224 (23.6) 224 (25.6) 68 (25.1)
Household Income
 < $24,999 29 (2.3) 8 (2.7) 21 (2.2) 0.88 15 (1.6) 14 (5.2) 0.011
 $25,000–$49,999 149 (12.0) 33 (11.1) 116 (12.2) 113 (11.7) 35 (12.9)
 $50,000–$99,999 395 (31.7) 100 (33.6) 295 (31.1) 309 (32) 83 (30.6)
 $100,000+ 622 (49.9) 146 (49.0) 476 (50.2) 493 (51) 125 (46.1)
 Missing/Declined 52 (4.2) 11 (3.7) 41 (4.3) 36 (3.7) 14 (5.2)
Personal History
 Any Breast Cancer 347 (27.8) 93 (31.2) 254 (26.8) 0.14 307 (31.8) 38 (14) < 0.0001
 Any Ovarian Cancer 29 (2.3) 5 (1.7) 24 (2.5) 0.40 24 (2.5) 5 (1.8) 0.53
 Any Other Cancer 52 (4.2) 14 (4.7) 38 (4.0) 0.60 37 (3.8) 14 (5.2) 0.34
 Cancer Free 824 (66.1) 191 (64.1) 633 (66.7) 0.41 601 (62.2) 217 (80.1) < 0.0001
Family History
 Any Breast Cancer 504 (40.4) 120 (40.3) 384 (4.0) 0.95 383 (39.6) 118 (43.5) 0.25
 Ovarian Cancer 97 (7.8) 26 (8.7) 71 (7.5) 0.48 84 (8.7) 12 (4.4) 0.014
 Any Other Cancer 222 (17.8) 45 (15.1) 177 (18.7) 0.16 150 (15.5) 71 (26.2) < 0.0001
 Cancer Free 367 (29.4) 92 (30.9) 27 (29.0) 0.53 294 (30.4) 71 (26.2) 0.17
BRCA1/2 Test Requester
 Any Doctor 891 (71.5) 193 (64.8) 698 (73.6) 0.0034 693 (71.7) 189 (69.7) 0.52
 Any Patient 392 (31.4) 120 (40.3) 272 (28.7) 0.0002 309 (32) 81 (29.9) 0.51
 Any Neither 17 (1.4) 6 (2.0) 11 (1.2) 0.26 3 (0.3) 14 (5.2) < 0.0001
 Any Other 41 (3.3) 11 (3.7) 30 (3.2) 0.65 34 (3.5) 7 (2.6) 0.43
Top Reasons for Pursuing BRCA1/2 Testing
 To determine risks for family members 605 (48.5) 146 (49.0) 459 (48.4) 0.85 474 (49.1) 126 (46.5) 0.45
 To help plan cancer screening 491 (39.4) 117 (39.3) 374 (39.4) 0.96 367 (38) 118 (43.5) 0.10
 To help plan cancer treatment 205 (16.4) 48 (16.1) 157 (16.5) 0.86 190 (19.7) 13 (4.8) < 0.0001
 Because mutations are a common cause of breast cancer 148 (11.9) 27 (9.1) 121 (12.8) 0.09 126 (13) 19 (7.0) 0.004
  1. Categories are non-exclusive