Table 1 Demographic and clinical features and genetic testing rationale
From: Impact of a genetic counseling requirement prior to genetic testing
Total N (%) | GC Requirement Policy | BRCA1/2 Testing | |||||
|---|---|---|---|---|---|---|---|
Before N (%) | After N (%) | P-value | Tested N (%) | Not Tested N (%) | P-value | ||
Total | 1247 | 297 (23.8) | 940 (75.4) | n/a | 966 (77.5) | 271 (21.7) | n/a |
Gender (F) | 1227 (98.4) | 293 (98.3) | 934 (98.4) | 0.99 | 950 (98.3) | 267 (98.5) | 0.29 |
Ethnicity | |||||||
Caucasian | 1028 (82.4) | 250 (83.9) | 778 (82.0) | 0.27 | 801 (82.9) | 219 (80.8) | 0.26 |
Hispanic/Latino | 83 (6.7) | 13 (4.4) | 70 (7.4) | 58 (6.0) | 24 (8.9) | ||
Black or African American | 69 (5.5) | 18 (6.0) | 51 (5.4) | 54 (5.6) | 15 (5.5) | ||
Other | 64 (5.1) | 17 (5.7) | 47 (5.0) | 50 (5.2) | 13 (4.8) | ||
Age Range (years) | |||||||
18–35 | 165 (13.2) | 26 (8.7) | 139 (14.7) | 0.01 | 125 (12.9) | 36 (13.3) | 0.47 |
36–45 | 347 (27.8) | 78 (26.2) | 269 (28.4) | 269 (27.8) | 77 (28.4) | ||
46–55 | 412 (33.0) | 98 (32.9) | 314 (33.1) | 323 (33.4) | 87 (32.1) | ||
56+ | 318 (25.5) | 94 (31.5) | 224 (23.6) | 224 (25.6) | 68 (25.1) | ||
Household Income | |||||||
< $24,999 | 29 (2.3) | 8 (2.7) | 21 (2.2) | 0.88 | 15 (1.6) | 14 (5.2) | 0.011 |
$25,000–$49,999 | 149 (12.0) | 33 (11.1) | 116 (12.2) | 113 (11.7) | 35 (12.9) | ||
$50,000–$99,999 | 395 (31.7) | 100 (33.6) | 295 (31.1) | 309 (32) | 83 (30.6) | ||
$100,000+ | 622 (49.9) | 146 (49.0) | 476 (50.2) | 493 (51) | 125 (46.1) | ||
Missing/Declined | 52 (4.2) | 11 (3.7) | 41 (4.3) | 36 (3.7) | 14 (5.2) | ||
Personal History | |||||||
Any Breast Cancer | 347 (27.8) | 93 (31.2) | 254 (26.8) | 0.14 | 307 (31.8) | 38 (14) | < 0.0001 |
Any Ovarian Cancer | 29 (2.3) | 5 (1.7) | 24 (2.5) | 0.40 | 24 (2.5) | 5 (1.8) | 0.53 |
Any Other Cancer | 52 (4.2) | 14 (4.7) | 38 (4.0) | 0.60 | 37 (3.8) | 14 (5.2) | 0.34 |
Cancer Free | 824 (66.1) | 191 (64.1) | 633 (66.7) | 0.41 | 601 (62.2) | 217 (80.1) | < 0.0001 |
Family History | |||||||
Any Breast Cancer | 504 (40.4) | 120 (40.3) | 384 (4.0) | 0.95 | 383 (39.6) | 118 (43.5) | 0.25 |
Ovarian Cancer | 97 (7.8) | 26 (8.7) | 71 (7.5) | 0.48 | 84 (8.7) | 12 (4.4) | 0.014 |
Any Other Cancer | 222 (17.8) | 45 (15.1) | 177 (18.7) | 0.16 | 150 (15.5) | 71 (26.2) | < 0.0001 |
Cancer Free | 367 (29.4) | 92 (30.9) | 27 (29.0) | 0.53 | 294 (30.4) | 71 (26.2) | 0.17 |
BRCA1/2 Test Requester | |||||||
Any Doctor | 891 (71.5) | 193 (64.8) | 698 (73.6) | 0.0034 | 693 (71.7) | 189 (69.7) | 0.52 |
Any Patient | 392 (31.4) | 120 (40.3) | 272 (28.7) | 0.0002 | 309 (32) | 81 (29.9) | 0.51 |
Any Neither | 17 (1.4) | 6 (2.0) | 11 (1.2) | 0.26 | 3 (0.3) | 14 (5.2) | < 0.0001 |
Any Other | 41 (3.3) | 11 (3.7) | 30 (3.2) | 0.65 | 34 (3.5) | 7 (2.6) | 0.43 |
Top Reasons for Pursuing BRCA1/2 Testing | |||||||
To determine risks for family members | 605 (48.5) | 146 (49.0) | 459 (48.4) | 0.85 | 474 (49.1) | 126 (46.5) | 0.45 |
To help plan cancer screening | 491 (39.4) | 117 (39.3) | 374 (39.4) | 0.96 | 367 (38) | 118 (43.5) | 0.10 |
To help plan cancer treatment | 205 (16.4) | 48 (16.1) | 157 (16.5) | 0.86 | 190 (19.7) | 13 (4.8) | < 0.0001 |
Because mutations are a common cause of breast cancer | 148 (11.9) | 27 (9.1) | 121 (12.8) | 0.09 | 126 (13) | 19 (7.0) | 0.004 |