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Table 2 Demographic and clinical characteristics

From: Impact on healthcare resource utilization of multiple sclerosis in Spain

  EDSS 0–3.5 EDSS 4.0–9.5 Total p-value
N = 152 N = 70 N = 222  
Geographic regions in Spain, %
 Asturias 30.9 22.9 28.4 0,587
 Catalonia 69.1 77.1 71.6 0,827
Age, years, mean (SD) 42.5 (11.5) 52.2 (12.2) 45.5 (12.5) <0.001
Gender, female, N (%) 68.4 65.7 64.4 0.292
Time since diagnostic, years, mean (SD) 10.5 (7.6) 19.8 (10.2) 13.4 (9.5) <0.001
MS type, %
 RRMS 74.3 35.7 62.2 <0.001
 SPMS 13.8 50.0 25.2 <0.001
 PPMS 7.2 14.3 9.5 0.009
 CIS 4.6 0.0 3.2 <0.001
Relapses during follow-up
 Number of relapses, mean (SD) 0.4 (0.6) 1.2 (1.0) 0.7 (0.9) <0.001
Proportion of population, N (%)
  ≥ 1 36.8 67.1 46.4 <0.001
 1 29.6 18.6 26.1 0.008
 2 6.6 40.0 17.1 <0.001
 3 0.7 8.6 3.2 0.790
Comorbidity, mean (SD)
 Number of comorbidities 4.5 (2.7) 6.0 (3.3) 5.0 (3.0) 0.001
 Charlson Index 0.7 (0.6) 1.0 (0.7) 0.8 (0.6) 0.005
 RUBs, mean 2.9 (0.8) 3.2 (0.7) 3.0 (0.8) 0.003
Proportion of population, N (%)
 1 (healthy o very low morbidity) 3.3 0.0 2.3 <0.001
 2 (low morbidity) 25.7 14.3 22.1 0.038
 3 (moderate morbidity) 52.0 54.3 52.7 0.873
 4 (high morbidity) 18.4 28.6 21.6 0.041
 5 (very high morbidity) 0.7 2.9 1.4 0.031
  1. CIS clinically isolated syndrome, EDSS expanded disability status scale, MS multiple sclerosis, PPMS primary progressive MS, RRMS relapsing remitting MS, RUBs resource utilization bands, SD standard deviation, SPMS secondary-progressive MS