Table 4 MHT-related health outcomes and data sources of relative risks included in reviewed evaluations
From: Menopausal hormone therapy: a systematic review of cost-effectiveness evaluations
MHT-related health outcomes | Publications | ||||
|---|---|---|---|---|---|
Salpeter et al. 2009 [41] | Lekander et al. 2009a [42] | Lekander et al. 2009b [43] | Ylikangas et al. 2007 [44] | Zethraeus et al. 2005 [45] | |
Breast Cancer | WHI (2002, 2004); meta-analysis of studies (2000, 2002); Cochrane database systematic review, 2005; HERS, 1998; MWS, 2003; Collabo-rative reanalysis of data on MHT and breast cancer, 1997; follow-up data from BCDDP, 2000; Danish cohort study, 2004; meta-analysis of WHI + HERS + WEST, 2002; | WHI (2003, 2006) | WHI (2002, 2004) | Events from intervention study: 279/ 419 women allocated to 3 of 4 dose combinations of EV&MA | WHI (2002, 2004) |
Colorectal Cancer | WHI (2002, 2004); review of studies, 2002; meta-analysis of WHI & HERS 2002; CPS-II, 1995; pooled RR from HERS I, II&WHI, 2004; meta-analysis of studies, 1999 | Two WHI study publications (2004) | WHI (2002, 2004) | Events from intervention study (see above) | WHI (2002, 2004) |
Coronary Heart Disease (CHD) | Cardiovascular events presented rather than CHD: NHS (2001, 2002); WHI (2002,2003, 2004, 2006, 2007); meta-analyses (1991, 2000, 2002, 2004, 2005); case control study 1991-1994, HERS,1998; | WHI (2007) | WHI (2002, 2004) | Events from study (see above) | WHI (2002, 2004) |
Deep vein thrombosis (DVT) | Not included | Included under VTD | Included under VTD | Events from study (see above) | Included under VTD |
Dementia | Not included | Not included | Not included | Not included | Not included |
Endometrial Cancer | Not applicable | Not applicable | Not applicable | Not specified but events from the study possibly included | Not applicable |
Fractures (hip, vertebral and other osteoporotic) | WHI (2002,2006); Cochrane systematic review, 2005; Danish osteoporosis prevention study, 2000; literature review, 2001; New Zealand study assessing bone density and factors determining bone loss, 2002; Danish study on MHT effect on fractures, 2006; | WHI (2003, 2006) | WHI (2002, 2004, 2006) | Events from study (see above) | WHI (2002, 2004) |
Gallbladder disease | Not included | Not included | Not included | Not included | Not included |
Ovarian Cancer | Not included | Not included | Not included | Not specified but events from the study possibly included | Not included |
Pulmonary Embolism (PE) | WHI (2002, 2004); two meta-analyses, 2002; data from a decision model of short term MHT on symptom relief, 2004; | Included under VTD | Included under VTD | Events from study (see above) | Included under VTD |
Stroke | Stroke was considered together with CHD as one disease category | WHI (2007) | WHI (2002, 2004) | Events from study (see above) | WHI (2002, 2004) |
Urinary incontinence | Not included | Not included | Not included | Not included | Not included |
Venous thrombo-embolic disease (VTD) | PE events included but not DVT | WHI (2004, 2006) | WHI (2002, 2004) | Covered by DVT and PE | WHI (2002, 2004) |